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1. 发明申请

US20080233049A1 Agents And Methods For Early Diagnosis And Monitoring Of Alzheimer's Disease And Other Neurological Disorders 审中-公开
标题翻译：早期诊断和监测阿尔茨海默病和其他神经系统疾病的代理和方法
公开(公告)号：US20080233049A1
公开(公告)日：2008-09-25
申请号：US11571241
申请日：2005-06-23
申请人： Hiroaki Tani , Ian Andrew Ferguson
发明人： Hiroaki Tani , Ian Andrew Ferguson
IPC分类号： A61K49/00 , A61K49/04
CPC分类号： A61K38/03 , A61K49/0043 , A61K49/0097 , C07K2319/735 , C12N2795/14043 , C12N2795/14045 , C12N2810/40 , C12N2810/859
摘要： This invention is in the fields of medicine and neurology, and relates to methods and agents for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders. More particularly, the present invention provides the method for evaluating the health of central nervous system neurons in a human patient, comprising the steps of: a) administering to said patient a population of molecular complexes comprising (i) a polypeptide capable of activating neuronal endocytosis, axonal transport, and synaptic transfer; and (ii) an imaging agent suited for determining location and evaluating neuronal transport of said molecular complexes within said patient; and b) using at least one imaging method to determine location and evaluate neuronal transport of said molecular complexes within said patient.
摘要翻译：本发明涉及医学和神经学领域，涉及用于早期诊断和监测阿尔茨海默病和其他神经障碍的方法和试剂。更具体地，本发明提供了评估人类患者中枢神经系统神经元健康的方法，包括以下步骤：a）向所述患者施用一组分子复合物，其包含（i）能够激活神经元内吞的多肽，轴突运输和突触转移; 和（ii）适于确定所述患者内所述分子复合物的位置和评估神经元运输的成像剂; 以及b）使用至少一种成像方法来确定所述患者内所述分子复合物的位置和评估神经元运输。

2. 发明申请

WO2008148164A1 NASAL-ADMINISTERED VACCINES USING MULTI-SCREENED NALT-TARGETING AND PHAGOCYTIC POLYPEPTIDE TRANSPORT SEQUENCES 审中-公开
标题翻译：使用多层筛选和药代动力学运输序列的NASAL-管理疫苗
公开(公告)号：WO2008148164A1
公开(公告)日：2008-12-11
申请号：PCT/AU2008/000811
申请日：2008-06-06
申请人： FERGUSON, Ian Andrew
发明人： FERGUSON, Ian Andrew
IPC分类号： A61K35/76 , A61K38/02 , A61K39/12
CPC分类号： A61K39/12 , A61K35/13 , A61K39/00 , A61K2039/543 , C12N2795/14042 , C12N2795/14045
摘要： Multiple sequential screening tests have been performed on phage display libraries, and polypeptide sequences have been identified that potently drive both: (i) intake into mucosal immune cells, including NALT cells in the nose and throat; and, (ii) phagocytic intake and processing by antigen-presenting cells, such as macrophages. Such polypeptide sequences can be used as potent "target and deliver" components in vaccines that can be administered nasally, or to other mucous membranes. Such vaccines can be made very rapidly and in huge quantities, from bacteriophages that will also carry antigenic sequences in their coat proteins, or other immunoactive components. Alternately, such "target and deliver" polypeptides can be incorporated into vaccines derived from eukaryotic viruses or cellular pathogens. Enhancements also are disclosed, such as agents that can activate one or more types of toll-like receptors, to increase immune responses and guide them in desired directions.
摘要翻译：已经对噬菌体展示文库进行了多次连续的筛选测试，并且已经鉴定出有效驱动两者的多肽序列：（i）摄入到粘膜免疫细胞，包括鼻和喉部的NALT细胞; 和（ii）由抗原呈递细胞如巨噬细胞吞噬摄入和加工。这样的多肽序列可以用作可以被鼻腔或其它粘膜施用的疫苗中的有效的“靶和递送”成分。这样的疫苗可以非常迅速地并且大量地从还会在其外壳蛋白或其它免疫活性成分中携带抗原序列的噬菌体制备。或者，这样的“靶和递送”多肽可以并入来自真核病毒或细胞病原体的疫苗中。还公开了增强剂，例如可以激活一种或多种类型的toll样受体的药剂，以增加免疫应答并将它们引导到期望的方向。

3. 发明公开

EP2167110A4 NASAL-ADMINISTERED VACCINES USING MULTI-SCREENED NALT-TARGETING AND PHAGOCYTIC POLYPEPTIDE TRANSPORT SEQUENCES 审中-公开
标题翻译：具有多筛选NALT定位和吞噬多肽序列TRANSPORT鼻使用的疫苗
公开(公告)号：EP2167110A4
公开(公告)日：2012-02-29
申请号：EP08756895
申请日：2008-06-06
申请人： FERGUSON IAN ANDREW
发明人： FERGUSON IAN ANDREW
IPC分类号： A61K35/76 , A61K38/02 , A61K39/12
CPC分类号： A61K39/12 , A61K35/13 , A61K39/00 , A61K2039/543 , C12N2795/14042 , C12N2795/14045
摘要： Multiple sequential screening tests have been performed on phage display libraries, and polypeptide sequences have been identified that potently drive both: (i) intake into mucosal immune cells, including NALT cells in the nose and throat; and, (ii) phagocytic intake and processing by antigen-presenting cells, such as macrophages. Such polypeptide sequences can be used as potent "target and deliver" components in vaccines that can be administered nasally, or to other mucous membranes. Such vaccines can be made very rapidly and in huge quantities, from bacteriophages that will also carry antigenic sequences in their coat proteins, or other immunoactive components. Alternately, such "target and deliver" polypeptides can be incorporated into vaccines derived from eukaryotic viruses or cellular pathogens. Enhancements also are disclosed, such as agents that can activate one or more types of toll-like receptors, to increase immune responses and guide them in desired directions.

4. 发明公开

EP1073671A1 TARGETED GENE DELIVERY TO CELLS BY FILAMENTOUS BACTERIOPHAGE 审中-公开
标题翻译：针对细胞丝状噬菌体基因传递
公开(公告)号：EP1073671A1
公开(公告)日：2001-02-07
申请号：EP99919789.0
申请日：1999-04-23
申请人： The Regents of the University of California
发明人： MARKS, James, D. , POUL, Marie, Alix , BECERRIL, Baltazar
IPC分类号： C07H21/04 , C12N7/00 , C12N7/04 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6843 , C07K16/2863 , C07K16/2881 , C07K16/32 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/02 , C12N15/86 , C12N2795/14022 , C12N2795/14043 , C12N2795/14045 , C12N2810/859
摘要： This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell.

5. 发明公开

EP2167110A1 NASAL-ADMINISTERED VACCINES USING MULTI-SCREENED NALT-TARGETING AND PHAGOCYTIC POLYPEPTIDE TRANSPORT SEQUENCES 审中-公开
标题翻译：具有多筛选NALT定位和吞噬多肽序列TRANSPORT鼻使用的疫苗
公开(公告)号：EP2167110A1
公开(公告)日：2010-03-31
申请号：EP08756895.2
申请日：2008-06-06
申请人： Ferguson, Ian Andrew
发明人： Ferguson, Ian Andrew
IPC分类号： A61K35/76 , A61K38/02 , A61K39/12
CPC分类号： A61K39/12 , A61K35/13 , A61K39/00 , A61K2039/543 , C12N2795/14042 , C12N2795/14045
摘要： Multiple sequential screening tests have been performed on phage display libraries, and polypeptide sequences have been identified that potently drive both: (i) intake into mucosal immune cells, including NALT cells in the nose and throat; and, (ii) phagocytic intake and processing by antigen-presenting cells, such as macrophages. Such polypeptide sequences can be used as potent "target and deliver" components in vaccines that can be administered nasally, or to other mucous membranes. Such vaccines can be made very rapidly and in huge quantities, from bacteriophages that will also carry antigenic sequences in their coat proteins, or other immunoactive components. Alternately, such "target and deliver" polypeptides can be incorporated into vaccines derived from eukaryotic viruses or cellular pathogens. Enhancements also are disclosed, such as agents that can activate one or more types of toll-like receptors, to increase immune responses and guide them in desired directions.

6. 发明公开

EP1073671A4 TARGETED GENE DELIVERY TO CELLS BY FILAMENTOUS BACTERIOPHAGE 审中-公开
标题翻译：针对细胞丝状噬菌体基因传递
公开(公告)号：EP1073671A4
公开(公告)日：2004-08-18
申请号：EP99919789
申请日：1999-04-23
申请人： UNIV CALIFORNIA
发明人： MARKS JAMES D , POUL MARIE ALIX , BECERRIL BALTAZAR
IPC分类号： A61K38/00 , A61K47/48 , C07K14/01 , C07K16/28 , C07K16/32 , C12N15/86 , C07H21/04 , C12N7/00 , C12N7/04 , C12N15/62 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6843 , C07K16/2863 , C07K16/2881 , C07K16/32 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/02 , C12N15/86 , C12N2795/14022 , C12N2795/14043 , C12N2795/14045 , C12N2810/859
摘要： This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell.

7. 发明申请

WO2006070290A8 AGENTS AND METHODS FOR EARLY DIAGNOSIS AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS 审中-公开
标题翻译：早期诊断和监测阿尔茨海默病和其他神经疾病的代理和方法
公开(公告)号：WO2006070290A8
公开(公告)日：2007-01-25
申请号：PCT/IB2005004077
申请日：2005-06-23
申请人： FERGUSON IAN A , TANI HIROAKA
发明人： FERGUSON IAN A , TANI HIROAKA
IPC分类号： A61P25/28 , A61K51/08 , A61K101/02 , A61P25/00
CPC分类号： A61K38/03 , A61K49/0043 , A61K49/0097 , C07K2319/735 , C12N2795/14043 , C12N2795/14045 , C12N2810/40 , C12N2810/859
摘要： Evaluating human central nervous system neuron health by (a) administering to a patient a population of molecular complexes comprising (i) a polypeptide capable of activating neuronal endocytosis, axonal transport, and synaptic transfer, and (ii) an imaging agent suited for determining location and evaluating neuronal transport of said molecular complexes, within said patient, and (b) using at least one imaging method to determine location and evaluate neuronal transport of said molecular complexes, within said patient.
摘要翻译：通过（a）向患者施用包含（i）能够激活神经元内吞，轴突运输和突触传递的多肽的分子复合物群体评估人类中枢神经系统神经元健康，以及（ii）适合于确定位置的成像剂以及评估所述患者内的所述分子复合物的神经元运输，和（b）使用至少一种成像方法来确定所述患者内所述分子复合物的位置和评估神经元运输。

8. 发明申请

WO03086276A2 COMPOSITIONS AND METHODS FOR PORTAL SPECIFIC GENE DELIVERY AND TREATMENT OF INFECTION 审中-公开
标题翻译：用于门诊特异性基因传递和感染治疗的组合物和方法
公开(公告)号：WO03086276A2
公开(公告)日：2003-10-23
申请号：PCT/US0310081
申请日：2003-04-01
申请人： SELECTIVE GENETICS INC , ABBOTT ROBERT , LAROCCA DAVID , BAIRD ANDREW
发明人： ABBOTT ROBERT , LAROCCA DAVID , BAIRD ANDREW
IPC分类号： A61K48/00 , C07K14/01 , C12N15/113 , C12N15/86 , A61K
CPC分类号： C12N15/1131 , A61K48/00 , C07K14/005 , C07K2319/01 , C12N15/86 , C12N2310/111 , C12N2760/12222 , C12N2795/14043 , C12N2795/14045 , C12N2810/50 , C12N2810/851
摘要： The invention provides platform technology for the treatment of intracellular infections. Compositions and methods of the invention include non-target specific vectors that target infectable cells via linked ligands that bind and internalize through cell surface receptors/moieties associated with infection. The vectors comprise exogenous nucleic acid sequences that are expressed upon internalization into a target cell. Vector associated ligands and nucleic acid molecules may be altered to target different infectious agents. In addition, the invention provides methods of identifying epitopes and ligands capable of directing internalization of a vector and capable of blocking viral entry.
摘要翻译：本发明提供了用于治疗细胞内感染的平台技术。本发明的组合物和方法包括通过连接的配体靶向可感染细胞的非靶特异性载体，其通过细胞表面受体/与感染相关的部分结合并内化。载体包含在内化到靶细胞中表达的外源核酸序列。可以改变载体相关配体和核酸分子以靶向不同的感染因子。此外，本发明提供了鉴定能够引导载体内化并能够阻断病毒进入的表位和配体的方法。

9. 发明申请

WO2006070290A2 AGENTS AND METHODS FOR EARLY DIAGNOSIS AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS 审中-公开
标题翻译：早期诊断和监测阿尔茨海默病和其他神经疾病的代理和方法
公开(公告)号：WO2006070290A2
公开(公告)日：2006-07-06
申请号：PCT/IB2005004077
申请日：2005-06-23
申请人： FERGUSON IAN A , TANI HIROAKA
发明人： FERGUSON IAN A , TANI HIROAKA
CPC分类号： A61K38/03 , A61K49/0043 , A61K49/0097 , C07K2319/735 , C12N2795/14043 , C12N2795/14045 , C12N2810/40 , C12N2810/859
摘要： This invention is in the fields of medicine and neurology, and relates to methods and agents for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders. More particularly, the present invention provides the method for evaluating the health of central nervous system neurons in a human patient, comprising the steps of: a) administering to said patient a population of molecular complexes comprising (i) a polypeptide capable of activating neuronal endocytosis, axonal transport, and synaptic transfer; and (ii) an imaging agent suited for determining location and evaluating neuronal transport of said molecular complexes within said patient; and b) using at least one imaging method to determine location and evaluate neuronal transport of said molecular complexes within said patient.
摘要翻译：本发明涉及医学和神经学领域，涉及用于早期诊断和监测阿尔茨海默病和其他神经障碍的方法和试剂。更具体地，本发明提供了评估人类患者中枢神经系统神经元健康的方法，包括以下步骤：a）向所述患者施用一组分子复合物，其包含（i）能够激活神经元内吞的多肽，轴突运输和突触转移; 和（ii）适于确定所述患者内所述分子复合物的位置和评估神经元运输的成像剂; 以及b）使用至少一种成像方法来确定所述患者内所述分子复合物的位置和评估神经元运输。

10. 发明申请

WO9955720A9 TARGETED GENE DELIVERY TO CELLS BY FILAMENTOUS BACTERIOPHAGE 审中-公开
标题翻译：通过FILAMENTOUS BACTERIOPHAGE将目标基因递送至细胞
公开(公告)号：WO9955720A9
公开(公告)日：2000-04-13
申请号：PCT/US9907398
申请日：1999-04-23
申请人： UNIV CALIFORNIA , MARKS JAMES D , POUL MARIE ALIX , BECERRIL BALTAZAR
发明人： MARKS JAMES D , POUL MARIE ALIX , BECERRIL BALTAZAR
IPC分类号： A61K38/00 , A61K47/48 , C07K14/01 , C07K16/28 , C07K16/32 , C12N15/86 , C07H21/04 , C12N7/00 , C12N7/04 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6843 , C07K16/2863 , C07K16/2881 , C07K16/32 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/02 , C12N15/86 , C12N2795/14022 , C12N2795/14043 , C12N2795/14045 , C12N2810/859
摘要： This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell.
摘要翻译：本发明提供了在靶细胞中特异性递送和表达异源核酸的方法。所述方法通常涉及提供外部显示异源靶向蛋白（例如scFv）并含有异源核酸的噬菌体; 并使靶细胞与所述噬菌体接触，由此将噬菌体内化到细胞中，并且其中异源核酸在细胞内被转录并任选地翻译。

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