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1. 发明授权

US08267914B1 Method and apparatus for AC electrospray 有权
标题翻译：交流电喷雾的方法和装置
公开(公告)号：US08267914B1
公开(公告)日：2012-09-18
申请号：US10965834
申请日：2004-10-18
申请人： Hsueh-Chia Chang , Shau-Chun (Paul) Wang , Dmitri Lastochkin , Leslie Yeo , Zachary Gagnon , Siddharth Maheshwari
发明人： Hsueh-Chia Chang , Shau-Chun (Paul) Wang , Dmitri Lastochkin , Leslie Yeo , Zachary Gagnon , Siddharth Maheshwari
IPC分类号： A61M31/00
CPC分类号： A61M15/02 , A61K9/0073 , A61M11/00 , A61M15/025 , A61M2037/0061
摘要： The present invention provides an electrospray device using a high frequency alternating current (AC) above 10 kHz to generate fine micron sized drops. The apparatus generally functions by applying a high frequency alternating current electric field across one or more micro-needles and one or more conducting elements. The present invention may be used to generate aerosol drops for respiratory drug delivery or as a microencapsulation technique for the encapsulation of drugs, DNA, protein, osteogenic or dermatological growth factors, bacteria, viruses, immobilized enzyme receptors and fluorescent particles for controlled release drug delivery, tissue or bone engineering, clinical or environmental field testing and as biosensors for clinical or drug monitoring. In addition, the present invention may be used to synthesize biodegradable fibers as bioscaffolds for tissue engineering, surgical sutures or medical gauze that enhance blood coagulation, and further may be encapsulated by other agents.
摘要翻译：本发明提供一种使用高于10kHz的高频交流电（AC）的电喷射装置，以产生精细微米级的液滴。该装置通常通过跨越一个或多个微针和一个或多个导电元件施加高频交流电场来起作用。本发明可用于产生用于呼吸药物递送的气溶胶滴剂或用于包封药物，DNA，蛋白质，成骨或皮肤病学生长因子，细菌，病毒，固定化酶受体和用于控释药物递送的荧光颗粒的微胶囊化技术，组织或骨骼工程，临床或环境现场测试以及用于临床或药物监测的生物传感器。此外，本发明可以用于合成可生物降解的纤维，作为用于组织工程的生物支架，外科缝线或医用纱布，其可增强血液凝固，并且还可以被其它试剂包封。

2. 发明申请

US20120199732A1 METHODS AND APPARATUS FOR MASS SPECTROMETRY UTILIZING AN AC ELECTROSPRAY DEVICE 有权
标题翻译：使用交流电泳装置进行质谱分析的方法和装置
公开(公告)号：US20120199732A1
公开(公告)日：2012-08-09
申请号：US13095288
申请日：2011-04-27
申请人： Nishant CHETWANI , Catherine CASSOU , David GO , Hsueh-Chia CHANG
发明人： Nishant CHETWANI , Catherine CASSOU , David GO , Hsueh-Chia CHANG
IPC分类号： H01J49/10
CPC分类号： H01J49/165 , B05B5/0255
摘要： An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mobility ions in the liquid cone. The AC electric field causes the emitter to discharge the liquid cone as a liquid aerosol drop, and a mass spectrometry device analyzes the ionized analyte sample to determine the composition of the contained analyte sample.
摘要翻译：交流电喷雾质谱装置包括具有至少一个发射器的电喷射装置，其提供用于透射分析物样品的通道。至少一个导电元件与至少一个发射器电连通。电源产生交流电场以在发射器的尖端处形成液体锥体，并离子化存在于液体锥体中的分析物样品。电场的频率牵引液体中的低迁移率离子。 AC电场使得发射器作为液体气溶胶滴放液，并且质谱装置分析电离的分析物样品以确定所包含的分析物样品的组成。

3. 发明授权

US07744738B1 Method and apparatus for rapid particle manipulation and characterization 有权
标题翻译：用于快速粒子处理和表征的方法和装置
公开(公告)号：US07744738B1
公开(公告)日：2010-06-29
申请号：US11117632
申请日：2005-04-29
申请人： Zachary Gagnon , Hsueh-Chia Chang
发明人： Zachary Gagnon , Hsueh-Chia Chang
IPC分类号： B03C5/02
CPC分类号： B03C5/026 , B03C5/005
摘要： The present invention provides a method and apparatus for use in rapid particle transportation, separation, focusing, characterization, and release. Dielectrophoresis and electro-osmotic driven fluid convection are used independently or in tandem as the driving forces for particle manipulation and on occasion characterization. Although dielectrophoresis has been acknowledged for decades as a powerful technique for particle manipulation and characterization, long processing times and measurement inaccuracies that emerge from using disjointed electrodes have limited its usefulness in diagnostic kits. The present invention provides for a continuous wire that enables fluid flow patterns and dielectrophoretic forces with optimal configurations for rapid and sensitive particle manipulation and characterization.
摘要翻译：本发明提供了一种用于快速颗粒运输，分离，聚焦，表征和释放的方法和装置。电泳和电渗驱动流体对流独立或串联使用，作为粒子操纵和有时表征的驱动力。尽管介电电泳几十年来一直被认为是用于粒子操纵和表征的强大技术，但是长时间的处理时间和使用不连续电极所产生的测量不准确限制了其在诊断试剂盒中的用途。本发明提供了一种连续导线，其能够使流体流动模式和介电电泳力具有用于快速和敏感的粒子操纵和表征的最佳配置。

4. 发明申请

US20090277792A1 Method for concentrating charged particles and apparatus thereof 审中-公开
标题翻译：浓缩带电粒子的方法及其装置
公开(公告)号：US20090277792A1
公开(公告)日：2009-11-12
申请号：US12383893
申请日：2009-03-30
申请人： Shau-Chun Wang , Hsueh-Chia Chang , Hsiao-Ping Chen , Hsien-Hung Wei , Chun-Ching Yu , Min-Hsuan Tsai
发明人： Shau-Chun Wang , Hsueh-Chia Chang , Hsiao-Ping Chen , Hsien-Hung Wei , Chun-Ching Yu , Min-Hsuan Tsai
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B03C5/02
摘要： The present invention discloses a method for concentrating charged particles and an apparatus thereof. The method comprises: providing a substrate comprising a reservoir; disposing a conducting granule in the reservoir, the conducting granule being negatively charged or positively charged and comprising nano-pores or nano-channels capable of permitting ion permeation; disposing a buffer solution in the reservoir, the buffer solution comprising counter-ions having an opposite electric property to the conducting granule; adding the charged particles into the buffer solution, the charged particles being co-ions having an identical electric property as the conducting granule; and applying an external electric field on the conducting granule. While the external electric field is applied on the conducting granule, the counter-ions exit from the nano-pores or nano-channels and have a nonuniform concentration on a surface of the conducting granule such that a transient ion super-concentration phenomenon occurs at an ejecting pole on the conducting granule. Hence the present invention has potential application in bead-based molecular assays.
摘要翻译：本发明公开了一种用于浓缩带电粒子的方法及其装置。该方法包括：提供包括储存器的基底; 在储存器中设置导电颗粒，导电颗粒带负电荷或带正电荷，并包含能够允许离子渗透的纳米孔或纳米通道; 在储存器中设置缓冲溶液，所述缓冲溶液包含与导电颗粒具有相反电性质的抗衡离子; 将带电粒子加入到缓冲溶液中，带电粒子是与导电颗粒具有相同电性质的共离子; 并在导电颗粒上施加外部电场。当外部电场施加在导电颗粒上时，抗衡离子从纳米孔或纳米通道离开，并且在导电颗粒的表面上具有不均匀的浓度，使得瞬时离子超浓度现象发生在在导电颗粒上喷射极。因此，本发明在基于珠的分子测定中具有潜在的应用。

5. 发明申请

US20080316854A1 Microfluid mixer 审中-公开
标题翻译：微流控搅拌机
公开(公告)号：US20080316854A1
公开(公告)日：2008-12-25
申请号：US12076378
申请日：2008-03-18
申请人： Shau-Chun Wang , Hsiao-Ping Chen , Chia Yu Lee , Hsueh-Chia Chang
发明人： Shau-Chun Wang , Hsiao-Ping Chen , Chia Yu Lee , Hsueh-Chia Chang
IPC分类号： B01F11/02
CPC分类号： B01F13/0076 , B01L3/502715
摘要： A microfluid mixer is provided. The non-linear electrokineticsis is applied to the design of the microfluid mixer. The microfluid mixer comprises a first and a second microfluidic elements, a mixing reservoir, and a micro channel unit, wherein the micro channel unit has at least two control channels for respectively connecting the first and the second microfluidic elements and the mixing reservoir. When two microfluids are mixed in the mixing reservoir, the electro-osmosis fluid field of the microfluids in the control channel of the mixing reservoir is changed by applying AC signal, such that powerful chaotic mixing effect is therefore produced by the two microfluids in the mixing reservoir.
摘要翻译：提供微流体混合器。非线性电动力学应用于微流体混合器的设计。微流体混合器包括第一和第二微流体元件，混合储存器和微通道单元，其中微通道单元具有用于分别连接第一和第二微流体元件和混合储存器的至少两个控制通道。当在混合容器中混合两个微流体时，通过施加AC信号来改变混合容器的控制通道中的微流体的电渗流体场，从而在混合中由两个微流体产生强大的混沌混合效应水库

6. 发明申请

US20080152509A1 INTEGRATED MICRO-PUMP AND ELECTRO-SPRAY 审中-公开
标题翻译：集成微型泵和电喷雾
公开(公告)号：US20080152509A1
公开(公告)日：2008-06-26
申请号：US11828133
申请日：2007-07-25
申请人： Hsueh-Chia Chang , Zilin Chen , Ping Wang
发明人： Hsueh-Chia Chang , Zilin Chen , Ping Wang
IPC分类号： F04B37/10
CPC分类号： F04B43/043
摘要： Disclosed is a micro-pump having at least one channel on a substrate where the channel has an inlet and an outlet. The micro-pump includes a first and second electrode coupled to the substrate, wherein the electrodes deliver a current that produces an electric field across the substrate to create a flow from the inlet to the outlet of a fluid contained in the channel. The micro-pump also includes an ion-specific membrane housing for the electrode reservoir minimizes bubble generation, fluid leakage and pressure loss. Further, at least a portion of the channel contains a chemically formed porous matrix.
摘要翻译：公开了一种微泵，其在基底上具有至少一个通道，其中通道具有入口和出口。微型泵包括耦合到衬底的第一和第二电极，其中电极传递电流，该电流在衬底上产生电场，以产生从通道中包含的流体的入口到出口的流动。微型泵还包括用于电极储存器的离子特异性膜壳体，使气泡产生，流体泄漏和压力损失最小化。此外，通道的至少一部分包含化学形成的多孔基质。

7. 发明申请

US20070267295A1 Apparatus and method for non-contact microfluidic sample manipulation 审中-公开
标题翻译：非接触微流体样品操作的装置和方法
公开(公告)号：US20070267295A1
公开(公告)日：2007-11-22
申请号：US11436436
申请日：2006-05-18
申请人： Hsueh-Chia Chang , Diana Hou , Siddharth Maheshwari , Leslie Yeo , Zachary Gagnon
发明人： Hsueh-Chia Chang , Diana Hou , Siddharth Maheshwari , Leslie Yeo , Zachary Gagnon
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B03C5/005 , B03C5/026
摘要： An electro-hydrodynamic apparatus and method of using the same is disclosed. The electro-hydrodynamic apparatus includes a liquid sample supported on a substrate, with at least one electrode located proximate the surface of the liquid sample without contacting the liquid sample. A power supply creates an electric field proximate the surface of the liquid sample, thereby inducing a motion to the liquid sample. The apparatus may be used for focusing and separating particles within a liquid, and pumping and mixing a liquid sample or a liquid mixture with or without particles. The apparatus creates a primary rotational flow on a liquid surface to create a secondary inertial flow. The apparatus may be used to focus particles and/or pathogens to increase the sensitivity of current detection techniques and to enhance immuno-sensing techniques, as well as to mix heterogeneous components of a liquid sample by acting as a stirring without mechanical moving parts and to enhance antibody-antigen interactions, to pump liquids in lab-on-a-chip, clinical and environmental diagnostic kits, or to separate particles and/or pathogens by utilizing different dielectrophoretic mobilities, magnetic susceptibilities and/or antibody affinities.
摘要翻译：公开了一种电动流体动力装置及其使用方法。电动液压装置包括支撑在基板上的液体样品，至少一个电极位于液体样品的表面附近，而不接触液体样品。电源在液体样品的表面附近产生电场，从而引起对液体样品的运动。该装置可用于聚焦和分离液体中的颗粒，并且泵送和混合液体样品或具有或不具有颗粒的液体混合物。该装置在液体表面上产生主旋转流以产生二次惯性流。该装置可以用于聚焦颗粒和/或病原体以提高当前检测技术的灵敏度并增强免疫感测技术，以及通过作为没有机械移动部件的搅拌而混合液体样品的异质组分，以及增强抗体 - 抗原相互作用，在芯片实验室，临床和环境诊断试剂盒中泵送液体，或通过利用不同的介电电泳迁移率，磁化率和/或抗体亲和力来分离颗粒和/或病原体。

8. 发明授权

US08771938B2 Microfluidic platforms for multi-target detection 有权
标题翻译：用于多目标检测的微流控平台
公开(公告)号：US08771938B2
公开(公告)日：2014-07-08
申请号：US12246987
申请日：2008-10-07
申请人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senpati , Zachary Gagnon , Sagnik Basuray
发明人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senpati , Zachary Gagnon , Sagnik Basuray
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/36 , C12M1/34 , G01N15/06 , G01N27/00 , B01J19/08 , B01D57/02 , B03C5/02 , C02F1/48 , C07H21/02 , C07H21/04
CPC分类号： B03C5/005 , B01J2219/00459 , B01J2219/005 , B01J2219/00511 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01L3/502761 , B03C5/026 , B03C2201/26 , C12Q1/6816 , G01N21/64 , C12Q2563/116 , C12Q2565/626 , C12Q2565/629
摘要： Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nanostructures are sorted and evaluated to determine at least one of a presence, an absence, or a quantity of the first target.
摘要翻译：公开了用于检测一个或多个目标的示例性方法和装置。示例性方法包括将包含第一靶的样品放置在微流体装置中并将第一靶的多个拷贝与多个纳米结构杂交。该示例性方法包括向多个纳米结构施加电流并且使用由电流产生的电场来移动多个纳米结构。此外，对多个纳米结构进行分类和评估以确定第一靶的存在，不存在或数量中的至少一个。

9. 发明申请

US20100264040A1 METHOD FOR CONCENTRATING PARTICLES OR MOLECULES AND APPARATUS THEREOF 审中-公开
标题翻译：浓缩颗粒或分子的方法及其装置
公开(公告)号：US20100264040A1
公开(公告)日：2010-10-21
申请号：US12826717
申请日：2010-06-30
申请人： SHAU-CHUN WANG , Hsueh-Chia Chang , Hsiao-Ping Chen , Chun-Ming Chang
发明人： SHAU-CHUN WANG , Hsueh-Chia Chang , Hsiao-Ping Chen , Chun-Ming Chang
IPC分类号： B01D43/00
CPC分类号： B03C5/02
摘要： The present invention provides a method for concentrating particles or molecules and an apparatus thereof. The apparatus comprises a substrate, a conducting granule having nano-pores or nano-channels capable of permitting ion permeation, an electrolyte solution comprising counter-ions having an opposite electric property to the conducting granule, and an external field. Wherein, particles or molecules to be concentrated have an identical electric property as the conducting granule at a predefined pH value, and are added into the electrolyte solution with the predefined pH value. While the external electric field is applied across the reservoir where the conducting granule is sitting, the counter-ions exit from the nano-pores or nano-channels and such that a transient ion super-concentration phenomenon occurs at an ejecting pole on the conducting granule so as to concentrate the particles or molecules. Hence the present invention has potential application in bead-based molecular assays.
摘要翻译：本发明提供了一种浓缩颗粒或分子的方法及其装置。该装置包括：具有纳米孔的导电颗粒或能够允许离子渗透的纳米通道，包含与导电颗粒具有相反电性的抗衡离子的电解质溶液和外部场。其中，要浓缩的颗粒或分子具有与导电颗粒相同的电特性，并且以预定的pH值加入到电解质溶液中。当外部电场施加在导电颗粒所在的储存器上时，反离子从纳米孔或纳米通道离开，并且在导电颗粒上的喷射极处发生瞬态离子超浓度现象以便集中颗粒或分子。因此，本发明在基于珠的分子测定中具有潜在的应用。

10. 发明授权

US06428754B1 Method and Apparatus for treating exhaust gases 失效
标题翻译：废气处理方法和装置
公开(公告)号：US06428754B1
公开(公告)日：2002-08-06
申请号：US08382296
申请日：1995-02-01
申请人： Hsueh-Chia Chang , David T. Leighton
发明人： Hsueh-Chia Chang , David T. Leighton
IPC分类号： B01D5386
CPC分类号： B01D53/9454 , Y02T10/22
摘要： An exhaust gas treatment system and method for treating the exhaust gas of an internal combustion engine includes a catalytic converter and a catalytic preheater or igniter upstream of the catalytic converter. A bypass passage extends around the igniter such that during the ignition period about two-thirds of the exhaust gas is bypassed around the igniter and one-third passes through the igniter. The igniter raises the temperature of the exhaust gases passing therethrough to an adiabatic temperature of about 900° K. Accordingly, the flow through the igniter combined with the flow through the bypass passage raises the average temperature of the combined exhaust gases to approximately 700° K., which is sufficient to ignite the catalytic converter at substantially the leading edge thereof. Accordingly, normal convective flow of the exhaust gases through the catalytic converter assists in propagating ignition of the converter. A temperature sensor in the catalytic converter causes a controller to operate a valve to divert substantially all of the exhaust gas flow through the bypass passage after the catalytic converter has ignited.
摘要翻译：用于处理内燃机废气的废气处理系统和方法包括催化转化器和催化转化器上游的催化预热器或点火器。旁路通道围绕点火器延伸，使得在点火期间，约三分之二的废气绕点火器旁路并且三分之一通过点火器。点火器将通过其的废气的温度提高到约900°K的绝热温度。因此，通过点火器的流量与通过旁路通道的流动相结合，将组合废气的平均温度提高到约700°K 其足以在其大致前沿点燃催化转化器。因此，通过催化转化器的废气的正常对流流动有助于传播转炉的点火。催化转化器中的温度传感器使得控制器操作阀门，以在催化转化器点燃之后基本上将所有废气流通过旁通通道。

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