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1. 发明申请

WO2008146005A3 FREEZE DRYING OF TARGET SUBSTANCES 审中-公开
公开(公告)号：WO2008146005A3
公开(公告)日：2008-12-04
申请号：PCT/GB2008/001835
申请日：2008-05-30
申请人： OXFORD BIOSENSORS LTD , BROUGHALL, John, Morton , WEDGE, Charles, Richard , MUNRO, Charles
发明人： BROUGHALL, John, Morton , WEDGE, Charles, Richard , MUNRO, Charles
IPC分类号： F26B5/06
摘要： In a process for freeze drying a target substance, the target substance is carried by a carrier, which is passed into a freeze chamber (31) to reduce the temperature of the target substance, and then on to a dryer chamber (32). Vacuum/ reduced pressure is applied during the process, during a final portion of the freeze process when the target substance and carrier are present in the freeze chamber (31); and/or when the target substance and carrier are transferred from the freeze chamber (31) to the dryer chamber (32). Vacuum/reduced pressure is also applied when the target substance and carrier are present in the dryer chamber. The process enables the freezing process to commence at temperatures close to the collapse temperature of the target substance and to maintain that temperature while compensating for evaporative cooling, thus giving the fastest and most efficient freeze drying cycle, resulting in a slower cooling rate producing structures that are optimal for use.

2. 发明申请

WO2007066132A1 FREEZE DRYING OF TARGET SUBSTANCES 审中-公开
标题翻译：冷冻干燥目标物质
公开(公告)号：WO2007066132A1
公开(公告)日：2007-06-14
申请号：PCT/GB2006/004600
申请日：2006-12-08
申请人： OXFORD BIOSENSORS LIMITED , BROUGHALL, John, Morton , WEDGE, Charles, Richard , MONROE, Charles
发明人： BROUGHALL, John, Morton , WEDGE, Charles, Richard , MONROE, Charles
IPC分类号： F26B5/06
CPC分类号： F26B5/06
摘要： A target substance (8) is subject to a freeze drying process in which the substance is first passed into a freeze chamber (31) to reduce the temperature of the substance, and then passed into a separate vacuum chamber (32) in which a vacuum is applied to promote drying of the target substance. Because the carrier (10) and target substance (8) is moved from a freeze chamber (31) to a separate vacuum chamber (32) the environment can be more closely controlled and the cycling of freezing to drying can be more rapid. In this way the carrier (10) and target substance (8) is subject to the full temperature cycling without the surrounding chamber and apparatus being subject to the full cycle. This reduces time and energy costs. The technique is particularly suited to manufacturing biosensors using freeze dried reagents.
摘要翻译：目标物质（8）经受冷冻干燥处理，其中物质首先进入冷冻室（31）以降低物质的温度，然后进入单独的真空室（32），其中真空用于促进目标物质的干燥。因为载体（10）和目标物质（8）从冷冻室（31）移动到单独的真空室（32），所以可以更加严格地控制环境，并且可以更快速地进行冷冻循环。以这种方式，载体（10）和目标物质（8）经受全温循环，而周围的室和装置不受整个循环的影响。这减少了时间和能源成本。该技术特别适用于使用冷冻干燥试剂制造生物传感器。

3. 发明申请

WO2008075072A3 FORMULATION 审中-公开
公开(公告)号：WO2008075072A3
公开(公告)日：2008-06-26
申请号：PCT/GB2007/004923
申请日：2007-12-20
申请人： OXFORD BIOSENSORS LIMITED , BATEMAN, Paul, Alexander , ORMAN, Howard, James , WEDGE, Charles, Richard
发明人： BATEMAN, Paul, Alexander , ORMAN, Howard, James , WEDGE, Charles, Richard
IPC分类号： C12Q1/00 , C12N9/96 , G01N33/543
摘要： The present invention relates to the stabilisation of an enzyme formulation for use in a sensor such as a biosensor.

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