专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0555397A1 POLYPEPTIDE WITH KD HMFG DIFFERENTIATION ANTIGEN BINDING SPECIFICITY 失效
标题翻译：多肽特异性联反对KD HMFG分化抗原。
公开(公告)号：EP0555397A1
公开(公告)日：1993-08-18
申请号：EP92901174.0
申请日：1991-09-16
申请人： JOHN MUIR CANCER & RESEARCH INSITUTE , Ceriani, Roberto Luis, Dr. , Peterson, Jerry Arthur, Dr. , LAROCCA, David James
发明人： CERIANI, Roberto, L. , PETERSON, Jerry, Arthur , LAROCCA, David, James
IPC分类号： A61K31 , A61K39 , A61K47 , A61K48 , A61K49 , A61K51 , A61P35 , A61P37 , C07K14 , C07K16 , C07K19 , C12N15 , C12P21 , C12Q1 , G01N33 , A61K38
CPC分类号： A61K51/1051 , A61K38/00 , A61K39/00 , A61K47/6855 , A61K2123/00 , C07K14/47 , C07K14/745 , C07K16/18 , C07K16/3015 , C07K2319/00 , C07K2319/40 , C12Q1/6881 , C12Q1/6886 , C12Q2600/158
摘要： On décrit un polypeptide qui possède l'activité de liaison d'anticorps de l'antigène de différenciation 46K dalton HMFG (globule gras de lait humain) et/ou une homologie avec au moins une des chaînes légères des facteurs de coagulation V et VIII; ledit polypeptide en tant que protéine de fusion avec un second polypeptide antigénique; un anticorps possédant une affinité pour le polypeptide de la présente invention ou un fragment fonctionnel dudit polypeptide; des méthodes in vivo ou in vitro de vaccination thérapeutique et de détection de la présence du polypeptide, de l'anticorps, de l'ADN et de l'ARN de la présente invention; des séquences d'ADN et d'ARN codant ledit polypeptide ou des fragments dudit polypeptide; des trousses d'essais immunologiques comprenant les anticorps et/ou les polypeptides susmentionnés.

2. 发明专利

AU9057091A POLYPEPTIDE WITH KD HMFG DIFFERENTIATION ANTIGEN BINDING SPECIFICITY 未知
公开(公告)号：AU9057091A
公开(公告)日：1992-05-26
申请号：AU9057091
申请日：1991-09-16
申请人： CERIANI ROBERTO LUIS , JOHN MUIR CANCER & RES INSTITUTE , LAROCCA DAVID JAMES , PETERSON JERRY ARTHUR
发明人： CERIANI ROBERTO L , PETERSON JERRY ARTHUR , LAROCCA DAVID JAMES
IPC分类号： A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , A61P37/02 , C07K14/435 , C07K14/47 , C07K14/705 , C07K14/745 , C07K14/755 , C07K16/00 , C07K16/18 , C07K16/30 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/577 , C07K15/06 , C12N15/11 , C12N15/62
摘要： A polypeptide has the antibody binding activity of the 46K dalton HMFG differentiation antigen and/or homology to at least one of the light chains of clotting factors V and VIII and is also provided as a fusion protein with a second antigenic polypeptide. An antibody has affinity for the polypeptide of the invention or a functional fragment thereof. in vivo and in vitro methods for therapy vaccination and detecting the presence of the polypeptide, the antibody, the DNA and RNA of the invention are provided. DNA and RNA sequences encode the polypeptide of the invention or fragments thereof and immunoassay kits comprise the antibodies and/or polypeptides of the invention.

3. 发明申请

WO03086276A2 COMPOSITIONS AND METHODS FOR PORTAL SPECIFIC GENE DELIVERY AND TREATMENT OF INFECTION 审中-公开
标题翻译：用于门诊特异性基因传递和感染治疗的组合物和方法
公开(公告)号：WO03086276A2
公开(公告)日：2003-10-23
申请号：PCT/US0310081
申请日：2003-04-01
申请人： SELECTIVE GENETICS INC , ABBOTT ROBERT , LAROCCA DAVID , BAIRD ANDREW
发明人： ABBOTT ROBERT , LAROCCA DAVID , BAIRD ANDREW
IPC分类号： A61K48/00 , C07K14/01 , C12N15/113 , C12N15/86 , A61K
CPC分类号： C12N15/1131 , A61K48/00 , C07K14/005 , C07K2319/01 , C12N15/86 , C12N2310/111 , C12N2760/12222 , C12N2795/14043 , C12N2795/14045 , C12N2810/50 , C12N2810/851
摘要： The invention provides platform technology for the treatment of intracellular infections. Compositions and methods of the invention include non-target specific vectors that target infectable cells via linked ligands that bind and internalize through cell surface receptors/moieties associated with infection. The vectors comprise exogenous nucleic acid sequences that are expressed upon internalization into a target cell. Vector associated ligands and nucleic acid molecules may be altered to target different infectious agents. In addition, the invention provides methods of identifying epitopes and ligands capable of directing internalization of a vector and capable of blocking viral entry.
摘要翻译：本发明提供了用于治疗细胞内感染的平台技术。本发明的组合物和方法包括通过连接的配体靶向可感染细胞的非靶特异性载体，其通过细胞表面受体/与感染相关的部分结合并内化。载体包含在内化到靶细胞中表达的外源核酸序列。可以改变载体相关配体和核酸分子以靶向不同的感染因子。此外，本发明提供了鉴定能够引导载体内化并能够阻断病毒进入的表位和配体的方法。

4. 发明申请

WO2002094995A2 METHODS AND COMPOSITIONS USING GENETIC PACKAGE DISPLAY 审中-公开
标题翻译：使用遗传包装显示的方法和组合
公开(公告)号：WO2002094995A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/016001
申请日：2002-05-17
申请人： SELECTIVE GENETICS, INC. , LAROCCA, David , KASSNER, Paul , BAIRD, Andrew , BURG, Michael, Alan
发明人： LAROCCA, David , KASSNER, Paul , BAIRD, Andrew , BURG, Michael, Alan
IPC分类号： C12N
CPC分类号： C40B40/02 , C12N15/1037 , C12Q2600/158
摘要： A genetic package display system and methodology for probing protein-protein interactions that lead to cell transduction, selecting and/or identifying internalizing ligands, target cells and tissues which internalize known or putative ligands, and cell transduction facilitating peptides is provided. A ligand displaying genetic package that carries a selectable marker ( e.g. , reporter, selection, etc.) and presents a ligand on its surface is utilized to identify internalizing ligands, tranduction facilitating peptides, and/or a variety of cells and tissue types for the ability to be successfully transduced by the ligand displaying genetic package. Also provided are methods for evolving a ligand displaying package to facilitate gene delivery or delivery of any desired agent ( e.g. , pharmaceutical, polypeptide, peptide, etc. ) into a cell and/or targeting cellular compartments such as the nucleus, endosome, chloroplast, mitochondria, etc.
摘要翻译：提供了导致细胞转导，选择和/或鉴定内在化配体，靶细胞和内在化已知或推定的配体的组织以及细胞转导促进肽的蛋白质 - 蛋白质相互作用的遗传包装显示系统和方法。用于显示携带可选标记（例如报道，选择等）的遗传包的配体并且在其表面上呈现配体被用于鉴定内化配体，促进肽的转导和/或多种的细胞和组织类型，以通过显示遗传包装的配体成功转导的能力。还提供了用于进化配体展示包以促进任何所需药剂（例如，例如药物，多肽，肽等等）的基因递送或递送至细胞的方法，以及 /或靶向细胞，如细胞核，内体，叶绿体，线粒体等。

5. 发明申请

WO2006130504A3 METHODS FOR IDENTIFYING LIGANDS FOR STEM CELLS AND CELLS DERIVED THEREFROM 审中-公开
标题翻译：用于识别干细胞和其衍生细胞的配体的方法
公开(公告)号：WO2006130504A3
公开(公告)日：2008-02-21
申请号：PCT/US2006020552
申请日：2006-05-26
申请人： ADVANCED CELL TECH INC , WEST MICHAEL D , CHAPMAN KAREN B , LAROCCA DAVID
发明人： WEST MICHAEL D , CHAPMAN KAREN B , LAROCCA DAVID
IPC分类号： C12Q1/68 , A61K38/00 , C07H21/04 , C12N1/20 , C12N7/00 , G01N33/53
CPC分类号： G01N33/56966
摘要： The present invention provides methods for the identification of novel ligands to pluripotent stem cells such as human embryonic stem cells, human embryo-derived cells, and from cells differentiated from such cells, and the use of such ligands in identifying differentiation conditions, purifying cells, and for eliminating such cells from mixtures of varied cell types. The invention also provides methods for the identification of target progenitor cells and cells identified thereby.
摘要翻译：本发明提供用于鉴定多能干细胞（例如人胚胎干细胞，人胚胎源细胞）和从这些细胞分化的细胞的新配体的方法，以及这些配体在鉴定分化条件，纯化细胞，并且用于从不同细胞类型的混合物中消除这种细胞。本发明还提供用于鉴定由此鉴定的靶祖细胞和细胞的方法。

6. 发明申请

WO2006130504A2 METHODS FOR IDENTIFYING LIGANDS FOR STEM CELLS AND CELLS DERIVED THEREFROM 审中-公开
标题翻译：用于识别干细胞和其衍生细胞的配体的方法
公开(公告)号：WO2006130504A2
公开(公告)日：2006-12-07
申请号：PCT/US2006/020552
申请日：2006-05-26
申请人： ADVANCED CELL TECHNOLOGY, INC. , WEST, Michael, D. , CHAPMAN, Karen, B. , LAROCCA, David
发明人： WEST, Michael, D. , CHAPMAN, Karen, B. , LAROCCA, David
CPC分类号： G01N33/56966
摘要： The present invention provides methods for the identification of novel ligands to pluripotent stem cells such as human embryonic stem cells, human embryo-derived cells, and from cells differentiated from such cells, and the use of such ligands in identifying differentiation conditions, purifying cells, and for eliminating such cells from mixtures of varied cell types. The invention also provides methods for the identification of target progenitor cells and cells identified thereby.
摘要翻译：本发明提供用于鉴定多能干细胞（例如人胚胎干细胞，人胚胎源细胞）和从这些细胞分化的细胞的新配体的方法，以及这些配体在鉴定分化条件，纯化细胞，并且用于从不同细胞类型的混合物中消除这种细胞。本发明还提供用于鉴定由此鉴定的靶祖细胞和细胞的方法。

7. 发明申请

WO02094995A3 METHODS AND COMPOSITIONS USING GENETIC PACKAGE DISPLAY 审中-公开
标题翻译：使用遗传包装显示的方法和组合
公开(公告)号：WO02094995A3
公开(公告)日：2003-08-21
申请号：PCT/US0216001
申请日：2002-05-17
申请人： SELECTIVE GENETICS INC , LAROCCA DAVID , KASSNER PAUL , BAIRD ANDREW , BURG MICHAEL ALAN
发明人： LAROCCA DAVID , KASSNER PAUL , BAIRD ANDREW , BURG MICHAEL ALAN
IPC分类号： C12N15/10 , C12Q1/68 , C40B40/02 , C12Q1/70 , C07H21/04 , C12N15/00 , C12P21/06
CPC分类号： C40B40/02 , C12N15/1037 , C12Q2600/158
摘要： A genetic package display system and methodology for probing protein-protein interactions that lead to cell transduction, selecting and/or identifying internalizing ligands, target cells and tissues which internalize known or putative ligands, and cell transduction facilitating peptides is provided. A ligand displaying genetic package that carries a selectable marker (e.g., reporter, selection, etc.) and presents a ligand on its surface is utilized to identify internalizing ligands, tranduction facilitating peptides, and/or a variety of cells and tissue types for the ability to be successfully transduced by the ligand displaying genetic package. Also provided are methods for evolving a ligand displaying package to facilitate gene delivery or delivery of any desired agent (e.g., pharmaceutical, polypeptide, peptide, etc.) into a cell and/or targeting cellular compartments such as the nucleus, endosome, chloroplast, mitochondria, etc.
摘要翻译：提供了导致细胞转导，选择和/或鉴定内在化配体，靶细胞和内在化已知或推定的配体的组织以及细胞转导促进肽的蛋白质 - 蛋白质相互作用的遗传包装显示系统和方法。用于显示携带选择标记（例如报告物，选择等）并在其表面上呈现配体的遗传包装的配体用于鉴定内化配体，促进肽的转导和/或多种细胞和组织类型，用于通过显示遗传包装的配体成功转导的能力。还提供了用于进化配体显示包以促进基因递送或将任何所需试剂（例如药物，多肽，肽等）递送至细胞和/或靶向细胞，例如细胞核，内体，叶绿体，线粒体等

8. 发明申请

WO1992007939A2 POLYPEPTIDE WITH KD HMFG DIFFERENTIATION ANTIGEN BINDING SPECIFICITY 审中-公开
标题翻译：具有KD HMFG差异抗原抗体结合特异性的多肽
公开(公告)号：WO1992007939A2
公开(公告)日：1992-05-14
申请号：PCT/US1991006656
申请日：1991-09-16
申请人： JOHN MUIR CANCER & RESEARCH INSTITUTE , CERIANI, Roberto, L. , PETERSON, Jerry, Arthur , LAROCCA, David, James
发明人： JOHN MUIR CANCER & RESEARCH INSTITUTE
IPC分类号： C12N15/12
CPC分类号： A61K51/1051 , A61K38/00 , A61K39/00 , A61K47/6855 , A61K2123/00 , C07K14/47 , C07K14/745 , C07K16/18 , C07K16/3015 , C07K2319/00 , C07K2319/40 , C12Q1/6881 , C12Q1/6886 , C12Q2600/158
摘要： A polypeptide has the antibody binding activity of the 46K dalton HMFG differentiation antigen and/or homology to at least one of the light chains of clotting factors V and VIII and is also provided as a fusion protein with a second antigenic polypeptide. An antibody has affinity for the polypeptide of the invention or a functional fragment thereof. In vivo and in vitro methods for therapy vaccination and detecting the presence of the polypeptide, the antibody, the DNA and RNA of the invention are provided. DNA and RNA sequences encode the polypeptide of the invention or fragments thereof and immunoassay kits comprise the antibodies and/or polypeptides of the invention.
摘要翻译：多肽具有46K道尔顿HMFG分化抗原的抗体结合活性和/或与凝血因子V和VIII的至少一个轻链的同源性，并且还作为与第二抗原多肽的融合蛋白提供。抗体对本发明的多肽或其功能片段具有亲和力。提供了用于治疗疫苗接种和检测本发明的多肽，抗体，DNA和RNA的存在的体内和体外方法。 DNA和RNA序列编码本发明的多肽或其片段，免疫测定试剂盒包含本发明的抗体和/或多肽。

9. 发明申请

WO9207939A3 POLYPEPTIDE WITH KD HMFG DIFFERENTIATION ANTIGEN BINDING SPECIFICITY 审中-公开
标题翻译：具有KD HMFG差异抗原抗体结合特异性的多肽
公开(公告)号：WO9207939A3
公开(公告)日：1992-10-15
申请号：PCT/US9106656
申请日：1991-09-16
申请人： MUIR JOHN CANCER & RES , CERIANI ROBERTO LUIS , PETERSON JERRY ARTHUR , LAROCCA DAVID JAMES
发明人： CERIANI ROBERTO L , PETERSON JERRY ARTHUR , LAROCCA DAVID JAMES
IPC分类号： A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/10 , A61P35/00 , A61P37/02 , C07K14/435 , C07K14/47 , C07K14/705 , C07K14/745 , C07K14/755 , C07K16/00 , C07K16/18 , C07K16/30 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/577 , C07K15/06 , C12N15/11 , C12N15/62
CPC分类号： A61K51/1051 , A61K38/00 , A61K39/00 , A61K47/6855 , A61K2123/00 , C07K14/47 , C07K14/745 , C07K16/18 , C07K16/3015 , C07K2319/00 , C07K2319/40 , C12Q1/6881 , C12Q1/6886 , C12Q2600/158
摘要： A polypeptide has the antibody binding activity of the 46K dalton HMFG differentiation antigen and/or homology to at least one of the light chains of clotting factors V and VIII and is also provided as a fusion protein with a second antigenic polypeptide. An antibody has affinity for the polypeptide of the invention or a functional fragment thereof. In vivo and in vitro methods for therapy vaccination and detecting the presence of the polypeptide, the antibody, the DNA and RNA of the invention are provided. DNA and RNA sequences encode the polypeptide of the invention or fragments thereof and immunoassay kits comprise the antibodies and/or polypeptides of the invention.

10. 发明申请

WO2003086276A3 COMPOSITIONS AND METHODS FOR PORTAL SPECIFIC GENE DELIVERY AND TREATMENT OF INFECTION 审中-公开
公开(公告)号：WO2003086276A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010081
申请日：2003-04-01
申请人： SELECTIVE GENETICS, INC. , ABBOTT, Robert , LAROCCA, David , BAIRD, Andrew
发明人： ABBOTT, Robert , LAROCCA, David , BAIRD, Andrew
IPC分类号： A61K48/00
摘要： The invention provides platform technology for the treatment of intracellular infections. Compositions and methods of the invention include non-target specific vectors that target infectable cells via linked ligands that bind and internalize through cell surface receptors/moieties associated with infection. The vectors comprise exogenous nucleic acid sequences that are expressed upon internalization into a target cell. Vector associated ligands and nucleic acid molecules may be altered to target different infectious agents. In addition, the invention provides methods of identifying epitopes and ligands capable of directing internalization of a vector and capable of blocking viral entry.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式