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1. 发明申请

US20100041643A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF 有权
标题翻译：苯并噻唑啉酮化合物及其药物用途
公开(公告)号：US20100041643A1
公开(公告)日：2010-02-18
申请号：US11916015
申请日：2006-05-30
申请人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人： Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号： A61K31/551 , C07D495/14
CPC分类号： C07D495/14
摘要： [Solving means] A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. [Effect]Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译： [解决方案]下述式（I）的噻吩并三唑并氮杂化合物是含有该化合物作为有效成分的药剂，以及噻吩并三唑并氮杂化合物的制造中间体和制造方法。 [效果]由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用，因此可用于预防或抑制移植器官或骨髓等中的排斥反应，以及预防或治疗自身免疫性疾病或过敏性疾病

2. 发明授权

US06214873B1 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same 有权
标题翻译： 2-氨基丙烷-1,3-二醇化合物，其药学用途和合成它们的中间体
公开(公告)号：US06214873B1
公开(公告)日：2001-04-10
申请号：US09402375
申请日：2000-01-05
申请人： Kunitomo Adachi , Yoshiyuki Aoki , Tokushi Hanano , Koji Teshima , Yukio Hoshino , Tetsuro Fujita
发明人： Kunitomo Adachi , Yoshiyuki Aoki , Tokushi Hanano , Koji Teshima , Yukio Hoshino , Tetsuro Fujita
IPC分类号： A61H3122
CPC分类号： C07C225/16 , C07C215/34 , C07C223/02 , C07F7/1804
摘要： The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.
摘要翻译：本发明涉及一般化学式R 1，R 2，R 3和R 4的化合物各自为氢或酰基，其药学上可接受的酸加成盐或其水合物; 包含该化合物的药物; 包含该化合物和药学上可接受的载体的药物组合物; 和2-氨基-2-（2-（4-（1-羟基-5-苯基戊基）苯基）乙基）丙烷-1,3-二醇或2-氨基-2-（2-（4-甲酰基苯基）乙基）丙烷-1,3-二醇，其氨基和/或羟基被保护的两种化合物的衍生物或其盐。本发明的化合物显示出较好的免疫抑制作用，毒性小，安全性更高，可用作预防或抑制器官排斥或骨髓移植的药物，或作为预防或治疗各种自身免疫性疾病或过敏性疾病的药物疾病

3. 发明授权

US06187821B1 Benzene compound and pharmaceutical use thereof 有权
标题翻译：苯化合物及其药物用途
公开(公告)号：US06187821B1
公开(公告)日：2001-02-13
申请号：US09309818
申请日：1999-05-12
申请人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
发明人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
IPC分类号： A61K31135
CPC分类号： C07C215/56 , C07C215/28 , C07C215/30 , C07C217/64 , C07C217/72 , C07C219/22 , C07C225/16 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/73 , C07C271/16 , C07C271/18 , C07C2601/02
摘要： A benzene compound of the formula: wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
摘要翻译：一种下式的苯化合物：其中每个符号如说明书中所定义;光学活性异构体或其盐，含有该化合物的药用组合物和含有该有效成分的免疫抑制剂。化合物，旋光异构体或盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮， Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症组织病，主动脉炎综合征，多发性肌炎，皮肌炎，威基 r肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和花粉症。它也可用作抗真菌剂和毛发生长兴奋剂。

4. 发明授权

US5952316A 2-amino-1,3-propanediol compound and immunosuppressant 失效
标题翻译： 2-氨基-1,3-丙二醇化合物和免疫抑制剂
公开(公告)号：US5952316A
公开(公告)日：1999-09-14
申请号：US911602
申请日：1997-08-14
申请人： Tetsuro Fujita , Shigeo Sasaki , Masahiko Yoneta , Tadashi Mishina , Kunitomo Adachi , Kenji Chiba
发明人： Tetsuro Fujita , Shigeo Sasaki , Masahiko Yoneta , Tadashi Mishina , Kunitomo Adachi , Kenji Chiba
IPC分类号： A01N33/02 , A01N43/40 , A01N43/60 , A01N57/00 , C07C215/10 , C07C215/18 , C07C215/20 , C07C215/24 , C07C215/26 , C07C215/28 , C07C215/34 , C07C215/42 , C07C215/54 , C07C215/56 , C07C215/68 , C07C217/28 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/64 , C07C217/72 , C07C217/76 , C07C219/06 , C07C219/24 , C07C219/30 , C07C225/04 , C07C225/06 , C07C225/10 , C07C225/14 , C07C225/16 , C07C229/22 , C07C229/38 , C07C229/46 , C07C233/18 , C07C233/31 , C07C233/35 , C07C233/36 , C07C233/41 , C07C233/43 , C07C233/47 , C07C237/06 , C07C237/24 , C07C237/30 , C07C251/38 , C07C271/20 , C07C271/24 , C07C271/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C323/34 , C07C323/41 , C07D207/06 , C07D207/09 , C07D207/32 , C07D207/325 , C07D207/335 , C07D211/14 , C07D211/26 , C07D213/38 , C07D213/40 , C07D233/54 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D279/12 , C07D295/13 , C07D295/135 , C07D307/52 , C07D309/32 , C07D317/28 , C07D333/20 , C07D521/00 , C07P211/00 , C07P401/00
CPC分类号： C07D207/325 , C07C215/10 , C07C215/18 , C07C215/20 , C07C215/24 , C07C215/26 , C07C215/28 , C07C215/34 , C07C215/42 , C07C215/54 , C07C215/56 , C07C215/68 , C07C217/28 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/64 , C07C217/72 , C07C217/76 , C07C219/06 , C07C219/24 , C07C219/30 , C07C225/04 , C07C225/06 , C07C225/10 , C07C225/14 , C07C225/16 , C07C229/22 , C07C229/38 , C07C229/46 , C07C233/18 , C07C233/31 , C07C233/35 , C07C233/36 , C07C233/41 , C07C233/43 , C07C233/47 , C07C237/06 , C07C237/24 , C07C237/30 , C07C251/38 , C07C271/20 , C07C271/24 , C07C271/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C323/34 , C07C323/41 , C07D207/06 , C07D207/09 , C07D207/335 , C07D211/14 , C07D211/26 , C07D213/38 , C07D213/40 , C07D231/12 , C07D233/56 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D279/12 , C07D295/13 , C07D295/135 , C07D307/52 , C07D309/32 , C07D317/28 , C07D333/20 , C07C2101/08 , C07C2101/14
摘要： 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each is a hydrogen, an alkyl, an aralkyl, an acyl or an alkoxycarbonyl, pharmaceutically acceptable salts thereof and immunosuppressants comprising these compounds as active ingredients.The 2-amino-1,3-propanediol compounds of the present invention show immunosuppressive action and are useful for suppressing rejection in organ or bone marrow tranplantation, prevention and treatment of autoimmune diseases or as reagents for use in medicinal and pharmaceutical fields.
摘要翻译：式（I）的2-氨基-1,3-丙二醇化合物，其中R是任选取代的直链或支链碳链，任选取代的芳基，任选取代的环烷基等，以及R 2，R 3，R 4和R 5 各自为氢，烷基，芳烷基，酰基或烷氧基羰基，其药学上可接受的盐和包含这些化合物作为活性成分的免疫抑制剂。本发明的2-氨基-1,3-丙二醇化合物显示免疫抑制作用，可用于抑制器官或骨髓移植中的排斥反应，预防和治疗自身免疫性疾病或用作药物和药物领域的试剂。

5. 发明授权

US5948820A Benzene compound and pharmaceutical use thereof 失效
标题翻译：苯化合物及其药物用途
公开(公告)号：US5948820A
公开(公告)日：1999-09-07
申请号：US801390
申请日：1997-02-20
申请人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
发明人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
IPC分类号： C07C215/28 , C07C215/30 , C07C215/56 , C07C217/64 , C07C217/72 , C07C219/22 , C07C225/16 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/73 , C07C271/16 , C07C271/18 , A61K31/135
CPC分类号： C07C215/56 , C07C215/28 , C07C215/30 , C07C217/64 , C07C217/72 , C07C219/22 , C07C225/16 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/73 , C07C271/16 , C07C271/18 , C07C2101/02
摘要： A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Beh.cedilla.et's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
摘要翻译：下式的苯化合物其中每个符号如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。化合物，光学活性异构体或盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎）Beh + 525 多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，多发性硬化症，再生障碍性贫血，特发性血小板减少性紫癜，过敏，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和花粉症它也可用作抗真菌剂和毛发生长兴奋剂。

6. 发明申请

US20070232614A1 Therapeutic Agent for Nonviral Hepatitis 审中-公开
标题翻译：非病毒性肝炎治疗剂
公开(公告)号：US20070232614A1
公开(公告)日：2007-10-04
申请号：US11587759
申请日：2005-04-27
申请人： Tetsuko Fukuda , Akira Mogami , Masao Hisadome , Kunitomo Adachi , Hirotsugu Komatsu
发明人： Tetsuko Fukuda , Akira Mogami , Masao Hisadome , Kunitomo Adachi , Hirotsugu Komatsu
IPC分类号： A61K31/497 , A61P41/00 , C07D241/04
CPC分类号： A61K31/506 , C07D213/74 , C07D239/42 , C07D239/52 , C07D277/42
摘要： The present invention provides a therapeutic drug for non-viral hepatitis, which contains a piperazine compound represented by the following formula (I) or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供一种非病毒性肝炎的治疗药物，其含有下述式（I）表示的哌嗪化合物或其药学上可接受的盐作为有效成分。

7. 发明授权

US06667025B2 Compositions and methods of using compositions with accelerated lymphocyte homing immunosuppressive properties 失效
标题翻译：使用具有加速淋巴细胞归巢免疫抑制性质的组合物的组合物和方法
公开(公告)号：US06667025B2
公开(公告)日：2003-12-23
申请号：US09334213
申请日：1999-06-15
申请人： Kenji Chiba , Kunitomo Adachi
发明人： Kenji Chiba , Kunitomo Adachi
IPC分类号： A61K4900
CPC分类号： A61K31/135 , Y10S514/885
摘要： The methods and compositions of the invention and the compounds used in the invention involve a novel immunosuppression mechanism, accelerated lymphocyte homing immunosuppression (ALH-immunosuppression). For example, the compound FTY720 specifically directs lymphocytes to the peripheral lymph nodes, mesenteric lymph nodes, and Peyer's patches. By reversibly sequestering lymphocytes in these tissues, the compounds can inhibit an immune response in a mammal. Understanding these mechanisms provides a novel immunosuppression therapy that can synergistically interact with other immunosuppressive compounds. Screening methods for identifying similar ALH-immunosuppression compounds are also described. The invention allows better treatments and therapies wherever an immunosuppression regimen is desired.
摘要翻译：本发明的方法和组合物和本发明中使用的化合物涉及新的免疫抑制机制，加速淋巴细胞归巢免疫抑制（ALH-免疫抑制）。例如，化合物FTY720特异性地将淋巴细胞引导到外周淋巴结，肠系膜淋巴结和派耶氏斑块。通过在这些组织中可逆地螯合淋巴细胞，化合物可以抑制哺乳动物的免疫应答。了解这些机制提供了可以与其他免疫抑制化合物协同相互作用的新型免疫抑制治疗。还描述了鉴定类似的ALH-免疫抑制化合物的筛选方法。本发明允许在需要免疫抑制方案的地方进行更好的治疗和治疗。

8. 发明授权

US06372800B1 Benzene compound and pharmaceutical use thereof 有权
标题翻译：苯化合物及其药物用途
公开(公告)号：US06372800B1
公开(公告)日：2002-04-16
申请号：US09691099
申请日：2000-10-19
申请人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
发明人： Tetsuro Fujita , Kunitomo Adachi , Toshiyuki Kohara , Masatoshi Kiuchi , Kenji Chiba , Koji Teshima , Tadashi Mishina
IPC分类号： A61K3135
CPC分类号： C07C215/56 , C07C215/28 , C07C215/30 , C07C217/64 , C07C217/72 , C07C219/22 , C07C225/16 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/73 , C07C271/16 , C07C271/18 , C07C2601/02
摘要： A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifingal agent and hair growth stimulant.
摘要翻译：每个符号的苯甲醛的苯化合物如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。该化合物，旋光异构体或盐具有优异的免疫抑制作用，可用作抑制反应发生的抑制剂在器官或骨髓移植中，作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮，Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁，肝硬化，克罗恩病，肾小球肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和花粉症。它也可用作抗衰老剂和毛发生长兴奋剂。

9. 发明申请

US20110263571A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE 有权
标题翻译：新药衍生物及其作为医药使用
公开(公告)号：US20110263571A1
公开(公告)日：2011-10-27
申请号：US13126119
申请日：2009-10-27
申请人： Seigo Ishibuchi , Hidemasa Hikawa , Akiko Tarao , Jun-ichi Endoh , Kunitomo Adachi , Kazuhiro Maeda , Kaoru Tashiro
发明人： Seigo Ishibuchi , Hidemasa Hikawa , Akiko Tarao , Jun-ichi Endoh , Kunitomo Adachi , Kazuhiro Maeda , Kaoru Tashiro
IPC分类号： A61K31/496 , C07D413/10 , A61K31/454 , A61K31/4545 , A61P1/00 , A61K31/497 , C07D417/14 , A61P37/06 , A61P29/00 , C07D413/14 , A61K31/551
CPC分类号： C07D413/14 , A61K31/454 , A61K31/496 , A61K31/551 , C07D263/22 , C07D263/24 , C07D413/10 , C07D413/12
摘要： Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof.
摘要翻译：提供了抑制诱导型MMP（特别是MMP-9）的生产的新型低分子量化合物，而不是止血型MMP-2的产生，以及用于自身免疫性疾病或骨关节炎的预防/治疗药物。由下式（I）表示的酰胺衍生物，其中每个符号如说明书中所定义，其药理学上可接受的盐，或其水合物或溶剂化物。

10. 发明授权

US5719176A 2-amino-1,3-propanediol compound and immunosuppressant 失效
标题翻译： 2-氨基-1,3-丙二醇化合物和免疫抑制剂
公开(公告)号：US5719176A
公开(公告)日：1998-02-17
申请号：US725890
申请日：1996-10-02
申请人： Tetsuro Fujita , Shigeo Sasaki , Masahiko Yoneta , Tadashi Mishina , Kunitomo Adachi , Kenji Chiba
发明人： Tetsuro Fujita , Shigeo Sasaki , Masahiko Yoneta , Tadashi Mishina , Kunitomo Adachi , Kenji Chiba
IPC分类号： A01N33/02 , A01N43/40 , A01N43/60 , A01N57/00 , C07C215/10 , C07C215/18 , C07C215/20 , C07C215/24 , C07C215/26 , C07C215/28 , C07C215/34 , C07C215/42 , C07C215/54 , C07C215/56 , C07C215/68 , C07C217/28 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/64 , C07C217/72 , C07C217/76 , C07C219/06 , C07C219/24 , C07C219/30 , C07C225/04 , C07C225/06 , C07C225/10 , C07C225/14 , C07C225/16 , C07C229/22 , C07C229/38 , C07C229/46 , C07C233/18 , C07C233/31 , C07C233/35 , C07C233/36 , C07C233/41 , C07C233/43 , C07C233/47 , C07C237/06 , C07C237/24 , C07C237/30 , C07C251/38 , C07C271/20 , C07C271/24 , C07C271/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C323/34 , C07C323/41 , C07D207/06 , C07D207/09 , C07D207/32 , C07D207/325 , C07D207/335 , C07D211/14 , C07D211/26 , C07D213/38 , C07D213/40 , C07D233/54 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D279/12 , C07D295/13 , C07D295/135 , C07D307/52 , C07D309/32 , C07D317/28 , C07D333/20 , C07D521/00 , C07C711/00
CPC分类号： C07D207/325 , C07C215/10 , C07C215/18 , C07C215/20 , C07C215/24 , C07C215/26 , C07C215/28 , C07C215/34 , C07C215/42 , C07C215/54 , C07C215/56 , C07C215/68 , C07C217/28 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/64 , C07C217/72 , C07C217/76 , C07C219/06 , C07C219/24 , C07C219/30 , C07C225/04 , C07C225/06 , C07C225/10 , C07C225/14 , C07C225/16 , C07C229/22 , C07C229/38 , C07C229/46 , C07C233/18 , C07C233/31 , C07C233/35 , C07C233/36 , C07C233/41 , C07C233/43 , C07C233/47 , C07C237/06 , C07C237/24 , C07C237/30 , C07C251/38 , C07C271/20 , C07C271/24 , C07C271/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C323/34 , C07C323/41 , C07D207/06 , C07D207/09 , C07D207/335 , C07D211/14 , C07D211/26 , C07D213/38 , C07D213/40 , C07D231/12 , C07D233/56 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D279/12 , C07D295/13 , C07D295/135 , C07D307/52 , C07D309/32 , C07D317/28 , C07D333/20 , C07C2101/08 , C07C2101/14
摘要： A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branched carbon chain, optionally substituted aryl or optionally substituted cycloalkyl; and R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which may be the same or different from one another, represent each hydrogen, alkyl, aralkyl, acyl or alkoxycarbonyl. The compound is immunodepressant and useful as an inhibitor against rejection in organ or bone marrow transplantation, as a preventive or remedy for autoimmune diseases and so forth, or a reagent in the medical and pharmaceutical fields. ##STR1##
摘要翻译：由通式（I）表示的2-氨基-1,3-丙二醇化合物或其药学上可接受的盐，和含有该活性成分的免疫抑制剂。在所述式中，R代表任选取代的直链或支链碳链，任选取代的芳基或任选取代的环烷基; 可以相同或不同的R 2，R 3，R 4和R 5表示氢，烷基，芳烷基，酰基或烷氧基羰基。该化合物是免疫抑制剂，可用作作为器官或骨髓移植排斥反应的抑制剂，作为自身免疫疾病等的预防或补救剂，或医药领域的试剂。（一）

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