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1. 发明申请

US20080207541A1 Compositions and Methods For Optimizing Cleavage of Rna By Rnase H 有权
标题翻译：通过Rnase H优化Rna切割的组合物和方法
公开(公告)号：US20080207541A1
公开(公告)日：2008-08-28
申请号：US10592919
申请日：2005-03-15
申请人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
发明人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
IPC分类号： A61K31/70 , C12N15/87 , A61P43/00
CPC分类号： C12N15/85 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/346 , C12N2310/3519 , C12N2310/3525
摘要： The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
摘要翻译：本发明提供了通过RNA酶H优化RNA种类的切割的组合物和方法。在一些实施方案中，本发明提供具有不同构象的两个或更多个区域的寡核苷酸，以及位于能够区分的区域之间的至少一个过渡核碱基调节与其3'-羟基结合的区域的螺旋构象特征转移到与其5'羟基结合的区域。

2. 发明申请

US20080105874A1 THIN FILM TRANSISTOR, MANUFACTURING METHOD THEREOF, AND TFT LCD USING THE SAME 有权
标题翻译：薄膜晶体管，其制造方法和使用其的TFT LCD
公开(公告)号：US20080105874A1
公开(公告)日：2008-05-08
申请号：US11935073
申请日：2007-11-05
申请人： Wei WANG , Hongjiang Wu , Chunping Long , Chang Hee Lee
发明人： Wei WANG , Hongjiang Wu , Chunping Long , Chang Hee Lee
IPC分类号： H01L29/04 , H01L21/336
CPC分类号： H01L29/78696 , G02F1/1368 , H01L27/12 , H01L27/124 , H01L29/41733
摘要： A thin film transistor (TFT) that comprises a gate electrode on a substrate, a gate insulation layer on the gate electrode, an active layer having a source region, a drain region, and a channel region on the gate insulation layer, and a source electrode and a drain electrode formed over the source region and drain region of the active layer respectively and facing each other with respect to the channel region. The profile of channel region between the source electrode and drain electrode is changed in a bend line. A method for forming the TFT is also provided.
摘要翻译：一种薄膜晶体管（TFT），其包括在基板上的栅电极，栅电极上的栅极绝缘层，在栅极绝缘层上具有源极区，漏极区和沟道区的有源层，以及源极电极和漏电极，分别形成在有源层的源极区域和漏极区域上，并且相对于沟道区域彼此面对。源电极和漏电极之间的沟道区域的轮廓在弯曲线中改变。还提供了一种用于形成TFT的方法。

3. 发明授权

US08790919B2 Compositions and methods for optimizing cleavage of RNA by RNase H 有权
标题翻译：用于优化RNA酶H切割RNA的组合物和方法
公开(公告)号：US08790919B2
公开(公告)日：2014-07-29
申请号：US10592919
申请日：2005-03-15
申请人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
发明人： Michael T. Migawa , Walter F. Lima , Eric E. Swayze , Joshua Nichols , Hongjiang Wu , Thazha P. Prakash , Tadeusz Krzysztof Wyrzykiewicz , Balkrishen Bhat , Stanley T. Crooke
IPC分类号： C12N15/85 , C07H21/02 , C07H21/04
CPC分类号： C12N15/85 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/346 , C12N2310/3519 , C12N2310/3525
摘要： The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
摘要翻译：本发明提供了通过RNA酶H优化RNA种类的切割的组合物和方法。在一些实施方案中，本发明提供具有不同构象的两个或更多个区域的寡核苷酸，以及位于能够区分的区域之间的至少一个过渡核碱基调节与其3'-羟基结合的区域的螺旋构象特征转移到与其5'羟基结合的区域。

4. 发明申请

US20120281170A1 COLOR FILTER SUBSTRATE AND PRODUCING PROCESS AND DEVICE FOR MANUFACTURING THE SAME 审中-公开
标题翻译：彩色滤光片基板和制造工艺及其制造装置
公开(公告)号：US20120281170A1
公开(公告)日：2012-11-08
申请号：US13461994
申请日：2012-05-02
申请人： Hongjiang WU , Min LI , Dong WANG , Song WANG , Seungmoo RIM
发明人： Hongjiang WU , Min LI , Dong WANG , Song WANG , Seungmoo RIM
IPC分类号： G02F1/1335 , B05D5/12 , B05D5/06 , G02B5/22
CPC分类号： G02F1/13394 , G02F2001/133519 , G02F2001/136236
摘要： The embodiments of the disclosed technology disclose a color filter substrate and the producing process and device for the same. The producing process of the color filter substrate according to the embodiments of the disclosed technology comprises: forming a transparent conductive layer on a side of a base substrate; forming a black matrix on the other side of the base substrate; forming a color filer layer within the black matrix; and forming an insulated material layer comprising both post spacers and a protection film formed integrally on the color filer layer.
摘要翻译：所公开技术的实施例公开了一种滤色器基板及其制造方法和装置。根据所公开技术的实施例的滤色器基板的制造方法包括：在基底基板的一侧上形成透明导电层; 在所述基底基板的另一侧上形成黑矩阵; 在黑矩阵内形成彩色滤光层; 以及形成包括柱状间隔物和整体形成在所述彩色滤光层上的保护膜的绝缘材料层。

5. 发明授权

US08163477B2 Nuclease-based method for detecting and quantitating oligonucleotides 有权
标题翻译：用于检测和定量寡核苷酸的基于核酸酶的方法
公开(公告)号：US08163477B2
公开(公告)日：2012-04-24
申请号：US10445996
申请日：2003-05-27
申请人： Zhengrong Yu , Brenda F. Baker , Hongjiang Wu
发明人： Zhengrong Yu , Brenda F. Baker , Hongjiang Wu
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2565/549 , C12Q2521/307
摘要： A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including administered modified oligonucleotides, for therapeutic and/or pharmacokinetic purposes.
摘要翻译：提供了用于定量体液和/或提取物样品中的寡核苷酸的方法。该方法提供用于治疗和/或药代动力学目的的寡核苷酸的检测和/或定位，包括施用修饰的寡核苷酸。

6. 发明申请

US20070292875A1 Human RNase H1 oligonucleotide compositions thereof 审中-公开
标题翻译：人类RNase H1寡核苷酸组合物
公开(公告)号：US20070292875A1
公开(公告)日：2007-12-20
申请号：US11726598
申请日：2007-03-21
申请人： Stanley Crooke , Walter Lima , Hongjiang Wu , Muthiah Monoharan
发明人： Stanley Crooke , Walter Lima , Hongjiang Wu , Muthiah Monoharan
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12N15/113 , C07H21/00 , C07K2319/00 , C12N9/22 , C12N2310/31 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
摘要翻译：本发明提供可用作人2型核糖核酸酶H的底物的寡核苷酸。本发明还涉及在增强反义寡核苷酸疗法中使用这些寡核苷酸的方法。

7. 发明申请

US20050153340A1 Human RNase H and compositions and uses thereof 审中-公开
标题翻译：人类RNase H及其组合物及用途
公开(公告)号：US20050153340A1
公开(公告)日：2005-07-14
申请号：US11005069
申请日：2004-12-06
申请人： Stanley Crooke , Walter Lima , Hongjiang Wu
发明人： Stanley Crooke , Walter Lima , Hongjiang Wu
IPC分类号： A61K38/00 , C12N9/22 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N9/22 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Y301/26004 , C12N2310/3525
摘要： The present invention relates to methods for using mammalian RNase H, including human RNase H, and compositions thereof, particularly for reduction of a selected cellular RNA target via antisense technology. A novel human RNAse HII polypeptide and the polynucleotide sequence encoding it are also disclosed.
摘要翻译：本发明涉及使用哺乳动物核糖核酸酶H（包括人核糖核酸酶H）及其组合物的方法，特别是通过反义技术还原所选择的细胞RNA靶。还公开了一种新的人类RNAse HII多肽和编码它的多核苷酸序列。

8. 发明授权

US06376661B1 Human RNase H and compositions and uses thereof 有权
公开(公告)号：US06376661B1
公开(公告)日：2002-04-23
申请号：US09684254
申请日：2000-10-06
申请人： Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
发明人： Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
IPC分类号： C07H2104
CPC分类号： C12N9/22 , A61K38/00 , C12N15/113 , C12N2310/11
摘要： The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.

9. 发明授权

US08929007B2 Color filter and manufacturing method thereof 有权
标题翻译：滤色器及其制造方法
公开(公告)号：US08929007B2
公开(公告)日：2015-01-06
申请号：US13466472
申请日：2012-05-08
申请人： Hongjiang Wu , Chongxi Wei , Yiming Chen , Seungmoo Rim , Xibin Shao
发明人： Hongjiang Wu , Chongxi Wei , Yiming Chen , Seungmoo Rim , Xibin Shao
IPC分类号： G02B5/22 , G02B5/20 , G03F7/00
CPC分类号： G02B5/201 , G03F7/0007
摘要： A color filter and a manufacturing method thereof are provided, in which a stacked structure composed of several color film layers having different colors is formed in a non-transmitting partitioning region of the color filter in such a way that the stacked structure can prevent light from passing through the color filter via the partitioning region.
摘要翻译：提供了一种滤色器及其制造方法，其中在彩色滤光片的非透光分隔区域中形成由具有不同颜色的多个彩色薄膜层组成的层叠结构，使得层叠结构能够防止来自通过分色区域通过滤色片。

10. 发明申请

US20120245725A1 MANUFACTURING METHOD AND SYSTEM OF TARGET 有权
标题翻译：目标的制造方法和系统
公开(公告)号：US20120245725A1
公开(公告)日：2012-09-27
申请号：US13428568
申请日：2012-03-23
申请人： Jikai ZHANG , Jiyu WAN , Hongjiang WU , Seungmoo RIM
发明人： Jikai ZHANG , Jiyu WAN , Hongjiang WU , Seungmoo RIM
IPC分类号： G06F19/00
CPC分类号： G01B21/18 , C23C14/3414 , G01B2210/56 , H01J37/3414 , H01J37/3491
摘要： The disclosed technology provides a manufacturing method of a target comprising obtaining an initial mass and a residual mass of the target sample, and calculating an etching mass; determining a relative etching depth of the target sample; calculating a relative etching mass based on the etching mass and the relative etching depth; determining a utilization parameter of the target sample based on the relative etching mass and the initial mass of the target sample before being used; and performing a simulation and optimization process on the utilization parameter of the target sample, obtaining target parameters corresponding to a preset value of the utilization parameter, and outputting the target parameters to a manufacturing control center for manufacturing a target. The disclosed technology also provides a manufacturing system of a target.
摘要翻译：所公开的技术提供了一种靶的制造方法，包括获得目标样品的初始质量和剩余质量，并计算蚀刻质量; 确定目标样品的相对蚀刻深度; 基于蚀刻质量和相对蚀刻深度计算相对蚀刻质量; 在使用前基于相对蚀刻质量和目标样品的初始质量确定目标样品的利用参数; 对所述目标样本的利用参数进行模拟和优化处理，获得与所述利用参数的预设值相对应的目标参数，并将所述目标参数输出到制造对象的制造控制中心。所公开的技术还提供了目标的制造系统。

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