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1. 发明公开

EP0199869A1 Tools for use in tightening or removing screw-threaded fasteners 失效
标题翻译：工具拧紧螺钉或锁紧固件的松动。
公开(公告)号：EP0199869A1
公开(公告)日：1986-11-05
申请号：EP85303602.8
申请日：1985-05-22
申请人： Lankry, Julien Jean Louis , Johnson, John Morton
发明人： Lankry, Julien Jean Louis
IPC分类号： B25B21/00
CPC分类号： B25B23/10 , B25B21/007 , B25B23/0064 , B25F3/00
摘要： A device for rotating a screw into or out of a workpiece, the device being connectible to a power drill and including a screw driving member. There is provided between the power drill and the screw driving member a mechanism for determining the direction of rotation of the screw-driving member and a torque-adjusting mechanism for controlling the depth a screw is to be driven into a workpiece and including clutch means rotatably associated with the rotational-direction determining mechanism. The rotational-direction determining mechanism comprises a planetary gear system, whereof the planet carrier is adapted to be locked to effect rotation of the screw-driving member in a screw-extraction sense (i.e. reverse rotation) or to be released to effect rotation of the screw-driving member in a screw-insertion sense (i.e. forwards rotation).

2. 发明申请

WO2008146005A3 FREEZE DRYING OF TARGET SUBSTANCES 审中-公开
公开(公告)号：WO2008146005A3
公开(公告)日：2008-12-04
申请号：PCT/GB2008/001835
申请日：2008-05-30
申请人： OXFORD BIOSENSORS LTD , BROUGHALL, John, Morton , WEDGE, Charles, Richard , MUNRO, Charles
发明人： BROUGHALL, John, Morton , WEDGE, Charles, Richard , MUNRO, Charles
IPC分类号： F26B5/06
摘要： In a process for freeze drying a target substance, the target substance is carried by a carrier, which is passed into a freeze chamber (31) to reduce the temperature of the target substance, and then on to a dryer chamber (32). Vacuum/ reduced pressure is applied during the process, during a final portion of the freeze process when the target substance and carrier are present in the freeze chamber (31); and/or when the target substance and carrier are transferred from the freeze chamber (31) to the dryer chamber (32). Vacuum/reduced pressure is also applied when the target substance and carrier are present in the dryer chamber. The process enables the freezing process to commence at temperatures close to the collapse temperature of the target substance and to maintain that temperature while compensating for evaporative cooling, thus giving the fastest and most efficient freeze drying cycle, resulting in a slower cooling rate producing structures that are optimal for use.

3. 发明申请

WO2008146005A2 FREEZE DRYING OF TARGET SUBSTANCES 审中-公开
标题翻译：冷冻干燥目标物质
公开(公告)号：WO2008146005A2
公开(公告)日：2008-12-04
申请号：PCT/GB2008001835
申请日：2008-05-30
申请人： OXFORD BIOSENSORS LTD , BROUGHALL JOHN MORTON , WEDGE CHARLES RICHARD , MUNRO CHARLES
发明人： BROUGHALL JOHN MORTON , WEDGE CHARLES RICHARD , MUNRO CHARLES
IPC分类号： F26B5/06
CPC分类号： F26B5/06
摘要： In a process for freeze drying a target substance, the target substance is carried by a carrier, which is passed into a freeze chamber to reduce the temperature of the target substance, and then on to a dryer chamber. Vacuum/reduced pressure is applied during the process, during a final portion of the freeze process when the target substance and carrier are present in the freeze chamber; and/or when the target substance and carrier are transferred from the freeze chamber to the dryer chamber. Vacuum/reduced pressure is also applied when the target substance and carrier are present in the dryer chamber. The process enables the freezing process to commence at temperatures close to the collapse temperature of the target substance and to maintain that temperature while compensating for evaporative cooling, thus giving the fastest and most efficient freeze drying cycle, resulting in a slower cooling rate producing structures that are optimal for use.
摘要翻译：在目标物质的冷冻干燥过程中，目标物质由载体进行运送，该载体进入冷冻室以降低目标物质的温度，然后进入干燥室。在该过程中，当目标物质和载体存在于冷冻室中时，在冷冻过程的最后部分期间施加真空/减压; 和/或当目标物质和载体从冷冻室转移到干燥室时。当目标物质和载体存在于干燥室中时，也施加真空/减压。该方法使得冷冻过程能够在接近目标物质的塌陷温度的温度下开始，并且在补偿蒸发冷却的同时保持该温度，从而给出最快和最有效的冷冻干燥循环，导致较慢的冷却速率产生结构，是最佳的使用。

4. 发明申请

WO2007132226A1 CHOLESTEROL SENSOR 审中-公开
标题翻译：胆固醇传感器
公开(公告)号：WO2007132226A1
公开(公告)日：2007-11-22
申请号：PCT/GB2007/001769
申请日：2007-05-14
申请人： OXFORD BIOSENSORS LTD , BROUGHALL, John, Morton , ASKEW, Herbert, Frank , MURPHY, Lindy
发明人： BROUGHALL, John, Morton , ASKEW, Herbert, Frank , MURPHY, Lindy
IPC分类号： G01N33/92 , C12Q1/60
CPC分类号： G01N33/92 , C12Q1/26 , C12Q1/60 , G01N33/5438
摘要： A method for the determination of the amount of cholesterol in lipoproteins other than high density lipoproteins in a lipoprotein-containing sample, said method comprising (a) electrochemically determining the amount of cholesterol bound to high density lipoproteins in the sample, (b) electrochemically determining the total amount of cholesterol in the sample, and subtracting the result of (a) from the result of (b).
摘要翻译：一种用于测定含脂蛋白样品中高密度脂蛋白以外的脂蛋白中胆固醇含量的方法，所述方法包括（a）电化学测定与样品中高密度脂蛋白结合的胆固醇量，（b）电化学测定样本中胆固醇的总量，并从（b）的结果中减去（a）的结果。

5. 发明申请

WO2007066132A1 FREEZE DRYING OF TARGET SUBSTANCES 审中-公开
标题翻译：冷冻干燥目标物质
公开(公告)号：WO2007066132A1
公开(公告)日：2007-06-14
申请号：PCT/GB2006/004600
申请日：2006-12-08
申请人： OXFORD BIOSENSORS LIMITED , BROUGHALL, John, Morton , WEDGE, Charles, Richard , MONROE, Charles
发明人： BROUGHALL, John, Morton , WEDGE, Charles, Richard , MONROE, Charles
IPC分类号： F26B5/06
CPC分类号： F26B5/06
摘要： A target substance (8) is subject to a freeze drying process in which the substance is first passed into a freeze chamber (31) to reduce the temperature of the substance, and then passed into a separate vacuum chamber (32) in which a vacuum is applied to promote drying of the target substance. Because the carrier (10) and target substance (8) is moved from a freeze chamber (31) to a separate vacuum chamber (32) the environment can be more closely controlled and the cycling of freezing to drying can be more rapid. In this way the carrier (10) and target substance (8) is subject to the full temperature cycling without the surrounding chamber and apparatus being subject to the full cycle. This reduces time and energy costs. The technique is particularly suited to manufacturing biosensors using freeze dried reagents.
摘要翻译：目标物质（8）经受冷冻干燥处理，其中物质首先进入冷冻室（31）以降低物质的温度，然后进入单独的真空室（32），其中真空用于促进目标物质的干燥。因为载体（10）和目标物质（8）从冷冻室（31）移动到单独的真空室（32），所以可以更加严格地控制环境，并且可以更快速地进行冷冻循环。以这种方式，载体（10）和目标物质（8）经受全温循环，而周围的室和装置不受整个循环的影响。这减少了时间和能源成本。该技术特别适用于使用冷冻干燥试剂制造生物传感器。

6. 发明申请

WO2006067424A1 HDL CHOLESTEROL SENSOR 审中-公开
标题翻译： HDL胆固醇传感器
公开(公告)号：WO2006067424A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004952
申请日：2005-12-21
申请人： OXFORD BIOSENSORS LIMITED , ROBLIN, Patricia, Mary, Elizabeth , BROUGHALL, John, Morton , WONG, Luet, Lok
发明人： ROBLIN, Patricia, Mary, Elizabeth , BROUGHALL, John, Morton , WONG, Luet, Lok
IPC分类号： C12Q1/32 , C12Q1/00 , C12Q1/60 , C12Q1/44 , C12Q1/26
CPC分类号： C12Q1/60 , C12Q1/001
摘要： A method for the determination of the amount of cholesterol in high density lipoproteins in a high density lipoprotein containing sample, said method comprising reacting the sample with a PEG-ylated protein to selectively complex non-HDL lipoproteins in the sample with said PEG-ylated protein, or with a PEG-ylated enzyme capable of selective reaction with high density lipoproteins, and subsequently measuring the amount of cholesterol in the high density lipoproteins, for example using an electrochemical technique.
摘要翻译：一种用于测定含有高密度脂蛋白的样品中高密度脂蛋白中胆固醇含量的方法，所述方法包括使样品与PEG-样蛋白质反应，以使所述样品中的所述PEG-样蛋白质选择性复合非HDL脂蛋白，或与能够与高密度脂蛋白选择性反应的PEG-样酶，以及随后测量高密度脂蛋白中胆固醇的量，例如使用电化学技术。

7. 发明申请

WO2006000829A3 ELECTROCHEMICAL SENSING METHOD 审中-公开
标题翻译：电化学传感方法
公开(公告)号：WO2006000829A3
公开(公告)日：2006-03-23
申请号：PCT/GB2005002558
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LTD , HYLAND MARK , BROUGHALL JOHN MORTON , BUTLER RONALD NEIL
发明人： HYLAND MARK , BROUGHALL JOHN MORTON , BUTLER RONALD NEIL
IPC分类号： G01N27/30 , C12Q1/00
CPC分类号： C12Q1/001 , G01N27/3272 , Y10T29/49108
摘要： A method of confining an electroactive substance (7) within an electrochemical cell in the form of a receptacle, said method comprising: (a) providing an electrochemical cell in the form of a receptacle, the receptacle having a first open part (3) to allow entry of a sample into the receptacle, and a second open part to allow escape of air displaced by the entering sample, the electrochemical cell having a working electrode (5) 1 and a counter electrode (6); (b) providing an electroactive substance (7), which substance is contained within the receptacle; (c) providing a permeable or semi-permeable membrane (4), comprising one or more layers, covering the first open part of the receptacle; and (d) inserting the sample into the receptacle through the membrane, such that (1) the electroactive substance and (2) the sample, are in contact with each other and with.-said working electrode; wherein the electroactive is confined within the receptacle during step (d). Preferably, the method additionally involves electrochemically testing a sample, by applying a voltage across the cell and measuring the resulting electrochemical response.
摘要翻译：将电活性物质（7）限制在容器形式的电化学电池内的方法，所述方法包括：（a）提供呈容器形式的电化学电池，所述容器具有第一开口部分（3）至允许样品进入容器，以及第二开放部分，以允许由进入的样品排出的空气逸出，所述电化学电池具有工作电极（5）1和对电极（6）; （b）提供电活性物质（7），该物质包含在容器内; （c）提供覆盖容器的第一开放部分的可渗透或半透膜（4），包括一层或多层; 和（d）通过膜将样品插入容器中，使得（1）电活性物质和（2）样品彼此接触并与所述工作电极接触; 其中在步骤（d）期间电活性被限制在容器内。优选地，该方法还涉及通过在电池上施加电压并测量所得到的电化学响应来电化学测试样品。

8. 发明申请

WO2007062449A1 BAITFISH HOLDER FISHING JIG 审中-公开
标题翻译：比利时渔船渔船
公开(公告)号：WO2007062449A1
公开(公告)日：2007-06-07
申请号：PCT/AU2006/001588
申请日：2006-10-25
申请人： CALDERWOOD, John, Morton
发明人： CALDERWOOD, John, Morton
IPC分类号： A01K83/00 , A01K83/06
CPC分类号： A01K83/06
摘要： A fishing jig able to hold a baitfish, the jig including a primary shaft having a fishing line attachment end and a bifurcated free end, the free end supporting opposed hook assemblies in a manner such that each hook assembly is offset from the primary shaft. The primary shaft is preferably long enough for the jig to be able to skewer a baitfish, to thereby hold the baitfish generally centrally, with the attachment end projecting out of the baitfish at or near its head and the bifurcated free end (and opposed hook assemblies) projecting out of the baitfish at or near its tail.
摘要翻译：一种钓鱼夹具，其能够容纳饵料，所述夹具包括具有钓线附接端和分叉自由端的主轴，所述自由端以相对于每个钩组件偏离所述主轴的方式支撑相对的钩组件。主轴优选地足够长以使夹具能够串入饵料，从而将饵料大致居中地保持，其中附接端在其头部处或其附近伸出饵料，并且分叉的自由端（和相对的钩组件）从其尾部或其附近的饵料投射出来。

9. 发明申请

WO2006030170A1 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2006030170A1
公开(公告)日：2006-03-23
申请号：PCT/GB2005/003054
申请日：2005-08-03
申请人： OXFORD BIOSENSORS LIMITED , LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark , ASKEW, Herbert, Frank , BROUGHALL, John, Morton
发明人： LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark , ASKEW, Herbert, Frank , BROUGHALL, John, Morton
IPC分类号： G01N27/416
CPC分类号： G01N27/48
摘要： In an electrochemical sensor, the potential difference applied to the electrochemical cell is raised to a measuring value at a rate determined to reduce the transient current.
摘要翻译：在电化学传感器中，施加到电化学电池的电势差以确定为减少瞬态电流的速率升高到测量值。

10. 发明申请

WO2006000829A2 ELECTROCHEMICAL SENSING METHOD 审中-公开
标题翻译：电化学传感方法
公开(公告)号：WO2006000829A2
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002558
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , BROUGHALL, John, Morton , BUTLER, Ronald, Neil
发明人： HYLAND, Mark , BROUGHALL, John, Morton , BUTLER, Ronald, Neil
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , Y10T29/49108
摘要： A method of confining an electroactive substance within an electrochemical cell in the form of a receptacle, said method comprising: (a) providing an electrochemical cell in the form of a receptacle, the receptacle having a first open part to allow entry of a sample into the receptacle, and a second open part to allow escape of air displaced by the entering sample, the electrochemical cell having a working electrode and a counter electrode; (b) providing an electroactive substance, which substance is contained within the receptacle; (c) providing a permeable or semi-permeable membrane, comprising one or more layers, covering the first open part of the receptacle; and (d) inserting the sample into the receptacle through the membrane, such that (1) the electroactive substance and (2) the sample, are in contact with each other and with said working electrode; wherein the electroactive substance is confined within the receptacle during step (d). Preferably, the method additionally involves electrochemically testing a sample, by applying a voltage across the cell and measuring the resulting electrochemical response.
摘要翻译：将电活性物质限制在容器形式的电化学电池内的方法，所述方法包括：（a）提供呈容器形式的电化学电池，所述容器具有第一开放部分以允许样品进入所述容器和第二开放部分，以允许由所述进入的样品排出的空气逸出，所述电化学电池具有工作电极和对电极; （b）提供电活性物质，该物质包含在容器内; （c）提供覆盖容器的第一开放部分的可渗透或半透膜，包括一层或多层; 和（d）通过膜将样品插入到容器中，使得（1）电活性物质和（2）样品彼此接触并与所述工作电极接触; 其中在步骤（d）期间电活性物质被限制在容器内。优选地，该方法还涉及通过在电池上施加电压并测量所得到的电化学响应来电化学测试样品。

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