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1. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

2. 发明申请

US20140045671A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译：红血球细胞分离系统
公开(公告)号：US20140045671A1
公开(公告)日：2014-02-13
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

3. 发明授权

US08075468B2 Systems and methods for mid-processing calculation of blood composition 有权
标题翻译：血液成分中期计算的系统和方法
公开(公告)号：US08075468B2
公开(公告)日：2011-12-13
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： B01D21/26 , B04B3/00
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate platelets from the blood. A flow of platelets is conveyed from the device by the outlet line and the platelets in the outlet line are optically measured. With said optical measurement, a current platelet yield, a platelet pre-count, the volume of blood to process to collect a target amount of platelets, and/or the processing time required to collect a target amount of platelets is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the platelets.
摘要翻译：提供血液分离方法用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血小板与血液分开。通过出口管线从装置输送血小板流，并且光学测量出口管线中的血小板。通过所述光学测量，计算目前的血小板产量，血小板预计数，用于收集目标量的血小板的血液的体积和/或收集目标量的血小板所需的处理时间。光学测量还可用于计算与血小板一起输送到收集容器中的储存液体的量。

4. 发明申请

US20090215602A1 SYSTEMS AND METHODS FOR MID-PROCESSING CALCULATION OF BLOOD COMPOSITION 有权
标题翻译：用于中间体计算血液组合物的系统和方法
公开(公告)号：US20090215602A1
公开(公告)日：2009-08-27
申请号：US12394375
申请日：2009-02-27
申请人： Kyungyoon Min , Richard I. Brown
发明人： Kyungyoon Min , Richard I. Brown
IPC分类号： A61M1/36 , B01D17/038 , B01D21/26 , B04B1/00 , B04B1/18
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M2205/3306 , B01D21/262 , B01D21/302 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and/or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.
摘要翻译：提供血液分离方法和系统用于血液成分的中间处理计算。将血液输送到具有出口管线的装置中，并且将该装置旋转以将血液成分与血液分离。通过出口管路从装置输送血液成分流，并且光学测量出口管线中的血液成分。通过所述光学测量，当前的血液成分收率，血液成分预计数，用于收集目标量的所述血液成分的血液的体积和/或收集目标量的所述血液成分所需的处理时间被计算。光学测量还可以用于计算要输送到具有血液成分的收集容器中的存储流体的量。

5. 发明授权

US06808503B2 Automated system and method for pre-surgical blood donation and fluid replacement 有权
标题翻译：手术前献血和液体置换的自动化系统和方法
公开(公告)号：US06808503B2
公开(公告)日：2004-10-26
申请号：US09800024
申请日：2001-03-06
申请人： Liam Farrell , Sandra Thom , Rohit Vishnoi , Richard I. Brown
发明人： Liam Farrell , Sandra Thom , Rohit Vishnoi , Richard I. Brown
IPC分类号： A61M3700
CPC分类号： A61M1/3687 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3451 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2205/12
摘要： Automated systems and methods for withdrawing and replacing fluids in a patient are disclosed. The system withdraws blood from a donor or patient, separates the blood into two or more components and collects the separated component. A replacement fluid capable of at least partially providing the biological function of the separated component is infused into the patient.
摘要翻译：公开了用于抽出和替换患者体内液体的自动化系统和方法。系统从供体或患者抽出血液，将血液分成两个或更多个组分并收集分离的组分。能够至少部分地提供分离的组分的生物学功能的替换流体被输入到患者体内。

6. 发明授权

US06263871B1 Mouthpiece with coupler 失效
标题翻译：带耦合器的嘴
公开(公告)号：US06263871B1
公开(公告)日：2001-07-24
申请号：US09558181
申请日：2000-04-26
申请人： Richard I. Brown , David S. Brown
发明人： Richard I. Brown , David S. Brown
IPC分类号： B63C1102
CPC分类号： B63C11/2227 , A62B9/06 , B63C11/186
摘要： A mouthpiece is provided having a quick connect coupler to facilitate the rapid replacement of mouthpieces for use with breathing devices that may be used by many different individuals, such as in diver training classes and rental operations. In a preferred embodiment, the mouthpiece has a coupler including a pin to engage and lock with a slot in an opening of the regulator housing. The mouthpiece can further include one-way inhalation and exhalation pathways to prevent pathogenic entities in the exhalation and saliva of the diver from contaminated the body of the regulator. An exhaust tee is provided to direct bubbles away from the diver's line of vision. The regulator housing can further include an independent exhaust valve opening. A seal is provided to prevent the regulator body from flooding through the exhaust valve opening when the regulator is used with a mouthpiece having its own exhalation pathway. A flapper valve replaces the exhaust valve opening seal to permit conventional operation when the regulator is used with a conventional mouthpiece after being taken out of service for use by multiple users.
摘要翻译：提供了一种具有快速连接联接器的接口，以便于快速更换用于与多个不同人员（例如潜水员训练课程和租赁操作）可能使用的呼吸装置一起使用的吸嘴。在优选实施例中，接口管具有联接器，该联接器包括销，以在调节器壳体的开口中与槽接合和锁定。吸嘴还可以包括单向吸入和呼气途径，以防止潜水员的呼出和唾液中的病原体污染调节器的体内。提供排气三通以引导泡沫远离潜水员的视线。调节器壳体还可包括独立的排气门开口。当调节器与具有其自身呼气路径的接口管一起使用时，提供密封件以防止调节器主体通过排气阀开口淹没。当调节器在停止使用以供多个用户使用之后，当调节器与常规接口管一起使用时，挡板阀替代排气阀打开密封件以允许常规操作。

7. 发明授权

US6103183A Supporting guide for oxyacetylene torch 失效
标题翻译：氧乙炔火炬配套指南
公开(公告)号：US6103183A
公开(公告)日：2000-08-15
申请号：US350895
申请日：1999-07-12
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： B23K7/10
CPC分类号： B23K7/102
摘要： A supporting guide for an oxyacetylene torch provides a body having spaced legs defining a recess therebetween to carry gas supply pipes of the torch for releasable attachment of the supporting guide to the supply pipes. A body portion distal from the recess pivotally carries a disk carrying a support arm extending spacedly therefrom for pivotal motion relative to the body to support the torch and guide it on a workpiece or a template. The support arm is carried by the disk for adjustable extension and angulation relative to the body to regulate the distance of a torch nozzle from a workpiece and the angulation of the torch nozzle relative to the workpiece.
摘要翻译：氧乙炔火炬的支撑引导件提供了具有限定其间的凹部的间隔开的主体的主体，以承载焊炬的气体供应管，用于将支撑引导件可释放地附接到供应管。远离凹口的主体部分枢转地承载一个带有支撑臂的盘，该支撑臂从其间隔开延伸，以相对于主体枢转运动，以支撑割炬并将其引导到工件或模板上。支撑臂由盘承载，用于相对于主体可调节的延伸和角度，以调节割炬喷嘴与工件的距离以及割炬喷嘴相对于工件的角度。

8. 发明授权

US5792372A Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma 失效
标题翻译：用于从富含血小板的血浆中获得浓缩血小板的增强收获系统和方法
公开(公告)号：US5792372A
公开(公告)日：1998-08-11
申请号：US774999
申请日：1996-12-27
申请人： Richard I. Brown , Dale R. Ellis
发明人： Richard I. Brown , Dale R. Ellis
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： B04B13/00 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , B01D17/0217 , B01D21/0003 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/34 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M1/30 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/08 , B01D2221/10 , B04B2005/045
摘要： A separation zone for separating platelets from a platelet-rich suspension establishes a relationship between its radial thickness (h) and axial height (Z) that, taking into account the given angular velocity of rotation and the given kinematic viscosity of the platelet-rich suspension introduced through the inlet, represents a (.lambda.) value that is less than 700, where ##EQU1## where: .OMEGA. is the angular velocity (in rad/sec); h is the radial depth (or thickness) of the chamber (in cm); .nu. is the kinematic viscosity of the fluid being separated (in cm.sup.2 /sec); and Z is the axial height of the chamber (in cm).
摘要翻译：用于从富含血小板的悬浮液分离血小板的分离区建立其径向厚度（h）和轴向高度（Z）之间的关系，考虑到给定的旋转角度和富含血小板的悬浮液的给定运动粘度通过入口引入，表示小于700的（λ）值，其中其中：OMEGA是角速度（rad / sec）; h是室的径向深度（或厚度）（cm）; nu是被分离的流体的运动粘度（cm 2 / sec）; Z是室的轴向高度（cm）。

9. 发明授权

US5759413A Systems and method for estimating platelet counts using a spleen mobilization function 失效
标题翻译：使用脾动员功能估算血小板计数的系统和方法
公开(公告)号：US5759413A
公开(公告)日：1998-06-02
申请号：US480601
申请日：1995-06-07
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： A61M1/14 , A61M1/02 , A61M1/36 , B01D17/12 , G01N15/05
CPC分类号： A61M1/385 , A61M1/02 , A61M1/3693 , A61M1/0209 , A61M1/3672 , A61M2202/0415 , A61M2202/0427
摘要： Systems and methods take into account that the spleen normally holds a number of platelets in reserve out of circulation. During blood processing, the spleen releases these platelets into the donor's circulatory system, making them available for collection. The systems and methods estimate the number of platelets N.sub.SPLEEN held in reserve by the spleen in a human body. The systems and methods derives a splenic mobilization function (Spleen), which can be expressed as a function of a precount of platelets Plt.sub.PRE. The systems and methods estimate N.sub.SPLEEN where: N.sub.SPLEEN =(Spleen-1).times.Plt.sub.PRE .times.DonVol where DonVol is blood volume in the body. The systems and methods can also estimate the total number of platelets N.sub.PLT in a human body, taking the Spleen function into account, where: N.sub.PLT =Plt.sub.PRE .times.Spleen.times.DonVol
摘要翻译：系统和方法考虑到脾脏通常保留一定数量的血小板保留在循环中。在血液处理过程中，脾脏将这些血小板释放到供体的循环系统中，使其可用于收集。系统和方法估计在人体内由脾脏保留的血小板NSPLEEN的数量。系统和方法得出脾脏动员功能（脾脏），可以表达为血小板PltPRE计数的函数。系统和方法估计NSPLEEN其中：NSPLEEN =（Spleen-1）xPltPRExDonVolwhere DonVol是体内血量。系统和方法还可以估计人体血小板NPLT的总数，考虑脾功能，其中：NPLT = PltPRExSpleenxDonVol

10. 发明授权

US5750039A Blood processing systems and methods for collecting mono nuclear cells 失效
标题翻译：用于收集单核细胞的血液处理系统和方法
公开(公告)号：US5750039A
公开(公告)日：1998-05-12
申请号：US745779
申请日：1996-11-08
申请人： Richard I. Brown , Kyungyoon Min
发明人： Richard I. Brown , Kyungyoon Min
IPC分类号： A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： A61M1/0209 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3693 , A61M1/3696 , B01D17/0217 , B01D21/003 , B01D21/0087 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/32 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M1/30 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： Systems and methods centrifugally separate mono nuclear cells from whole blood in a separation chamber. The systems and methods control the exit hematocrit value of red blood cells separated in the chamber by recirculating a portion of the red blood cells removed from the chamber for mixing whole blood entering the separation chamber. The systems and methods also control the entry hematocrit value of whole blood entering the separation chamber by recirculating a portion of the plasma constituent removed from the separation chamber for mixing whole blood entering the separation chamber.
摘要翻译：系统和方法在分离室中离心分离单核细胞与全血。系统和方法通过再循环从腔室中取出的一部分红细胞来控制在腔室中分离的红细胞的出血血细胞比值，用于混合进入分离室的全血。系统和方法还通过再循环从分离室除去的等离子体成分的一部分来混合进入分离室的全血，从而控制进入分离室的全血进入血细胞比容值。

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