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1. 发明申请

US20090270433A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 失效
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20090270433A1
公开(公告)日：2009-10-29
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
IPC分类号： A61K31/506 , C07D413/14 , C07D405/14 , A61K31/427
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]

2. 发明申请

US20090203911A1 BENZIMIDAZOLE COMPOUND 有权
标题翻译：苯并咪唑化合物
公开(公告)号：US20090203911A1
公开(公告)日：2009-08-13
申请号：US12189590
申请日：2008-08-11
申请人： Shuhei MIYAZAWA , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
发明人： Shuhei MIYAZAWA , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
IPC分类号： C07D405/14 , C07D401/12
CPC分类号： C07D491/04 , C07D405/14 , C07D493/08 , C07D493/10
摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.
摘要翻译：提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高长时间，具有更多的安全性和适当的物理化学稳定性。提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

3. 发明申请

US20090182149A1 SALT OF SULFINYLBENZIMIDAZOLE COMPOUND, AND CRYSTAL AND AMORPHOUS FORM THEREOF 审中-公开
标题翻译：磺酰苯胺唑化合物的盐，以及其晶体和非晶形式
公开(公告)号：US20090182149A1
公开(公告)日：2009-07-16
申请号：US12296902
申请日：2006-10-13
申请人： Tetsuya Kawahara , Hitoshi Harada , Hiroki Terauchi , Nobuhisa Watanabe , Masato Ueda , Atsushi Kamada , Sachiko Kikuchi , Hiroshi Ishihara , Koichi Koyama
发明人： Tetsuya Kawahara , Hitoshi Harada , Hiroki Terauchi , Nobuhisa Watanabe , Masato Ueda , Atsushi Kamada , Sachiko Kikuchi , Hiroshi Ishihara , Koichi Koyama
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： Salts of 2-[({4-[(2,2-dimethyl-1,3-dioxan-5-yl)methoxy]-3,5-dimethylpyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole and their crystalline and amorphous forms.
摘要翻译： 2 - [（{4 - [（2,2-二甲基-1,3-二恶烷-5-基）甲氧基] -3,5-二甲基吡啶-2-基}甲基）亚磺酰基] -1H-苯并咪唑的盐及其晶体和无定形形式。

4. 发明申请

US20090028572A1 FREE-SPACE OPTICAL RECEIVING APPARATUS AND ELECTRONIC DEVICE EQUIPPED WITH THAT APPARATUS 审中-公开
标题翻译：免费空间光接收装置和配备设备的电子设备
公开(公告)号：US20090028572A1
公开(公告)日：2009-01-29
申请号：US12168523
申请日：2008-07-07
申请人： Nobuhisa WATANABE
发明人： Nobuhisa WATANABE
IPC分类号： H04B10/06
CPC分类号： G08C23/04 , H04B10/1141
摘要： A free-space optical receiving apparatus in one embodiment of the invention is provided with: a signal receiving light-sensitive element that converts an infrared signal to an electric current signal; a current-voltage conversion circuit that converts the electric current signal to a voltage signal; a shared processing circuit that amplifies this voltage signal, performs digital conversion on the voltage signal, and outputs a digital signal; and a mode conversion circuit that switches the shared processing circuit to a remote control mode when an infrared signal is received, and switches the shared processing circuit to an IrSimple mode when an IrSimple signal is received. The shared processing circuit converts the remote control signal to a digital signal when in the remote control mode, and converts the IrSimple signal to a digital signal when in the IrSimple mode.
摘要翻译：在本发明的一个实施例中的自由空间光接收装置具有：将红外信号转换为电流信号的信号接收光敏元件; 将电流信号转换为电压信号的电流 - 电压转换电路; 放大该电压信号的共享处理电路对电压信号进行数字转换，并输出数字信号; 以及当接收到红外信号时将共享处理电路切换到遥控模式的模式转换电路，并且当接收到IrSimple信号时，将共享处理电路切换为IrSimple模式。当处于远程控制模式时，共享处理电路将遥控信号转换为数字信号，并在IrSimple模式下将IrSimple信号转换为数字信号。

5. 发明授权

US07317538B2 Optical two-dimensional velocity and/or movement detector 失效
标题翻译：光学二维速度和/或运动检测器
公开(公告)号：US07317538B2
公开(公告)日：2008-01-08
申请号：US11028610
申请日：2005-01-05
申请人： Hideo Wada , Nobuhisa Watanabe , Takayuki Taminaga
发明人： Hideo Wada , Nobuhisa Watanabe , Takayuki Taminaga
IPC分类号： G01B11/14
CPC分类号： G01P3/366 , G01S17/58
摘要： In an optical movement information detector, light emitted from a laser diode (1) is split into a first beam (10), a second beam (11) and a third beam (12) by beam splitters (2a, 2b). The first, second and third beams are converged by a condenser lens (4) upon a surface of an object to be measured (5) to form a beam spot (13) thereon. Diffused light from the beam spot (13) is received by a photodiode (6) and an output signal of the photodiode (6) is processed by a signal processing circuit (20) including an analog-digital converter (8) and a Fourier transforming unit (9). A detecting section (21) obtains, for example, a moving velocity and a moving direction of the object based on spectrum peak frequencies obtained by the Fourier transform.
摘要翻译：在光学运动信息检测器中，从激光二极管（1）发射的光通过分束器（2a，2b）分成第一光束（10），第二光束（11）和第三光束（12）。第一，第二和第三光束由聚光透镜（4）会聚在待测物体（5）的表面上，以在其上形成光斑（13）。来自光束点（13）的漫射光由光电二极管（6）接收，并且光电二极管（6）的输出信号由包括模数转换器（8）的信号处理电路（20）和傅立叶变换单位（9）。检测部（21）基于通过傅里叶变换获得的频谱峰值频率，获得例如物体的移动速度和移动方向。

6. 发明授权

US06916837B2 Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them 失效
标题翻译：脒衍生物和含有它们的抗凝血剂和血栓形成治疗剂
公开(公告)号：US06916837B2
公开(公告)日：2005-07-12
申请号：US10294198
申请日：2002-11-14
申请人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
发明人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
IPC分类号： A61K31/192 , A61K31/194 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/472 , A61K31/606 , A61P7/02 , A61P43/00 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07C317/32 , C07D217/06 , C07D217/22 , C07D233/84 , C07D317/68 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40 , C07D333/62 , C40B40/04 , A61K31/415 , A61K31/21 , A61K31/24 , A61K31/38
CPC分类号： C07D333/62 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07D217/22 , C07D233/84 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40
摘要： Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 aryl, etc. and R2 represents hydrogen atom, etc.), etc., Ar1 represents 2,6-naphthylene, etc., R3 represents hydrogen atom, etc. and Y represents carboxyphenyl, etc.} and their pharmacologically acceptable salts or solvates.
摘要翻译：由以下通式（I）表示的脒基衍生物：其中X是由R 1表示的基团SO 2 - （其中 R 1表示任选取代的C 6-14芳基等，R 2表示氢原子等）等，Ar 1， SUP> 1表示2,6-亚萘基等，R 3表示氢原子等，Y表示羧基苯基等}及其药理学上可接受的盐或溶剂化物。

7. 发明申请

US20050146707A1 Optical movement information detector and electronic equipment having same 失效
标题翻译：光学运动信息检测器和具有相同功能的电子设备
公开(公告)号：US20050146707A1
公开(公告)日：2005-07-07
申请号：US11028610
申请日：2005-01-05
申请人： Hideo Wada , Nobuhisa Watanabe , Takayuki Taminaga
发明人： Hideo Wada , Nobuhisa Watanabe , Takayuki Taminaga
IPC分类号： G01S7/48 , G01B11/00 , G01P3/36 , G01S17/02 , G01S17/58
CPC分类号： G01P3/366 , G01S17/58
摘要： In an optical movement information detector, light emitted from a laser diode (1) is split into a first beam (10), a second beam (11) and a third beam (12) by beam splitters (2a, 2b). The first, second and third beams are converged by a condenser lens (4) upon a surface of an object to be measured (5) to form a beam spot (13) thereon. Diffused light from the beam spot (13) is received by a photodiode (6) and an output signal of the photodiode (6) is processed by a signal processing circuit (20) including an analog-digital converter (8) and a Fourier transforming unit (9). A detecting section (21) obtains, for example, a moving velocity and a moving direction of the object based on spectrum peak frequencies obtained by the Fourier transform.
摘要翻译：在光学运动信息检测器中，从激光二极管（1）发射的光通过分束器（2a，2b）分成第一光束（10），第二光束（11）和第三光束（12）。第一，第二和第三光束由聚光透镜（4）会聚在待测物体（5）的表面上，以在其上形成光斑（13）。来自光束点（13）的漫射光由光电二极管（6）接收，并且光电二极管（6）的输出信号由包括模数转换器（8）的信号处理电路（20）和傅立叶变换单位（9）。检测部（21）基于通过傅里叶变换获得的频谱峰值频率，获得例如物体的移动速度和移动方向。

8. 发明授权

US06841549B1 Condensed imidazole compounds and a therapeutic agent for diabetes mellitus 失效
标题翻译：缩合咪唑化合物和糖尿病治疗剂
公开(公告)号：US06841549B1
公开(公告)日：2005-01-11
申请号：US10018688
申请日：2000-06-30
申请人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
发明人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
IPC分类号： A61P3/10 , A61P43/00 , C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , A16K31/33 , C07D239/70 , C07D471/00 , C07D487/00 , A16K31/52
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40
摘要： The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action.That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
摘要翻译：本发明提供了一种基于腺苷A2受体拮抗剂作用的新型糖尿病和糖尿病并发症的预防或治疗剂。即提供了具有腺苷A2受体拮抗剂作用的新颖的缩合咪唑化合物，是有效预防或治疗糖尿病和糖尿病并发症，并由式（I）表示;（其中R 1表示例如可被烷基取代的氨基; R 2表示例如氢原子，可以被羟基取代的烷基，环烷基或烷基，烯基或炔基; R 3表示例如任选取代的烷基，烯基，炔基，芳基，杂芳基，吡啶酮基，嘧啶酮基或哌嗪酮基; Ar表示例如任选取代的芳基或杂芳基; Q和W彼此相同或不同，每个代表 N或CH），其药理学上可接受的盐或其水合物。

9. 发明授权

US06568580B2 Bump bonding apparatus and method 失效
公开(公告)号：US06568580B2
公开(公告)日：2003-05-27
申请号：US09911802
申请日：2001-07-25
申请人： Shoriki Narita , Makoto Imanishi , Takaharu Mae , Shinji Kanayama , Nobuhisa Watanabe
发明人： Shoriki Narita , Makoto Imanishi , Takaharu Mae , Shinji Kanayama , Nobuhisa Watanabe
IPC分类号： B23K3704
CPC分类号： H01L24/78 , H01L21/67138 , H01L21/681 , H01L24/11 , H01L2224/05568 , H01L2224/05573 , H01L2224/1134 , H01L2224/78268 , H01L2224/78301 , H01L2224/786 , H01L2224/85045 , H01L2224/851 , H01L2224/85205 , H01L2924/00013 , H01L2924/00014 , H01L2924/01006 , H01L2924/01033 , H01L2924/01039 , H01L2924/01057 , H01L2924/01061 , H01L2924/14 , Y10T29/53178 , H01L2224/13099 , H01L2224/48 , H01L2224/45099 , H01L2224/05599
摘要： Wafers are previously positioned so that the wafer orientation flat is oriented in a particular direction. A transporting means then moves and places the previously positioned wafer on a bonding stage where bumps are formed on the wafer by means of a bonding head. The transporting means has a sensor for detecting the position of the orientation flat of a wafer on the bonding stage from a position above the bonding stage, thereby avoiding the adverse effects of heat from the bonding stage during orientation flat detection.

10. 发明授权

US5801180A Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US5801180A
公开(公告)日：1998-09-01
申请号：US904260
申请日：1997-07-31
申请人： Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
发明人： Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
IPC分类号： C07D215/42 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/454 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P37/00 , A61P43/00 , B60S1/16 , B60S1/24 , C07D215/48 , C07D235/06 , C07D235/08 , C07D239/78 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/90 , C07D239/94 , C07D239/95 , C07D239/96 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/056 , C07D521/00 , F16C7/02 , F16C11/04
CPC分类号： C07D235/06 , C07D215/42 , C07D231/12 , C07D233/56 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/94 , C07D239/95 , C07D239/96 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/12 , C07D471/04 , C07D491/04
摘要： The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring; ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent each a hydrogen atom, a halogen atom or a group such as a lower alkoxy group; R.sup.5 represents a group represented by the formula --NR.sup.11 R.sup.12 (wherein R.sup.11 and R.sup.12 represent each a hydrogen atom or a group such as a lower alkyl group) or the like; and R.sup.6 represents a group represented by the formula ##STR2## (wherein R.sup.19 represents a hydrogen atom, a lower alkyl group or the like; R.sup.20, R.sup.21 and R.sup.22 represent each a hydrogen atom, a halogen atom, a hydroxyl group or the like; and r represents 0 or an integer of 1 to 8)!.
摘要翻译：本发明提供由以下通式（1）表示的含氮杂环化合物或其药理学上可接受的盐，其可用于各种缺血性心脏病等：（1）[式（1）中，环A 表示苯环，吡啶环或环己烷环; 环B表示吡啶环，嘧啶环或咪唑环，R1，R2，R3和R4分别表示氢原子，卤素原子或低级烷氧基等基团。 R5表示由式-NR11R12表示的基团（其中R11和R12各自表示氢原子或低级烷基等基团）等; R 6表示氢原子，低级烷基等，R 20，R 21，R 22分别表示氢原子，卤素原子，羟基等。和r表示0或1〜8的整数）]。

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