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1. 发明授权

US08999129B2 Liquid and gel electrodes for transverse free flow electrophoresis 有权
标题翻译：用于横向自由电泳的液体和凝胶电极
公开(公告)号：US08999129B2
公开(公告)日：2015-04-07
申请号：US13413161
申请日：2012-03-06
申请人： Byoungsok Jung , Klint A. Rose , Maxim Shusteff , Alexandre Persat , Juan Santiago
发明人： Byoungsok Jung , Klint A. Rose , Maxim Shusteff , Alexandre Persat , Juan Santiago
IPC分类号： G01N27/447 , B01D57/02 , B01D43/00
CPC分类号： B01D43/00 , B01D57/02 , G01N27/44769
摘要： The present invention provides a mechanism for separating or isolating charged particles under the influence of an electric field without metal electrodes being in direct contact with the sample solution. The metal electrodes normally in contact with the sample are replaced with high conductivity fluid electrodes situated parallel and adjacent to the sample. When the fluid electrodes transmit the electric field across the sample, particles within the sample migrate according to their electrophoretic mobility.
摘要翻译：本发明提供了一种用于在没有金属电极与样品溶液直接接触的电场的影响下分离或分离带电粒子的机理。通常与样品接触的金属电极被替换为与样品平行且相邻的高导电性流体电极。当流体电极跨越样品传播电场时，样品内的颗粒根据其电泳迁移率而迁移。

2. 发明授权

US08524064B2 Three dimensional microelectrode system for dielectrophoresis 有权
标题翻译：用于介电电泳的三维微电极系统
公开(公告)号：US08524064B2
公开(公告)日：2013-09-03
申请号：US12843269
申请日：2010-07-26
申请人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, Jr.
发明人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, Jr.
IPC分类号： G01N27/26 , G01N27/453 , B03C5/02 , B01D57/02
CPC分类号： B03C5/005 , B01L2400/0424 , B03C5/026 , G01N27/447
摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.
摘要翻译：一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 第二台面从底部突出到介电电泳通道中，并从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

3. 发明申请

US20130043170A1 Microfluidic ultrasonic particle separators with engineered node locations and geometries 有权
标题翻译：具有工程节点位置和几何形状的微流体超声波颗粒分离器
公开(公告)号：US20130043170A1
公开(公告)日：2013-02-21
申请号：US13571640
申请日：2012-08-10
申请人： Klint A. Rose , Karl A. Fisher , Douglas A. Wajda , Raymond P. Mariella, JR. , Christopher Bailey , Dietrich Dehlinger , Maxim Shusteff , Byoungsok Jung , Kevin D. Ness
发明人： Klint A. Rose , Karl A. Fisher , Douglas A. Wajda , Raymond P. Mariella, JR. , Christopher Bailey , Dietrich Dehlinger , Maxim Shusteff , Byoungsok Jung , Kevin D. Ness
IPC分类号： B03B5/60
CPC分类号： B01L3/50273 , B01D21/28 , B01D21/283 , B01D2221/10 , B01L3/502761 , B01L2200/0631 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , G01N1/4077 , G01N33/48728 , G01N33/491 , G01N2001/4094
摘要： An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.
摘要翻译：超声波微流体系统包括用于输送包含小颗粒和大颗粒的样品流体的分离通道，所述样品流体基本上平行于与其接触的回收流体相邻流动。声换能器产生超声驻波，其产生具有至少一个最小压力振幅节点的压力场。声学延伸结构位于所述分离通道附近，用于将所述声音节点偏离所述声学区域的中心，并将大颗粒集中在所述回收流体流中。

4. 发明授权

US07030411B2 Electronic unit integrated into a flexible polymer body 有权
标题翻译：电子单元集成到柔性聚合物体内
公开(公告)号：US07030411B2
公开(公告)日：2006-04-18
申请号：US10939771
申请日：2004-09-13
申请人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
发明人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
IPC分类号： H01L29/04 , H01L31/20 , H01L31/036 , H01L31/0376
CPC分类号： A61N1/0456 , A61B2560/0412 , A61N1/0452 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/0534 , H01L23/5387 , H01L25/065 , H01L2924/0002 , H01L2924/09701 , H05K1/0313 , H05K1/0393 , H05K2201/0162 , H05K2201/09118 , H01L2924/00
摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.
摘要翻译：剥离和粘贴电子系统包括硅树脂体和至少一个可操作地连接到硅氧烷体的电子单元。该电子系统是通过在衬底上提供硅树脂层，在硅树脂层上提供金属层，并提供至少一个与金属层连接的电子单元来制造的。

5. 发明授权

US09285340B2 Methods for separating particles and/or nucleic acids using isotachophoresis 有权
标题翻译：使用等速电泳法分离颗粒和/或核酸的方法
公开(公告)号：US09285340B2
公开(公告)日：2016-03-15
申请号：US12542215
申请日：2009-08-17
申请人： Byoungsok Jung , Kevin Ness , Klint A. Rose
发明人： Byoungsok Jung , Kevin Ness , Klint A. Rose
IPC分类号： G01N27/447
CPC分类号： G01N27/44747 , G01N27/44773 , G01N2030/8827
摘要： According to one embodiment, a method includes co-feeding fluids comprising a leading electrolyte, a trailing electrolyte, and at least one of DNA and RNA to a channel, and applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. In another embodiment, a method includes co-feeding fluids to a channel. The fluids include a leading electrolyte, a trailing electrolyte, biological objects, at least one of DNA and RNA, and a spacer electrolyte having an electrophoretic mobility that is between an electrophoretic mobility of at least some of the biological objects and an electrophoretic mobility of the at least one of the DNA and the RNA. The method also includes applying an electric field to the fluids in a direction perpendicular to an axis of the channel for inducing transverse isotachophoresis. Other methods of isotachophoresis are disclosed in addition to these.
摘要翻译：根据一个实施方案，一种方法包括将包含前导电解质，尾电解质和至少一种DNA和RNA的流体的流体共同输送到通道，以及在垂直于诱导横向等电泳的通道。在另一个实施例中，一种方法包括将流体共同供给到通道。流体包括前导电解质，尾电解质，生物物体，DNA和RNA中的至少一种以及具有电泳迁移率的间隔电解质，所述间隔电解质位于至少一些生物体的电泳迁移率和电泳迁移率之间至少一个DNA和RNA。该方法还包括在垂直于通道的轴线的方向上向流体施加电场以诱导横向等速电泳。除此之外还公开了其他的等速电泳法。

6. 发明授权

US08727129B2 Microfluidic ultrasonic particle separators with engineered node locations and geometries 有权
标题翻译：具有工程节点位置和几何形状的微流体超声波颗粒分离器
公开(公告)号：US08727129B2
公开(公告)日：2014-05-20
申请号：US13571640
申请日：2012-08-10
申请人： Klint A. Rose , Karl A. Fisher , Douglas A. Wajda , Raymond P. Mariella, Jr. , Christopher Bailey , Dietrich Dehlinger , Maxim Shusteff , Byoungsok Jung , Kevin D. Ness
发明人： Klint A. Rose , Karl A. Fisher , Douglas A. Wajda , Raymond P. Mariella, Jr. , Christopher Bailey , Dietrich Dehlinger , Maxim Shusteff , Byoungsok Jung , Kevin D. Ness
IPC分类号： B03B5/00
CPC分类号： B01L3/50273 , B01D21/28 , B01D21/283 , B01D2221/10 , B01L3/502761 , B01L2200/0631 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , G01N1/4077 , G01N33/48728 , G01N33/491 , G01N2001/4094
摘要： An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.
摘要翻译：超声波微流体系统包括用于输送包含小颗粒和大颗粒的样品流体的分离通道，所述样品流体基本上平行于与其接触的回收流体相邻流动。声换能器产生超声驻波，其产生具有至少一个最小压力振幅节点的压力场。声学延伸结构位于所述分离通道附近，用于将所述声音节点偏离所述声学区域的中心，并将大颗粒集中在所述回收流体流中。

7. 发明申请

US20120052511A1 METHODS FOR CONTROLLING PORE MORPHOLOGY IN AEROGELS USING ELECTRIC FIELDS AND PRODUCTS THEREOF 有权
标题翻译：使用电场及其产品控制空间形态的方法
公开(公告)号：US20120052511A1
公开(公告)日：2012-03-01
申请号：US13180440
申请日：2011-07-11
申请人： Marcus A. Worsley , Theodore F. Baumann , Joe H. Satcher, JR. , Tammy Y. Olson , Joshua D. Kuntz , Klint A. Rose
发明人： Marcus A. Worsley , Theodore F. Baumann , Joe H. Satcher, JR. , Tammy Y. Olson , Joshua D. Kuntz , Klint A. Rose
IPC分类号： B32B3/26 , C12N5/00 , B32B5/22 , H01B1/08 , H01B1/04 , G01N33/53 , H01B1/00
CPC分类号： H01B1/08 , B01J13/0091 , Y10T428/249953 , Y10T428/249986
摘要： In one embodiment, an aerogel or xerogel includes column structures of a material having minor pores therein and major pores devoid of the material positioned between the column structures, where longitudinal axes of the major pores are substantially parallel to one another. In another embodiment, a method includes heating a sol including aerogel or xerogel precursor materials to cause gelation thereof to form an aerogel or xerogel and exposing the heated sol to an electric field, wherein the electric field causes orientation of a microstructure of the sol during gelation, which is retained by the aerogel or xerogel. In one approach, an aerogel has elongated pores extending between a material arranged in column structures having structural characteristics of being formed from a sol exposed to an electric field that causes orientation of a microstructure of the sol during gelation which is retained by the elongated pores of the aerogel.
摘要翻译：在一个实施方案中，气凝胶或干凝胶包括其中具有小孔的材料的柱结构，以及没有位于柱结构之间的材料的主要孔，其中主孔的纵轴基本上彼此平行。在另一个实施方案中，一种方法包括加热包括气凝胶或干凝胶前体材料的溶胶，使其凝胶形成气凝胶或干凝胶，并将加热的溶胶暴露于电场，其中电场引起凝胶化过程中溶胶微结构的取向，由气凝胶或干凝胶保留。在一种方法中，气凝胶具有延伸的细孔，所述孔在布置在柱结构中的材料之间延伸，所述材料具有由暴露于电场的溶胶形成的结构特征，所述溶胶引起凝胶化期间溶胶的微结构的取向，气凝胶

8. 发明申请

US20110259745A1 Three Dimensional Microelectrode System For Dielectrophoresis 有权
标题翻译：用于电泳的三维微电极系统
公开(公告)号：US20110259745A1
公开(公告)日：2011-10-27
申请号：US12843269
申请日：2010-07-26
申请人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
发明人： Dietrich A. Dehlinger , Klint A. Rose , Maxim Shusteff , Christopher G. Bailey , Raymond P. Mariella, JR.
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B01L2400/0424 , B03C5/026 , G01N27/447
摘要： A dielectrophoresis apparatus for separating particles from a sample, including an apparatus body; a dielectrophoresis channel in the apparatus body, the dielectrophoresis channel having a central axis, a bottom, a top, a first side, and a second side; a first mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the first mesa extending at an angle to the central axis of the dielectrophoresis channel; a first electrode extending along the first mesa; a second mesa projecting into the dielectrophoresis channel from the bottom and extending from the first side across the dielectrophoresis channel to the second side, the second mesa extending at an angle to the central axis of the dielectrophoresis channel; a space between at least one of the first electrode and the second side or the second electrode and the second side; and a gap between the first electrode and the second electrode.
摘要翻译：一种用于从样品中分离颗粒的介电电泳装置，包括装置体; 所述设备主体中的介电电泳通道，所述介电电泳通道具有中心轴线，底部，顶部，第一侧面和第二侧面; 第一台面从底部突出到介电电泳通道中并且从第一侧穿过介电电泳通道延伸到第二侧，第一台面以与介电电泳通道的中心轴线成一定角度延伸; 沿第一台面延伸的第一电极; 第二台面从底部突出到介电电泳通道中，并从第一侧穿过介电电泳通道延伸到第二侧，第二台面以与介电电泳通道的中心轴成一定角度延伸; 第一电极和第二电极和第二电极和第二侧中的至少一个之间的空间; 以及第一电极和第二电极之间的间隙。

9. 发明申请

US20110124098A1 Modular Microfluidic System for Biological Sample Preparation 有权
标题翻译：用于生物样品制备的模块化微流体系统
公开(公告)号：US20110124098A1
公开(公告)日：2011-05-26
申请号：US12943677
申请日：2010-11-10
申请人： Klint A. Rose , Raymond P. Mariella, JR. , Christopher G. Bailey , Kevin Dean Ness
发明人： Klint A. Rose , Raymond P. Mariella, JR. , Christopher G. Bailey , Kevin Dean Ness
IPC分类号： C12M1/12
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/027 , B01L2200/04 , B01L2300/0681 , B01L2400/0436 , B01L2400/0439 , B03C5/026 , B03C2201/26 , G01N2035/00326
摘要： A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.
摘要翻译：一种用于制备生物样品的可重构模块化微流体系统，包括用于自动化样品制备的一系列可重新配置模块，其适于选择性地包括a）微流体声学聚焦滤光器模块，b）介电电泳细菌滤膜模块，c）介电泳病毒过滤器模块， d）等速电泳核酸过滤器模块，e）裂解模块和f）基于等电泳的核酸过滤器。

10. 发明授权

US07342311B2 Electronic unit integrated into a flexible polymer body 有权
标题翻译：电子单元集成到柔性聚合物体内
公开(公告)号：US07342311B2
公开(公告)日：2008-03-11
申请号：US11326967
申请日：2006-01-05
申请人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
发明人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
IPC分类号： H01L23/04 , H01L23/34
CPC分类号： H01L25/165 , B81C1/0023 , H01L21/6835 , H01L31/048 , H01L31/0543 , H01L2221/68345 , H01L2924/0002 , H01L2924/09701 , H01L2924/19041 , H01L2924/19105 , Y02E10/52 , H01L2924/00
摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.
摘要翻译：剥离和粘贴电子系统包括硅树脂体和至少一个可操作地连接到硅氧烷体的电子单元。该电子系统是通过在衬底上提供硅树脂层，在硅树脂层上提供金属层，并提供至少一个与金属层连接的电子单元来制造的。

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