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1. 发明申请

WO1993011107A1 NOVEL N-HYDROXYALKYL-SUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE AND PIPERIDINE DERIVATIVES 审中-公开
标题翻译：新型N-羟基烷基取代的1,2,3,6-四氢吡啶和哌啶衍生物
公开(公告)号：WO1993011107A1
公开(公告)日：1993-06-10
申请号：PCT/HU1992000050
申请日：1992-12-01
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , HARSANYI, Kálmán , GIZUR, Tibor , AGAI-CSONGOR, Éva , KALLAY-SOHONYAI, Anna , KAPOLNAS-PAP, Márta , CSIZÉR, Éva , HEGEDÜS, Béla , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SZOMBATHELYI, Zsolt , SARKADI, Adám , GERE, Anikó , BODO, Mihály , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , BOD, Péter , CSEHI, Attila
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/06
CPC分类号： C07D211/52 , C07D211/14 , C07D211/70
摘要： The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of formula (I) wherein A stands for hydrogen or halogen; alkoxy; cyano; phenyl; phenyl monosubstituted by halogen; benzyl; benzyl monosubstituted by halogen; 2-phenylethyl monosubstituted by halogen on the phenyl moiety; or 2-picolyl group; B represents hydrogen; alkoxy or nitro group; D represents hydrogen or halogen; or alkoxy group; or B and D together stand for a -CH=CH-CH=CH- group; R represents hydrogen; alkyl or phenyl group; G is hydrogen; I stands for hydrogen or hydroxy group; or G and I together represent a single chemical bond; E stands for hydrogen or halogen; alkoxy or trifluoromethyl group; and m is 0, 1 or 2, with the proviso that: m is 0 or 2, or both G and I mean hydrogen, when A stands for benzyl or halogen-monosubstituted benzyl group; and m is 1, when A stands for 2-picolyl group, as well as their acid addition salts. The invention further relates to pharmaceutical compositions containing these compounds as active ingredients as well as to a process for the preparation of compounds of formula (I) and their intermediates. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic insults.
摘要翻译：本发明涉及式（I）的新型N-羟基取代的1,2,3,6-四氢吡啶和哌啶衍生物，其中A代表氢或卤素; 烷氧基; 氰基; 苯基; 被卤素单取代的苯基; 苄基; 被卤素单取代的苄基; 在苯基部分被卤素单取代的2-苯基乙基; 或2-吡啶甲基; B表示氢; 烷氧基或硝基; D表示氢或卤素; 或烷氧基; 或B和D一起代表-CH = CH-CH = CH-基团; R代表氢; 烷基或苯基; G是氢; 我代表氢或羟基; 或G和I一起代表单一化学键; E代表氢或卤素; 烷氧基或三氟甲基; m为0,1或2，条件是：m为0或2，或者G和I均为氢，A表示苄基或卤素 - 单取代苄基; 并且当A代表2-吡啶甲基时，m为1，以及它们的酸加成盐。本发明还涉及含有这些化合物作为活性成分的药物组合物以及制备式（I）化合物及其中间体的方法。式（I）化合物可用于增强哺乳动物（包括人）对缺氧和/或缺血状态的耐受性，以及用于治疗由缺氧和/或缺血损伤引起的退行性和功能障碍。

2. 发明申请

WO1992010495A1 NOVEL 14-(N-SUBSTITUTED AMINOMETHYL)EBURNANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型14-（N-取代氨基甲基）衍生物衍生物及其制备方法及其组合物
公开(公告)号：WO1992010495A1
公开(公告)日：1992-06-25
申请号：PCT/HU1991000051
申请日：1991-12-06
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SZOMBATHELYI, Zsolt , SARKADI, Adám , GERE, Anikó , BODO, Mihály , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAY, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , KREIDL, János , VISKY, György , CZIBULA, László , NEMES, András
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D461/00
CPC分类号： C07D461/00
摘要： The invention relates to novel, optically active cis and trans 14-(N-substituted aminomethyl)eburnane derivatives of formula (I), wherein R1 stands for hydrogen, a C1-6alkyl or C2-6alkenyl group; R2 means a C1-6alkyl, C2-6alkenyl or a hydroxy-C1-6alkyl group; or R1 and R2 represent together with the adjacent nitrogen atom to which they are attached, a 5 to 7-membered saturated ring, optionally containing one oxygen atom and/or one optionally substituted nitrogen atom as heteroatom; and n is 2 or 3, as well as pharmaceutically acceptable salts of these compounds. The compounds of the invention possess an antioxidative (lipid peroxidation-inhibiting) effect and therefore, they are useful for treating diseases connected with lipid peroxidation, such as ischaemic intestinal diseases, myocardial ischaemia, ischaemic cerebrovascular disturbances as well as some diseases of connective tissues, e.g. rheumatoid arthritis. The compounds of the invention are also suitable for treating or preventing cognitive disorders.
摘要翻译：本发明涉及式（I）的新型光学活性顺式和反式14-（N-取代氨基甲基）艾本烷衍生物，其中R1代表氢，C1-6烷基或C2-6烯基; R 2表示C 1-6烷基，C 2-6烯基或羟基-C 1-6烷基; 或R 1和R 2与它们所连接的相邻氮原子一起表示5至7元饱和环，任选地含有一个氧原子和/或一个任选取代的氮原子作为杂原子; 和n为2或3，以及这些化合物的药学上可接受的盐。本发明的化合物具有抗氧化（脂质过氧化抑制）效果，因此可用于治疗与脂质过氧化相关的疾病，例如缺血性肠病，心肌缺血，缺血性脑血管障碍以及结缔组织的一些疾病，例如类风湿关节炎。本发明的化合物也适用于治疗或预防认知障碍。

3. 发明申请

WO1996006828A1 PIPERIDINOALKYL ARYL ETHERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：哌嗪类药物及其含有药物组合物
公开(公告)号：WO1996006828A1
公开(公告)日：1996-03-07
申请号：PCT/HU1995000041
申请日：1995-08-28
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , BARTA, Gizella , DOMANY, György , SCHO"e;N, István , TRISCHLER, Ferenc , SZANTAY, Csaba, Jr. , BRLIK, János , KISS, Béla , GERE, Anikó , LAPIS, Erzsébet , LASZLOVSZKY, István , SARKADI, Adám , PELLIONISZ, Margit , PALOSI, Éva , SZABO, Sándor , HORVATH, Csilla , FARKAS, Sándor , CSOMAR, Katalin , KARPATI, Egon , SZPORNY, László
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/58
CPC分类号： C07D211/58
摘要： The invention relates to new piperidinoalkyl aryl ethers of formula (I), wherein R means hydrogen or a C1-4alkyl group; X stands for hydrogen; halogen; C1-4alkyl; C1-4alkoxy; phenyl; 2,3-(CH=CH)2-; 3,4-(CH=CH)2-; or 3,4-(CH2)3-CO-group; n is an integer from 2 to 4; v is an integer from 1 to 5; m is an integer from 1 to 3; Y means hydrogen or halogen, as well as their pharmaceutically acceptable acid addition salts. The invention relates also to a process for the preparation of compounds of formula (I), as well as to pharmaceutical compositions containing the compounds of formula (I) as active ingredients. The compounds of the invention are new and possess a significant biological activity, such as antioxidant (lipid peroxidation-inhibiting), antihypoxic and antiamnesic effects.
摘要翻译：本发明涉及式（I）的新的哌啶子基烷基芳基醚，其中R表示氢或C 1-4烷基; X代表氢; 卤素; C 1-4烷基; C1-4烷; 苯基; 2,3-（CH = CH）2 - ; 3,4-（CH = CH）2 - ; 或3,4-（CH 2）3 -CO-基; n是2至4的整数; v是1至5的整数; m为1〜3的整数; Y表示氢或卤素，以及它们的药学上可接受的酸加成盐。本发明还涉及制备式（I）化合物的方法，以及含有式（I）化合物作为活性成分的药物组合物。本发明的化合物是新的并且具有显着的生物学活性，例如抗氧化（抑制脂质过氧化作用），抗缺氧和抗病毒作用。

4. 发明申请

WO1995003291A1 NOVEL SUBSTITUTED 1-PROPENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型取代的1-丙酮衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1995003291A1
公开(公告)日：1995-02-02
申请号：PCT/HU1994000030
申请日：1994-07-26
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , GIZUR, Tibor , HARSANYI, Kálmán , CSEHI, Attila , DEMETERNÉ, Szabó, Anikó , VAJDA, Éva , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SARKADI, Adám , THUROCZYNÉ, Kálmán, Eszter , LASZY, Judit , CSOMOR, Katalin , LAPIS, Erzsébet , SZABO, Sándor , GERE, Anikó , SZENTIRMAI, Zsolt
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D295/027
CPC分类号： C07D295/03 , C07D295/073
摘要： The invention relates to novel, substituted 1-propene derivatives of formula (I), wherein X and Y are independently from each other unsubstituted or halogen substituted phenyl or benzyl group, as well as acid addition salts thereof, pharmaceutical compositions containing these compounds and a process for the preparation of the above compounds and compositions. The compounds of the invention possess antiischaemic and/or antihypoxic activity. The invention relates also to a method for treating mammals (including human) suffering from ischaemia or hypoxia, by administering one or more therapeutically effective dose(s) of the compounds of the invention.
摘要翻译：本发明涉及式（I）的新型取代的1-丙烯衍生物，其中X和Y彼此独立地为未取代的或卤素取代的苯基或苄基，以及其酸加成盐，含有这些化合物的药物组合物和制备上述化合物和组合物的方法。本发明的化合物具有抗缺血性和/或抗低氧活性。本发明还涉及通过施用一种或多种治疗有效剂量的本发明化合物来治疗患有缺血或缺氧的哺乳动物（包括人）的方法。

5. 发明申请

WO1993025528A1 NOVEL AMINOPROPANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型氨基酚类衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1993025528A1
公开(公告)日：1993-12-23
申请号：PCT/HU1993000033
申请日：1993-06-07
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , DOMANY, György , BARTANÉ, Szalai, Gizella , SCHON, István , HEGEDÜS, Béla , TRISCHLER, Ferenc , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SARKADI, Adám , GERE, Anikó , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , THUROCZYNÉ, Kálmán, Eszter , CSEHI, Attila
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/58
CPC分类号： C07D211/58
摘要： The invention relates to novel optically active and racemic aminopropanol derivatives of formula (I) wherein R means hydrogen or a C1-4alkyl group; Ar stands for a phenyl group optionally substituted by at most two halogens, C1-4alkyl, C1-4alkoxy or nitro group(s); or a naphthyl group; Y represents halogen, C1-4alkyl, C1-4alkoxy, phenyl, 2,3-(CH=CH)2- or 3,4-(CH=CH)2- group; and n is an integer of 0, 1, 2, 3, 4, or 5 as well as acid addition salt of these compounds. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the compounds of formula (I). The compounds of formula (I) are useful for inhibiting the peroxidation of lipids and treating the sequels thereof as well as for protection from or treatment of the sequels of calcium-mediated injuries induced e.g. by ischemia, hypoxia or reperfusion and for treating various degenerative neurological diseases e.g. Alzheimer's disease or Parkinson's disease.
摘要翻译：本发明涉及式（I）的新型光学活性和外消旋氨基丙醇衍生物，其中R表示氢或C 1-4烷基; Ar代表任选被至多两个卤素取代的苯基，C 1-4烷基，C 1-4烷氧基或硝基; 或萘基; Y表示卤素，C 1-4烷基，C 1-4烷氧基，苯基，2,3-（CH = CH）2 - 或3,4-（CH = CH）2 - 基; 且n为0,1,2,3,4或5的整数，以及这些化合物的酸加成盐。本发明还涉及含有这些化合物的药物组合物以及制备式（I）化合物的方法。式（I）的化合物可用于抑制脂质的过氧化和治疗其后续，以及用于保护或治疗钙介导的损伤的后遗症，例如，通过缺血，缺氧或再灌注和用于治疗各种退行性神经疾病，例如，阿尔茨海默病或帕金森病。

6. 发明申请

WO1993025570A1 NOVEL STEROIDS WITH PREGNANE SKELETON, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：带有PREGNANE SKELETON的新型甾体化合物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1993025570A1
公开(公告)日：1993-12-23
申请号：PCT/HU1993000035
申请日：1993-06-08
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , MAHO, Sándor , TUBA, Zoltán , GERE, Anikó , VITTAY, Pál , KISS, Béla , PALOSI, Éva , SZPORNY, László , FRANCSICSNÉ CZINEGE, Erzsébet , BOORNÉ, MEZEI, Anna , BALOGH, Gábor , GÖROG, Sándor
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07J43/00
CPC分类号： C07D239/42 , C07D239/48 , C07D239/50 , C07D491/10 , C07J43/003
摘要： The invention relates to novel, therapeutically active 21-aminosteroids of formula (I) with pregnane skeleton, wherein two of X, Y and Z mean a nitrogen atom each and the third one is a methine group; R and R represent, independently from each other, a primary amino group bearing as substituent a branched-chain C4-8alkyl, -alkenyl or -alkynyl group, or a C4-10cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by C1-3alkyl group(s); or R and R stand together for a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R and R means an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by C1-4alkyl group(s); and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The compounds of formula (I) possess antioxidant, particularly lipid peroxidation-inhibiting effect, and therefore they may useful for the treatment of pathologic sequels of lipid peroxidation occurring in mammals, including man.
摘要翻译：本发明涉及具有孕烷骨架的式（I）的新型治疗活性的21-氨基甾体，其中X，Y和Z中的两个分别表示氮原子，第三个是次甲基; R 1和R 2彼此独立地表示带有支链C4-8烷基， - 烯基或 - 炔基的取代基的伯氨基或包含1〜3个环的C 4-10环烷基（ s）并任选被C 1-3烷基取代; 或R 1和R 2连在一起用于含有至多10个碳原子和任选的至少一个氧原子作为附加杂原子的螺杂环仲氨基; 或者R 1和R 2中的一个是指含有4〜7个碳原子的未取代的杂环仲氨基，另一个是上述的伯氨基，上述的螺杂环仲氨基或含有4-7个碳原子并被C 1-4烷基取代的杂环仲氨基; 和n为1或2，以及它们的酸加成盐和含有这些化合物的药物组合物。此外，本发明涉及制备上述化合物的方法。式（I）化合物具有抗氧化剂，特别是脂质过氧化抑制作用，因此它们可用于治疗哺乳动物（包括人）中发生的脂质过氧化物的病理遗传。

7. 发明申请

WO1993025550A1 NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型生物活性艾滋病毒衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1993025550A1
公开(公告)日：1993-12-23
申请号：PCT/HU1993000036
申请日：1993-06-08
申请人： RICHETER GEDEON VEGYÉSZETI GYAR RT. , TUBA, Zoltán , MAHO, Sándor , GERE, Anikó , VITTAY, Pál , KISS, Béla , PALOSI, Éva , SZPORNY, László , SZANTAY, Csaba , SOTI, Ferenc , BALOGHNÉ KARDOS, Zsuzsa , INCZE, Mária , BALOGH, Gábor , GAZDAG, Mária
发明人： RICHETER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D461/00
CPC分类号： C07D461/00
摘要： The invention relates to novel eburnamenine derivatives of formula (I) wherein R and R as well as R and R , independently from each other, stand for hydrogen, C2-6alkyl group, C2-6alkenyl group; or a C3-10alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C1-6alkyl or C2-6alkenyl group; or R and R and/or R and R , together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C1-6alkyl or C2-6alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means alpha -/ alpha -, alpha -/ beta - or beta -/ alpha - steric position, as well as their acid addition salts and solvates. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for preparing the compounds of formula (I). The compounds of formula (I) possess antioxidant effect and therefore, they are useful for inhibiting the peroxidation of lipids occurring in mammals (including human).
摘要翻译：本发明涉及式（I）的新颖的本哈明宁衍生物，其中R 1和R 2以及R 3和R 4彼此独立地代表氢，C 2-6烷基，C 2 -6个烯基; 或含有1〜3个环的C 3〜10环亚烷基，后者可以被C 1-6烷基或C 2-6烯基取代; 或R 1和R 2和/或R 3和R 4连同相邻的氮原子和任选地与另外的氧或氮原子一起形成4-至6-元饱和或可被C 1-6烷基或C 2-6烯基取代的不饱和环基; X，Y和Z中的两个是氮，而第三个是次甲基; n为1或2; W表示氧或两个氢原子; 波浪线表示α - /α - ，α - /β - 或β - / - - - 立体位置，以及它们的酸加成盐和溶剂合物。本发明还涉及含有上述化合物的药物组合物以及制备式（I）化合物的方法。式（I）化合物具有抗氧化作用，因此它们可用于抑制哺乳动物（包括人）中发生的脂质的过氧化反应。

8. 发明申请

WO1993012118A1 NOVEL SUBSTITUTED OXAZINOISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME 审中-公开
标题翻译：新型取代的氧杂环丁烷衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：WO1993012118A1
公开(公告)日：1993-06-24
申请号：PCT/HU1992000053
申请日：1992-12-11
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , KOBOR, Jeno , LAZAR, László , HUBER, Imre , ARVA, Judit , SZPORNY, László , KISS, Béla , KARPATI, Egon , PALOSI, Éva , SZOMBATHELYI, Zsolt , SARKADI, Adám , GERE, Anikó , BODO, Mihály , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt , LAPIS, Erzsébet , SZABO, Sándor , BERNATH, Gábor , FÜLÖP, Ferenc
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： This invention relates to novel, therapeutically active oxazinoisoquinoline derivatives of formula (I), wherein R means hydrogen, a C1-4 alkyl, phenyl or phenyl-C1-4 alkyl group; one of R and R stands for a C1-4 alkoxy group and the other one represents a phenyl-C1-4 alkoxy group optionally substituted by a C1-4 alkyl group in the aromatic nucleus; and R stands for a phenyl group optionally substituted by a C1-4 alkyl group in the aromatic nucleus and their solvates, their individual optically active and geometric isomers and mixtures of isomers as well as acid additon salts thereof. The invention further relates to pharmaceutical compositions containing the above compounds and a process for their preparation. The compounds of formula (I) are capable of inhibiting the calcium uptake to brain cells and have a protective effect in hypobaric hypoxia. Thus, they are useful in the protection from brain injuries of hypoxic origin.
摘要翻译：本发明涉及式（I）的新型治疗活性的恶嗪基异喹啉衍生物，其中R 1表示氢，C 1-4烷基，苯基或苯基-C 1-4烷基; R 2和R 3中的一个代表C 1-4烷氧基，另一个表示任选被芳族核中的C 1-4烷基取代的苯基-C 1-4烷氧基; 并且R 4代表任选被芳族核中的C 1-4烷基取代的苯基及其溶剂合物，它们各自的光学活性和几何异构体以及异构体的混合物以及其酸加成盐。本发明还涉及含有上述化合物的药物组合物及其制备方法。式（I）的化合物能够抑制钙对脑细胞的吸收，并且在低压缺氧中具有保护作用。因此，它们可用于保护缺氧来源的脑损伤。

9. 发明申请

WO1991008200A1 NOVEL TETRAHYDROPYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AS ACTIVE AGENTS 审中-公开
标题翻译：新型四氢吡啶衍生物，其制备和含有这些化合物作为活性剂的药物组合物的方法
公开(公告)号：WO1991008200A1
公开(公告)日：1991-06-13
申请号：PCT/HU1990000076
申请日：1990-11-22
申请人： RICHTER GEDEON VEGYÉSZETI GYAR RT. , NADOR, Károly , SCHEIBER, Pál , NEMES, Péter , KARPATT, Egon , KISS, Béla , SZPORNY, László , PALOSI, Éva , GROO, Dóra , LAPIS, Erzsébet , SZOMBATHELYI, Zsolt , SARKADI, Adám , BODO, Mihály , LASZLOVSZKY, István , GERE, Aniko , CSOMOR, Katalin , LASZY, Judit , SZENTIRMAI, Zsolt
发明人： RICHTER GEDEON VEGYÉSZETI GYAR RT.
IPC分类号： C07D211/70
CPC分类号： C07D211/70
摘要： The invention relates to novel tetrahydropyridine derivatives, a process for their preparation and pharmaceutical compositions containing such compounds as active agents. In formula (I), Ar means a phenyl group optionally mono- or polysubstituted, Ar means a phenyl group optionally substituted, R means a hydrogen atom or an alkyl group with 1-6 carbon atoms, n can be either 0 or 1 with the proviso that if n = 0 then R can only mean a hydrogen atom and Ar is in any case substituted.
摘要翻译：本发明涉及新的四氢吡啶衍生物，其制备方法和含有这些化合物作为活性剂的药物组合物。在式（I）中，Ar 1表示任选被一个或多个取代的苯基，Ar 2表示任选被取代的苯基，R 1表示氢原子或1-6个碳原子的烷基， n可以是0或1，条件是如果n = 0，则R 1只能表示氢原子，Ar 2在任何情况下都被取代。

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