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1. 发明申请

US20090156917A1 Controlling Transfer of Objects Affecting Optical Characteristics 有权
标题翻译：控制影响光学特性的物体的传输
公开(公告)号：US20090156917A1
公开(公告)日：2009-06-18
申请号：US11957610
申请日：2007-12-17
申请人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

2. 发明申请

US20060079811A1 Test media cassette for bodily fluid testing device 有权
公开(公告)号：US20060079811A1
公开(公告)日：2006-04-13
申请号：US11283079
申请日：2005-11-18
申请人： Jeffrey Roe , Steven Roe
发明人： Jeffrey Roe , Steven Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/1411 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150419 , A61B5/150473 , A61B5/150503 , A61B5/150633 , A61B5/150702 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B10/0045 , A61B2562/0295 , G01N33/48 , G01N33/48764 , G01N2001/028 , G01N2035/00019 , Y10T436/25
摘要： A bodily fluid sampling device includes a piercing device and a sensor enclosed in a housing. A cassette, which contains test media, is positioned proximal to the sensor so that the sensor is able to analyze a bodily fluid sample collected on the test media. The cassette includes a supply portion from which unused test media is supplied and a storage portion in which contaminated test media is stored after exposure to the bodily fluid. The cassette is adapted to collect a series of bodily fluid samples without requiring disposal of the test media.

3. 发明申请

US20050251064A1 Integrated disposable for automatic or manual blood dosing 失效
标题翻译：集成一次性用于自动或手动血液给药
公开(公告)号：US20050251064A1
公开(公告)日：2005-11-10
申请号：US10840931
申请日：2004-05-07
申请人： Jeffrey Roe
发明人： Jeffrey Roe
IPC分类号： A61B5/00 , A61B5/15 , B65D81/00
CPC分类号： A61B5/15142 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150442 , A61B5/150534 , A61B5/15105 , A61B5/15107 , A61B2562/0295
摘要： An integrated sampling device defines a first opening and a second opening. The first opening is connected to a channel for drawing fluid automatically towards a test media upon incision by an incision portion. The second opening is positioned over the test media allowing manual sampling of fluid if the channel fails to draw a sufficient amount of fluid onto the test media.
摘要翻译：集成采样装置限定第一开口和第二开口。第一开口连接到用于通过切口部分切开时自动向测试介质抽取流体的通道。第二个开口定位在测试介质上方，如果通道不能将足够量的流体吸入到测试介质上，则允许对流体进行手动取样。

4. 发明申请

US20080015425A1 METHODS AND APPARATUS FOR SAMPLING AND ANALYZING BODY FLUID 失效
标题翻译：用于采样和分析体液的方法和装置
公开(公告)号：US20080015425A1
公开(公告)日：2008-01-17
申请号：US11778331
申请日：2007-07-16
申请人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Brent Duchon
发明人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Brent Duchon
IPC分类号： A61B5/157
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150755 , A61B5/150824 , A61B5/151 , A61B5/15107 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/0003 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.
摘要翻译：用于体液取样的采样装置包括用于切开的刺血针，用于从切口吸取体液的毛细管，以及固定到毛细管的上端以接收流体的测试条。可以在测试条和毛细管之间设置吸收垫，以便将被传送到测试条的流体展开。可以在用于分析流体的装置中安装诸如光学分析仪和/或电化学分析仪的现场分析仪。或者，测试条可以滑动通过形成在装置的底端的槽，使得通过在形成切口之后使装置抵靠皮肤，测试条将直接接触从切口发出的体液。

5. 发明申请

US20050010134A1 Blood and interstitial fluid sampling device 有权
标题翻译：血液和间质液取样装置
公开(公告)号：US20050010134A1
公开(公告)日：2005-01-13
申请号：US10835094
申请日：2004-04-29
申请人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
发明人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Henry Grage , Michael Sanchez
IPC分类号： A61B5/00 , A61B5/15 , A61B10/00 , A61B17/00
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150083 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150396 , A61B5/150503 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15136 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle (16), drive mechanism (11), kneading or vibration mechanism (25), optional suction system (7), and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component (83) for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.
摘要翻译：用于穿刺患者的装置和方法，实际上同时从身体产生和收集小的液体样品。该装置包括采血系统，其包括穿刺针（16），驱动机构（11），揉搓或振动机构（25），可选的抽吸系统（7）和样品排出机构。该装置的尺寸优选为一只手中的手持式并且用一只手可操作。该设备可以可选地包含用于接收样品并为用户提供测试或分析指示或读出的整体测试或分析组件（83）。一种方法包括以快速的速度刺穿皮肤，通过超声波作用，压电或机械振动来捏合周围区域，以刺激来自伤口的血液流动，使用泵送系统拉伸流体。

6. 发明申请

US20070293747A1 METHODS AND APPARATUS FOR SAMPLING AND ANALYZING BODY FLUID 失效
标题翻译：用于采样和分析体液的方法和装置
公开(公告)号：US20070293747A1
公开(公告)日：2007-12-20
申请号：US11765045
申请日：2007-06-19
申请人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Brent Duchon
发明人： Joel Douglas , Jeffrey Roe , Ryszard Radwanski , Brent Duchon
IPC分类号： A61B5/151
CPC分类号： A61B10/0045 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150755 , A61B5/150824 , A61B5/151 , A61B5/15107 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2010/0003 , A61B2010/008 , A61B2017/00765 , A61B2562/0295
摘要： A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.
摘要翻译：用于体液取样的采样装置包括用于切开的刺血针，用于从切口吸取体液的毛细管，以及固定到毛细管的上端以接收流体的测试条。可以在测试条和毛细管之间设置吸收垫，以便将被传送到测试条的流体展开。可以在用于分析流体的装置中安装诸如光学分析仪和/或电化学分析仪的现场分析仪。或者，测试条可以滑动通过形成在装置的底端的槽，使得通过在形成切口之后使装置抵靠皮肤，测试条将直接接触从切口发出的体液。

7. 发明申请

US20060088945A1 Electrochemical test device and related methods 失效
公开(公告)号：US20060088945A1
公开(公告)日：2006-04-27
申请号：US11287522
申请日：2005-11-23
申请人： Joel Douglas , Jeffrey Roe , John Priest
发明人： Joel Douglas , Jeffrey Roe , John Priest
IPC分类号： G01N33/543
CPC分类号： C12Q1/001 , C12Q1/004 , C12Q1/006 , Y10S435/817 , Y10S436/805 , Y10S436/806
摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode. The test device electrodes can be constructed on a flexible film substrate, such as a polymeric film or a metal foil coated with a non-conductive coating.

8. 发明申请

US20050283094A1 Disposable lancet and lancing cap combination for increased hygiene 失效
标题翻译：一次性刺血针和采血帽组合，增加卫生
公开(公告)号：US20050283094A1
公开(公告)日：2005-12-22
申请号：US10872945
申请日：2004-06-21
申请人： Detlef Thym , Jeffrey Roe
发明人： Detlef Thym , Jeffrey Roe
IPC分类号： A61B5/15 , A61B5/00 , A61B1/06 , B65D81/00
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150068 , A61B5/150297 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150717 , A61B5/15107 , A61B5/15115 , A61B5/1519 , A61B5/15192 , A61B2562/0295
摘要： A body fluid testing device includes a test strip, an incision forming member, and a housing. The test strip includes an expression surface. In addition, the test strip is attached to the housing to form a cavity, and the cavity slidably receives the incision forming member. The body fluid testing device is positioned over the incision site where the incision forming member makes an incision. The user presses the expression surface against the skin to express body fluid. The cavity collects body fluid via capillary action, and the test strip analyzes the body fluid.
摘要翻译：体液检查装置包括测试条，切口形成部件和壳体。测试条包括表达表面。此外，测试条附接到壳体以形成空腔，并且空腔可滑动地容纳切口形成构件。体液检查装置位于切口形成部件进行切口的切口部位上。使用者将表达表面压在皮肤上以表达体液。空腔通过毛细作用收集体液，测试条分析体液。

9. 发明申请

US20050025195A1 Serial data validity monitor 失效
标题翻译：串行数据有效性监视器
公开(公告)号：US20050025195A1
公开(公告)日：2005-02-03
申请号：US10860548
申请日：2004-06-02
申请人： Ian Barrett , Gregory Erker , Michael Smith , Scott Muma , Jeffrey Roe , Bernard Guay
发明人： Ian Barrett , Gregory Erker , Michael Smith , Scott Muma , Jeffrey Roe , Bernard Guay
IPC分类号： H04J3/06 , H04L1/00 , H04J3/04
CPC分类号： H04L1/0061 , H04J3/0608 , Y10S370/907
摘要： A data detection system includes, in part, a CID detector, a DC balance monitor and a transition density detector. The CID detector is configured to detect whether the received data stream includes a CID exceeding a predetermined threshold count. The DC balance monitor is configured to detect DC imbalances in the incoming data and that may be indicative of errors in the data. The transition density detector is configured to detect whether a minimum transition density exists during a given time period. If a violation is detected by any one of these three detectors, an out-of-frame signal is asserted. The incoming data stream may be a scrambled SONET or SDH data stream.
摘要翻译：数据检测系统部分地包括CID检测器，DC平衡监视器和转换密度检测器。 CID检测器被配置为检测所接收的数据流是否包括超过预定阈值计数的CID。 DC平衡监视器被配置为检测输入数据中的直流不平衡，并且可以指示数据中的错误。转移密度检测器被配置为检测在给定时间段内是否存在最小转移密度。如果这三个检测器中的任一个检测到违规，则断言失帧信号。输入数据流可以是加扰的SONET或SDH数据流。

10. 发明申请

US20070038126A1 System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status 审中-公开
标题翻译：通过测量体内细胞能量状态来监测末端器官氧合的系统和方法
公开(公告)号：US20070038126A1
公开(公告)日：2007-02-15
申请号：US11473976
申请日：2006-06-23
申请人： Jason Pyle , Alexander Aravanis , Jeffrey Roe , Myer Rosenthal
发明人： Jason Pyle , Alexander Aravanis , Jeffrey Roe , Myer Rosenthal
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/14556 , A61B5/412 , A61B5/413
摘要： A method is provided of measuring in vivo of an endogenous fluorophore in a tissue site. A known excitation wavelength of the endogenous flurophore is selected within a range of wavelengths at which the endogenous flurophore undergoes fluorescence. The tissue site is irradiated with irradiated light having at least the selected excitation wavelength within the range of wavelengths. A fluorescence emission of the tissue site resulting from the irradiation thereof is detected. A relative or absolute concentration of the endogenous fluorophore is determined by multiplying it by a calibration factor that depends one at least one of, a known excitation and emission property of the endogenous fluorophore, an intensity of the irradiated light, optical properties of an excitation probe, and specific properties of the tissue. The relative or absolute concentration of the endogenous fluorphore is used to estimate at least one of a, in vivo cellular energy production status or state of end-organ tissue oxygenation.
摘要翻译：提供了在体内测量组织部位内源性荧光团的方法。内源荧光的已知激发波长在内源性荧光体经历荧光的波长范围内选择。用在波长范围内至少具有选定的激发波长的照射光照射组织部位。检测由其照射引起的组织部位的荧光发射。内源荧光团的相对或绝对浓度通过将依赖于以下至少一个的校准因子相乘来确定：已知的内源荧光团的激发和发射性质，照射光的强度，激发探针的光学性质，以及组织的特定性质。内源性荧光素的相对或绝对浓度用于估计体内细胞能量产生状态或末端器官组织氧合状态中的至少一种。

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