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1. 发明授权

US06523698B1 Bone marrow kit 失效
标题翻译：骨髓袋
公开(公告)号：US06523698B1
公开(公告)日：2003-02-25
申请号：US09597653
申请日：2000-06-21
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： B01D2700
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译：提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器使得流体必须流过预过滤器以通过出口开口离开收集容器。第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器，进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。还提供了处理骨髓和构建在线过滤器的方法。

2. 发明授权

US06189704B1 Inline filter 失效
标题翻译：在线过滤器
公开(公告)号：US06189704B1
公开(公告)日：2001-02-20
申请号：US08955409
申请日：1997-10-23
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： B01D2900
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译：提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器使得流体必须流过预过滤器以通过出口开口离开收集容器。第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器，进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。还提供了处理骨髓和构建在线过滤器的方法。

3. 发明授权

US5078671A Centrifugal fluid processing system and method 失效
标题翻译：离心流体处理系统及方法
公开(公告)号：US5078671A
公开(公告)日：1992-01-07
申请号：US598753
申请日：1990-10-12
申请人： T. Michael Dennehey , Joseph C. West, Jr.
发明人： T. Michael Dennehey , Joseph C. West, Jr.
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B2005/045
摘要： A centrifugal processing system and method introduces fluid to be processed into a centrifugation chamber, while directing the fluid away from the region of the chamber where the largest centrifugal (or "G") forces exist. The fluid is also conveyed into the force field as a generally uniform stream having reduced turbulence or being essentially free of turbulence. The system and method thereby establish, upon the entry of a high velocity fluid stream into the centrifugal field, non-turbulent and uniform flow conditions conducive to effective separation. The system and method also direct the fluid in a way the maximizes the effective surface area of the centrifugation chamber for separation. Effective separation can thereby be achieved at high inlet flow rates.
摘要翻译：离心处理系统和方法将待处理的流体引入离心室，同时使流体远离存在最大离心（或“G”）力的室的区域。流体也被传送到力场中，作为具有减小的湍流或基本上没有湍流的大致均匀的流。该系统和方法从而在高速流体流进入离心场时建立有利于有效分离的非湍流和均匀的流动条件。该系统和方法还以使离心室的有效表面积最大化以分离的方式引导流体。因此可以在高入口流速下实现有效的分离。

4. 发明授权

US5224921A Small volume collection chamber 失效
标题翻译：小容量收集室
公开(公告)号：US5224921A
公开(公告)日：1993-07-06
申请号：US531175
申请日：1990-05-31
申请人： T. Michael Dennehey , Joseph C. West, Jr.
发明人： T. Michael Dennehey , Joseph C. West, Jr.
IPC分类号： B04B5/02 , A61M1/02 , A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , B04B5/0428 , B04B5/0442 , A61M2202/0415
摘要： A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet for receiving plasma, an area for receiving mononuclear cells, and an outlet for receiving mononuclear cell depleted plasma. The distance and flow path between the inlet and outlet being so constructed and arranged as to cause mononuclear cells to sediment out into the area for receiving the mononuclear cells and causing at least 66% of the platelets contained in the plasma to flow to and through the outlet.
摘要翻译：提供了一种用于在离心机血细胞分离器中将单核细胞与红细胞消耗的血浆分离的装置和方法。该装置包括用于接收血浆的入口，用于接收单核细胞的区域和用于接收单核细胞耗尽的血浆的出口。入口和出口之间的距离和流动路径被构造和布置成使得单核细胞沉淀到用于接收单核细胞的区域中，并且使血浆中包含的至少66％的血小板流入并通过出口。

5. 发明授权

US4940543A Plasma collection set 失效
标题翻译：等离子体收集套
公开(公告)号：US4940543A
公开(公告)日：1990-07-10
申请号：US277890
申请日：1988-11-30
申请人： Richard I. Brown , David E. Cerny , John T. Foley , Joseph C. West, Jr.
发明人： Richard I. Brown , David E. Cerny , John T. Foley , Joseph C. West, Jr.
IPC分类号： B04B5/04
CPC分类号： B04B5/0428 , B04B5/0442 , A61M2205/15 , B04B2005/045
摘要： An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
摘要翻译：从收集的流体中分离组分的装置和方法。该装置包括双组分离心机和相关联的流体流动传递装置。传送组具有收集容器，其中可以初始地累积一定量的流体。收集容器形成为盘形塑料构件，其中形成有细长的大致径向延伸的阻挡构件。组件收集容器与盘形容器流体流动连通。该方法提供了双组分离心机中的收集容器的离心，从而分离出所选择的流体组分。然后，该部件可以从收集容器中泵送到部件堆积容器中。剩余流体可以密封在收集容器中以供以后使用。组件收集容器可以分离和密封以供以后使用。

6. 发明授权

US4806252A Plasma collection set and method 失效
标题翻译：等离子体收集套和方法
公开(公告)号：US4806252A
公开(公告)日：1989-02-21
申请号：US8718
申请日：1987-01-30
申请人： Richard I. Brown , David E. Cerny , John T. Foley , Joseph C. West, Jr.
发明人： Richard I. Brown , David E. Cerny , John T. Foley , Joseph C. West, Jr.
IPC分类号： A61M1/02 , B01D21/26 , B04B5/00 , B04B5/04
CPC分类号： B04B5/0442 , B04B5/0428 , A61M2205/15 , B04B2005/045
摘要： An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
摘要翻译：从收集的流体中分离组分的装置和方法。该装置包括双组分离心机和相关联的流体流动传递装置。传送组具有收集容器，其中可以初始地累积一定量的流体。收集容器形成为盘形塑料构件，其中形成有细长的大致径向延伸的阻挡构件。组件收集容器与盘形容器流体流动连通。该方法提供了双组分离心机中的收集容器的离心，从而分离出所选择的流体组分。然后，该部件可以从收集容器中泵送到部件堆积容器中。剩余流体可以密封在收集容器中以供以后使用。组件收集容器可以分离和密封以供以后使用。

7. 发明授权

US5724988A Bone marrow kit 失效
公开(公告)号：US5724988A
公开(公告)日：1998-03-10
申请号：US90552
申请日：1993-07-12
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： A61J1/05 , A61B10/00 , A61B10/02 , A61M1/00 , A61B5/02 , A61B19/00 , A61M5/60
CPC分类号： A61B10/025 , A61M1/0056 , A61B2010/0258
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.

8. 发明授权

US4936820A High volume centrifugal fluid processing system and method for cultured cell suspensions and the like 失效
标题翻译：用于培养细胞悬浮液的大体积离心流体处理系统和方法等
公开(公告)号：US4936820A
公开(公告)日：1990-06-26
申请号：US404008
申请日：1989-09-05
申请人： T. Michael Dennehey , Stanley J. Pernic , Joseph C. West, Jr.
发明人： T. Michael Dennehey , Stanley J. Pernic , Joseph C. West, Jr.
IPC分类号： B04B5/04 , C12M1/26 , C12M3/00
CPC分类号： C12M45/05 , B04B5/0442 , C12M47/04 , B04B2005/045
摘要： A centrifugal processing system for cultured cellular suspensions comprises a reservoir for pooling a desired volume of the cellular suspension from a plurality of individual containers in which the cellular suspension have been cultured. A centrifugation chamber is provided operative in response to centrifugal force for separating the cellular suspension into a cellular component and a supernatant. Fluid is conveyed from the reservoir into the centrifugation chamber at a high flow rate exceeding 1 liter per minute. The cellular component and supernatant are collected from the centrifugation chamber.
摘要翻译：用于培养的细胞悬浮液的离心处理系统包括用于从其中培养细胞悬浮液的多个单独容器中收集所需体积的细胞悬浮液的储存器。提供离心室，其响应于用于将细胞悬浮液分离成细胞组分和上清液的离心力而操作。流体以超过每分钟1升的高流速从储存器输送到离心室中。从离心室收集细胞成分和上清液。

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