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    • 2. 发明申请
    • FREEZE DRYING OF TARGET SUBSTANCES
    • 冷冻干燥目标物质
    • WO2008146005A2
    • 2008-12-04
    • PCT/GB2008001835
    • 2008-05-30
    • OXFORD BIOSENSORS LTDBROUGHALL JOHN MORTONWEDGE CHARLES RICHARDMUNRO CHARLES
    • BROUGHALL JOHN MORTONWEDGE CHARLES RICHARDMUNRO CHARLES
    • F26B5/06
    • F26B5/06
    • In a process for freeze drying a target substance, the target substance is carried by a carrier, which is passed into a freeze chamber to reduce the temperature of the target substance, and then on to a dryer chamber. Vacuum/reduced pressure is applied during the process, during a final portion of the freeze process when the target substance and carrier are present in the freeze chamber; and/or when the target substance and carrier are transferred from the freeze chamber to the dryer chamber. Vacuum/reduced pressure is also applied when the target substance and carrier are present in the dryer chamber. The process enables the freezing process to commence at temperatures close to the collapse temperature of the target substance and to maintain that temperature while compensating for evaporative cooling, thus giving the fastest and most efficient freeze drying cycle, resulting in a slower cooling rate producing structures that are optimal for use.
    • 在目标物质的冷冻干燥过程中,目标物质由载体进行运送,该载体进入冷冻室以降低目标物质的温度,然后进入干燥室。 在该过程中,当目标物质和载体存在于冷冻室中时,在冷冻过程的最后部分期间施加真空/减压; 和/或当目标物质和载体从冷冻室转移到干燥室时。 当目标物质和载体存在于干燥室中时,也施加真空/减压。 该方法使得冷冻过程能够在接近目标物质的塌陷温度的温度下开始,并且在补偿蒸发冷却的同时保持该温度,从而给出最快和最有效的冷冻干燥循环,导致较慢的冷却速率产生结构, 是最佳的使用。