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1. 发明授权

US08771938B2 Microfluidic platforms for multi-target detection 有权
标题翻译：用于多目标检测的微流控平台
公开(公告)号：US08771938B2
公开(公告)日：2014-07-08
申请号：US12246987
申请日：2008-10-07
申请人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senpati , Zachary Gagnon , Sagnik Basuray
发明人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senpati , Zachary Gagnon , Sagnik Basuray
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/36 , C12M1/34 , G01N15/06 , G01N27/00 , B01J19/08 , B01D57/02 , B03C5/02 , C02F1/48 , C07H21/02 , C07H21/04
CPC分类号： B03C5/005 , B01J2219/00459 , B01J2219/005 , B01J2219/00511 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01L3/502761 , B03C5/026 , B03C2201/26 , C12Q1/6816 , G01N21/64 , C12Q2563/116 , C12Q2565/626 , C12Q2565/629
摘要： Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nanostructures are sorted and evaluated to determine at least one of a presence, an absence, or a quantity of the first target.
摘要翻译：公开了用于检测一个或多个目标的示例性方法和装置。示例性方法包括将包含第一靶的样品放置在微流体装置中并将第一靶的多个拷贝与多个纳米结构杂交。该示例性方法包括向多个纳米结构施加电流并且使用由电流产生的电场来移动多个纳米结构。此外，对多个纳米结构进行分类和评估以确定第一靶的存在，不存在或数量中的至少一个。

2. 发明申请

US20090092989A1 MICROFLUIDIC PLATFORMS FOR MULTI-TARGET DETECTION 有权
标题翻译：用于多目标检测的微流平台
公开(公告)号：US20090092989A1
公开(公告)日：2009-04-09
申请号：US12246987
申请日：2008-10-07
申请人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senapati , Zachary Gagnon , Sagnik Basuray
发明人： Hsueh-Chia Chang , Jason Gordon , Satyajyoti Senapati , Zachary Gagnon , Sagnik Basuray
IPC分类号： C12Q1/68 , G01N27/26 , C12M1/00
CPC分类号： B03C5/005 , B01J2219/00459 , B01J2219/005 , B01J2219/00511 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01L3/502761 , B03C5/026 , B03C2201/26 , C12Q1/6816 , G01N21/64 , C12Q2563/116 , C12Q2565/626 , C12Q2565/629
摘要： Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nanostructures are sorted and evaluated to determine at least one of a presence, an absence, or a quantity of the first target.
摘要翻译：公开了用于检测一个或多个目标的示例性方法和装置。示例性方法包括将包含第一靶的样品放置在微流体装置中并将第一靶的多个拷贝与多个纳米结构杂交。该示例性方法包括向多个纳米结构施加电流并且使用由电流产生的电场来移动多个纳米结构。此外，对多个纳米结构进行分类和评估以确定第一靶的存在，不存在或数量中的至少一个。

3. 发明授权

US08267914B1 Method and apparatus for AC electrospray 有权
标题翻译：交流电喷雾的方法和装置
公开(公告)号：US08267914B1
公开(公告)日：2012-09-18
申请号：US10965834
申请日：2004-10-18
申请人： Hsueh-Chia Chang , Shau-Chun (Paul) Wang , Dmitri Lastochkin , Leslie Yeo , Zachary Gagnon , Siddharth Maheshwari
发明人： Hsueh-Chia Chang , Shau-Chun (Paul) Wang , Dmitri Lastochkin , Leslie Yeo , Zachary Gagnon , Siddharth Maheshwari
IPC分类号： A61M31/00
CPC分类号： A61M15/02 , A61K9/0073 , A61M11/00 , A61M15/025 , A61M2037/0061
摘要： The present invention provides an electrospray device using a high frequency alternating current (AC) above 10 kHz to generate fine micron sized drops. The apparatus generally functions by applying a high frequency alternating current electric field across one or more micro-needles and one or more conducting elements. The present invention may be used to generate aerosol drops for respiratory drug delivery or as a microencapsulation technique for the encapsulation of drugs, DNA, protein, osteogenic or dermatological growth factors, bacteria, viruses, immobilized enzyme receptors and fluorescent particles for controlled release drug delivery, tissue or bone engineering, clinical or environmental field testing and as biosensors for clinical or drug monitoring. In addition, the present invention may be used to synthesize biodegradable fibers as bioscaffolds for tissue engineering, surgical sutures or medical gauze that enhance blood coagulation, and further may be encapsulated by other agents.
摘要翻译：本发明提供一种使用高于10kHz的高频交流电（AC）的电喷射装置，以产生精细微米级的液滴。该装置通常通过跨越一个或多个微针和一个或多个导电元件施加高频交流电场来起作用。本发明可用于产生用于呼吸药物递送的气溶胶滴剂或用于包封药物，DNA，蛋白质，成骨或皮肤病学生长因子，细菌，病毒，固定化酶受体和用于控释药物递送的荧光颗粒的微胶囊化技术，组织或骨骼工程，临床或环境现场测试以及用于临床或药物监测的生物传感器。此外，本发明可以用于合成可生物降解的纤维，作为用于组织工程的生物支架，外科缝线或医用纱布，其可增强血液凝固，并且还可以被其它试剂包封。

4. 发明授权

US07744738B1 Method and apparatus for rapid particle manipulation and characterization 有权
标题翻译：用于快速粒子处理和表征的方法和装置
公开(公告)号：US07744738B1
公开(公告)日：2010-06-29
申请号：US11117632
申请日：2005-04-29
申请人： Zachary Gagnon , Hsueh-Chia Chang
发明人： Zachary Gagnon , Hsueh-Chia Chang
IPC分类号： B03C5/02
CPC分类号： B03C5/026 , B03C5/005
摘要： The present invention provides a method and apparatus for use in rapid particle transportation, separation, focusing, characterization, and release. Dielectrophoresis and electro-osmotic driven fluid convection are used independently or in tandem as the driving forces for particle manipulation and on occasion characterization. Although dielectrophoresis has been acknowledged for decades as a powerful technique for particle manipulation and characterization, long processing times and measurement inaccuracies that emerge from using disjointed electrodes have limited its usefulness in diagnostic kits. The present invention provides for a continuous wire that enables fluid flow patterns and dielectrophoretic forces with optimal configurations for rapid and sensitive particle manipulation and characterization.
摘要翻译：本发明提供了一种用于快速颗粒运输，分离，聚焦，表征和释放的方法和装置。电泳和电渗驱动流体对流独立或串联使用，作为粒子操纵和有时表征的驱动力。尽管介电电泳几十年来一直被认为是用于粒子操纵和表征的强大技术，但是长时间的处理时间和使用不连续电极所产生的测量不准确限制了其在诊断试剂盒中的用途。本发明提供了一种连续导线，其能够使流体流动模式和介电电泳力具有用于快速和敏感的粒子操纵和表征的最佳配置。

5. 发明申请

US20070267295A1 Apparatus and method for non-contact microfluidic sample manipulation 审中-公开
标题翻译：非接触微流体样品操作的装置和方法
公开(公告)号：US20070267295A1
公开(公告)日：2007-11-22
申请号：US11436436
申请日：2006-05-18
申请人： Hsueh-Chia Chang , Diana Hou , Siddharth Maheshwari , Leslie Yeo , Zachary Gagnon
发明人： Hsueh-Chia Chang , Diana Hou , Siddharth Maheshwari , Leslie Yeo , Zachary Gagnon
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B03C5/005 , B03C5/026
摘要： An electro-hydrodynamic apparatus and method of using the same is disclosed. The electro-hydrodynamic apparatus includes a liquid sample supported on a substrate, with at least one electrode located proximate the surface of the liquid sample without contacting the liquid sample. A power supply creates an electric field proximate the surface of the liquid sample, thereby inducing a motion to the liquid sample. The apparatus may be used for focusing and separating particles within a liquid, and pumping and mixing a liquid sample or a liquid mixture with or without particles. The apparatus creates a primary rotational flow on a liquid surface to create a secondary inertial flow. The apparatus may be used to focus particles and/or pathogens to increase the sensitivity of current detection techniques and to enhance immuno-sensing techniques, as well as to mix heterogeneous components of a liquid sample by acting as a stirring without mechanical moving parts and to enhance antibody-antigen interactions, to pump liquids in lab-on-a-chip, clinical and environmental diagnostic kits, or to separate particles and/or pathogens by utilizing different dielectrophoretic mobilities, magnetic susceptibilities and/or antibody affinities.
摘要翻译：公开了一种电动流体动力装置及其使用方法。电动液压装置包括支撑在基板上的液体样品，至少一个电极位于液体样品的表面附近，而不接触液体样品。电源在液体样品的表面附近产生电场，从而引起对液体样品的运动。该装置可用于聚焦和分离液体中的颗粒，并且泵送和混合液体样品或具有或不具有颗粒的液体混合物。该装置在液体表面上产生主旋转流以产生二次惯性流。该装置可以用于聚焦颗粒和/或病原体以提高当前检测技术的灵敏度并增强免疫感测技术，以及通过作为没有机械移动部件的搅拌而混合液体样品的异质组分，以及增强抗体 - 抗原相互作用，在芯片实验室，临床和环境诊断试剂盒中泵送液体，或通过利用不同的介电电泳迁移率，磁化率和/或抗体亲和力来分离颗粒和/或病原体。

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