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1. 发明专利

IL290331D0 Rna-targeting ligands, compositions thereof, and methods of making and using the same 未知
公开(公告)号：IL290331D0
公开(公告)日：2022-04-01
申请号：IL29033122
申请日：2022-02-03
申请人： UNIV NORTH CAROLINA CHAPEL HILL , WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
发明人： WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
IPC分类号： A61K31/498 , A61P43/00
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.

2. 发明专利

IL290331A Rna-targeting ligands, compositions thereof, and methods of making and using the same 未知
公开(公告)号：IL290331A
公开(公告)日：2022-04-01
申请号：IL29033122
申请日：2022-02-03
申请人： UNIV NORTH CAROLINA CHAPEL HILL , WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
发明人： WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.

3. 发明申请

WO2008055292A1 A FLOOR PIER SUPPORT 审中-公开
标题翻译：地板支撑
公开(公告)号：WO2008055292A1
公开(公告)日：2008-05-15
申请号：PCT/AU2007/001680
申请日：2007-11-01
申请人： WEEKS GROUP PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04B5/17 , B66F7/12 , E04C3/00
CPC分类号： E04B5/10 , E02D27/14 , E04B1/003 , E04C3/07 , E04C2003/0452 , E04C2003/0473 , E04F15/02183 , E04F15/02458 , E04F15/02464 , E04F2015/02061
摘要： The present invention relates to a floor pier support and, in particular, to a pier support which allows for in-situ height adjustment of a floor frame mounted thereabove. In particular, the pier support includes a base adapted to be fixed to said surface, a connection member including a first and a second attachment means, the first attachment means used to fix the connection member to a frame element, and the second attachment means being connectable to the base in a configuration which facilitates height adjustment of the frame relative to the base. The pier support of the present invention provides for a strong, robust support for floor frames and is advantageous in that the height of the frame can be easily adjusted at regular intervals post-construction, for maintenance purposes, or for height re-adjustment where for example the ground has subsided over time.
摘要翻译：本发明涉及一种地板墩架支架，特别涉及一种允许现场高度调节安装在其上的地板框架的码头支架。特别地，码头支撑件包括适于固定到所述表面的基部，包括第一和第二附接装置的连接构件，用于将连接构件固定到框架元件的第一附接装置，第二附接装置可以以便于框架相对于基座的高度调节的构造连接到基座。本发明的码头支撑件提供了对于地板框架的坚固的，坚固的支撑，并且有利的是，框架的高度可以容易地在施工后，维护目的或为了高度重新调整而以规则的间隔进行调整，例如，随着时间的推移，地面已经平息下来。

4. 发明申请

WO2004098845A1 ROTARY ON-THE-FLY TOOLING SYSTEM 审中-公开
标题翻译：旋转式在线驱动系统
公开(公告)号：WO2004098845A1
公开(公告)日：2004-11-18
申请号：PCT/AU2004/000585
申请日：2004-05-07
申请人： WEEKS PEACOCK QUALITY HOMES PTY. LTD. , WEEKS, Kevin, William
发明人： WEEKS, Kevin, William
IPC分类号： B26F1/08
CPC分类号： B21D43/028 , B21D28/243 , B21D43/06
摘要： A rotary on-the-fly tooling system including: opposed and synchronised counter-rotating tool assemblies (12, 14) for receiving a workpiece (10) having a direction of travel therebetween during a tooling operation: each counter-rotating tool assembly including (a) at least two co-rotating crank arms (16, 18) of equal length, each crank arm having proximal and distal ends, the proximal ends rotating about a pair of crank axes spaced from, and spaced along, the direction of travel of the workpiece, and (b) a tool mounting portion (24), the distal ends of the crank arms being pivotably mounted to the tool mounting portion at locations spaced along the direction of travel of the workpiece such that the tool mounting portion remains in the same orientation relative to the direction of travel of the workpiece at least during the tooling operation.
摘要翻译：一种旋转飞行模具系统，包括：相对和同步的反向旋转工具组件（12,14），用于在工具操作期间接收具有其间的行进方向的工件（10）;每个反向旋转工具组件包括 a）至少两个相等长度的共同旋转曲柄臂（16,18），每个曲柄臂具有近端和远端，所述近端围绕一对曲柄轴线旋转，所述一对曲柄轴线与所述工件，和（b）工具安装部分（24），所述曲柄臂的所述远端可沿着所述工件行进方向间隔开的位置枢转地安装到所述工具安装部分，使得所述工具安装部分保持在所述工具安装部分至少在加工操作期间相对于工件的行进方向具有相同的取向。

5. 发明申请

WO0103865A3 METHOD OF FORMING A TUBE 审中-公开
标题翻译：形成管的方法
公开(公告)号：WO0103865A3
公开(公告)日：2004-02-05
申请号：PCT/AU0000781
申请日：2000-06-30
申请人： WEEKS PEACOCK QUALITY HOMES , WEEKS KEVIN WILLIAM
发明人： WEEKS KEVIN WILLIAM
IPC分类号： B21C37/10 , B21D39/02 , B21D51/26 , B21D39/03
CPC分类号： B21C37/10 , B21C37/101 , B21D39/02 , Y10T29/49922 , Y10T29/49936
摘要： A method of forming a tube involves the punching of tabs (18) from an overlapping longitudinal seam (12) and folding the tabs (18) to mechanically fix the opposed lateral edges of the sheet material forming the tube (10).
摘要翻译：形成管的方法包括从重叠的纵向接缝（12）冲压突片（18）并折叠翼片（18）以机械地固定形成管（10）的片材的相对的侧边缘。

6. 发明申请

WO0123612A9 DETERMINING MUTATIONS BY SELECTIVE REACTION OF THE 2'-RIBOSE POSITION IN HYBRIDIZED OLIGONUCLEOTIDES 审中-公开
标题翻译：通过选择性反应混合寡核苷酸中的2'-位置决定突变
公开(公告)号：WO0123612A9
公开(公告)日：2002-10-03
申请号：PCT/US0026320
申请日：2000-09-25
申请人： UNIV NORTH CAROLINA , WEEKS KEVIN , CHAMBERLIN STACY I , JOHN DEBORAH M
发明人： WEEKS KEVIN , CHAMBERLIN STACY I , JOHN DEBORAH M
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： New chemical tagging methods and kits of the present invention utilize the discovery that chemical modification ( e.g. , acylation) of 2'-substituted ribonucleotides or deoxyribonucleotides by reactive compounds ( e.g. , activated esters) is sensitive to the base-paired state of the nucleotide. Perfectly base-paired positions are generally unreactive, while mismatched or unmatched bases are reactive under a wide variety of reaction conditions. The methods of the invention include a method of detecting a mutation in a nucleic acid molecule suspected of containing a mutation. The nucleic acid is hybridized to an oligonucleotide having a sequence complementary to the sequence the nucleic acid would have if a mutation were not present. The oligonucleotide comprises at least one nucleotide with a substitution at the 2'-ribose position. After the oligonucleotide is hybridized to the nucleic acid molecule, the hybridized oligonucleotide is then contacted with a reactive compound comprising a reporter moiety. Detection of the binding of the reporter moiety to the hybridized oligonucleotide indicates a mismatch i.e. , a mutation) in the nucleic acid molecule. The methods and kits of the present invention are useful in detecting point mutations and other defects in nucleic acid sequences. These methods and kits are also useful for detecting single nucleotide polymorphisms (SNPs) and mutations responsible for cancer and other genetic diseases in humans; for quantifying amounts of nucleic acids; and for detecting conformational changes in nucleic acid structures, including those found in the products of in vitro selection experiments i.e. , aptamers).
摘要翻译：本发明的新化学标记方法和试剂盒利用了通过反应性化合物（例如活化酯）对2'-取代的核糖核苷酸或脱氧核糖核苷酸的化学修饰（例如酰化）对核苷酸的碱基配对状态敏感的发现。完全碱基配对的位置通常是不反应的，而不匹配或不匹配的碱基在多种反应条件下是反应性的。本发明的方法包括检测疑似含有突变的核酸分子中的突变的方法。如果不存在突变，则核酸与具有与核酸将具有的序列互补的序列的寡核苷酸杂交。寡核苷酸包含至少一个在2'-核糖位置具有取代的核苷酸。寡核苷酸与核酸分子杂交后，然后将杂交的寡核苷酸与包含报道部分的反应性化合物接触。检测报道部分与杂交寡核苷酸的结合表示核酸分子中的错配即突变）。本发明的方法和试剂盒可用于检测核酸序列中的点突变和其他缺陷。这些方法和试剂盒也可用于检测负责人类癌症和其他遗传疾病的单核苷酸多态性（SNPs）和突变; 用于量化核酸量; 并用于检测核酸结构中的构象变化，包括在体外选择实验的产物（即适体）中发现的结构变化。

7. 发明申请

WO2007145940A2 HIGH-THROUGHPUT RNA STRUCTURE ANALYSIS 审中-公开
标题翻译：高通量RNA结构分析
公开(公告)号：WO2007145940A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013226
申请日：2007-06-05
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , WEEKS, Kevin, M. , WILKINSON, Kevin , VASA, Suzy, A. , GIDDINGS, Morgan, C. , GUEX, Nicolas , MORTIMER, Stefanie, A.
发明人： WEEKS, Kevin, M. , WILKINSON, Kevin , VASA, Suzy, A. , GIDDINGS, Morgan, C. , GUEX, Nicolas , MORTIMER, Stefanie, A.
IPC分类号： C12Q1/68
CPC分类号： G06F19/16 , C12Q1/6811 , C12Q2565/133
摘要： Te presently disclosed subject matter relates to technology and methods for analyzing the structure of RNA molecules. More particularly, the presently disclosed subject matter is directed to methods of, compositions for, and computer program products for RNA structure analysis through alkoxide- selective 2'-hydroxyl acylation analyzed by primer extension.
摘要翻译：目前公开的主题涉及用于分析RNA分子结构的技术和方法。更具体地，本公开的主题涉及通过引物延伸分析的通过醇盐选择性2'-羟基酰化进行RNA结构分析的方法，组合物和计算机程序产品。

8. 发明申请

WO2001023612A3 DETERMINING MUTATIONS BY SELECTIVE REACTION OF THE 2'-RIBOSE POSITION IN HYBRIDIZED OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2001023612A3
公开(公告)日：2001-04-05
申请号：PCT/US2000/026320
申请日：2000-09-25
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , WEEKS, Kevin , CHAMBERLIN, Stacy, I. , JOHN, Deborah, M.
发明人： WEEKS, Kevin , CHAMBERLIN, Stacy, I. , JOHN, Deborah, M.
IPC分类号： C12Q1/68
摘要： New chemical tagging methods and kits of the present invention utilize the discovery that chemical modification ( e.g. , acylation) of 2'-substituted ribonucleotides or deoxyribonucleotides by reactive compounds ( e.g. , activated esters) is sensitive to the base-paired state of the nucleotide. Perfectly base-paired positions are generally unreactive, while mismatched or unmatched bases are reactive under a wide variety of reaction conditions. The methods of the invention include a method of detecting a mutation in a nucleic acid molecule suspected of containing a mutation. The nucleic acid is hybridized to an oligonucleotide having a sequence complementary to the sequence the nucleic acid would have if a mutation were not present. The oligonucleotide comprises at least one nucleotide with a substitution at the 2'-ribose position. After the oligonucleotide is hybridized to the nucleic acid molecule, the hybridized oligonucleotide is then contacted with a reactive compound comprising a reporter moiety. Detection of the binding of the reporter moiety to the hybridized oligonucleotide indicates a mismatch i.e. , a mutation) in the nucleic acid molecule. The methods and kits of the present invention are useful in detecting point mutations and other defects in nucleic acid sequences. These methods and kits are also useful for detecting single nucleotide polymorphisms (SNPs) and mutations responsible for cancer and other genetic diseases in humans; for quantifying amounts of nucleic acids; and for detecting conformational changes in nucleic acid structures, including those found in the products of in vitro selection experiments i.e. , aptamers).

9. 发明申请

WO2013016773A1 A MULTI ANGLE ROOF TRUSS TIE-DOWN APPARATUS AND METHOD 审中-公开
标题翻译：多角度倒角装置和方法
公开(公告)号：WO2013016773A1
公开(公告)日：2013-02-07
申请号：PCT/AU2012/000921
申请日：2012-08-06
申请人： WEEKS HOLDINGS PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04C3/02 , E04B1/00 , E04B7/02
CPC分类号： E04B7/045 , E04B1/24 , E04B7/04 , E04B7/063 , E04B2001/2439 , E04B2001/2448 , E04B2001/249 , E04C2003/0482
摘要： The present invention relates to a roof truss tie-down apparatus including a pin and bracket engagement which enables a wall frame to accommodate any style of roof truss at any angle, and a method of constructing such a roof frame.
摘要翻译：屋顶桁架固定装置技术领域本发明涉及一种屋顶桁架固定装置，其包括销和支架接合，其能够使壁架以任何角度适应任何风格的屋顶桁架，以及构造这种屋顶框架的方法。

10. 发明申请

WO2011003143A1 A PREFABRICATED STRUCTURAL BUILDING FRAME AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：一种预制结构建筑框架及其制作方法
公开(公告)号：WO2011003143A1
公开(公告)日：2011-01-13
申请号：PCT/AU2010/000869
申请日：2010-07-07
申请人： WEEKS GROUP PTY LTD , WEEKS, Kevin
发明人： WEEKS, Kevin
IPC分类号： E04C2/22 , E04B1/62
CPC分类号： E04C2/386 , E04B1/08 , E04C2/22 , E04C2/384
摘要： The present invention relates to prefabricated structural building frames and, in particular, to foam-filled exterior wall frames for a building structure such as a house. In a preferred embodiment, each wall frame includes a foam facade on one side of the frame for receiving a finishing material and service cut-outs on the opposed internal side of the frame. The present invention also relates to a method of manufacturing the frames in accordance with building design data.
摘要翻译：本发明涉及预制结构建筑框架，特别涉及用于诸如房屋的建筑结构的泡沫填充的外墙框架。在优选实施例中，每个壁架包括在框架的一侧上的泡沫立面，用于在框架的相对的内侧上接收整理材料和服务切口。本发明还涉及根据建筑物设计数据制造框架的方法。

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