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1. 发明授权

US06477411B1 Bioelectrode having a crushable hydrating assembly and associated method 有权
标题翻译：具有可压溃水合组装和相关方法的生物电极
公开(公告)号：US06477411B1
公开(公告)日：2002-11-05
申请号：US09587006
申请日：2000-06-05
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N130
CPC分类号： A61N1/303
摘要： A hydratable bioelectrode for use in an iontophoretic delivery device comprising a hydrating component and a bioelectrode component. The hydrating component includes a cradle having a chamber containing one or more fluid containing ampule(s) and ampule breaking means associated with the cradle for rapidly breaking the one or more fluid containing ampule(s).
摘要翻译：一种用于包含水合组分和生物电极组分的离子电渗递送装置的可水合生物电极。所述保湿组分包括具有包含一种或多种含有安瓿的流体的腔室和与所述支架相连的安瓿破碎装置的支架，用于快速破坏所述一种或多种含有液体的安瓿。

2. 发明授权

US06319240B1 Methods and apparatus for ocular iontophoresis 失效
标题翻译：眼用离子电渗法的方法和装置
公开(公告)号：US06319240B1
公开(公告)日：2001-11-20
申请号：US09318181
申请日：1999-05-25
申请人： Jon E. Beck
发明人： Jon E. Beck
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/30 , A61N1/306
摘要： An iontophoretic apparatus for ocular iontophoresis comprising a housing element formed to cooperate with the eye. In cooperation with the housing element is a flexible current distribution element that is capable of transmitting electrical current. Coupled to the current distribution element is a conformable medicament containment element that is filled with a medicament which is released under the influence of an electrical current, while a barrier element is provided that is configured to reduce current flow outside of the barrier and aid in the preferential delivery of medicament.
摘要翻译：一种用于眼部离子电渗疗法的离子电渗疗法装置，其包括形成为与眼睛配合的壳体元件。与外壳元件配合是能够传输电流的柔性电流分配元件。与电流分配元件相耦合的是符合要求的药物容纳元件，其填充有在电流影响下被释放的药物，同时提供了阻挡元件，该阻挡元件被配置为减少屏障外部的电流并帮助药物优先递送。

3. 发明授权

US5558632A Electrodes for iontophoresis 失效
标题翻译：离子电渗电极
公开(公告)号：US5558632A
公开(公告)日：1996-09-24
申请号：US333844
申请日：1994-11-03
申请人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
发明人： Lindsay B. Lloyd , Jon E. Beck , Tomasz J. Petelenz , Clay H. Holt , William F. Felman
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448
摘要： An improved electrode is disclosed for use in administering drug by means of iontophoresis, comprising a conductive element for receiving an electric current from a current source; a reticulated element having a plurality of reticulum for receiving an ionic drug solution for iontophoretic delivery, the reticulum being loaded or having applied thereto a hydrophilic polymer which is viscous when hydrated; and means for securing the reticulated element to the conductive element so that electric current will be distributed substantially uniformly through the reticulated element when hydrated and when current is delivered to the conductive element. The presently preferred embodiment utilizes open cell polyurethane foam as the reticulated element and high molecular weight polyethylene oxide as the hydrophilic polymer. The reticulum is further loaded with Tween 20, a surfactant, which serves to improve the rate of hydration. A reticulated element formed in accordance with the present invention is pliable and conformable both when in wet or dry state, making an electrode formed in accordance with the present invention susceptible of a wide variety of shapes and sizes and relatively easy to manufacture at reasonably low cost.
摘要翻译：公开了一种用于通过离子电渗法施用药物的改进的电极，其包括用于从电流源接收电流的导电元件; 具有多个网状物的网状元件，用于接收用于离子电渗疗法输送的离子药物溶液，所述网状物被加载或已经施加到其上，当水合时粘稠的亲水性聚合物; 以及用于将网状元件固定到导电元件的装置，使得当水合时和当电流被传送到导电元件时，电流将基本上均匀地分布通过网状元件。目前优选的实施方案使用开孔聚氨酯泡沫作为网状元素和高分子量聚环氧乙烷作为亲水性聚合物。网状物进一步装载有用于提高水合速率的表面活性剂吐温20。根据本发明形成的网状元件在湿或干态下既柔韧又顺应，使得根据本发明形成的电极易于形成多种形状和尺寸，并且以相当低的成本相对容易制造。

4. 发明授权

US06728573B1 Ocular iontophoretic apparatus handle 失效
标题翻译：眼部离子电渗疗法手柄
公开(公告)号：US06728573B1
公开(公告)日：2004-04-27
申请号：US09599245
申请日：2000-06-22
申请人： Jon E. Beck , Alexander K. Koss
发明人： Jon E. Beck , Alexander K. Koss
IPC分类号： A61N130
CPC分类号： A61N1/303
摘要： An iontophoretic apparatus comprising a housing member, a current distribution member, a medicament containment member and a handle member. The current distribution member is associated with the housing member. The medicament containment member is associated with the current distribution member. The handle member is associated with the housing member. The handle member facilitates the positioning and placement of the iontophoretic apparatus.
摘要翻译：一种离子电渗疗法装置，包括壳体构件，电流分配构件，药物容纳构件和手柄构件。电流分配构件与壳体构件相关联。药物容纳构件与电流分配构件相关联。手柄构件与壳体构件相关联。手柄构件便于离子电渗疗法装置的定位和放置。

5. 发明授权

US5328455A Rehydratable product and method of preparation thereof 失效
标题翻译：可水化产品及其制备方法
公开(公告)号：US5328455A
公开(公告)日：1994-07-12
申请号：US38798
申请日：1993-03-29
申请人： Lindsay B. Llyod , Jon E. Beck , Tomasz J. Petelenz
发明人： Lindsay B. Llyod , Jon E. Beck , Tomasz J. Petelenz
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： A hydratable iontophoretic bioelectrode including a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. In one embodiment, a layer of a highly crosslinked dry hydrogel is used with a second layer of a more lightly crosslinked dry hydrogel. When the lightly crosslinked hydrogel layer is located so as to be in contact with the skin during iontophoresis, the medicament ions will be concentrated next to the skin. When the more highly crosslinked layer is located next to the conductive member, the undesirable effects of hydrolysis or corrosion of the conductive member are lessened. In another embodiment, adjacent layers are maintained at least partially out of contact from one another so as to improve the rate of hydration by disposition between the layers of spacing elements such as sugar or other dissolvable particles or cellulose or by forming a three dimensional pattern thereon.
摘要翻译：一种可水合的离子电渗生物电极，其包括多个能够在与流体接触放置时吸收和保持电离流体的材料层。在一个实施方案中，使用高度交联的干水凝胶层与较轻交联的干水凝胶的第二层。当离子电渗疗法中轻度交联的水凝胶层被定位成与皮肤接触时，药物离子将集中在皮肤附近。当更高度交联的层位于导电构件旁边时，导电构件的水解或腐蚀的不良影响减小。在另一个实施方案中，相邻层保持至少部分不相互接触，以便通过在诸如糖或其它可溶解颗粒或纤维素之间的间隔元件层之间的配置或通过在其上形成三维图案来改善水合速率。

6. 发明授权

US08386029B2 Apparatus for electrotherapy drug delivery with added impurities 有权
标题翻译：电疗药物递送装置，附加杂质
公开(公告)号：US08386029B2
公开(公告)日：2013-02-26
申请号：US10907429
申请日：2005-03-31
申请人： Robert F. Hause, Jr. , Jon E. Beck
发明人： Robert F. Hause, Jr. , Jon E. Beck
IPC分类号： A61N1/30 , A61K9/22
CPC分类号： A61N1/0436 , A61N1/0428 , A61N1/30 , A61N1/325
摘要： The present invention is directed to a method and apparatus for an electrotherapeutic system including a first and second electrode. Each electrode includes a respective resistance wherein during operation of the electrotherapeutic system, an electrochemical reaction involving one or both of the electrodes varies the respective resistance of at least one of the electrodes.
摘要翻译：本发明涉及一种包括第一和第二电极的电疗系统的方法和装置。每个电极包括相应的电阻，其中在电疗系统的操作期间，涉及电极中的一个或两个的电化学反应改变至少一个电极的相应电阻。

7. 发明授权

US08214030B2 Iontophoresis apparatus and method 有权
标题翻译：离子渗透装置及方法
公开(公告)号：US08214030B2
公开(公告)日：2012-07-03
申请号：US11733700
申请日：2007-04-10
申请人： Robert F. Hause, Jr. , Jon E. Beck
发明人： Robert F. Hause, Jr. , Jon E. Beck
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoresis apparatus and method is disclosed that is suited to deliver a plurality of treatment methods such as, but not limited to, body site conductivity enhancement followed by low voltage iontophoresis.
摘要翻译：公开了一种离子电渗疗法装置和方法，其适于递送多种治疗方法，例如但不限于体部电导率增强，接着是低电压离子电渗疗法。

8. 发明授权

US07996077B2 Iontophoresis apparatus and method 有权
标题翻译：离子渗透装置及方法
公开(公告)号：US07996077B2
公开(公告)日：2011-08-09
申请号：US11733692
申请日：2007-04-10
申请人： Robert F. Hause, Jr. , Jon E. Beck
发明人： Robert F. Hause, Jr. , Jon E. Beck
IPC分类号： A61N1/30 , A61N1/00
CPC分类号： A61N1/0428
摘要： An iontophoresis apparatus and method is disclosed that is suited to deliver a plurality of treatment methods such as, but not limited to, body site conductivity enhancement followed by low voltage iontophoresis.
摘要翻译：公开了一种离子电渗疗法装置和方法，其适于递送多种治疗方法，例如但不限于体部电导率增强，接着是低电压离子电渗疗法。

9. 发明申请

US20080058699A1 IONTOPHORESIS APPARATUS AND METHOD 有权
公开(公告)号：US20080058699A1
公开(公告)日：2008-03-06
申请号：US11733692
申请日：2007-04-10
申请人： Robert F. Hause , Jon E. Beck
发明人： Robert F. Hause , Jon E. Beck
IPC分类号： A61N1/30
CPC分类号： A61N1/0428
摘要： An iontophoresis apparatus and method is disclosed that is suited to deliver a plurality of treatment methods such as, but not limited to, body site conductivity enhancement followed by low voltage iontophoresis.

10. 发明授权

US06539251B2 Ocular iontophoretic apparatus 失效
标题翻译：眼部离子电渗疗法
公开(公告)号：US06539251B2
公开(公告)日：2003-03-25
申请号：US09922558
申请日：2001-08-03
申请人： Jon E. Beck , Alex Koss
发明人： Jon E. Beck , Alex Koss
IPC分类号： A61B1720
CPC分类号： A61N1/30 , A61N1/303
摘要： An ocular iontophoretic apparatus comprising a reservoir which includes a outer rim. The outer rim includes a barrier. The barrier is positionable upon the surface of the eye and serves to provide a seal between the reservoir and the surface of the eye. In turn the passage of fluid across the barrier into and out of the reservoir is substantially precluded.
摘要翻译：一种眼部离子电渗疗法装置，包括一个包含外缘的储液器。外缘包括屏障。屏障可定位在眼睛的表面上，并用于在储存器和眼睛表面之间提供密封。反过来，流体穿过隔离物进入和离开储存器的通道基本上被排除。

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