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1. 发明授权

US08657775B2 Method of treating a subject suffering from end stage renal disease against cardiovascular disease 有权
标题翻译：治疗终末期肾病患者抗心血管疾病的方法
公开(公告)号：US08657775B2
公开(公告)日：2014-02-25
申请号：US12585054
申请日：2009-09-01
申请人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
发明人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
IPC分类号： A61M1/14 , A61M1/18 , A61M1/34 , B01D61/24 , B01D61/28 , B01D69/08 , B01D63/02
CPC分类号： B01D61/243 , A61M1/16 , B01D67/0013 , B01D69/08 , B01D69/12 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.
摘要翻译：本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化血液。单核细胞是涉及心血管疾病进展的主要循环血细胞。慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展，导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

2. 发明授权

US07644825B2 Membrane and use thereof 失效
标题翻译：膜及其用途
公开(公告)号：US07644825B2
公开(公告)日：2010-01-12
申请号：US10532131
申请日：2003-10-17
申请人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
发明人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
IPC分类号： B01D71/06 , B01D71/68 , B01D71/28 , B01D71/00
CPC分类号： B01D67/002 , B01D67/0083 , B01D69/02 , B01D71/68 , B01D71/80 , B01D2325/36 , B29C44/3403
摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.
摘要翻译：该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载，高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。

3. 发明授权

US06841255B2 Biocompatible polymer film 有权
标题翻译：生物相容性聚合物膜
公开(公告)号：US06841255B2
公开(公告)日：2005-01-11
申请号：US10245115
申请日：2002-09-17
申请人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
发明人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
IPC分类号： A61L33/00 , A61L27/34 , A61L29/08 , A61L31/10 , A61L33/06 , B32B27/06 , C08G81/00 , C08J5/18 , B32B25/20
CPC分类号： C08J5/18 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/068 , C08G81/00 , Y10T428/31504 , Y10T428/31598 , C08L83/10
摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.
摘要翻译：本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物能够与-OH基团反应。举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

4. 发明授权

US06500549B1 Biocompatible polymer film 有权
标题翻译：生物相容性聚合物膜
公开(公告)号：US06500549B1
公开(公告)日：2002-12-31
申请号：US09415943
申请日：1999-10-08
申请人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
发明人： Reinhold Deppisch , Ulrich Bauer , Werner Beck , Ruth Dietrich , Hermann Göhl , Katja Krämer
IPC分类号： B32B2520
CPC分类号： C08J5/18 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/068 , C08G81/00 , Y10T428/31504 , Y10T428/31598 , C08L83/10
摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.
摘要翻译：本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物能够与-OH基团反应。举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

5. 发明授权

US08496122B2 Permselective membrane and process for manufacturing thereof 有权
标题翻译：选择性渗透膜及其制造方法
公开(公告)号：US08496122B2
公开(公告)日：2013-07-30
申请号：US10540123
申请日：2003-12-17
申请人： Hermann Göhl , Reinhold Buck
发明人： Hermann Göhl , Reinhold Buck
IPC分类号： B01D63/02 , B01D69/00 , B01D39/14 , B01D39/16 , D02G3/00
CPC分类号： B29D99/005 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M2205/3368 , B01D67/0009 , B01D67/0011 , B01D67/0013 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/08 , B01D2323/12 , B01D2323/36 , B01D2323/38 , B01D2325/022 , D01D5/24 , Y10T428/2975 , Y10T442/3106 , Y10T442/3325 , Y10T442/612 , Y10T442/647
摘要： The present invention relates to a membrane being suitable for, for example, hemodialysis. Said membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer. According to the present invention the outer surface of the hollow fiber has pores in the range of 0.5-3 μm and the numbers of said pores in the outer surface are in the range of 10,000 to 150,000 pores per mm2, preferably in the range of 18,000 to 100,000 pores per mm2, and most preferably in the range of 20,000 to 100,000 pores per mm2. The present invention further relates to a process for the preparation of said membrane and use of said membrane in hemodialysis, hemodiafiltration and hemofiltration, and in dialysis and filtration in general, for example in water purification or dehydration.
摘要翻译：本发明涉及一种适用于例如血液透析的膜。所述膜包含至少一种疏水性聚合物和至少一种亲水性聚合物。根据本发明，中空纤维的外表面具有在0.5-3μm范围内的孔，并且外表面中所述孔的数量在每平方毫米10,000至150,000个孔的范围内，优选在18,000范围内至10万个孔/ mm 2，最优选在20,000至100,000个孔/ mm 2的范围内。本发明还涉及一种制备所述膜的方法和所述膜在血液透析，血液透析滤过和血液滤过中的用途，以及在透析和过滤中，通常例如在水净化或脱水中。

6. 发明授权

US07968153B2 Continuous method for production of a regioselective porous hollow fibre membrane 有权
标题翻译：连续法生产区域选择性多孔中空纤维膜
公开(公告)号：US07968153B2
公开(公告)日：2011-06-28
申请号：US11631786
申请日：2005-07-04
申请人： Bernd Krause , Hermann Göhl , Christoph Beck , Jürgen Dannenmaier , Michael Müller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
发明人： Bernd Krause , Hermann Göhl , Christoph Beck , Jürgen Dannenmaier , Michael Müller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
IPC分类号： B01D39/00 , B01D67/00 , H05H1/00
CPC分类号： B01D61/00 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/38 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3085 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3274 , B01J2220/445
摘要： A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.
摘要翻译：公开了一种用于生产在血液或所述流体净化期间除去的血液或其它生物活性流体中的化合物的区域选择性亲和性的多孔中空纤维膜的连续方法，以及通过所述方法制备的多孔中空纤维膜，含有这种多孔中空纤维膜的吸附装置，以及这种多孔中空纤维膜的使用。

7. 发明申请

US20100084339A1 High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients 有权
标题翻译：高截止血液透析膜用于治疗慢性血液透析患者
公开(公告)号：US20100084339A1
公开(公告)日：2010-04-08
申请号：US12585054
申请日：2009-09-01
申请人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
发明人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
IPC分类号： B01D61/32
CPC分类号： B01D61/243 , A61M1/16 , B01D67/0013 , B01D69/08 , B01D69/12 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.
摘要翻译：本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化血液。单核细胞是涉及心血管疾病进展的主要循环血细胞。慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展，导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

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