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1. 发明授权

US5328455A Rehydratable product and method of preparation thereof 失效
标题翻译：可水化产品及其制备方法
公开(公告)号：US5328455A
公开(公告)日：1994-07-12
申请号：US38798
申请日：1993-03-29
申请人： Lindsay B. Llyod , Jon E. Beck , Tomasz J. Petelenz
发明人： Lindsay B. Llyod , Jon E. Beck , Tomasz J. Petelenz
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： A hydratable iontophoretic bioelectrode including a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. In one embodiment, a layer of a highly crosslinked dry hydrogel is used with a second layer of a more lightly crosslinked dry hydrogel. When the lightly crosslinked hydrogel layer is located so as to be in contact with the skin during iontophoresis, the medicament ions will be concentrated next to the skin. When the more highly crosslinked layer is located next to the conductive member, the undesirable effects of hydrolysis or corrosion of the conductive member are lessened. In another embodiment, adjacent layers are maintained at least partially out of contact from one another so as to improve the rate of hydration by disposition between the layers of spacing elements such as sugar or other dissolvable particles or cellulose or by forming a three dimensional pattern thereon.
摘要翻译：一种可水合的离子电渗生物电极，其包括多个能够在与流体接触放置时吸收和保持电离流体的材料层。在一个实施方案中，使用高度交联的干水凝胶层与较轻交联的干水凝胶的第二层。当离子电渗疗法中轻度交联的水凝胶层被定位成与皮肤接触时，药物离子将集中在皮肤附近。当更高度交联的层位于导电构件旁边时，导电构件的水解或腐蚀的不良影响减小。在另一个实施方案中，相邻层保持至少部分不相互接触，以便通过在诸如糖或其它可溶解颗粒或纤维素之间的间隔元件层之间的配置或通过在其上形成三维图案来改善水合速率。

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