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1. 发明申请

US20070038126A1 System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status 审中-公开
标题翻译：通过测量体内细胞能量状态来监测末端器官氧合的系统和方法
公开(公告)号：US20070038126A1
公开(公告)日：2007-02-15
申请号：US11473976
申请日：2006-06-23
申请人： Jason Pyle , Alexander Aravanis , Jeffrey Roe , Myer Rosenthal
发明人： Jason Pyle , Alexander Aravanis , Jeffrey Roe , Myer Rosenthal
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/14556 , A61B5/412 , A61B5/413
摘要： A method is provided of measuring in vivo of an endogenous fluorophore in a tissue site. A known excitation wavelength of the endogenous flurophore is selected within a range of wavelengths at which the endogenous flurophore undergoes fluorescence. The tissue site is irradiated with irradiated light having at least the selected excitation wavelength within the range of wavelengths. A fluorescence emission of the tissue site resulting from the irradiation thereof is detected. A relative or absolute concentration of the endogenous fluorophore is determined by multiplying it by a calibration factor that depends one at least one of, a known excitation and emission property of the endogenous fluorophore, an intensity of the irradiated light, optical properties of an excitation probe, and specific properties of the tissue. The relative or absolute concentration of the endogenous fluorphore is used to estimate at least one of a, in vivo cellular energy production status or state of end-organ tissue oxygenation.
摘要翻译：提供了在体内测量组织部位内源性荧光团的方法。内源荧光的已知激发波长在内源性荧光体经历荧光的波长范围内选择。用在波长范围内至少具有选定的激发波长的照射光照射组织部位。检测由其照射引起的组织部位的荧光发射。内源荧光团的相对或绝对浓度通过将依赖于以下至少一个的校准因子相乘来确定：已知的内源荧光团的激发和发射性质，照射光的强度，激发探针的光学性质，以及组织的特定性质。内源性荧光素的相对或绝对浓度用于估计体内细胞能量产生状态或末端器官组织氧合状态中的至少一种。

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