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1. 发明申请

WO2010045258A3 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译： SPIROCYCLIC GPR40调节剂
公开(公告)号：WO2010045258A3
公开(公告)日：2010-07-01
申请号：PCT/US2009060549
申请日：2009-10-13
申请人： AMGEN INC , BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
发明人： BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
IPC分类号： C07C62/34 , A61K31/185 , A61K31/33 , A61P3/10 , C07D221/00 , C07D231/00 , C07D249/00 , C07D271/00 , C07D277/00 , C07D311/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供可用于例如治疗受试者的代谢紊乱的化合物。这样的化合物具有通式IA，IB，I'A或I'B，其中变量的定义在本文中提供。本发明还提供组合物，其包括所述化合物在制备药物和用于治疗代谢病症例如II型糖尿病中的用途以及所述化合物的使用方法。

2. 发明申请

WO2010093849A3 PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗胰岛素相关疾病和病症的苯丙氨酸酰胺衍生物
公开(公告)号：WO2010093849A3
公开(公告)日：2010-10-28
申请号：PCT/US2010023988
申请日：2010-02-12
申请人： AMGEN INC , DU XIAOHUI , FU ZICE , HOUZE JONATHAN B , JIAO XIANYUN , KIM YONG-JAE , LI LEPING , LIU JINQIAN , LIZARZABURU MIKE , MEDINA JULIO , SHEN WANG , TURCOTTE SIMON , YU MING
发明人： DU XIAOHUI , FU ZICE , HOUZE JONATHAN B , JIAO XIANYUN , KIM YONG-JAE , LI LEPING , LIU JINQIAN , LIZARZABURU MIKE , MEDINA JULIO , SHEN WANG , TURCOTTE SIMON , YU MING
IPC分类号： C07D213/24 , A61K31/4427 , A61K31/506 , A61P3/00 , C07D239/26 , C07D277/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译：本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。

3. 发明公开

EP2403497A4 COMPOUNDS, COMPOSITIONS AND USE FOR ANTICANCER THERAPY 审中-公开
标题翻译：化合物，组合物和使用的抗癌治疗
公开(公告)号：EP2403497A4
公开(公告)日：2014-01-22
申请号：EP10748321
申请日：2010-03-01
申请人： YU MING
发明人： YU MING
IPC分类号： A61K31/41 , A61K31/352 , A61K31/353 , A61K31/498 , A61K45/06 , A61P35/00
CPC分类号： C07D257/04 , A61K31/353 , A61K31/41 , A61K2300/00

4. 发明申请

WO2008124169A3 ISLET CELLS COMPOSITION AND METHODS 审中-公开
标题翻译： ISLET细胞组成和方法
公开(公告)号：WO2008124169A3
公开(公告)日：2008-11-27
申请号：PCT/US2008004596
申请日：2008-04-10
申请人： UNIV PENNSYLVANIA , NAJI ALI , YU MING , LIU CHENGYANG , NOORCHASHM HOORMAN , VELAZQUEZ OMAIDA C
发明人： NAJI ALI , YU MING , LIU CHENGYANG , NOORCHASHM HOORMAN , VELAZQUEZ OMAIDA C
IPC分类号： C12N5/00
CPC分类号： A61K35/39 , A61K38/28 , A61K38/30 , A61K38/39 , A61K38/40
摘要： A composition comprising islet cells and an extracellular matrix component as well as methods of transplanting same are described. Retroperitoneal and subcutaneous islet cells transplants maintain their viability and increased insulin production for prolonged periods of time.
摘要翻译：描述了包含胰岛细胞和细胞外基质组分的组合物以及移植方法。腹膜后皮下胰岛细胞移植维持其生存能力并延长胰岛素生产时间。

5. 发明申请

WO2011116712A2 METHOD FOR CONFIGURING NEIGHBOR CELLS AND POLICY CONFIGURATION SERVER 审中-公开
标题翻译：用于配置邻居单元和策略配置服务器的方法
公开(公告)号：WO2011116712A2
公开(公告)日：2011-09-29
申请号：PCT/CN2011073426
申请日：2011-04-28
申请人： HUAWEI TECH CO LTD , YU MING
发明人： YU MING
IPC分类号： H04W16/18
CPC分类号： H04W16/20 , H04W24/02 , H04W84/045
摘要： A method for configuring neighbor cells and a policy configuration server are provided in the present invention. The method includes: obtaining information of macro cells neighboring to femto cells; determining configuration information of the femto cells neighboring to the macro cells according to the information of the neighbor macro cells; sending the configuration information of the neighbor femto cells to a configuration element so as to enable the configuration element to perform neighbor cell configuration according to the configuration information of the neighbor femto cells. The policy configuration server includes an obtaining module, a determination module, and a first transmission module. With the method and the policy configuration server for configuring neighbor cells in the embodiments of the present invention, the mobility of users within macro cells and femto cells is supported, the efficiency and the accuracy of neighbor cell configuration are improved, and the operation cost is reduced.
摘要翻译：本发明提供了一种用于配置相邻小区和策略配置服务器的方法。该方法包括：获取与毫微微小区相邻的宏小区的信息; 根据相邻宏小区的信息确定与宏小区相邻的毫微微小区的配置信息; 将相邻毫微微小区的配置信息发送给配置单元，使配置单元能够根据邻居毫微微小区的配置信息进行相邻小区配置。策略配置服务器包括获取模块，确定模块和第一传输模块。在本发明的实施例中，通过配置相邻小区的方法和策略配置服务器，支持宏小区和毫微微小区内用户的移动性，提高了邻居小区配置的效率和准确性，运营成本是降低。

6. 发明申请

WO0196593A3 NOVEL MOTOR PROTEINS AND METHODS FOR THEIR USE 审中-公开
标题翻译：新型电机蛋白及其使用方法
公开(公告)号：WO0196593A3
公开(公告)日：2002-05-16
申请号：PCT/US0119308
申请日：2001-06-15
申请人： CYTOKINETICS INC , BERAUD CHRISTOPHE , CRAVEN ANDREW , YU MING , SAKOWICZ ROMAN , PATEL UMESH A , DAVIES KATHERINE A
发明人： BERAUD CHRISTOPHE , CRAVEN ANDREW , YU MING , SAKOWICZ ROMAN , PATEL UMESH A , DAVIES KATHERINE A
IPC分类号： G01N33/50 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N15/09 , C12Q1/34 , G01N33/15 , G01N33/53 , G01N37/00 , C07H21/04 , C07K14/00 , C12N9/12 , C12N15/63 , C12N15/85 , C12N15/86 , C12Q1/00 , C12Q1/42
CPC分类号： C12N9/14
摘要： The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
摘要翻译：本发明提供HsKip3的分离的核酸和氨基酸序列，HsKip3的抗体，使用生物活性HsKip3筛选HsKip3a调节剂的方法，以及用于筛选HsKip3a调节剂的试剂盒。

7. 发明申请

WO2009110984A3 CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING 审中-公开
标题翻译：包括灌注成像在内的应用对比剂
公开(公告)号：WO2009110984A3
公开(公告)日：2009-12-10
申请号：PCT/US2009001247
申请日：2009-02-27
申请人： LANTHEUS MEDICAL IMAGING INC , ROBINSON SIMON P , CASEBIER DAVID S , YU MING , KAGAN MIKHAIL , LAZEWATSKY JOEL
发明人： ROBINSON SIMON P , CASEBIER DAVID S , YU MING , KAGAN MIKHAIL , LAZEWATSKY JOEL
IPC分类号： A61K49/04 , A61P25/28 , A61P35/00
CPC分类号： A61K51/0459
摘要： The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging.
摘要翻译：本发明部分地涉及用于对中枢神经系统或癌症进行成像的化合物和方法，包括向受试者施用包含结合MC-1的化合物和成像部分的造影剂，并且使用诊断成像。

8. 发明申请

WO2009108376A3 CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING 审中-公开
标题翻译：包括灌注成像在内的应用对比剂
公开(公告)号：WO2009108376A3
公开(公告)日：2009-11-19
申请号：PCT/US2009001296
申请日：2009-02-27
申请人： LANTHEUS MEDICAL IMAGING INC , ROBINSON SIMON P , CASEBIER DAVID S , YU MING , KAGAN MIKHAIL , LAZEWATSKY JOEL
发明人： ROBINSON SIMON P , CASEBIER DAVID S , YU MING , KAGAN MIKHAIL , LAZEWATSKY JOEL
IPC分类号： A61K49/06 , A61P25/28
CPC分类号： A61K51/0459
摘要： The present invention is directed, in part, to compounds and methods for imaging the brain or central nervous system, or portions thereof, comprising administering to a subject a contrast agent of the invention, and scanning the subject using diagnostic imaging.
摘要翻译：本发明部分涉及用于使脑或中枢神经系统或其部分成像的化合物和方法，包括向受试者施用本发明的造影剂，并且使用诊断成像扫描受试者。

9. 发明申请

WO2008083056A3 LIGANDS FOR IMAGING CARDIAC INNERVATION 审中-公开
标题翻译：用于成像心脏感染的配对
公开(公告)号：WO2008083056A3
公开(公告)日：2009-04-30
申请号：PCT/US2007088500
申请日：2007-12-21
申请人： LANTHEUS MEDICAL IMAGING INC , PUROHIT AJAY , HARRIS THOMAS D , RADEKE HEIKE S , ROBINSON SIMON P , YU MING , CASEBIER DAVID S
发明人： PUROHIT AJAY , HARRIS THOMAS D , RADEKE HEIKE S , ROBINSON SIMON P , YU MING , CASEBIER DAVID S
IPC分类号： C07C279/04 , A61K51/04
CPC分类号： A61K51/04 , A61K51/0453 , A61K51/0459 , C07B59/001 , C07B2200/05 , C07C215/60 , C07C217/70 , C07C279/06 , C07C279/08
摘要： Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
摘要翻译：公开了用于心脏神经支配成像的核医学应用（PET成像）中用作成像剂的新型化合物。这些基于PET的放射性示踪剂可能表现出增加的稳定性，减少NE释放（从而减少副作用），改进的定量数据，和/或对先前的放射性示踪剂对VMAT的高亲和力。还提供了使用化合物成像心脏神经支配的方法。在某些情况下，化合物通过在各种位置上衍生化某些化合物而形成：芳基，烷基，酮基，苄基，β-烷基醚，γ-丙基烷基醚和β-丙基烷基醚。或者或另外，将甲基a加入到胺中，和/或儿茶酚官能团被消除或掩蔽，作为使这些化合物更稳定的方式。

10. 发明申请

WO2013036869A3 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 审中-公开
标题翻译：用于合成和使用成像剂的组合物，方法和系统
公开(公告)号：WO2013036869A3
公开(公告)日：2013-05-02
申请号：PCT/US2012054309
申请日：2012-09-07
申请人： LANTHEUS MEDICAL IMAGING INC , RADEKE HEIKE S , CESATI RICHARD R , PUROHIT AJAY , HARRIS THOMAS D , ROBINSON SIMON P , YU MING , CASEBIER DAVID S , HU CAROL HUI , BROEKEMA MATTHIAS , ONTHANK DAVID C
发明人： RADEKE HEIKE S , CESATI RICHARD R , PUROHIT AJAY , HARRIS THOMAS D , ROBINSON SIMON P , YU MING , CASEBIER DAVID S , HU CAROL HUI , BROEKEMA MATTHIAS , ONTHANK DAVID C
IPC分类号： C07D233/44 , A61K49/00 , A61K49/06
CPC分类号： A61K51/0459 , A61K51/04 , A61K51/041 , A61K51/0453 , A61K51/0497 , C07B2200/05 , C07C217/70 , C07C257/14 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07C279/14 , C07C281/18 , C07D209/14 , C07D233/46
摘要： The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
摘要翻译：本发明涉及用于合成和使用显像剂或其前体的系统，组合物和方法。使用本文所述的方法可将显像剂前体转化成显像剂。在一些情况下，显像剂富含18 F.在一些情况下，显像剂可以用于对受试者中感兴趣的区域成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官。在一些实施方案中，提供了用于评估受试者的一部分中的灌注和神经支配错配的方法和组合物。

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