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1. 发明授权

US06476185B1 Preparation of an organic compound by a condensation reaction 失效
标题翻译：通过缩合反应制备有机化合物
公开(公告)号：US06476185B1
公开(公告)日：2002-11-05
申请号：US09713167
申请日：2000-11-15
申请人： Wridzer Jan Willem Bakker , Wilhelmus Louisa Petrus Maria Rutten , Johannes Theodorus Faustinus Keurentjes , Matthias Wessling
发明人： Wridzer Jan Willem Bakker , Wilhelmus Louisa Petrus Maria Rutten , Johannes Theodorus Faustinus Keurentjes , Matthias Wessling
IPC分类号： C08F600
CPC分类号： B01J19/2475 , B01J4/04 , B01J19/2465 , B01J2219/00103 , B01J2219/00105 , B01J2219/0011
摘要： The invention pertains to a process for the preparation of an organic compound by a condensation reaction in which besides the organic compound other products are formed and one or more of the products formed during the preparation are extracted from the reaction mixture with the aid of a membrane. The reaction is carried out at a temperature above 80° C. and one or more of the products formed during the reaction are extracted from the reaction mixture by the aid of an inorganic membrane with an average pore size of the separating layer of less than 0.5 nm.
摘要翻译：本发明涉及通过缩合反应制备有机化合物的方法，其中除了有机化合物形成其它产物之外，还有一种或多种在制备过程中形成的产物借助于膜从反应混合物中提取出来。反应在高于80℃的温度下进行，并且在反应期间形成的一种或多种产物借助于分离层的平均孔径小于0.5的无机膜从反应混合物中提取 nm。

2. 发明授权

US5711882A Gas separation membrane module and process 失效
标题翻译：气体分离膜组件及工艺
公开(公告)号：US5711882A
公开(公告)日：1998-01-27
申请号：US536633
申请日：1995-09-29
申请人： Thomas Hofmann , Matthias Wessling , Richard W. Baker
发明人： Thomas Hofmann , Matthias Wessling , Richard W. Baker
IPC分类号： B01D53/22 , B01D63/10 , B01D15/00
CPC分类号： B01D63/103 , B01D53/22 , B01D63/10 , B01D2313/086 , B01D2313/14 , B01D2313/143 , Y02C10/10
摘要： A spiral-wound, gas-separation membrane module and a gas-separation process. The module and process provide at least partial counter-current flow between the feed and permeate gas streams without requiring a permeate sweep. The counter-current flow pattern can be achieved by appropriate placement of barriers or baffles in the feed channel. Similar modules and processes may also be used for pervaporation.
摘要翻译：螺旋缠绕，气体分离膜组件和气体分离过程。模块和工艺在进料和渗透气体流之间提供至少部分逆流，而不需要渗透物扫描。逆流流动模式可以通过在进料通道中适当地放置障碍物或挡板来实现。类似的模块和工艺也可用于渗透蒸发。

3. 发明申请

US20110009282A1 HIGH THROUGHPUT SCREENING METHOD AND APPARATUS FOR ANALYSING INTERACTIONS BETWEEN SURFACES WITH DIFFERENT TOPOGRAPHY AND THE ENVIRONMENT 审中-公开
标题翻译：用于分析不同地形和环境的表面之间的相互作用的高通量筛选方法和装置
公开(公告)号：US20110009282A1
公开(公告)日：2011-01-13
申请号：US12741019
申请日：2008-10-31
申请人： Jan de Boer , Clemens Antoni Van Blitterswijk , Hemant Vijaykumar Unadkat , Dimitrios Stamatialis , Berendien Jacoba Papenburg , Matthias Wessling
发明人： Jan de Boer , Clemens Antoni Van Blitterswijk , Hemant Vijaykumar Unadkat , Dimitrios Stamatialis , Berendien Jacoba Papenburg , Matthias Wessling
IPC分类号： C40B30/04 , C40B40/02 , C40B40/06 , C40B40/10
CPC分类号： G01N33/54306 , G01N33/54366
摘要： The invention is directed to a high throughput screening method for analyzing and interaction between a surface of a material and an environment. The screening method of the invention comprises: providing a micro-array comprising said material and having a multitude of units at least part of which have different topography; contacting at least part of said multitude of units with said environment; and screening said micro-array for an interaction between one or more of said units and said environment.
摘要翻译：本发明涉及用于分析材料表面和环境之间的相互作用的高通量筛选方法。本发明的筛选方法包括：提供包括所述材料并具有多个单元的微阵列，其中至少一部分具有不同的形貌; 将所述多个单元的至少一部分与所述环境接触; 以及筛选所述微阵列以用于所述单元和所述环境中的一个或多个之间的相互作用。

4. 发明授权

US07644825B2 Membrane and use thereof 失效
标题翻译：膜及其用途
公开(公告)号：US07644825B2
公开(公告)日：2010-01-12
申请号：US10532131
申请日：2003-10-17
申请人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
发明人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
IPC分类号： B01D71/06 , B01D71/68 , B01D71/28 , B01D71/00
CPC分类号： B01D67/002 , B01D67/0083 , B01D69/02 , B01D71/68 , B01D71/80 , B01D2325/36 , B29C44/3403
摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.
摘要翻译：该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载，高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。

5. 发明授权

US07531120B2 Method of making a product with a micro or nano sized structure and product 有权
标题翻译：制造具有微米或纳米尺寸结构和产品的产品的方法
公开(公告)号：US07531120B2
公开(公告)日：2009-05-12
申请号：US10433275
申请日：2001-12-03
申请人： Cornelis Johannes Maria Van Rijn , Laura Vogelaar , Wietze Nijdam , Jonathan Nathaniel Barsema , Matthias Wessling
发明人： Cornelis Johannes Maria Van Rijn , Laura Vogelaar , Wietze Nijdam , Jonathan Nathaniel Barsema , Matthias Wessling
IPC分类号： B29C39/00
CPC分类号： B01D67/0088 , A61F2/06 , A61F2002/044 , A61F2002/046 , A61L27/50 , A61L27/56 , B01D67/0009 , B01D67/0018 , B01D67/002 , B01D67/0069 , B01D67/0072 , B01D67/0093 , B01D69/00 , B01D69/02 , B01D69/08 , B01D69/12 , B01D71/02 , B01D71/64 , B01D71/68 , B01D2323/06 , B01D2323/08 , B01D2323/30 , B01D2325/022 , B01D2325/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/0086 , B01J2219/00864 , B01J2219/00907 , B01L3/0241 , B01L3/5085 , B01L2200/12 , B01L2300/0819 , B29C33/0033 , B29C41/08 , B29C41/38 , B29C67/02 , B29K2105/0073 , B29L2031/737 , B81B2201/10 , B81C99/008 , B81C2201/0115 , B81C2201/034 , G01N27/44704 , H01L31/18 , Y10T428/24
摘要： Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.
摘要翻译：使用相分离技术穿孔以及非穿孔聚合物结构可以制成高纵横比（> 5）。通过改变相分离方法，可以调节模制产品的性质（例如多孔，无孔，致密，开放的皮肤）。应用在微流体学（例如微阵列，电泳板），光学，聚合太阳能电池，球栅阵列和组织工程领域中描述。

6. 发明申请

US20080053891A1 Functional Porous Multilayer Fibre and its Preparation 审中-公开
标题翻译：功能多孔多层纤维及其制备
公开(公告)号：US20080053891A1
公开(公告)日：2008-03-06
申请号：US11573837
申请日：2005-08-17
申请人： Geert-Hendrik Koops , Matthias Wessling , Willem Dederik Van Wijk
发明人： Geert-Hendrik Koops , Matthias Wessling , Willem Dederik Van Wijk
IPC分类号： B01D24/10
CPC分类号： D01D5/247 , B01J20/28023 , B01J20/3293 , D01D5/06 , D01D5/24 , D01D5/34 , Y10T428/2967
摘要： The invention relates to a hollow or solid fibre having multiple porous layers concentrically arranged, and wherein at least one of the layers comprises functionalized or active particles that are well accessible and maintain their function after preparation. The layer containing high loads of particles can be either the outer or the inner layer. The main function of the other porous layer is to provide mechanical stability to the fibre. It can further act as a sieve and prevent unwanted compounds or species to come in contact with the functionalized particulate matter. Where it is the inner layer, the second layer can advantageously be a biocompatible material. With the second being the outer layer it is now possible to reach a particle content of 100 wt % in the inner layer. These fibres comprising high densities of functionalized particulate matter and of still sufficient mechanical strength can be used for (selective) adsorption, conversion, isolation or purification of compounds from a mixture of compounds, in particular from a fermentation broth, tissue broth, plant broth, cell broth or blood.
摘要翻译：本发明涉及具有同心排列的多个多孔层的中空或固体纤维，并且其中至少一个层包含官能化或活性的颗粒，其在制备后可以很好地接近并保持其功能。含有高负载粒子的层可以是外层或内层。另一个多孔层的主要功能是为纤维提供机械稳定性。它可以进一步作为筛子，并防止不需要的化合物或物质与官能化颗粒物接触。在内层的地方，第二层可以有利地是生物相容的材料。第二个是外层，现在可以在内层中达到100重量％的颗粒含量。包含高密度官能化颗粒物质和仍然具有足够机械强度的这些纤维可用于化合物的混合物（特别是发酵液，组织肉汤，植物肉汤）的（选择性）吸附，转化，分离或纯化，细胞肉汤或血液。

7. 发明申请

US20060138044A1 Membrane and use thereof 失效
标题翻译：膜及其用途
公开(公告)号：US20060138044A1
公开(公告)日：2006-06-29
申请号：US10532131
申请日：2003-10-17
申请人： Bernd Krause , Matthias Wessling , Hermann Gohl , Markus Storr
发明人： Bernd Krause , Matthias Wessling , Hermann Gohl , Markus Storr
IPC分类号： B01D71/68
CPC分类号： B01D67/002 , B01D67/0083 , B01D69/02 , B01D71/68 , B01D71/80 , B01D2325/36 , B29C44/3403
摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.
摘要翻译：该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载，高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。

8. 发明授权

US09067180B2 Hollow fibre membrane 有权
标题翻译：中空纤维膜
公开(公告)号：US09067180B2
公开(公告)日：2015-06-30
申请号：US13582949
申请日：2011-03-04
申请人： Matthias Wessling , Dimitrios Stamatialis , Karina Katarzyna Kopec , Szymon Maria Dutczak
发明人： Matthias Wessling , Dimitrios Stamatialis , Karina Katarzyna Kopec , Szymon Maria Dutczak
IPC分类号： B01D69/12 , B01D53/22 , B01D69/08 , B01D71/60 , D01D5/24
CPC分类号： B01D69/125 , B01D69/088 , B01D69/12 , B01D71/60 , D01D5/24
摘要： The present invention relates to a process for manufacturing a hollow fibre membrane having a supporting layer and a separating layer, said process comprising: (a) extruding a spinning composition comprising a first polymer and a solvent for the first polymer through an inner annular orifice of a hollow-fibre die; (b) co-extruding a composition comprising an organic nucleophilic reagent and a mixtures of a solvent and a non-solvent for the first polymer, wherein the composition is either extruded through a central annular orifice of the hollow-fibre die or through an outer annular orifice of a hollow-fibre die; and (c) passing the hollow-fibre through a coagulation bath. The hollow fibre membrane according to the present invention can be used in gas separation processes, vapour separation processes and liquid filtration processes.
摘要翻译：本发明涉及一种制造具有支撑层和分离层的中空纤维膜的方法，所述方法包括：（a）通过内部环形孔挤出第一聚合物的第一聚合物和溶剂的纺丝组合物，中空纤维模; （b）共挤出包含有机亲核试剂的组合物和用于第一聚合物的溶剂和非溶剂的混合物，其中所述组合物通过中空纤维模头的中心环形孔口挤出或通过外部中空纤维模具的环形孔; 和（c）使中空纤维通过凝固浴。根据本发明的中空纤维膜可用于气体分离过程，蒸气分离过程和液体过滤过程。

9. 发明申请

US20130192459A1 HOLLOW FIBRE MEMBRANE 有权
标题翻译：中空纤维膜
公开(公告)号：US20130192459A1
公开(公告)日：2013-08-01
申请号：US13582949
申请日：2011-03-04
申请人： Matthias Wessling , Dimitrios Stamatialis , Karina Katarzyna Kopec , Szymon Maria Dutczak
发明人： Matthias Wessling , Dimitrios Stamatialis , Karina Katarzyna Kopec , Szymon Maria Dutczak
IPC分类号： B01D69/12
CPC分类号： B01D69/125 , B01D69/088 , B01D69/12 , B01D71/60 , D01D5/24
摘要： The present invention relates to a process for manufacturing a hollow fibre membrane having a supporting layer and a separating layer, said process comprising: (a) extruding a spinning composition comprising a first polymer and a solvent for the first polymer through an inner annular orifice of a hollow-fibre die; (b) co-extruding a composition comprising an organic nucleophilic reagent and a mixtures of a solvent and a non-solvent for the first polymer, wherein the composition is either extruded through a central annular orifice of the hollow-fibre die or through an outer annular orifice of a hollow-fibre die; and (c) passing the hollow-fibre through a coagulation bath. The hollow fibre membrane according to the present invention can be used in gas separation processes, vapour separation processes and liquid filtration processes.
摘要翻译：本发明涉及一种制造具有支撑层和分离层的中空纤维膜的方法，所述方法包括：（a）通过内部环形孔挤出第一聚合物的第一聚合物和溶剂的纺丝组合物，中空纤维模; （b）共挤出包含有机亲核试剂的组合物和用于第一聚合物的溶剂和非溶剂的混合物，其中所述组合物通过中空纤维模头的中心环形孔口挤出或通过外部中空纤维模具的环形孔; 和（c）使中空纤维通过凝固浴。根据本发明的中空纤维膜可用于气体分离过程，蒸气分离过程和液体过滤过程。

10. 发明申请

US20100065490A1 ION-PERMEABLE MEMBRANE AND THE PRODUCTION THEREOF 审中-公开
标题翻译：离子透膜及其生产
公开(公告)号：US20100065490A1
公开(公告)日：2010-03-18
申请号：US12595269
申请日：2008-04-10
申请人： Jörg Henning Balster , Dimitrios Stamatialis , Matthias Wessling
发明人： Jörg Henning Balster , Dimitrios Stamatialis , Matthias Wessling
IPC分类号： B01D61/28 , B32B3/30 , C25B9/00 , B01J19/00 , B01D67/00 , B29C71/00 , B01D71/68 , B29C59/02 , B29C41/08
CPC分类号： B01D61/46 , B01D67/0013 , B01D69/02 , B01D69/10 , B01D71/52 , B01D71/68 , B01D2325/08 , C02F1/469 , C02F1/4693 , C02F2103/08 , H01M8/1023 , H01M8/1027 , H01M8/1032 , H01M8/1039 , H01M8/1058 , H01M8/1065 , H01M8/1067 , H01M8/1081 , H01M8/109 , H01M8/1093 , H01M8/227 , H01M2300/0082 , Y02A20/134 , Y02P70/56 , Y10T428/24479 , Y10T428/24612
摘要： A method for producing an ion-permeable membrane which has at least one profiled surface includes contacting a shaping element with an uncured polymer film which contains at least one polymer, impressing the shaping element onto the polymer film and generating a regular pattern of identically or differently structured elevations and/or recesses on the polymer film.
摘要翻译：一种具有至少一个异型表面的离子渗透膜的制造方法，包括使成形元件与含有至少一种聚合物的未固化的聚合物膜接触，将该成型元件压印在聚合物膜上并产生相同或不同的规则图案在聚合物膜上的结构化海拔和/或凹陷。

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