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1. 发明授权

US06189704B1 Inline filter 失效
标题翻译：在线过滤器
公开(公告)号：US06189704B1
公开(公告)日：2001-02-20
申请号：US08955409
申请日：1997-10-23
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： B01D2900
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译：提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器使得流体必须流过预过滤器以通过出口开口离开收集容器。第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器，进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。还提供了处理骨髓和构建在线过滤器的方法。

2. 发明授权

US06523698B1 Bone marrow kit 失效
标题翻译：骨髓袋
公开(公告)号：US06523698B1
公开(公告)日：2003-02-25
申请号：US09597653
申请日：2000-06-21
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： B01D2700
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译：提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器使得流体必须流过预过滤器以通过出口开口离开收集容器。第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器，进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。还提供了处理骨髓和构建在线过滤器的方法。

3. 发明授权

US5724988A Bone marrow kit 失效
公开(公告)号：US5724988A
公开(公告)日：1998-03-10
申请号：US90552
申请日：1993-07-12
申请人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
发明人： T. Michael Dennehey , Joseph C. West, Jr. , James W. Yang
IPC分类号： A61J1/05 , A61B10/00 , A61B10/02 , A61M1/00 , A61B5/02 , A61B19/00 , A61M5/60
CPC分类号： A61B10/025 , A61M1/0056 , A61B2010/0258
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.

4. 发明授权

US4829002A System for metering nutrient media to cell culture containers and method 失效
标题翻译：用于计量营养培养基至细胞培养容器和方法的系统
公开(公告)号：US4829002A
公开(公告)日：1989-05-09
申请号：US862344
申请日：1986-05-12
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
IPC分类号： C12M3/00 , C12M1/00 , C12M1/26 , C12N5/00 , C12N5/10
CPC分类号： C12M23/14 , C12M33/07
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译：用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。在优选的实施方案中，无菌连接器可用于基本上无菌的条件。分支导管在与端部间隔开的位置处从流动管道延伸。分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

5. 发明授权

US4937194A Method for metering nutrient media to cell culture containers 失效
标题翻译：计量营养培养基至细胞培养容器的方法
公开(公告)号：US4937194A
公开(公告)日：1990-06-26
申请号：US303188
申请日：1989-01-30
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
IPC分类号： C12M1/00 , C12M1/26 , C12N5/02
CPC分类号： C12M23/14 , C12M33/07 , Y10S435/80
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译：用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。在优选的实施方案中，无菌连接器可用于基本上无菌的条件。分支导管在与端部间隔开的位置处从流动管道延伸。分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

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