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    • 6. 发明授权
    • Benzene compound and salt thereof
    • 苯化合物及其盐
    • US07244861B2
    • 2007-07-17
    • US10471254
    • 2002-03-27
    • Fumiyoshi MatsuuraEita EmoriMasanobu ShinodaRichard ClarkShunji KasaiHideki YoshitomiKazuto YamazakiTakashi InoueSadakazu MiyashitaTaro Hihara
    • Fumiyoshi MatsuuraEita EmoriMasanobu ShinodaRichard ClarkShunji KasaiHideki YoshitomiKazuto YamazakiTakashi InoueSadakazu MiyashitaTaro Hihara
    • C07C229/00C07C227/00
    • C07D307/79A61K31/00C07C233/87C07C235/12C07C235/52C07C255/60C07C2601/08C07C2601/14C07D261/18C07D277/56C07D417/12
    • The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, X represents 1) a C6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, Ry1, Ry2 and Ry3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a C3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; Rz1, Rz2, Rz3 and Rz4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group, a halogenated C1-6 alkyl group, a halogenated C1-6 alkoxy group etc.); and R1, R2, R3 and R4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group etc.
    • 本发明提供一种药物,其包含可用作胰岛素敏化剂的苯化合物,其盐或它们的水合物及其衍生物作为活性成分。 具体地说,它提供由下式表示的苯化合物,其盐或它们的水合物。 在该式中,X表示1)可具有一个或多个取代基的C 6-14芳基,或2)可具有一个或多个取代基的5至10元杂芳基; Y表示由下式表示的基团:(在上式中,R y1,R y2,R y2,R y3和Y 3都相同或不同) 各自表示氢原子,卤素原子,C 1-6烷基,C 1-6烷氧基或C 1 -C 6烷氧基, 3-7环烷基)等; Z表示由下式表示的基团:(式中,m表示0〜2的整数,R 0,Z 1,R z,Z 2,R z, SUP>和R z4彼此相同或不同,并且各自表示氢原子,卤素原子,C 1-6烷基,C 1〜 C 1-6烷基,C 3-7环烷基,卤代C 1-6烷基,卤代C 1 -6个烷氧基等); 且R 1,R 2,R 3和R 4彼此相同或不同,并且 各自表示氢原子,卤素原子,C 1-6烷基,C 1-6烷氧基,C 3-7烷基, SUB>环烷基等