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1. 发明申请

WO1994014784A1 NEW THIAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：新的噻唑烷酮衍生物及其制备方法
公开(公告)号：WO1994014784A1
公开(公告)日：1994-07-07
申请号：PCT/HU1993000080
申请日：1993-12-22
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , SZABADKAI, István , HARSANYI, Kálmán , CSALA, Edina , SZANTAY, Csaba , BIHARI, Mária , HEGEDÜS, Béla , EZER, Elemér , MATUZ, Judit , SAGHY, Katalin , SZPORNY, László , HAJOS, György
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D277/14
CPC分类号： C07D277/14
摘要： The invention relates to new 3-benzyl-2-thiazolidinone derivatives of general formula (I), wherein X represents halogen atom, C1-4-alkyl, nitro or trifluoromethyl group, Y represents halogen atom, C1-4-alkyl, C1-4-alkoxy or trifluoromethyl group, Z represents hydrogen or halogen atom, and to pharmaceutical compositions containing the same, furthermore to processes for the preparation of these derivatives or pharmaceutical compositions containing them. Compounds of general formula (I) are potent inhibitors of gastric acid secretion furthermore exert antiinflammatory activity which is comparable to that of the known indomethacin, thus can be active ingredients of pharmaceutical compositions with significant therapeutic effect serving for the treatment of mammals including humans.
摘要翻译：本发明涉及通式（I）的新的3-苄基-2-噻唑烷酮衍生物，其中X代表卤素原子，C1-4烷基，硝基或三氟甲基，Y代表卤素原子，C1-4烷基，C1- 4-烷氧基或三氟甲基，Z表示氢或卤素原子，以及含有它们的药物组合物，此外用于制备这些衍生物或含有它们的药物组合物的方法。通式（I）的化合物是胃酸分泌的有效抑制剂，进一步具有与已知的吲哚美辛相当的抗炎活性，因此可以是具有显着治疗作用的药物组合物的活性成分，用于治疗包括人的哺乳动物。

2. 发明申请

WO1983001502A1 METHOD AND DEVICE FOR LOW ENERGY CONSUMPTION DRYING, PARTICULARLY OF GRANULAR, AGRICULTURAL PRODUCTS OR THE LIKE CONTAINING MOISTURE FIXED OR DEPOSITED AT THE SURFACE, WITH A CONSTANT YIELD 审中-公开
标题翻译：低能消耗干燥的方法和装置，特别是颗粒，农业产品或类似含水量固定或沉积在表面上，具有恒定的含量
公开(公告)号：WO1983001502A1
公开(公告)日：1983-04-28
申请号：PCT/HU1982000053
申请日：1982-10-18
申请人： "e;OKTOBER 6"e; MEZÖGAZDASAGI TERMELÖSZÖVETKEZET , ASZLANYI, József , BARTA, György , BALINT, Sándor , HEGEDÜS, Béla , HUDAK, János
发明人： "e;OKTOBER 6"e; MEZÖGAZDASAGI TERMELÖSZÖVETKEZET
IPC分类号： F26B03/14
CPC分类号： F26B25/22 , F26B17/122 , Y02P70/40
摘要： The product to be dried is brought in contact with a heat-conveyor drying fluid when it circulates the drying chamber. The damp drying fluid is released to the atmosphere directly or after partial heat recovery; the released dried product with a desired dampness content is fowarded towards a further treatment or towards its consumption place. The hot and relatively dry drying fluid which comes out of a section of the drying chamber is recirculated towards the inlet of the drying chamber. The dampness content of the humid product entering the drying chamber and of the dried product coming out of said chamber are measured and the analog differential signal thus obtained is used for the feed speed control of the product to be dried and optionally for the heating control of the drying fluid. The device comprises a drying chamber provided with an inlet for the damp product and with a discharge opening, a pressure fan connected by an inlet conduit and optionally a section fan for the drying fluid connected through a discharge conduit. A device for heating the drying fluid is arranged before or after the pressure fan. The drying chamber is divided in one section for preheating and intensive drying, one section for carrying away the fixed dampness and one cooling section. The carrying section is connected with the preheating and intensive drying section through a transfer conduit and the signals provided by the dampness sensors located at the inlet of the damp product and close to the discharge opening are transmitted to the control unit for controlling the value of the discharge rate or through-put of the dried product.
摘要翻译：当干燥室循环时，待干燥的产品与热输送干燥流体接触。潮湿的干燥液体直接或部分热回收后释放到大气中; 释放的具有所需湿度含量的干燥产品被进一步处理或朝向其消费地方。从干燥室的一部分出来的热和相对干燥的干燥流体被再循环到干燥室的入口。测量进入干燥室的湿产品和从所述室出来的干燥产品的湿度含量，并将由此获得的模拟差分信号用于待干燥产品的进料速度控制，并且可选地用于加热控制干燥液。该装置包括一个干燥室，该干燥室设置有用于潮湿产品的入口和一个排出口，一个通过入口导管连接的压力风扇和可选的用于通过排放管道连接的干燥流体的分段风扇。用于加热干燥流体的装置布置在压力风扇之前或之后。干燥室分为一段，用于预热和强化干燥，一段用于带走固定湿度和一个冷却段。运送部分通过传送管道与预热和密集干燥部分连接，位于潮湿产品入口处并靠近排放口的湿度传感器提供的信号传送到控制单元，用于控制排出速率或干燥产品的放入。

3. 发明申请

WO1993011107A1 NOVEL N-HYDROXYALKYL-SUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE AND PIPERIDINE DERIVATIVES 审中-公开
标题翻译：新型N-羟基烷基取代的1,2,3,6-四氢吡啶和哌啶衍生物
公开(公告)号：WO1993011107A1
公开(公告)日：1993-06-10
申请号：PCT/HU1992000050
申请日：1992-12-01
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , HARSANYI, Kálmán , GIZUR, Tibor , AGAI-CSONGOR, Éva , KALLAY-SOHONYAI, Anna , KAPOLNAS-PAP, Márta , CSIZÉR, Éva , HEGEDÜS, Béla , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SZOMBATHELYI, Zsolt , SARKADI, Adám , GERE, Anikó , BODO, Mihály , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , BOD, Péter , CSEHI, Attila
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/06
CPC分类号： C07D211/52 , C07D211/14 , C07D211/70
摘要： The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of formula (I) wherein A stands for hydrogen or halogen; alkoxy; cyano; phenyl; phenyl monosubstituted by halogen; benzyl; benzyl monosubstituted by halogen; 2-phenylethyl monosubstituted by halogen on the phenyl moiety; or 2-picolyl group; B represents hydrogen; alkoxy or nitro group; D represents hydrogen or halogen; or alkoxy group; or B and D together stand for a -CH=CH-CH=CH- group; R represents hydrogen; alkyl or phenyl group; G is hydrogen; I stands for hydrogen or hydroxy group; or G and I together represent a single chemical bond; E stands for hydrogen or halogen; alkoxy or trifluoromethyl group; and m is 0, 1 or 2, with the proviso that: m is 0 or 2, or both G and I mean hydrogen, when A stands for benzyl or halogen-monosubstituted benzyl group; and m is 1, when A stands for 2-picolyl group, as well as their acid addition salts. The invention further relates to pharmaceutical compositions containing these compounds as active ingredients as well as to a process for the preparation of compounds of formula (I) and their intermediates. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic insults.
摘要翻译：本发明涉及式（I）的新型N-羟基取代的1,2,3,6-四氢吡啶和哌啶衍生物，其中A代表氢或卤素; 烷氧基; 氰基; 苯基; 被卤素单取代的苯基; 苄基; 被卤素单取代的苄基; 在苯基部分被卤素单取代的2-苯基乙基; 或2-吡啶甲基; B表示氢; 烷氧基或硝基; D表示氢或卤素; 或烷氧基; 或B和D一起代表-CH = CH-CH = CH-基团; R代表氢; 烷基或苯基; G是氢; 我代表氢或羟基; 或G和I一起代表单一化学键; E代表氢或卤素; 烷氧基或三氟甲基; m为0,1或2，条件是：m为0或2，或者G和I均为氢，A表示苄基或卤素 - 单取代苄基; 并且当A代表2-吡啶甲基时，m为1，以及它们的酸加成盐。本发明还涉及含有这些化合物作为活性成分的药物组合物以及制备式（I）化合物及其中间体的方法。式（I）化合物可用于增强哺乳动物（包括人）对缺氧和/或缺血状态的耐受性，以及用于治疗由缺氧和/或缺血损伤引起的退行性和功能障碍。

4. 发明申请

WO1991008203A1 NOVEL THIAZOLIDINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型噻唑烷酮衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1991008203A1
公开(公告)日：1991-06-13
申请号：PCT/HU1990000077
申请日：1990-11-23
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT , SZABADKAI, István , HARSANYI, Kálmán , SZABO, Zsoltné , HEGEDÜS, Béla , EZER, Elemér , MATUZ, Judit , SZPORNY, László , SAGHY, Katalin , HAJOS, György , CSEHI, Attila , BALOGH, Gábor
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT
IPC分类号： C07D277/14
CPC分类号： C07D277/14
摘要： The present invention relates to novel compounds of general formula (I), wherein R means hydrogen or C1-4alkyl group; and Y stands for cyano, trifluoromethyl, aryloxy or aryl(C1-4alkyl)oxy group. The compounds according to the invention show a gastric acid secretion-inhibiting effect and therefore, they are useful for the treatment of gastric and duodenal ulcers. In addition, they exert a cytoprotective action against gastric laesions induced, e.g. by indomethacin or acid-containing alcohol.
摘要翻译：本发明涉及通式（I）的新化合物，其中R表示氢或C 1-4烷基; Y代表氰基，三氟甲基，芳氧基或芳基（C 1-4烷基）氧基。根据本发明的化合物显示出胃酸分泌抑制作用，因此它们可用于治疗胃和十二指肠溃疡。此外，它们对诱导的胃液进行细胞保护作用，例如，通过吲哚美辛或含酸的酒精。

5. 发明申请

WO2008062244A1 POLYMORPHS OF 5-{2-[4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL]-ETHYL}-6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROBROMIDE AND PROCESSES FOR PREPARATION THEREOF 审中-公开
标题翻译： 5- {2- [4-（1,2-苄基联苯-3-基）-1-哌嗪基] - 乙基} -6-氯-1,3-二氢-2H-吲哚-2-酮氢溴酸盐和方法的多异构体为了准备
公开(公告)号：WO2008062244A1
公开(公告)日：2008-05-29
申请号：PCT/HU2007/000112
申请日：2007-11-23
申请人： RICHTER GEDEON NYRT. , NEU, József , DEMETER, Ádám , VARGA, Zoltán , HAVASI, Balázs , GARADNAY, Sándor , HEGEDÜS, Béla
发明人： NEU, József , DEMETER, Ádám , VARGA, Zoltán , HAVASI, Balázs , GARADNAY, Sándor , HEGEDÜS, Béla
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention provides pharmaceutically applicable compounds and polymorphs belonging to the ziprasidone hydrobromide compound group with antipsychotic effect. The present invention provides hydrobromide polymorphs of 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one, ziprasidone of Formula (I) having neuroleptic activity.
摘要翻译：本发明提供具有抗精神病作用的属于齐拉西酮氢溴酸盐化合物组的药学上可应用的化合物和多晶型物。本发明提供了5- {2- [4-（1,2-苯并异噻唑-3-基）-1-哌嗪基] - 乙基} -6-氯-1,3-二氢-2H-吲哚-2的氢溴酸盐多晶型物 - 一种具有神经安定药活性的式（I）的齐拉西酮。

6. 发明申请

WO1989005799A1 NOVEL TETRAHYDROPYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型四氢吡啶衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1989005799A1
公开(公告)日：1989-06-29
申请号：PCT/HU1988000078
申请日：1988-12-13
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , SOLYOM, Sándor , HARSANYI, Kálmán , EZER, Elemér , MATUZ, Judit , SZPORNY, László , SAGHY, Katalin , HAJOS, György , SZÉKELY, Krisztina , HEGEDÜS, Béla
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/70
CPC分类号： C07D211/70
摘要： The invention relates to novel tetrahydropyridine derivatives of formula (I) and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In formula (I), R1 means hydrogen or a C1-6 alkyl group; R2 and R3 stand, independently from each other, for hydrogen or a C1-6 alkyl group; or alternatively R2 and R3 together represent a chemical bond; R4 means halogen, a trifluoromethyl or a C1-6 alkyl group; R1 and R3 are in Z (cis) or E (trans) position in their mutual relation when R2 and R3 do not form together a chemical bond or the meaning of R1 is different from that of R2, with the proviso that R1 and R2 are different from hydrogen when R4 means a 4-methyl group. The compounds of formula (I) show a strong cytoprotective action on the gastric mucosa by inhibiting the gastric acid secretion and are useful antiulcer agents.
摘要翻译：本发明涉及式（I）的新型四氢吡啶衍生物及其药学上可接受的酸加成盐，含有它们的药物组合物及其制备方法。在式（I）中，R 1表示氢或C 1-6烷基; R2和R3彼此独立地表示氢或C1-6烷基; 或者R2和R3一起表示化学键; R4表示卤素，三氟甲基或C1-6烷基; 当R 2和R 3不一起形成化学键时，R 1和R 3在它们的相互关系中为Z（顺式）或E（反）位，或者R1的含义不同于R 2，条件是R 1和R 2为当R4表示4-甲基时，与氢不同。式（I）化合物通过抑制胃酸分泌显示对胃粘膜的强的细胞保护作用，并且是有用的抗溃疡剂。

7. 发明申请

WO2003082816A1 NEW ATORVASTATIN SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新的ATORVASTATIN SALTS和含有它们的药物组合物
公开(公告)号：WO2003082816A1
公开(公告)日：2003-10-09
申请号：PCT/HU2003/000024
申请日：2003-03-27
申请人： RICHTER GEDEON VEGYÉSZETI GYÁR RT. , FISCHER, János , VUKICS, Krisztina , ERDÉLYI, Péter , HEGEDÜS, Béla , TIHANYI, Károly , VASTAG, Mónika , LÉVAI, Sándor , BÁLINT, Sándorné , LÁNCZOS, Krisztina
发明人： FISCHER, János , VUKICS, Krisztina , ERDÉLYI, Péter , HEGEDÜS, Béla , TIHANYI, Károly , VASTAG, Mónika , LÉVAI, Sándor , BÁLINT, Sándorné , LÁNCZOS, Krisztina
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： The invention relates to salts of atorvastatin formed with a basic amino acid of the general formula (I), where the meaning of R is a group originated from lysine, arginine or ornithine, and the amorphous or polymorph modifications thereof. The invention also relates to the synthesis of the compounds of the general formula (I).
摘要翻译：本发明涉及与通式（I）的碱性氨基酸形成的阿托伐他汀的盐，其中R的含义是衍生于赖氨酸，精氨酸或鸟氨酸的基团，以及其无定形或多晶型修饰。本发明还涉及通式（I）的化合物的合成。

8. 发明申请

WO1993025528A1 NOVEL AMINOPROPANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型氨基酚类衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1993025528A1
公开(公告)日：1993-12-23
申请号：PCT/HU1993000033
申请日：1993-06-07
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , DOMANY, György , BARTANÉ, Szalai, Gizella , SCHON, István , HEGEDÜS, Béla , TRISCHLER, Ferenc , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SARKADI, Adám , GERE, Anikó , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , THUROCZYNÉ, Kálmán, Eszter , CSEHI, Attila
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/58
CPC分类号： C07D211/58
摘要： The invention relates to novel optically active and racemic aminopropanol derivatives of formula (I) wherein R means hydrogen or a C1-4alkyl group; Ar stands for a phenyl group optionally substituted by at most two halogens, C1-4alkyl, C1-4alkoxy or nitro group(s); or a naphthyl group; Y represents halogen, C1-4alkyl, C1-4alkoxy, phenyl, 2,3-(CH=CH)2- or 3,4-(CH=CH)2- group; and n is an integer of 0, 1, 2, 3, 4, or 5 as well as acid addition salt of these compounds. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the compounds of formula (I). The compounds of formula (I) are useful for inhibiting the peroxidation of lipids and treating the sequels thereof as well as for protection from or treatment of the sequels of calcium-mediated injuries induced e.g. by ischemia, hypoxia or reperfusion and for treating various degenerative neurological diseases e.g. Alzheimer's disease or Parkinson's disease.
摘要翻译：本发明涉及式（I）的新型光学活性和外消旋氨基丙醇衍生物，其中R表示氢或C 1-4烷基; Ar代表任选被至多两个卤素取代的苯基，C 1-4烷基，C 1-4烷氧基或硝基; 或萘基; Y表示卤素，C 1-4烷基，C 1-4烷氧基，苯基，2,3-（CH = CH）2 - 或3,4-（CH = CH）2 - 基; 且n为0,1,2,3,4或5的整数，以及这些化合物的酸加成盐。本发明还涉及含有这些化合物的药物组合物以及制备式（I）化合物的方法。式（I）的化合物可用于抑制脂质的过氧化和治疗其后续，以及用于保护或治疗钙介导的损伤的后遗症，例如，通过缺血，缺氧或再灌注和用于治疗各种退行性神经疾病，例如，阿尔茨海默病或帕金森病。

9. 发明申请

WO1989005805A1 NOVEL 2,3-THIOMORPHOLINEDIONE-2-OXIME DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型2,3-噻唑啉-2-氧化物衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1989005805A1
公开(公告)日：1989-06-29
申请号：PCT/HU1988000080
申请日：1988-12-13
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , SZABADKAI, István , HARSANYI, Kálmán , LAMPERT, Agnes , DOMANY, György , HEGEDÜS, Béla , EZER, Elemér , MATUZ, Judit , SAGHY, Katalin , SZPORNY, László , HAJOS, György , SZÉKELY, Krisztina
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D279/12
CPC分类号： C07D279/12
摘要： The present invention relates to novel compounds of general formula (I), wherein R1 stands for hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or nitro group; R2 means a C1-7 alkyl group optionally substituted by: a hydroxyl or oxo group; or an ester group containing 1 to 4 carbon atoms in the alkoxy moiety; or a C1-4 alkoxy, cyano, amino, C1-4 alkylamino, or diakylamino group; or an acyl group containing 1 to 7 carbon atoms in the alkyl moiety; or R2 means an aryl-C1-7 alkyl group optionally bearing the substituents defined above for R2 in the alkyl chain and optionally substituted by halogen, nitro, C1-4 alkyl or alkoxy group in the benzene ring; or R2 represents an allyl, phenylallyl or phenylsulfonyl group, both latter groups optionally being substituted by halogen or a C1-4 alkyl group in the benzene ring; or R2 stands for a carbamoyl group substituted by one or two C1-4 alkyl group(s) or phenyl group on the nitrogen atom. The compounds according to the invention show a cytoprotective and acid secretion-inhibiting action and are effective against gastric and duodenal ulcers.
摘要翻译：本发明涉及通式（I）的新化合物，其中R1代表氢，卤素，C1-4烷基，C1-4烷氧基或硝基; R 2表示任选被羟基或氧代基取代的C 1-7烷基; 或在烷氧基部分含有1至4个碳原子的酯基; 或C 1-4烷氧基，氰基，氨基，C 1-4烷基氨基或二烷基氨基; 或在烷基部分含有1至7个碳原子的酰基; 或R 2表示任选具有上述对烷基链中R2的取代基并且任选地被苯环中的卤素，硝基，C 1-4烷基或烷氧基取代的芳基-C 1-7烷基; 或R 2表示烯丙基，苯基烯丙基或苯基磺酰基，后两个基团任选被苯环中的卤素或C 1-4烷基取代; 或R 2表示被一个或两个C 1-4烷基或氮原子上的苯基取代的氨基甲酰基。根据本发明的化合物显示出细胞保护和酸分泌抑制作用，并且对胃和十二指肠溃疡有效。

10. 发明申请

WO1989005804A1 2-THIAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译： 2-噻唑烷酮衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1989005804A1
公开(公告)日：1989-06-29
申请号：PCT/HU1988000079
申请日：1988-12-13
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT , BOD, Péter , HARSANYI, Kálmán , TRISCHLER, Ferenc , FEKECS, Éva , HEGEDÜS, Béla , EZER, Elemér , MATUZ, Judit , SAGHY, Katalin , SZPORNY, László , HAJOS, György , SZÉKELY, Krisztina
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT
IPC分类号： C07D277/34
CPC分类号： C07D277/34
摘要： The present invention relates to novel 2-thiazolone derivatives of general formula (I), wherein X stands for -CN, -CONH2, -CO2H or -CO2R group, wherein R is a C1-5 alkyl group; and n is 0, 1 or 2, with the proviso, that when X stands for CO2H, CO2R, n is other than 0. The compounds according to the invention possess advantageous cytoprotective and gastric acid secretion-inhibiting effects and thus, they may be used in the therapy of gastric ulcer.
摘要翻译：本发明涉及通式（I）的新型2-噻唑酮衍生物，其中X代表-CN，-CONH 2，-CO 2 H或-CO 2 R基团，其中R是C 1-5烷基; 并且n为0,1或2，条件是当X代表CO 2 H时，CO 2 R，n不为0.本发明化合物具有有利的细胞保护和胃酸分泌抑制作用，因此它们可以是用于治疗胃溃疡。

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