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    • 1. 发明授权
    • High-sensitivity magnetic resonance imaging nano-contrast agent based on an anionic polymer and cationic polymer ion complex, and a production method therefor
    • 基于阴离子聚合物和阳离子聚合物离子络合物的高灵敏度磁共振成像纳米造影剂及其制备方法
    • US09138491B2
    • 2015-09-22
    • US14110138
    • 2011-04-07
    • Moon-Hee SungYong Taik LimYoung-Woock NohIl Han LeeHyun Min Kim
    • Moon-Hee SungYong Taik LimYoung-Woock NohIl Han LeeHyun Min Kim
    • A61K49/12A61B5/055A61K49/18
    • A61K49/126A61K49/1863A61K49/1872
    • The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.
    • 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法,更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸(γ-PGA)/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸(γ-PGA)和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂,其包括封装在阴离子聚-γ-谷氨酸(γPGA)和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应,因此与作为单个颗粒存在时相比具有相对优异的对比效果。
    • 6. 发明申请
    • ORGANIC LIGHT EMITTING DISPLAY AND DRIVING METHOD FOR THE SAME
    • 有机发光显示及其驱动方法
    • US20090135106A1
    • 2009-05-28
    • US12195337
    • 2008-08-20
    • Hyo-Jin LeeIl-Han LeeYoon Kang
    • Hyo-Jin LeeIl-Han LeeYoon Kang
    • G09G3/30
    • G09G3/3233G09G2300/0842G09G2310/08
    • An organic light emitting display and a driving method for the same for preventing picture playback disruption during the playback of a moving picture. An organic light emitting display includes: a display region including a plurality of pixels for displaying an image; a frame memory for storing image signals of the image; a data driver for receiving the image signals to generate data signals; a scan driver for generating scan signals; and a controller for controlling the frame memory to store the image signals and to transfer the image signals stored in the frame memory to the data driver. The controller controls the frame memory to store the image signals for at least two horizontal synchronization periods before they are transferred to the data driver.
    • 一种有机发光显示器及其驱动方法,用于在运动图像的回放期间防止图像重放中断。 有机发光显示器包括:显示区域,包括用于显示图像的多个像素; 用于存储图像的图像信号的帧存储器; 用于接收图像信号以生成数据信号的数据驱动器; 用于产生扫描信号的扫描驱动器; 以及控制器,用于控制帧存储器以存储图像信号并将存储在帧存储器中的图像信号传送到数据驱动器。 控制器控制帧存储器,以将图像信号存储至少两个水平同步周期,然后再转移到数据驱动器。
    • 7. 发明授权
    • Composition for preventing virus infection comprising poly-gamma-glutamic acid
    • 用于预防包含聚-γ-谷氨酸的病毒感染的组合物
    • US09095605B2
    • 2015-08-04
    • US13234670
    • 2011-09-16
    • Moon-Hee SungChul Joong KimHaryoung PooYoung-Ki ChoiIl Han LeeDai-Won Yoo
    • Moon-Hee SungChul Joong KimHaryoung PooYoung-Ki ChoiIl Han LeeDai-Won Yoo
    • A61K38/16A61K31/785
    • A61K31/785A61K38/164
    • The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.
    • 本发明涉及用于抑制或预防病毒感染的药物组合物,其包含有效剂量的聚-γ-谷氨酸(γ-PGA),更具体地,涉及药物组合物,功能性食品和饲料添加剂 能够抑制病毒感染和预防病毒性疾病,其包含对病毒(例如流感病毒)诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。 含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性 食物促进人体健康。
    • 9. 发明申请
    • Plasmid having a function of t-vector and expression vector, and expression of the target gene using the same
    • 具有t载体和表达载体的功能的质粒以及使用其的靶基因的表达
    • US20060199185A1
    • 2006-09-07
    • US10564880
    • 2003-12-31
    • Young SongHaryoung PooMoon-Hee SungSeung-Pyo HongYoon Ho ChoiKwang KimIl Han LeeJe Hyun Park
    • Young SongHaryoung PooMoon-Hee SungSeung-Pyo HongYoon Ho ChoiKwang KimIl Han LeeJe Hyun Park
    • C40B40/02C40B40/08C12Q1/68C12N15/74
    • C12N15/64
    • The present invention relates to a plasmid (pHCE-FOREX) functioning as both a T-vector and an expression vector, which is produced by imparting a T-vector function to an HCE promoter derived from a constitutive high-level expression vector and can express a target protein in a simple and rapid manner. Also, the present invention relates to an expression vector having the target gene inserted into the plasmid, and the expression of the target gene using the same. The plasmid of the present invention can be converted into a vector that expresses the target protein by one-step T-vector cloning in a simple and rapid manner. The plasmid converted into the expression vector does not require a re-transformation step and allows the high-level expression of the target protein only by the culturing of transformed E. coli without the addition of an expensive inducer. Thus, according to the present invention, expression plasmids for large amounts of target genes can be produced at the same time, so that the present invention will be very efficient in establishing expression systems for certain genomes and gene groups.
    • 本发明涉及用作T载体和表达载体两者的质粒(pHCE-FOREX),其通过赋予来自组成型高水平表达载体的HCE启动子产生T载体功能而产生,并可表达 目标蛋白以简单快速的方式。 此外,本发明涉及将靶基因插入质粒的表达载体,以及使用该表达载体的靶基因的表达。 本发明的质粒可通过简单快速的一步T载体克隆转化为表达靶蛋白的载体。 转化成表达载体的质粒不需要再转化步骤,并且仅通过培养转化的大肠杆菌而不添加昂贵的诱导物才允许靶蛋白的高水平表达。 因此,根据本发明,可以同时生产大量靶基因的表达质粒,从而本发明在建立某些基因组和基因组的表达系统方面将非常有效。