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1. 发明专利

IL282487D0 Tyk2 inhibitors and uses thereof 未知
公开(公告)号：IL282487D0
公开(公告)日：2021-06-30
申请号：IL28248721
申请日：2021-04-20
申请人： ESKER THERAPEUTICS INC , JIN BOHAN , DONG QING , HUNG GENE , KALDOR STEPHEN W
发明人： JIN BOHAN , DONG QING , HUNG GENE , KALDOR STEPHEN W
摘要： Described herein are pyridine compounds of Formula (XIII) that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation

2. 发明专利

IL286248D0 Tyk2 inhibitors and uses thereof 未知
公开(公告)号：IL286248D0
公开(公告)日：2021-10-31
申请号：IL28624821
申请日：2021-09-09
申请人： ESKER THERAPEUTICS INC , JIN BOHAN , DONG QING , HUNG GENE
发明人： JIN BOHAN , DONG QING , HUNG GENE
IPC分类号： A61P25/00 , A61P29/00 , A61P37/00
摘要： Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

3. 发明申请

WO2007089584A2 COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN 审中-公开
标题翻译：组合物及其与HUNTINGTIN有关的用途
公开(公告)号：WO2007089584A2
公开(公告)日：2007-08-09
申请号：PCT/US2007002171
申请日：2007-01-26
申请人： ISIS PHARMACEUTICALS INC , CHDI INC , HUNG GENE , LEEDS JANET
发明人： HUNG GENE , LEEDS JANET
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译：本文公开了用于调节细胞，组织或动物中亨廷丁蛋白表达的化合物，组合物和方法。进一步提供的是使用靶向亨廷顿汀的反义化合物减缓或预防亨廷顿病进展的方法。另外提供的方法是延缓或预防亨廷顿病易感患者亨廷顿病发病的方法。还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

4. 发明申请

WO2005051984A3 METHODS FOR PRODUCING OLFACTORY GPCRS 审中-公开
公开(公告)号：WO2005051984A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/038339
申请日：2004-11-15
申请人： ARENA PHARMACEUTICALS, INC. , HUNG, Gene , ORTUNO, Daniel , UNETT, David , GATLIN, Joel
发明人： HUNG, Gene , ORTUNO, Daniel , UNETT, David , GATLIN, Joel
IPC分类号： C12N15/12
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

5. 发明申请

WO2003073996A3 HUMAN SCHWANNOMA CELL LINE 审中-公开
公开(公告)号：WO2003073996A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006314
申请日：2003-03-03
申请人： HOUSE EAR INSTITUTE , HUNG, Gene , LI, Xiankui
发明人： HUNG, Gene , LI, Xiankui
IPC分类号： A01N65/00
摘要： In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7 genes. The cell line has a unique splice site mutation of the NF2 gene. The immortalized cell line is non-tumorigenic but has altered growth properties such as higher proliferation rate and independence of Schwann cell growth factors. Methods of using this unique cell line for pharmacologic screening are disclosed.

6. 发明申请

WO2007089584A3 COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN 审中-公开
公开(公告)号：WO2007089584A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/002171
申请日：2007-01-26
申请人： ISIS PHARMACEUTICALS, INC. , CHDI, INC. , HUNG, Gene , LEEDS, Janet
发明人： HUNG, Gene , LEEDS, Janet
IPC分类号： A61K48/00 , C12N15/11
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

7. 发明申请

WO2011032045A1 MODULATION OF HUNTINGTIN EXPRESSION 审中-公开
标题翻译： HUNTINGTIN表达的调制
公开(公告)号：WO2011032045A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048532
申请日：2010-09-10
申请人： ISIS PHARMACEUTICALS, INC. , GENZYME CORPORATION , HUNG, Gene , BENNETT, C., Frank , FREIER, Susan, M. , KORDASIEWICZ, Holly , STANEK, Lisa , CLEVELAND, Don, W.
发明人： HUNG, Gene , BENNETT, C., Frank , FREIER, Susan, M. , KORDASIEWICZ, Holly , STANEK, Lisa , CLEVELAND, Don, W.
IPC分类号： C07H21/04 , C12N15/11
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof.
摘要翻译：本文提供了用于降低动物中亨廷丁蛋白mRNA和蛋白质表达的方法，化合物和组合物。这些方法，化合物和组合物可用于治疗，预防，延迟或改善亨廷顿病或其症状。

8. 发明申请

WO2010019270A1 MODULATION OF PRION EXPRESSION 审中-公开
标题翻译：调制表达式
公开(公告)号：WO2010019270A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/004680
申请日：2009-08-14
申请人： ISIS PHARMACEUTICALS, INC. , BENNETT, C., Frank , HUNG, Gene
发明人： BENNETT, C., Frank , HUNG, Gene
IPC分类号： A01N43/00 , A61K31/70
CPC分类号： A61K31/7125
摘要： Disclosed herein are compounds and methods for decreasing PrP and preventing, ameliorating, or treating a prion disease or conformational neurodegenerative disorder, in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to PrP include Creutzfeldt- Jakob disease (CJD); variant Creutzfeldt- Jakob Disease (vCJD); Gerstmann-Straussler-Scheinker syndrome; fatal familial insomnia; kuru; Bovine Spongiform Encephalopathy (BSE), e.g. "mad cow disease"; Chronic Wasting Disease (CWD); scrapie; transmissible mink encephalopathy; feline spongiform encephalopathy; ungulate spongiform encephalopathy; Alzheimer's disease; Parkinson's disease; Huntington's disease; and Amyotrophic Lateral Sclerosis (ALS).
摘要翻译：本文公开了在有需要的个体中减少PrP并预防，改善或治疗朊病毒疾病或构象神经变性疾病的化合物和方法。通过施用针对PrP的反义化合物可以改善的疾病状况的实例包括Creutzfeldt-Jakob病（CJD）; 变种克雅氏病（vCJD）; Gerstmann-Straussler-Scheinker综合征; 致命性家族性失眠; 库鲁病; 牛海绵状脑病（BSE），例如。 “疯牛病”; 慢性疾病（CWD）; 羊瘙痒病; 传染性貂脑病猫海绵状脑病有蹄型海绵状脑病阿尔茨海默氏病; 帕金森病亨廷顿氏病和肌萎缩性侧索硬化（ALS）。

9. 发明申请

WO2005051984A2 METHODS FOR PRODUCING OLFACTORY GPCRS 审中-公开
标题翻译：生产OLFACTORY GPCRS的方法
公开(公告)号：WO2005051984A2
公开(公告)日：2005-06-09
申请号：PCT/US2004038339
申请日：2004-11-15
申请人： ARENA PHARM INC , HUNG GENE , ORTUNO DANIEL , UNETT DAVID , GATLIN JOEL
发明人： HUNG GENE , ORTUNO DANIEL , UNETT DAVID , GATLIN JOEL
IPC分类号： C07K14/705 , C07K14/72 , C07K14/00
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。一般而言，所述方法涉及将包含与编码嗅觉PCR的核酸可操作连接的启动子的表达盒导入大神经胶质细胞例如雪旺氏或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅觉GPCR活性调节剂的方法以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最广泛地用于香料和香料的研究，因此具有多种研究和工业应用。

10. 发明申请

WO2003073996A2 HUMAN SCHWANNOMA CELL LINE 审中-公开
标题翻译：人造丝细胞线
公开(公告)号：WO2003073996A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006314
申请日：2003-03-03
申请人： HOUSE EAR INSTITUTE , HUNG, Gene , LI, Xiankui
发明人： HUNG, Gene , LI, Xiankui
IPC分类号： A61K
CPC分类号： G01N33/5011 , C07K14/005 , C12N5/0693 , C12N7/00 , C12N2500/25 , C12N2500/38 , C12N2500/84 , C12N2501/01 , C12N2501/195 , C12N2501/392 , C12N2503/02 , C12N2510/04 , C12N2710/20022 , G01N33/5008 , G01N33/5017 , G01N33/502 , G01N33/5044
摘要： In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7 genes. The cell line has a unique splice site mutation of the NF2 gene. The immortalized cell line is non-tumorigenic but has altered growth properties such as higher proliferation rate and independence of Schwann cell growth factors. Methods of using this unique cell line for pharmacologic screening are disclosed.
摘要翻译：在优选的实施方案中，本发明涉及在具有神经纤维瘤病2型（NF2）的患者中衍生自施万氏肿瘤并用HPV E6-E7基因永生化的神经瘤细胞系。细胞系具有NF2基因的独特剪接位点突变。永生化细胞系是非致瘤性的，但具有改变的生长特性，例如更高的增殖率和施旺细胞生长因子的独立性。公开了将该独特细胞系用于药理学筛选的方法。

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