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1. 发明授权

US11036219B2 Self-propelled device 有权
公开(公告)号：US11036219B2
公开(公告)日：2021-06-15
申请号：US15999460
申请日：2017-02-13
申请人： Kevin Li , Anthony Ko-Ping Chien , Goh Jian Kai , Jessica A. Williamson
发明人： Kevin Li , Anthony Ko-Ping Chien , Goh Jian Kai , Jessica A. Williamson
IPC分类号： G05D1/00 , A63H33/00 , H04N5/225 , H04N5/232 , G02B27/64
摘要： A spherical, self-propelled device responds to remote controls from a user. The self-propelled device has an internal drive system and an internal vision system. The vision system remains in a constant orientation with respect to the spherical, self-propelled device. As the spherical, self-propelled device rolls along a surface, the internal vision system captures video data from an upward field of view.

2. 发明申请

US20180042280A1 HIGH REBAUDIOSIDE-A PLANT VARIETAL, METHODS OF EXTRACTION AND PURIFICATION THEREFROM, OF COMPOSITIONS WITH ENHANCED REBAUDIOSIDE-A CONTENT AND USES OF SAID COMPOSITION 审中-公开
公开(公告)号：US20180042280A1
公开(公告)日：2018-02-15
申请号：US15552839
申请日：2016-02-24
申请人： Qibin WANG , Yong Luke ZHANG , Cunbiao Kevin LI
发明人： Qibin WANG , Yong Luke ZHANG , Cunbiao Kevin LI
IPC分类号： A23L27/30 , A01H5/12 , A61K31/704 , A23L33/105 , A61K8/60 , A61Q11/00 , A01H1/02 , A23L2/60
CPC分类号： A23L27/36 , A01H1/02 , A01H5/12 , A23L2/60 , A23L27/10 , A23L27/30 , A23L33/105 , A61K8/602 , A61K8/97 , A61K31/704 , A61K2800/10 , A61Q11/00 , A61Q19/00 , C07H15/256
摘要： A Stevia rebaudiana plant is characterized by Rebaudioside A (RA) content of 6-20% dry weight and total steviol glycosides content of 15-28% dry weight in the leaf. The plant is developed using selective breeding technologies and identified by RAPD gene analysis.

3. 发明授权

US08755880B2 Intraocular iontophoretic device and associated methods 有权
公开(公告)号：US08755880B2
公开(公告)日：2014-06-17
申请号：US11414137
申请日：2006-04-27
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61N1/044 , A61N1/0448
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.

4. 发明授权

US08634907B2 Intraocular iontophoretic device and associated methods 有权
标题翻译：眼内离子电渗疗法及相关方法
公开(公告)号：US08634907B2
公开(公告)日：2014-01-21
申请号：US11414134
申请日：2006-04-27
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61N1/044 , A61N1/0448
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.
摘要翻译：本发明包括用于将活性剂递送到受试者的眼睛中的方法和装置。一个这样的装置可以包括阳极组件，阳极组件具有阳极壳体和被配置为电耦合到电源的阳极，阳极组件构造成接触并保持在眼睛的表面上。该装置还可以包括具有阴极壳体和阴极的阴极组件，该阴极壳体和阴极被配置为电耦合到电源，阴极组件构造成接触并保持抵靠眼睛的表面。另外，该装置可以包括与阳极组件和阴极组件中的至少一个功能性相关联的至少一个活性剂储存器。

5. 发明授权

US08246949B2 Methods and devices for sustained in-vivo release of an active agent 有权
标题翻译：用于持续体内释放活性剂的方法和装置
公开(公告)号：US08246949B2
公开(公告)日：2012-08-21
申请号：US11238144
申请日：2005-09-27
申请人： John Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
发明人： John Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
IPC分类号： A61K38/43 , A61K47/36 , A61K31/74
CPC分类号： A61K9/0009 , A61F9/0017 , A61K9/0048 , A61K31/573 , A61K31/58 , A61K41/00 , A61K45/06 , A61N1/0412 , A61N1/044 , A61N1/303 , A61N1/327 , A61K2300/00
摘要： The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.
摘要翻译：本发明包括用于向受试者提供活性剂的持续体内释放的方法和装置。在一些方面，这样的释放可以通过活体活性剂与贮库形成剂反应来实现，以便在受试者内形成缓释活性剂贮库。然后，仓库可以在持续的时间段内释放活性剂。

6. 发明授权

US07785578B2 Non-invasive ocular drug delivery 失效
标题翻译：非侵入性眼药物递送
公开(公告)号：US07785578B2
公开(公告)日：2010-08-31
申请号：US10269911
申请日：2002-10-11
申请人： David J. Miller , S. Kevin Li , William Higuchi
发明人： David J. Miller , S. Kevin Li , William Higuchi
IPC分类号： A61K31/74
CPC分类号： A61K31/137 , A61K9/0051
摘要： The present invention is drawn to a pharmaceutical compound for the treatment of posterior retinal diseases through topical application of the compound. The compound includes an effective amount of a therapeutic compound, and at least one additional agent that helps to prolong the residence time of the therapeutic compound within the extraocular space, or increase the transport of the therapeutic compound across a tissue of an eye toward and into a posterior ocular region, or both. The invention is additionally drawn to a device and method for delivering the compound.
摘要翻译：本发明涉及用于通过局部施用化合物治疗后视网膜疾病的药物化合物。该化合物包括有效量的治疗化合物和至少一种另外的有助于延长治疗化合物在眼外空间内的停留时间的另外的药剂，或者增加治疗化合物在眼睛组织中的转运和进入后眼部或两者。本发明另外涉及用于递送化合物的装置和方法。

7. 发明申请

US20090143752A1 Passive intraocular drug delivery devices and associated methods 审中-公开
标题翻译：被动眼内药物输送装置及相关方法
公开(公告)号：US20090143752A1
公开(公告)日：2009-06-04
申请号：US11999266
申请日：2007-12-03
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： The present invention provides methods and devices for the passive delivery of active agents into the eye of a subject. In one aspect, for example, a device for passively delivering an active agent into an eye of a subject may include a housing configured to conform to at least a portion of an eye surface, and a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, where the first reservoir contains an ionized active agent. The device may further include a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, where the second reservoir component contains a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent. The ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium. Additionally, the device does not include an electrode.
摘要翻译：本发明提供了将活性剂被动递送到受试者的眼睛中的方法和装置。在一个方面，例如，用于将活性剂被动地递送到受试者的眼睛中的装置可以包括构造成符合眼表面的至少一部分的壳体和位于壳体内的第一储存器部件，并且被配置为流体耦合到第一眼表面，其中第一储存器包含电离活性剂。该装置还可以包括位于壳体内并被配置为流体耦合到位于邻近第一眼表面的第二眼表面的第二储存器部件，其中第二储存器部件包含具有与极性相反的电荷的贮库形成剂与电离活性剂相比。离子化活性剂和贮库形成剂被配置为当在水性介质中在室温和约4至约8的pH下接触在一起时形成沉淀物。另外，该装置不包括电极。

8. 发明授权

US06512950B2 Methods for delivering agents using alternating current 失效
标题翻译：使用交流电输送药剂的方法
公开(公告)号：US06512950B2
公开(公告)日：2003-01-28
申请号：US09783138
申请日：2001-02-13
申请人： S. Kevin Li , William I. Higuchi , Honggang Zhu , Yang Song
发明人： S. Kevin Li , William I. Higuchi , Honggang Zhu , Yang Song
IPC分类号： A64B505
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which transport occurs, thereby allowing agent to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be included to assist in promoting transfer of the agent. The methods have utility in a variety of different clinical settings and applications.
摘要翻译：提供了用于在组织上输送诸如药剂，营养物和遗传物质的不同试剂的各种方法。所述方法利用AC信号在组织的区域中保持基本上恒定的电状态，通过该区域传输发生，从而允许药剂以受控和可预测的方式跨组织输送。某些方法包括可选的AC或DC预脉冲信号，以初始实现目标电状态。还可以包括可选的直流偏移信号，以帮助促进代理的转移。该方法在各种不同的临床设置和应用中具有实用性。

9. 发明授权

US06496728B2 Methods for extracting substances using alternating current 失效
标题翻译：使用交流电提取物质的方法
公开(公告)号：US06496728B2
公开(公告)日：2002-12-17
申请号：US09783696
申请日：2001-02-13
申请人： S. Kevin Li , William I. Higuchi , Honggang Zhu , Yang Song
发明人： S. Kevin Li , William I. Higuchi , Honggang Zhu , Yang Song
IPC分类号： A61B505
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： A variety of methods for extracting different substances such as endogenous substances, pharmaceutical substances, markers of disease, and their metabolites across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which extraction occurs, thereby allowing substances to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be utilized to assist in promoting extraction of the substance. The methods have utility in a variety of different clinical settings and applications.
摘要翻译：提供了各种用于提取不同物质的方法，例如内源性物质，药物物质，疾病标志物及其跨组织的代谢物。该方法利用AC信号在组织的区域中保持基本上恒定的电状态，通过该区域进行提取，从而允许以受控和可预测的方式将物质运送到组织上。某些方法包括可选的AC或DC预脉冲信号，以初始实现目标电状态。也可以使用可选的DC偏移信号来辅助促进物质的提取。该方法在各种不同的临床设置和应用中具有实用性。

10. 发明授权

US06466173B1 Antenna assembly, and associated method, having plural antenna transducers selectably connectable to radio circuitry of a radio device 失效
标题翻译：天线组件和相关方法，具有可选择地连接到无线电设备的无线电电路的多个天线换能器
公开(公告)号：US06466173B1
公开(公告)日：2002-10-15
申请号：US09653477
申请日：2000-09-01
申请人： Kevin Li
发明人： Kevin Li
IPC分类号： H01Q124
CPC分类号： H04B1/3838 , H01Q1/244
摘要： An antenna assembly, and an associated method, for a portable radio device, such as a mobile station. The antenna assembly includes a whip antenna transducer capable of translation between a retracted position and an extracted position. When positioned in the extracted position, a switch element interconnects the whip antenna transducer together with radio circuitry of the radio device. When positioned in a retracted position, the switch element, instead, connects the radio circuitry of the radio device to a non-movable antenna transducer, such as a patch or PIFA antenna transducer, housed within the housing of the radio device.
摘要翻译：一种用于便携式无线电设备（例如移动台）的天线组件和相关联的方法。天线组件包括能够在缩回位置和提取位置之间平移的鞭状天线换能器。当位于提取位置时，开关元件将鞭状天线换能器与无线电设备的无线电电路相互连接。当定位在缩回位置时，开关元件代替地将无线电设备的无线电电路连接到容纳在无线电设备的外壳内的不可移动的天线换能器，例如补片或PIFA天线换能器。

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