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1. 发明授权

US07767812B2 Crystals of pyrimidine compound and process for producing the same 失效
标题翻译：嘧啶化合物的晶体及其制备方法
公开(公告)号：US07767812B2
公开(公告)日：2010-08-03
申请号：US12346544
申请日：2008-12-30
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ;±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体 °和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

2. 发明申请

US20080066295A1 Magnetostrictive coat forming method, magnetostrictive torque sensor manufacturing method, and electric power steering apparatus employing the sensor 有权
标题翻译：磁致伸缩涂层成形方法，磁致伸缩扭矩传感器制造方法以及使用该传感器的电动助力转向装置
公开(公告)号：US20080066295A1
公开(公告)日：2008-03-20
申请号：US11983085
申请日：2007-11-07
申请人： Yasuo Shimizu , Yoshito Nakamura , Shunichiro Sueyoshi , Nobuhiko Yoshimoto , Koji Kobayashi , Yuichi Fukuda , Mizuho Doi , Hitoshi Harada , Tomohiro Hoshi
发明人： Yasuo Shimizu , Yoshito Nakamura , Shunichiro Sueyoshi , Nobuhiko Yoshimoto , Koji Kobayashi , Yuichi Fukuda , Mizuho Doi , Hitoshi Harada , Tomohiro Hoshi
IPC分类号： H01F7/02 , B62D5/04
CPC分类号： G01L3/102 , G01L3/103 , Y10T29/49002 , Y10T29/49005 , Y10T29/4902 , Y10T29/49078 , Y10T29/49224
摘要： For forming an annular magnetostrictive coat on an outer peripheral surface of a rotational shaft associated with a magnetostrictive torque sensor, a magnetostrictive-coat forming method comprises a step of fitting a cylindrical masking jig over the outer peripheral surface of the rotational shaft and securing the masking jig to the outer peripheral surface, a step of placing the rotational shaft in a plating tank to thereby form the magnetostrictive coat by plating on the outer peripheral surface, and a step of detaching the masking jig from the rotational shaft.
摘要翻译：为了在与磁致伸缩扭矩传感器相关联的旋转轴的外周表面上形成环形磁致伸缩涂层，磁致伸缩涂层形成方法包括将圆柱形掩模夹具安装在旋转轴的外周表面上并确保掩模夹具到外周面，将旋转轴放置在镀槽中，由此通过在外周面上电镀形成磁致伸缩涂层的步骤，以及将掩模夹具从旋转轴上分离的步骤。

3. 发明申请

US20060235225A1 Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same 失效
标题翻译： 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体及其制备方法
公开(公告)号：US20060235225A1
公开(公告)日：2006-10-19
申请号：US11378315
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 12.8°, 18.1° and/or 23.5° in a powder X-ray diffraction are excellent in stability against light, therefore are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为12.8°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体，18.1°和/或23.5°，对于光的稳定性优异，因此适用于诸如便秘的疾病的预防和治疗剂的活性成分。

4. 发明申请

US20050004149A1 Pyrimidine compound and medicinal composition thereof 失效
公开(公告)号：US20050004149A1
公开(公告)日：2005-01-06
申请号：US10492905
申请日：2002-10-22
申请人： Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
发明人： Hitoshi Harada , Osamu Asano , Masato Ueda , Shuhei Miyazawa , Yoshihiko Kotake , Yasuhiro Kabasawa , Masahiro Yasuda , Nobuyuki Yasuda , Daisuke Iida , Junichi Nagakawa , Kazuo Hirota , Makoto Nakagawa
IPC分类号： A61K31/506 , A61P1/00 , A61P1/10 , A61P3/04 , A61P3/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P19/10 , A61P25/16 , A61P25/28 , A61P43/00 , C07D401/04 , C07D405/14 , C07D409/14 , C07
CPC分类号： C07D405/14 , A61K31/506 , C07D401/04 , C07D409/14
摘要： The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R4 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aromatic heterocyclic group having at least one or more unsaturated bonds which may be substituted; and R5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.

5. 发明授权

US4624884A Heat radiating insulation for coil 失效
标题翻译：线圈散热绝缘
公开(公告)号：US4624884A
公开(公告)日：1986-11-25
申请号：US775108
申请日：1985-09-11
申请人： Hitoshi Harada , Yasumi Ohsera
发明人： Hitoshi Harada , Yasumi Ohsera
IPC分类号： C08K3/00 , C08K3/22 , C08L33/00 , C08L33/02 , C08L67/00 , H01B3/30 , H01B3/40 , H02K3/30 , H02K3/32 , B32B5/16 , B44D1/094 , B44D1/44
CPC分类号： H02K3/32 , C08K3/0033 , H01B3/40 , Y10T428/24992 , Y10T428/256 , Y10T428/257 , Y10T428/2993 , Y10T428/31522 , Y10T428/31721 , Y10T428/31786 , Y10T428/31906
摘要： A thermosetting synthetic resin composition consisting mainly of, for example, an epoxy resin is melted at a temperature of 70.degree. to 130.degree. C. After adding a filler to the resin composition, the resultant mixture is kneaded and rapidly cooled. The composition consists of a thixotropy agent, a leveling agent, etc., in addition to the epoxy resin and a curing agent for the epoxy resin. Aluminum as the filler is added in the amount of 30 wt % to 100 wt % of the mixture. The mixture of the composition with the filler is kneaded and rapidly cooled and is then pulverized to prepare a powder. The powder coating thus obtained is coated on a coil and is cured to provide a heat radiating insulator.
摘要翻译：主要由例如环氧树脂组成的热固性合成树脂组合物在70〜130℃的温度下熔融。在树脂组合物中加入填料后，将其混合并快速冷却。组合物除了环氧树脂和环氧树脂的固化剂之外还包含触变剂，流平剂等。作为填料的铝的添加量为混合物的30重量％至100重量％。将组合物与填料的混合物捏合并快速冷却，然后粉碎以制备粉末。由此获得的粉末涂层涂覆在线圈上并被固化以提供散热绝缘体。

6. 发明申请

US20130065925A1 PYRROLIDIN-3-YLACETIC ACID DERIVATIVE 有权
标题翻译：吡咯烷-3-基酸衍生物
公开(公告)号：US20130065925A1
公开(公告)日：2013-03-14
申请号：US13609716
申请日：2012-09-11
申请人： Ichiro YOSHIDA , Tadashi OKABE , Yasunobu MATSUMOTO , Nobuhisa WATANABE , Yuji ONIZAWA , Yoshiaki OHASHI , Hitoshi HARADA
发明人： Ichiro YOSHIDA , Tadashi OKABE , Yasunobu MATSUMOTO , Nobuhisa WATANABE , Yuji ONIZAWA , Yoshiaki OHASHI , Hitoshi HARADA
IPC分类号： C07D401/12 , A61P1/04 , A61K31/4025 , A61P1/00 , A61K31/454 , C07D403/12
CPC分类号： A61K31/4025 , A61K31/454 , C07D401/12 , C07D403/12
摘要： A compound represented by formula (1) or a pharmaceutically acceptable salt thereof has an inhibitory effect in the fractalkine-CX3CR1 pathway: wherein R represents a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, a C3-8 cycloalkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, or a C3-8 cycloalkenyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group A, X represents a C1-6 alkyl group, Y and Z are the same or different from each other and each represents a halogen atom or a C1-6 alkyl group unsubstituted or having 1 to 3 substituents selected from Substituent Group B, n represents 0 or 1, Substituent Group A consists of halogen atoms, and Substituent Group B consists of halogen atoms.
摘要翻译：由式（1）表示的化合物或其药学上可接受的盐具有抑制作用：其中R表示未取代的或具有1至3个选自取代基组A的取代基的C 1-6烷基，C3- 8个未取代的或具有1〜3个选自取代基组A的取代基的环烷基，或未取代或具有1-3个选自取代基组A的取代基的C 3-8环烯基，X表示C 1-6烷基，Y和Z是相同或不同，各自表示卤素原子或未取代或具有1〜3个选自取代基组B的取代基的C 1-6烷基，n表示0或1，取代基组A由卤素原子和取代基组B 由卤素原子组成。

7. 发明申请

US20110006922A1 BUS LOCATION INDICATING METHOD, BUS VIDEO ACQUIRING METHOD, INTERSECTION VIDEO ACQUIRING METHOD AND VIDEO DELIVERY 审中-公开
标题翻译：总线位置指示方法，总线视频采集方法，接口视频采集方法和视频传送
公开(公告)号：US20110006922A1
公开(公告)日：2011-01-13
申请号：US12830387
申请日：2010-07-05
申请人： Tsutomu TSUBOI , Izuru YAMADA , Hitoshi HARADA
发明人： Tsutomu TSUBOI , Izuru YAMADA , Hitoshi HARADA
IPC分类号： G08G1/123 , H04N7/18
CPC分类号： G08G1/123 , H04N7/18
摘要： The present invention provides a method for detecting the current location of a bus at lower cost without using a wideband wireless communication device and displaying it on each bus stop. A center system of a center and each of bus stop systems are coupled to each other via Internet. A roadside wireless unit of the bus stop system contained in the bus stop periodically outputs a beacon containing a bus stop ID to a route bus system equipped on a route bus. The route bus system outputs an ID notification signal including a bus stop ID and a bus ID to the bus stop system. The center system of the center updates location information using the bus stop ID and the bus ID and transmits bus location update data to a suitable target. The bus stop system displays a bus location thereon using the transmitted bus location update data.
摘要翻译：本发明提供了一种用于以较低的成本检测总线的当前位置的方法，而不使用宽带无线通信设备并将其显示在每个总线站上。中心的中心系统和每个公交车站系统通过互联网相互耦合。包含在总线站内的总线站系统的路边无线单元周期性地将包含总线站点ID的信标输出到配置在路线总线上的路线总线系统。路线总线系统向公车站系统输出包括总线停车ID和总线ID的ID通知信号。中心的中心系统使用总线停车ID和总线ID更新位置信息，并将总线位置更新数据发送到合适的目标。公共汽车站系统使用所发送的总线位置更新数据在其上显示总线位置。

8. 发明授权

US07544835B2 Carboxylic acid derivative and salt thereof 失效
标题翻译：羧酸衍生物及其盐
公开(公告)号：US07544835B2
公开(公告)日：2009-06-09
申请号：US10472543
申请日：2002-04-18
申请人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara , Hitoshi Harada , Kaya Ohashi
发明人： Fumiyoshi Matsuura , Eita Emori , Masanobu Shinoda , Richard Clark , Shunji Kasai , Hideki Yoshitomi , Kazuto Yamazaki , Takashi Inoue , Sadakazu Miyashita , Taro Hihara , Hitoshi Harada , Kaya Ohashi
IPC分类号： C07C55/28 , C07C63/00
CPC分类号： C07D413/12 , C07C59/58 , C07C59/68 , C07C59/72 , C07C233/25 , C07C235/24 , C07C251/48 , C07C251/52 , C07C251/54 , C07C255/37 , C07C255/54 , C07C259/10 , C07C271/14 , C07C271/16 , C07C271/22 , C07C271/28 , C07C271/58 , C07C309/73 , C07C309/75 , C07C311/19 , C07C317/18 , C07C317/22 , C07C323/20 , C07D209/08 , C07D209/18 , C07D209/24 , C07D213/30 , C07D213/65 , C07D213/68 , C07D213/73 , C07D213/75 , C07D215/14 , C07D215/18 , C07D215/26 , C07D235/06 , C07D235/12 , C07D277/56 , C07D295/096 , C07D295/192 , C07D307/79 , C07D317/54 , C07D417/12
摘要： Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein R1 represents hydrogen, hydroxyl, halogen, carboxyl, or C1-6 alkyl, L represents single bond or C1-6-alkylene, C2-6-alkenylene, or C2-6-alkynylene, M represents single bond or C1-6-alkylene, C2-6-alkenylene, or C2-6-alkynylene, T represents single bond, or C1-3-alkylene, C2-3-alkenylene, or C2-3-alkynylene, W represents carboxyl, represents single bond, X represents single bond, oxygen, —NRX1CQ1O—, —OCQ1NRX1—, —CQ1NRX1O—, ONRX1CQ1—, —Q2SO2—, or —SO2Q2—, Y represents 5- to 14-membered aromatic group, and ring Z represents 5- to 14-membered aromatic group.
摘要翻译：可用作胰岛素敏化剂的羧酸化合物或其盐或水合物，其由下式表示：其中R 1表示氢，羟基，卤素，羧基或C 1-6烷基，L表示单键或C 1-6 - 亚烷基，C 2-6亚烯基或C 2-6亚炔基，M表示单键或C 1-6 - 亚烷基，C 2-6亚烯基或C 2-6亚炔基，T表示单键，或C 1-3 - 亚烷基，C 2-3亚烯基，或C2-3亚炔基，W表示羧基，表示单键，X表示单键，氧，-NRX1CQ10，-OCQ1NRX1，-CQ1NRX10，ONRX1CQ1，-Q2SO2-或-SO2Q2-，Y表示5- 至14元芳族基团，并且环Z表示5至14元芳族基团。

9. 发明授权

US07538117B2 Crystalline and amorphous pyrimidine compounds and processes for preparing pyrimidine compounds 失效
标题翻译：结晶和无定形嘧啶化合物及制备嘧啶化合物的方法
公开(公告)号：US07538117B2
公开(公告)日：2009-05-26
申请号：US11378307
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
发明人： Hitoshi Harada , Hiroyuki Chiba , Yuki Komatsu , Susumu Inoue , Naoki Ozeki
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D405/14 , C07D405/06
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 9.7° and/or 21.9° in a powder X-ray diffraction are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation. Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate and amorphous 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one hydrate are also suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为9.7°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体和/或21.9°在粉末X射线衍射中适用于诸如便秘的疾病的预防和治疗剂的活性成分。 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物和无定形的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮水合物也适用于诸如便秘等疾病的预防和治疗剂的活性成分。

10. 发明授权

US07396928B2 Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same 失效
标题翻译： 5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体及其制备方法
公开(公告)号：US07396928B2
公开(公告)日：2008-07-08
申请号：US11378315
申请日：2006-03-20
申请人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
发明人： Hitoshi Harada , Hiroshi Ishihara , Yoshiaki Sato , Hiroyuki Chiba , Teiji Takigawa
IPC分类号： C07D401/04
CPC分类号： C07D405/14
摘要： Crystals of 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one having a diffraction peak at a diffraction angle (2θ±0.2°) of 12.8°, 18.1° and/or 23.5° in a powder X-ray diffraction are excellent in stability against light, therefore are suitable for an active ingredient of a preventing and therapeutic agent for diseases such as constipation.
摘要翻译：在衍射角（2θ±0.2°）为12.8°的衍射峰的5- [2-氨基-4-（2-呋喃基）嘧啶-5-基] -1-甲基吡啶-2（1H） - 酮的晶体，18.1°和/或23.5°，对于光的稳定性优异，因此适用于诸如便秘的疾病的预防和治疗剂的活性成分。

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