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1. 发明申请

WO2005051984A2 METHODS FOR PRODUCING OLFACTORY GPCRS 审中-公开
标题翻译：生产OLFACTORY GPCRS的方法
公开(公告)号：WO2005051984A2
公开(公告)日：2005-06-09
申请号：PCT/US2004038339
申请日：2004-11-15
申请人： ARENA PHARM INC , HUNG GENE , ORTUNO DANIEL , UNETT DAVID , GATLIN JOEL
发明人： HUNG GENE , ORTUNO DANIEL , UNETT DAVID , GATLIN JOEL
IPC分类号： C07K14/705 , C07K14/72 , C07K14/00
CPC分类号： C07K14/723
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.
摘要翻译：本发明提供了一种在细胞中产生嗅觉GPCR的方法。一般而言，所述方法涉及将包含与编码嗅觉PCR的核酸可操作连接的启动子的表达盒导入大神经胶质细胞例如雪旺氏或少突胶质细胞，并将细胞维持在适于产生嗅觉GPCR的条件下。还提供了含有编码嗅觉GPCR的重组核酸的大胶质细胞，筛选嗅觉GPCR活性调节剂的方法以及用于在大胶质细胞中产生嗅觉GPCR的试剂盒。本发明最广泛地用于香料和香料的研究，因此具有多种研究和工业应用。

2. 发明申请

WO2007089584A2 COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN 审中-公开
标题翻译：组合物及其与HUNTINGTIN有关的用途
公开(公告)号：WO2007089584A2
公开(公告)日：2007-08-09
申请号：PCT/US2007002171
申请日：2007-01-26
申请人： ISIS PHARMACEUTICALS INC , CHDI INC , HUNG GENE , LEEDS JANET
发明人： HUNG GENE , LEEDS JANET
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译：本文公开了用于调节细胞，组织或动物中亨廷丁蛋白表达的化合物，组合物和方法。进一步提供的是使用靶向亨廷顿汀的反义化合物减缓或预防亨廷顿病进展的方法。另外提供的方法是延缓或预防亨廷顿病易感患者亨廷顿病发病的方法。还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

3. 发明专利

IL282487D0 Tyk2 inhibitors and uses thereof 未知
公开(公告)号：IL282487D0
公开(公告)日：2021-06-30
申请号：IL28248721
申请日：2021-04-20
申请人： ESKER THERAPEUTICS INC , JIN BOHAN , DONG QING , HUNG GENE , KALDOR STEPHEN W
发明人： JIN BOHAN , DONG QING , HUNG GENE , KALDOR STEPHEN W
摘要： Described herein are pyridine compounds of Formula (XIII) that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation

4. 发明专利

CA2545553A1 METHODS FOR PRODUCING OLFACTORY GPCRS 未知
公开(公告)号：CA2545553A1
公开(公告)日：2005-06-09
申请号：CA2545553
申请日：2004-11-15
申请人： ARENA PHARM INC
发明人： ORTUNO DANIEL , HUNG GENE , GATLIN JOEL , UNETT DAVID
IPC分类号： C12N15/12 , C07K14/705 , C07K14/72 , C12N5/10 , G01N33/50
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

5. 发明专利

AU2004292536A1 Methods for producing olfactory GPCRS 未知
公开(公告)号：AU2004292536A1
公开(公告)日：2005-06-09
申请号：AU2004292536
申请日：2004-11-15
申请人： ARENA PHARM INC
发明人： UNETT DAVID , ORTUNO DANIEL , HUNG GENE , GATLIN JOEL
IPC分类号： C07K14/72 , C07K14/705
摘要： The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications.

6. 发明专利

IL286248D0 Tyk2 inhibitors and uses thereof 未知
公开(公告)号：IL286248D0
公开(公告)日：2021-10-31
申请号：IL28624821
申请日：2021-09-09
申请人： ESKER THERAPEUTICS INC , JIN BOHAN , DONG QING , HUNG GENE
发明人： JIN BOHAN , DONG QING , HUNG GENE
IPC分类号： A61P25/00 , A61P29/00 , A61P37/00
摘要： Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

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