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1. 发明申请

US20130122577A1 KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID 审中-公开
标题翻译：包含序列特异性结合蛋白的试剂盒和用于测定靶核酸核酸序列的方法和装置
公开(公告)号：US20130122577A1
公开(公告)日：2013-05-16
申请号：US13577418
申请日：2011-02-07
申请人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
发明人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/5308 , Y10S977/774 , Y10S977/92 , C12Q2522/101 , C12Q2563/107
摘要： Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined.
摘要翻译：提供了用于确定靶核酸的核苷酸序列的试剂盒，该试剂盒包括至少一种序列特异性结合蛋白和可检测标签。根据一个示例性实施方案的用于确定靶核酸的核苷酸序列的试剂盒以及用于确定靶核酸的核苷酸序列的方法和装置，可以更有效地确定靶核酸的核苷酸序列。

2. 发明授权

US08993340B2 Device and method of separating cells by using magnetic force 有权
标题翻译：使用磁力分离细胞的装置和方法
公开(公告)号：US08993340B2
公开(公告)日：2015-03-31
申请号：US13051251
申请日：2011-03-18
申请人： Hun-joo Lee , Jeong-gun Lee , Mi-jeong Song , Jong-myeon Park , Tae-seok Sim , Min-seok S. Kim
发明人： Hun-joo Lee , Jeong-gun Lee , Mi-jeong Song , Jong-myeon Park , Tae-seok Sim , Min-seok S. Kim
IPC分类号： G01N1/28 , C12N5/00 , C12M1/00 , B01L3/00 , B03C1/14 , G01N1/40 , C12M1/26 , B03C1/02
CPC分类号： C12M47/04 , B01L3/502753 , B01L3/502761 , B01L2300/0864 , B03C1/02 , B03C1/14 , B03C1/145 , C12M1/266 , G01N1/4077 , Y10T436/25
摘要： A cell separation device includes a channel or chamber in which a sample flows or moves, the sample including target cells marked with magnetic particles, and non-target cells, and a magnet which generates a magnetic first force in a first direction with respect to the sample within the channel or chamber. The channel or chamber of the cell separation device is applied with a second force in a second direction opposite to the first direction of the magnetic force. According to the cell separation device and a method of separating cells, the target cells move in the first direction by the magnetic force, and the non-target cells move in the second direction by the second force, by simultaneously applying the magnetic force and the second force in opposing directions, thereby separating the target cells from the non-target cells.
摘要翻译：细胞分离装置包括样品流动或移动的通道或室，包括标记有磁性颗粒的靶细胞的样品和非靶细胞，以及相对于第一方向产生第一方向的磁性第一力的磁体样品在通道或室内。细胞分离装置的通道或腔室以与磁力的第一方向相反的第二方向施加第二力。根据细胞分离装置和分离细胞的方法，靶细胞通过磁力在第一方向上移动，非靶细胞通过第二力在第二方向上移动，同时施加磁力和从而将目标细胞与非靶细胞分离。

3. 发明授权

US08753870B2 Device for detecting and separating target molecules and method for detecting and separating target molecules by using the same 有权
标题翻译：用于检测和分离靶分子的装置和通过使用它们来检测和分离靶分子的方法
公开(公告)号：US08753870B2
公开(公告)日：2014-06-17
申请号：US13605787
申请日：2012-09-06
申请人： Hun-joo Lee , Jeong-gun Lee , Jeong-woo Choi , Yeon-jeong Kim , Jong-myeon Park , Mi-jeong Song , Jin-mi Oh
发明人： Hun-joo Lee , Jeong-gun Lee , Jeong-woo Choi , Yeon-jeong Kim , Jong-myeon Park , Mi-jeong Song , Jin-mi Oh
IPC分类号： C12M1/00 , C12Q1/68 , G01N33/53 , C12M1/34 , C12M3/00 , G01N30/96 , C07H21/02
CPC分类号： G01N33/54306 , G01N33/54366
摘要： A device, system, and method for detecting or separating target molecules allowing efficient detection even when only a small amount of target molecules or target cells are included in a sample involving the use of a target molecule linkage portion, a signal production portion, and first and second separation portions.
摘要翻译：用于检测或分离目标分子的装置，系统和方法，即使当仅使用少量靶分子或靶细胞包括使用靶分子连接部分，信号产生部分和第一和第二分离部。

4. 发明授权

US07531138B2 Device and method for rapidly lysing cells or viruses 失效
标题翻译：用于快速裂解细胞或病毒的装置和方法
公开(公告)号：US07531138B2
公开(公告)日：2009-05-12
申请号：US11560890
申请日：2006-11-17
申请人： Su-hyeon Kim , Jeong-gun Lee
发明人： Su-hyeon Kim , Jeong-gun Lee
IPC分类号： B01L3/00 , G01N1/00 , C12M1/00
CPC分类号： C12M47/06 , B01L3/5027 , C12N1/066 , C12N13/00 , G01N1/44 , Y10T137/2496 , Y10T436/25
摘要： A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for generating a laser is provided. Further, a method of lysing cells or viruses using the cell lysis device is provided. The method comprises introducing a sample containing cells or viruses and optionally magnetic beads to the cell lysis tube through the sample inlet; transferring the sample to a specific region in the cell lysis tube by means of the pump; temporarily sealing the region of the cell lysis tube where the sample is placed with the sealing unit; irradiating the sample with the laser; removing the sealing unit from the cell lysis tube; and discharging the sample from the cell lysis tube by means of the pump.
摘要翻译：一种用于裂解细胞或病毒的细胞裂解装置，包括具有样品入口的细胞裂解管; 连接到细胞裂解管的泵，用于将样品转移到管中; 用于可逆地密封管的特定区域的密封单元; 并提供用于产生激光的激光源。此外，提供了使用细胞裂解装置裂解细胞或病毒的方法。该方法包括通过样品入口将含有细胞或病毒的样品和任选的磁珠引入细胞裂解管; 通过泵将样品转移到细胞裂解管中的特定区域; 用密封单元临时密封放置样品的细胞溶解管的区域; 用激光照射样品; 从细胞裂解管中取出密封单元; 并通过泵从细胞裂解管排出样品。

5. 发明授权

US07910343B2 Device and method for rapidly lysing cells or viruses 失效
标题翻译：用于快速裂解细胞或病毒的装置和方法
公开(公告)号：US07910343B2
公开(公告)日：2011-03-22
申请号：US12059250
申请日：2008-03-31
申请人： Su-hyeon Kim , Jeong-gun Lee
发明人： Su-hyeon Kim , Jeong-gun Lee
IPC分类号： C12N13/00
CPC分类号： C12M47/06 , B01L3/5027 , C12N1/066 , C12N13/00 , G01N1/44 , Y10T137/2496 , Y10T436/25
摘要： A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for generating a laser is provide. Further, a method of lysing cells or viruses using the cell lysis device is provide. The method comprises introducing a sample containing cells or viruses and optionally magnetic beads to the cell lysis tube through the sample inlet; transferring the sample to a specific region in the cell lysis tube by means of the pump; temporarily sealing the region of the cell lysis tube where the sample is placed with the sealing unit; irradiating the sample with the laser; removing the sealing unit from the cell lysis tube; and discharging the sample from the cell lysis tube by means of the pump.
摘要翻译：一种用于裂解细胞或病毒的细胞裂解装置，包括具有样品入口的细胞裂解管; 连接到细胞裂解管的泵，用于将样品转移到管中; 用于可逆地密封管的特定区域的密封单元; 并提供用于产生激光的激光源。此外，提供使用细胞裂解装置裂解细胞或病毒的方法。该方法包括通过样品入口将含有细胞或病毒的样品和任选的磁珠引入细胞裂解管; 通过泵将样品转移到细胞裂解管中的特定区域; 用密封单元临时密封放置样品的细胞溶解管的区域; 用激光照射样品; 从细胞裂解管中取出密封单元; 并通过泵从细胞裂解管中排出样品。

6. 发明申请

US20070035567A1 Device for printing droplet or ink on substrate or paper 有权
标题翻译：用于在底物或纸上印刷液滴或墨水的装置
公开(公告)号：US20070035567A1
公开(公告)日：2007-02-15
申请号：US11503786
申请日：2006-08-14
申请人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
发明人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
IPC分类号： B41J29/38
CPC分类号： B41J2/06 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B41J2/04535 , B41J2/0456 , B41J2/04576
摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.
摘要翻译：用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

7. 发明授权

US07909427B2 Device for printing droplet or ink on substrate or paper 有权
标题翻译：用于在底物或纸上印刷液滴或墨水的装置
公开(公告)号：US07909427B2
公开(公告)日：2011-03-22
申请号：US12552567
申请日：2009-09-02
申请人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
发明人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
IPC分类号： B41J29/393
CPC分类号： B41J2/06 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B41J2/04535 , B41J2/0456 , B41J2/04576
摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.
摘要翻译：用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

8. 发明授权

US08137523B2 Apparatus for and method of separating polarizable analyte using dielectrophoresis 有权
标题翻译：使用介电电泳分离可极化分析物的装置和方法
公开(公告)号：US08137523B2
公开(公告)日：2012-03-20
申请号：US11754523
申请日：2007-05-29
申请人： Yoon-kyoung Cho , Su-hyeon Kim , Chin-sung Park , Kyu-sang Lee , Jeong-gun Lee
发明人： Yoon-kyoung Cho , Su-hyeon Kim , Chin-sung Park , Kyu-sang Lee , Jeong-gun Lee
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： B03C5/005 , B03C5/026 , B03C2201/26
摘要： An apparatus separating a polarizable analyte using dielectrophoresis includes a vessel including a membrane having a plurality of nano- to micro-sized pores, the membrane disposed inside the vessel, electrodes generating spatially non-uniform electric fields in the nano- to micro-sized pores of the membrane when an AC voltage is applied to the electrodes, and a power source applying the AC voltage to the electrodes, wherein a sectional area of the pores varies along a depth of the pores. A method of separating a polarizable material uses the apparatus.
摘要翻译：使用介电电泳分离可极化分析物的装置包括容器，其包括具有多个纳米至微米尺寸孔的膜，所述膜设置在容器内部，电极在纳米至微孔中产生空间上不均匀的电场当向电极施加AC电压时，将膜施加到膜上，并且向电极施加AC电压的电源，其中孔的截面积沿着孔的深度而变化。分离可极化材料的方法使用该装置。

9. 发明授权

US07600840B2 Device for printing droplet or ink on substrate or paper 有权
标题翻译：用于在底物或纸上印刷液滴或墨水的装置
公开(公告)号：US07600840B2
公开(公告)日：2009-10-13
申请号：US11503786
申请日：2006-08-14
申请人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
发明人： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
IPC分类号： B41J29/38
CPC分类号： B41J2/06 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B41J2/04535 , B41J2/0456 , B41J2/04576
摘要： A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.
摘要翻译：用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

10. 发明授权

US08597572B2 Automatic analyzing method and apparatus for microfluidic system 失效
标题翻译：微流体系统的自动分析方法和装置
公开(公告)号：US08597572B2
公开(公告)日：2013-12-03
申请号：US12128680
申请日：2008-05-29
申请人： Su-hyeon Kim , Yoon-kyoung Cho , Jeong-gun Lee
发明人： Su-hyeon Kim , Yoon-kyoung Cho , Jeong-gun Lee
IPC分类号： G01N33/50
CPC分类号： G01N35/00732 , G01N35/00069 , G01N35/08 , G01N2035/00752 , Y10T436/11
摘要： Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantization of a test.
摘要翻译：本发明提供一种微流体系统的自动分析方法和装置。该装置包括用于识别微流体系统中的盘或芯片的装置，通过根据识别的类型自动加载DB执行操作和检测，并执行测试的量化。

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