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1. 发明授权

US09726685B2 Microfluidic device for simultaneously conducting multiple analyses 有权
公开(公告)号：US09726685B2
公开(公告)日：2017-08-08
申请号：US13269249
申请日：2011-10-07
申请人： Beom-seok Lee , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
发明人： Beom-seok Lee , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
IPC分类号： B01L3/00 , G01N35/00 , F16K99/00
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0803 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/084 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N35/00069
摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

2. 发明授权

US09180418B2 Method of mixing at least two kinds of fluids in centrifugal micro-fluid treating substrate 有权
标题翻译：在离心微流体处理基材中混合至少两种流体的方法
公开(公告)号：US09180418B2
公开(公告)日：2015-11-10
申请号：US11751677
申请日：2007-05-22
申请人： Yoon-kyoung Cho , Jeong-gun Lee , Beom-seok Lee , Jong-myeon Park
发明人： Yoon-kyoung Cho , Jeong-gun Lee , Beom-seok Lee , Jong-myeon Park
IPC分类号： B01F11/00 , B01F13/00 , B01F15/02
CPC分类号： B01F13/0059 , B01F11/0002 , B01F11/0014 , B01F15/0201 , B01F15/0233
摘要： Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.
摘要翻译：提供了一种混合流体的方法，包括将至少两种流体引入到包括微通道结构的基板的室中; 并且顺时针和逆时针地交替地旋转衬底，直到混合至少两种流体，其中在通过单向旋转在混合室中产生的涡流消失之前，旋转从一个方向改变到相反的方向。

3. 发明授权

US08658359B2 Method and apparatus for disrupting cells and purifying nucleic acid using a single chip 有权
标题翻译：使用单个芯片破坏细胞并纯化核酸的方法和装置
公开(公告)号：US08658359B2
公开(公告)日：2014-02-25
申请号：US13079926
申请日：2011-04-05
申请人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
发明人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00
CPC分类号： C12Q1/68 , C12M47/06 , C12N15/1006
摘要： Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited.
摘要翻译：本文提供了在单个芯片中破坏细胞并纯化核酸的方法和装置。该方法包括用激光束照射芯片，其中芯片包括其上沉积有细胞裂解增强金属氧化物层和细胞结合金属氧化物层的固体支持物。

4. 发明授权

US08590710B2 Target particles-separating device and method using multi-orifice flow fractionation channel 有权
$Target particles-separating device and method using multi-orifice flow fractionation channel$
标题翻译：目标颗粒分离装置和使用多孔流量分馏通道的方法
公开(公告)号：US08590710B2
公开(公告)日：2013-11-26
申请号：US13156630
申请日：2011-06-09
申请人： Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
发明人： Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
IPC分类号： B07C5/00
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0652 , B01L2300/087 , B01L2400/0487
摘要： A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.
摘要翻译：分离流体样品中的目标颗粒的装置包括第一至第三多孔流动分馏（“MOFF”）通道，每个通道包括具有相对端的入口和出口的多孔段，以及交替的一系列收缩通道和膨胀室沿长度方向互相连接; 第一分离单元，其包括与第一MOFF通道的出口的中心区域流体连通的第一分离通道和与第一MOFF通道的出口的侧壁区域流体连通地互连的第一分支通道，并分别具有第二和第三MOFF通道的入口; 以及连接到第二和第三MOFF通道的入口并且缓冲器通过其流入第二和第三MOFF通道的缓冲器入口。

5. 发明申请

US20130122577A1 KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID 审中-公开
标题翻译：包含序列特异性结合蛋白的试剂盒和用于测定靶核酸核酸序列的方法和装置
公开(公告)号：US20130122577A1
公开(公告)日：2013-05-16
申请号：US13577418
申请日：2011-02-07
申请人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
发明人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/5308 , Y10S977/774 , Y10S977/92 , C12Q2522/101 , C12Q2563/107
摘要： Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined.
摘要翻译：提供了用于确定靶核酸的核苷酸序列的试剂盒，该试剂盒包括至少一种序列特异性结合蛋白和可检测标签。根据一个示例性实施方案的用于确定靶核酸的核苷酸序列的试剂盒以及用于确定靶核酸的核苷酸序列的方法和装置，可以更有效地确定靶核酸的核苷酸序列。

6. 发明申请

US20120325749A1 HYDRODYNAMIC FILTER UNIT, HYDRODYNAMIC FILTER INCLUDING THE HYDRODYNAMIC FILTER UNIT, AND METHOD OF FILTERING TARGET MATERIAL BY USING THE HYDRODYNAMIC FILTER UNIT AND THE HYDRODYNAMIC FILTER 有权
标题翻译：水力过滤装置，包括水力过滤装置的水力过滤器，以及使用水力过滤装置和水力过滤器过滤目标材料的方法
公开(公告)号：US20120325749A1
公开(公告)日：2012-12-27
申请号：US13434252
申请日：2012-03-29
申请人： Minseok S. KIM , Won-ho LEE , Sun-soo KIM , Jin-hoon KIM , Jeong-gun LEE , Tae-seok SIM
发明人： Minseok S. KIM , Won-ho LEE , Sun-soo KIM , Jin-hoon KIM , Jeong-gun LEE , Tae-seok SIM
IPC分类号： B01D33/00 , B01D15/00 , B01D33/41 , B01D37/00 , B82Y99/00
CPC分类号： B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/086
摘要： A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
摘要翻译：流体动力过滤器单元包括连接到流体室的入口通道，包括目标材料的流体被引入到该流体室中，以及连接到流体室的多个出口通道，流体被排出。过滤方法包括通过入口通道将包括目标材料的流体引入到流体动力过滤器单元中，捕获流体动力过滤器单元中的目标材料，以及通过出口通道将流体动力过滤器单元外剩余部分排出。

7. 发明申请

US20120138540A1 HYDRODYNAMIC FILTER, FILTERING APPARATUS INCLUDING THE SAME, AND FILTERING METHOD USING THE HYDRODYNAMIC FILTER 有权
标题翻译：水力过滤器，包括其的过滤装置和使用水力过滤器的过滤方法
公开(公告)号：US20120138540A1
公开(公告)日：2012-06-07
申请号：US13283636
申请日：2011-10-28
申请人： Minseok S. KIM , Taeseok SIM , Jongmyeon PARK , Jeong-Gun LEE , Hun Joo LEE
发明人： Minseok S. KIM , Taeseok SIM , Jongmyeon PARK , Jeong-Gun LEE , Hun Joo LEE
IPC分类号： B01D29/50 , B01D37/00 , B01D29/44 , B01D35/00
CPC分类号： B01L3/502761 , B01L2300/0816 , B01L2300/0851 , B01L2400/086 , Y10T436/25 , Y10T436/25375
摘要： A hydrodynamic filter includes a first portion, and a second portion which is spaced apart from and faces the first portion. The first portion includes a plurality of protrusions protruding in a first direction, and the second portion includes a plurality of protrusions protruding in a second direction opposite to the first direction. A filtering apparatus including a body which includes a plurality of the hydrodynamic filters and filters a fluid including target molecules, an inlet portion in connection with the body, and an outlet portion in connection with the body.
摘要翻译：流体动力过滤器包括第一部分和与第一部分间隔开并面向第一部分的第二部分。第一部分包括沿第一方向突出的多个突起，并且第二部分包括沿与第一方向相反的第二方向突出的多个突起。一种过滤装置，包括：主体，其包括多个流体动力过滤器，并且对包括目标分子的流体进行过滤，与主体相关的入口部分和与主体相关的出口部分。

8. 发明申请

US20120028852A1 MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES 审中-公开
公开(公告)号：US20120028852A1
公开(公告)日：2012-02-02
申请号：US13269411
申请日：2011-10-07
申请人： Beom-seok LEE , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
发明人： Beom-seok LEE , Yoon-kyoung Cho , Jong-myeon Park , Jeong-gun Lee
IPC分类号： C40B60/12
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0803 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/084 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N35/00069
摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

9. 发明申请

US20120024505A1 HEAT TRANSFER MEDIUM AND HEAT TRANSFER METHOD USING THE SAME 有权
标题翻译：传热介质和传热方法
公开(公告)号：US20120024505A1
公开(公告)日：2012-02-02
申请号：US13270790
申请日：2011-10-11
申请人： Seonmi Yoon , Jaeyoung Choi , Hyeon Jin Shin , Jeong Gun Lee , Jongmyeon Park
发明人： Seonmi Yoon , Jaeyoung Choi , Hyeon Jin Shin , Jeong Gun Lee , Jongmyeon Park
IPC分类号： F28F13/18
CPC分类号： C09K5/14 , C03C17/006 , C03C17/256 , C03C2217/42 , C08J7/06 , C08J7/08 , C23C18/14 , Y02E10/50 , Y10T428/24355 , Y10T428/24372 , Y10T428/24802 , Y10T428/24909 , Y10T428/31678
摘要： A heat transfer medium and a heat transfer method using the same are provided. The heat transfer medium comprises a film coated with a plurality of nano particles, which absorb light incident to the film to thereby transfer heat to a target object. When nano particles are applied onto a target object, the particles are removed by etching, and when a transparent film coated thereon with the nano particles is positioned, as a mask, on a target object requiring heat transfer, and then is exposed to infrared rays, heat is transferred to a specified portion of a target object under the coated nano particles, thereby obtaining a heat transfer effect without leaving unnecessary heat generating materials.
摘要翻译：提供了一种传热介质和使用该传热介质的传热方法。传热介质包括涂覆有多个纳米颗粒的膜，其吸收入射到膜的光，从而将热量传递到目标物体。当将纳米颗粒施加到目标物体上时，通过蚀刻除去颗粒，并且当将其上涂覆有纳米颗粒的透明膜作为掩模定位在需要传热的目标物体上，然后暴露于红外线在涂覆的纳米颗粒下将热转移到目标物体的指定部分，从而获得传热效果而不留下不必要的发热材料。

10. 发明申请

US20110232832A1 MICROFLUIDIC VALVE, METHOD OF MANUFACTURING THE SAME, AND MICROFLUIDIC DEVICE COMPRISING THE MICROFLUIDIC VALVE 审中-公开
标题翻译：微流控阀，其制造方法和包含微流控阀的微流体装置
公开(公告)号：US20110232832A1
公开(公告)日：2011-09-29
申请号：US13157535
申请日：2011-06-10
申请人： Jong-myeon PARK , Yoon-kyoung CHO , Beom-seok LEE , Jeong-gun LEE
发明人： Jong-myeon PARK , Yoon-kyoung CHO , Beom-seok LEE , Jeong-gun LEE
IPC分类号： B21K1/20 , H05B6/10 , B32B37/00
CPC分类号： F16K99/0001 , F16K99/0032 , F16K99/004 , F16K2099/0084 , Y10T29/49412 , Y10T137/2191 , Y10T137/2196
摘要： Provided is a microfluidic valve, a method of manufacturing the microfluidic valve, and a microfluidic device that employs the microfluidic valve. The microfluidic valve includes a platform that includes two substrates combined facing each other; a channel having a first depth allowing a fluid to flow between the two substrates; a valve gap that is disposed on at least a region of the channel and has a second depth which is smaller than the first depth; and a valve plug that is disposed to fill the valve gap and is formed of a valve material made by mixing a phase change material, which is solid at room temperature, with a plurality of exothermic particles that emit an amount of heat sufficient to melt the phase change material by absorbing electromagnetic waves.
摘要翻译：本发明提供一种微流体阀，微流体阀的制造方法和采用该微流体阀的微流体装置。该微流体阀包括一个平台，该平台包括彼此相结合的两个基板; 具有允许流体在两个基板之间流动的第一深度的通道; 阀间隙，其设置在所述通道的至少一个区域上，并且具有小于所述第一深度的第二深度; 以及阀塞，其设置成填充阀间隙，并且由阀室材料形成，所述阀门材料是通过将在室温下为固体的相变材料与多个放出足以熔化的相变材料通过吸收电磁波。

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