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1. 发明申请

WO0178754A3 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells compositionsand treatments thereof 审中-公开
标题翻译：使用肌肉来源的祖细胞组合物及其处理软组织和骨增大和膨胀
公开(公告)号：WO0178754A3
公开(公告)日：2002-04-25
申请号：PCT/US0112084
申请日：2001-04-12
申请人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER C , QU ZHUQING , UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER C , QU ZHUQING
IPC分类号： A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P43/00 , C12N5/077 , A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the use of MDCs for the increase of skeletal muscle.

2. 发明申请

WO2004096245A3 MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATION 审中-公开
标题翻译：肌肉衍生细胞（MDCS）用于促进和增强神经修复和再生
公开(公告)号：WO2004096245A3
公开(公告)日：2005-02-10
申请号：PCT/US2004013115
申请日：2004-04-26
申请人： UNIV PITTSBURGH , CHANCELLOR MICHAEL B , HUARD JOHNNY , MINNERY BRANDON
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , MINNERY BRANDON
IPC分类号： A61P25/00 , C12N5/077 , A61K35/34
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34
摘要： The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs, particularly associated with nerve damage or neuropathy. The invention relates to MDCs for use in methods for promoting or enhancing innervation of nerve cells, particularly in the peripheral nervous system, and their ability to contribute to the development of neuronal tissue when MDCs are introduced at or near a tissue or organ site in need of repair due to injury, damage, disease, or dysfunction. Such methods are useful for the treatment of central and peripheral nervous system disorders and to alleviate, abate, or eliminate the symptoms of neurologic or neurodegenerative diseases in animals, particularly mammals, including humans. The methods are also useful for treating both nerve and muscle tissue following injury, damage, or dysfunction to these tissue types.
摘要翻译：本发明描述了使用优选从骨骼肌获得的肌肉衍生细胞（MDC）来支持损伤的组织和器官的神经支配和修复，特别是与神经损伤或神经病有关的方法。本发明涉及用于促进或增强神经细胞神经细胞，特别是周围神经系统神经支配的方法中使用的MDC，以及当将MDCs引入到需要的组织或器官部位处或附近时有助于神经元组织发育的能力由于受伤，损伤，疾病或功能障碍引起的修复。这样的方法可用于治疗中枢和周围神经系统疾病并减轻，减轻或消除动物，特别是包括人在内的哺乳动物的神经退行性疾病或神经变性疾病的症状。这些方法对于在损伤，损伤或这些组织类型的功能障碍之后治疗神经和肌肉组织也是有用的。

3. 发明申请

WO2010022083A3 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用生物化学基质中的肌肉衍生的原料组合物的骨质保护及其治疗
公开(公告)号：WO2010022083A3
公开(公告)日：2010-06-24
申请号：PCT/US2009054200
申请日：2009-08-18
申请人： UNIV PITTSBURGH , PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
发明人： PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加非软组织进入非软组织部位（例如，骨）与生物相容性基质（优选SIS）组合时。本发明还提供使用包含肌源性祖细胞的组合物与生物相容性基质的方法，用于在治疗各种功能状况（包括骨质疏松症，佩吉特氏病，成骨不全，骨折）的哺乳动物，包括人类骨组织的增大和膨胀中，骨软化，骨小梁强度降低，骨皮质强度下降，老年骨密度降低。

4. 发明申请

WO2010022083A9 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 审中-公开
标题翻译：利用生物相容性基质中的肌肉衍生的前列腺组合物进行骨增强及其治疗
公开(公告)号：WO2010022083A9
公开(公告)日：2010-04-22
申请号：PCT/US2009054200
申请日：2009-08-18
申请人： UNIV PITTSBURGH , PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
发明人： PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植入身体组织后显示出长期存活并且可以在引入（例如经由注射，移植或植入）之后增强非软组织（例如通过注射，移植或植入）到非软组织部位骨）当与生物相容性基质（优选SIS）组合时。本发明进一步提供了使用包含肌肉衍生的祖细胞和生物相容性基质的组合物在包括骨质疏松症，佩吉特氏病，成骨不全，骨折在内的各种功能性病症的治疗中用于增强和增大哺乳动物包括人骨组织的方法，骨软化，骨小梁强度降低，骨皮质强度降低以及随年龄增长骨密度降低。

5. 发明公开

EP1372398A4 RAPID PREPARATION OF STEM CELL MATRICES FOR USE IN TISSUE AND ORGAN TREATEMENT AND REPAIR 有权
标题翻译：干细胞爱玛快速生产trices器官和组织修复和治疗
公开(公告)号：EP1372398A4
公开(公告)日：2009-06-24
申请号：EP02706457
申请日：2002-02-22
申请人： UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER , CHUNG STEVE , SACKS MICHAEL S
IPC分类号： C12N11/02 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/077 , A01N63/00 , A01N1/00
CPC分类号： A61L27/3834 , A61K35/12 , A61L27/225 , A61L27/3629 , A61L27/3679 , A61L2430/22 , C12N5/0068 , C12N5/0658 , C12N5/0668 , C12N5/0697 , C12N2533/56 , C12N2533/74 , C12N2533/90 , C12N2533/92
摘要： The present invention describes a rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications. The stem cells can be from numerous sources and may be homogeneous, heterogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions as described provide point of service utility for the practitioner, wherein the stem cells and matrix can be combined not long before use, thereby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.
摘要翻译：本发明描述了用于制备干细胞和生理上可接受的基质组合物在组织和器官修复使用的快速方法。与以前的组织工程材料相比，本发明的干细胞 - 基质组合物不要求长期培养或种植在体内应用在使用前体外。干细胞可以是自许多来源，并且可以是均匀的，不均匀的，自体的，和/或在基体材料的同种异体。所述干细胞基质组合物所描述的，提供服务的效用点医师，worin的干细胞和基质可以组合不长使用前，从而减轻昂贵且冗长的制造过程。此外，干细胞提供了独特的结构特性在使用之后的结果和愈合的矩阵组成。从肌肉收缩获得的干细胞的使用，得到的基质组合物。

6. 发明公开

EP2328596A4 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 有权
标题翻译： PRE的骨骼结构BASIS组合物在生物相容性基质和治疗肌
公开(公告)号：EP2328596A4
公开(公告)日：2013-04-10
申请号：EP09808733
申请日：2009-08-18
申请人： UNIV PITTSBURGH
发明人： PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10 , C12N5/071
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

7. 发明申请

WO9956785A3 CELL MEDIATED GENE DELIVERY USING MUSCLE DERIVED CELLS FOR TREATING MUSCLE-AND BONE-RELATED INJURY OR DYSFUNCTION 审中-公开
标题翻译：使用肌肉衍生细胞进行细胞介导的基因交付，用于治疗肌肉和骨骼相关的伤害或功能障碍
公开(公告)号：WO9956785A3
公开(公告)日：2001-04-19
申请号：PCT/US9909451
申请日：1999-04-30
申请人： UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY
IPC分类号： A61K35/34 , A61K38/18 , A61K38/44 , A61K48/00 , A61P13/02 , A61P19/08 , A61P21/00 , C12N5/077 , C12N5/06 , C12N5/08 , C12N5/10
CPC分类号： A61K35/34 , A61K48/00 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/113 , C12N2501/115 , C12N2501/13 , C12N2510/00 , C12N2510/04
摘要： The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional segments of such genes, for delivery of the encoded gene products at or near sites of musculoskeletal, bone, ligament, meniscus, cartilage or genitourinary disease, injury, defect, or dysfunction. Ex vivo myoblast mediated gene delivery of human inducible nitric oxide synthase, and the resulting production of nitric oxide at and around the site of injury, are particularly provided by the invention as a treatment for lower genitourinary tract dysfunctions. Ex vivo gene transfer for the musculoskeletal system includes genes encoding acidic fibroblast growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor, platelet derived growth factor, transforming growth factor- beta , transforming growth factor- alpha , nerve growth factor and interleukin-1 receptor antagonist protein (IRAP), bone morphogenetic protein (BMPs), cartilage derived morphogenetic protein (CDMPs), vascular endothelial growth factor (VEGF), and sonic hedgehog proteins.
摘要翻译：本发明提供肌肉衍生的细胞，优选成肌细胞和来自肌肉的干细胞，其被遗传工程化以含有和表达这种基因的一个或多个异源基因或功能区段，用于在肌肉骨骼的位点或附近递送编码的基因产物，骨，韧带，半月板，软骨或泌尿生殖系疾病，损伤，缺陷或功能障碍。本发明特别提供离体成肌细胞介导的人诱导型一氧化氮合酶的基因递送以及所产生的损伤部位周围及其周围的一氧化氮，作为降低泌尿生殖道功能障碍的治疗。肌肉骨骼系统的离体基因转移包括编码酸性成纤维细胞生长因子，碱性成纤维细胞生长因子，表皮生长因子，胰岛素样生长因子，血小板衍生生长因子，转化生长因子-β，转化生长因子-α，神经生长的基因因子和白细胞介素-1受体拮抗蛋白（IRAP），骨形态发生蛋白（BMPs），软骨来源的形态发生蛋白（CDMPs），血管内皮生长因子（VEGF）和声音刺猬蛋白。

8. 发明申请

WO02067867A2 RAPID PREPARATION OF STEM CELL MATRICES FOR USE IN TISSUE AND ORGAN TREATMENT AND REPAIR 审中-公开
标题翻译：用于组织和组织治疗和修复的干细胞基质的快速制备
公开(公告)号：WO02067867A2
公开(公告)日：2002-09-06
申请号：PCT/US0206125
申请日：2002-02-22
申请人： UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER , CHUNG STEVE , SACKS MICHAEL S
IPC分类号： C12N11/02 , A61L27/00 , A61L27/38 , C12N5/00 , C12N5/077 , A61K
CPC分类号： A61L27/3834 , A61K35/12 , A61L27/225 , A61L27/3629 , A61L27/3679 , A61L2430/22 , C12N5/0068 , C12N5/0658 , C12N5/0668 , C12N5/0697 , C12N2533/56 , C12N2533/74 , C12N2533/90 , C12N2533/92
摘要： The present invention describes a rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the prestn invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications. The stem cells can be from numerous sources and may behomogeneous, heterrogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions as described provide point of service utility for the practitioner, wherin the stem cells and matrix can be combined not long before use, therby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.
摘要翻译：本发明描述了用于制备用于组织和器官修复的干细胞和生理上可接受的基质组合物的快速方法。与以前的组织工程材料相比，本发明的干细胞 - 基质组合物在用于体内应用之前不需要在体外长期孵育或培养。干细胞可以来自多种来源，并且在基质材料中可以是均匀的，异源的，自体的和/或同种异体的。如上所述的干细胞 - 基质组合物为实践者提供了服务实用性，干细胞和基质的使用可以在使用前不久组合，从而减轻昂贵且冗长的制造程序。此外，干细胞为基质组合物提供独特的结构特性，可改善使用后的结果和愈合。使用从肌肉获得的干细胞可提供收缩性的基质组成。

9. 发明专利

ES2678416T3 Células derivadas de músculo para el tratamiento de patologías de las vías urinarias y métodos de fabricación y uso de las mismas 未知
公开(公告)号：ES2678416T3
公开(公告)日：2018-08-10
申请号：ES08705573
申请日：2008-01-11
申请人： UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION
发明人： CHANCELLOR MICHAEL , JANKOWSKI RONALD , PRUCHNIC RYAN , HUARD JOHNNY
IPC分类号： C12N5/077 , A61K35/12 , A61K35/34 , A61P13/10
摘要： Un proceso de preparación de un agente de relleno de tejido blando de las vías urinarias, que comprende células progenitoras derivadas de músculo (CDM), comprendiendo el proceso: (a) suspender las células de músculo esquelético aisladas de un ser humano, en un primer recipiente de cultivo celular durante entre 30 y 120 minutos; (b) decantar los medios del primer recipiente de cultivo celular a un segundo recipiente de cultivo celular; (c) cultivar las células en el segundo recipiente de cultivo celular durante 1-3 días para permitir que las células restantes que permanecen en los medios se unan a las paredes del segundo recipiente de cultivo celular; (d) aislar las células de las paredes del segundo recipiente de cultivo celular, en el que las células aisladas son CDM.

10. 发明专利

AU2008205278A1 Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same 未知
公开(公告)号：AU2008205278A1
公开(公告)日：2008-07-17
申请号：AU2008205278
申请日：2008-01-11
申请人： UNIV PITTSBURGH
发明人： PRUCHNIC RYAN , JANKOWSKI RONALD , HUARD JOHNNY , CHANCELLOR MICHAEL B
IPC分类号： A61K35/12 , A61K35/34 , A61P13/10 , C12N5/077
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.

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