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2. 发明申请

WO1989006649A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO1989006649A2
公开(公告)日：1989-07-27
申请号：PCT/US1989000278
申请日：1989-01-23
申请人： WARNER-LAMBERT COMPANY , DOMAGALA, John, Michael , HAGEN, Susan, Elizabeth , KIELY, John, Steven
发明人： WARNER-LAMBERT COMPANY
IPC分类号： C07D215/56
CPC分类号： C07D263/10 , C07D215/56 , C07D401/04 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/08 , C07F7/0812
摘要： Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

3. 发明申请

WO1989001933A2 4-QUINOLINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译： 4-QUINOLIN-3-羧酸衍生物及其作为抗菌剂的用途
公开(公告)号：WO1989001933A2
公开(公告)日：1989-03-09
申请号：PCT/US1988002938
申请日：1988-08-23
申请人： WARNER-LAMBERT COMPANY , CULBERTSON, Townley, Payne , DOMAGALA, John, Michael , HAGEN, Susan, Elizabeth , SANCHEZ, Josheph, Peter
发明人： WARNER-LAMBERT COMPANY
IPC分类号： C07D215/56
CPC分类号： C07D207/08 , C07D207/09 , C07D207/12 , C07D207/20 , C07D211/34 , C07D211/52 , C07D211/70 , C07D215/56 , C07D401/04
摘要： A novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids (I), useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections. In formula (I), where Z is (II), wherein one endocyclic double bond may be present between any two consecutive ring positions or two alternating or nonalternating endocyclic double bonds may be present in the ring; wherein n, n', n''', and n"" are each independently 0, 1, or 2; n'' is 0, 1, 2, or 3; y is 0 or 1; x is 0 or 1; A and B are each independently CH, CH2, NR7 wherein R7 is hydrogen or R7 is R8CO wherein R8 is alkyl of from one to ten carbon atoms, arylalkyl, aryl wherein the aryl or alkyl may be substituted by hydroxy, halogen, COOH, or CONHR9 where R9 is hydrogen or alkyl of from one to four carbon atoms and when A is NR7, B can be O or S or when B is NR7, A can be absent; (CR13R14)n''' wherein R13 and R14 are each independently hydrogen or lower alkyl and E is hydrogen, alkyl, OR10 wherein R10 is hydrogen or alkyl, NR11R12 wherein R11 and R12 are each independently hydrogen, lower alkyl, cycloalkyl, alkylaryl, alkylheteroaryl, alkanoyl, amidine, peptide, urethane, or R11 and R14 when taken together with the nitrogen to which they are attached form a ring of from three to six carbon atoms or (a), (b), or (c).
摘要翻译：描述了一系列可用作抗菌剂的喹啉 - ，萘啶 - 和苯并恶嗪羧酸（I）。还公开了制备这些化合物的新方法以及新的中间体。还描述了它们的制剂方法和它们在治疗细菌感染中的用途。这些新的酸具有其中Z是由式（II）表示，其中桥环双键可以是连续的周期的任何两个位置，或两个双键内环交替或之间存在的式（I）不交替可目前的周期; 其中n，n'，n''和n“'独立地为0,1或2; n“是0,1,2或3; y是0或1; x是0或1; A和B各自独立地为CH，CH 2，NR 7，其中R 7为氢或R 7为R 8 CO，其中R 8为1-10个碳原子的烷基，芳基烷基，芳基，芳基等。该烷基可以被羟基，卤素，COOH或CONHR9取代，其中R9是氢或具有1至4个碳原子的烷基，并且当A是NR7时，B是O或S，或者当B是 NR7，A可能不存在; 其中R 13和R 14各自独立地为氢或低级烷基，E为氢，烷基，OR 10，其中R 10为氢或烷基，NR 11 R 12，其中R 11和R 12各自独立地为氢，低级烷基，环烷基，烷基芳基，烷基杂芳基，生物碱，脒，肽，氨基甲酸酯或R 11和R 14与它们所连接的氮一起形成环（a），（b）或（c）。

4. 发明申请

WO2006120563A3 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2006120563A3
公开(公告)日：2007-04-12
申请号：PCT/IB2006001276
申请日：2006-04-27
申请人： WARNER LAMBERT CO , BARBACHYN MICHAEL ROBERT , DOBROWOLSKI PAUL JOSEPH , HAGEN SUSAN ELIZABETH , HEIMBACH TYCHO HEINAR , HURD ALEXANDER ROSS , JOHNSON TIMOTHY ALLEN , MCNAMARA DENNIS JOSEPH , RUBLE JAMES CRAIG , SHERRY DEBRA ANN , THOMASCO LISA MARIE , TOOGOOD PETER LAURENCE
发明人： BARBACHYN MICHAEL ROBERT , DOBROWOLSKI PAUL JOSEPH , HAGEN SUSAN ELIZABETH , HEIMBACH TYCHO HEINAR , HURD ALEXANDER ROSS , JOHNSON TIMOTHY ALLEN , MCNAMARA DENNIS JOSEPH , RUBLE JAMES CRAIG , SHERRY DEBRA ANN , THOMASCO LISA MARIE , TOOGOOD PETER LAURENCE
IPC分类号： C07D498/20 , A61K31/5386 , A61P31/04
CPC分类号： C07D498/20
摘要： Described herein are antibacterial compounds of the formula (I), methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
摘要翻译：本文描述的是式（I）的抗菌化合物，制备化合物的方法，含有该化合物的药物组合物和使用该化合物和药物组合物治疗细菌感染的方法。

5. 发明申请

WO2005026161A1 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2005026161A1
公开(公告)日：2005-03-24
申请号：PCT/IB2004/002894
申请日：2004-09-06
申请人： WARNER-LAMBERT COMPANY LLC , HAGEN, Susan, Elizabeth , JOSYULA, Vara, Prasad, Venkata, Nagendra
发明人： HAGEN, Susan, Elizabeth , JOSYULA, Vara, Prasad, Venkata, Nagendra
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D401/14 , C07D471/04
摘要： Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications, including using the invention compounds to treat bacterial infections. Formula (I).
摘要翻译：公开了式（I）化合物及其制备方法。还公开了制备式（I）的生物活性化合物以及包含式（I）化合物的药学上可接受的组合物的方法。本文公开的式（I）化合物可用于多种应用，包括使用本发明化合物治疗细菌感染。式（I）。

6. 发明申请

WO2004069832A3 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004069832A3
公开(公告)日：2004-10-21
申请号：PCT/IB2004000237
申请日：2004-01-27
申请人： WARNER LAMBERT CO , CHUPAK LOUIS STANLEY , KANEKO TAKUSHI , JOSYULA VARA PRASAD VENKATA NA , KIM JI-YOUNG , CHOY ALLISON LAURA , HAGEN SUSAN ELIZABETH , BOYER FREDERICK EARL JR
发明人： CHUPAK LOUIS STANLEY , KANEKO TAKUSHI , JOSYULA VARA PRASAD VENKATA NA , KIM JI-YOUNG , CHOY ALLISON LAURA , HAGEN SUSAN ELIZABETH , BOYER FREDERICK EARL JR
IPC分类号： A61K31/55 , A61P31/04 , C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D498/04 , A61K31/42 , A61K31/44
CPC分类号： C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents. Formula (I): wherein P is Formula (II), Formula (III), Formula (IV) or Formula (V).
摘要翻译：公开了式（I）化合物及其制备方法。还公开了制备式I的生物活性化合物的方法以及包含式（I）化合物的药学上可接受的组合物。本文公开的式I化合物可用于多种应用，包括用作抗菌剂。式（I）：其中P是式（II），式（III），式（IV）或式（V）。

7. 发明申请

WO2006120563A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2006120563A2
公开(公告)日：2006-11-16
申请号：PCT/IB2006/001276
申请日：2006-04-27
申请人： WARNER-LAMBERT COMPANY LLC , BARBACHYN, Michael, Robert , DOBROWOLSKI, Paul, Joseph , HAGEN, Susan, Elizabeth , HEIMBACH, Tycho, Heinar , HURD, Alexander, Ross , JOHNSON, Timothy, Allen , MCNAMARA, Dennis, Joseph , RUBLE, James, Craig , SHERRY, Debra, Ann , THOMASCO, Lisa, Marie , TOOGOOD, Peter, Laurence
发明人： BARBACHYN, Michael, Robert , DOBROWOLSKI, Paul, Joseph , HAGEN, Susan, Elizabeth , HEIMBACH, Tycho, Heinar , HURD, Alexander, Ross , JOHNSON, Timothy, Allen , MCNAMARA, Dennis, Joseph , RUBLE, James, Craig , SHERRY, Debra, Ann , THOMASCO, Lisa, Marie , TOOGOOD, Peter, Laurence
CPC分类号： C07D498/20
摘要： Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
摘要翻译：本文描述的是抗菌化合物，制备化合物的方法，含有该化合物的药物组合物和利用该化合物和药物组合物治疗细菌感染的方法。

8. 发明申请

WO2004069832A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004069832A2
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000237
申请日：2004-01-27
申请人： WARNER-LAMBERT COMPANY LLC , CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , KIM, Ji-Young , CHOY, Allison, Laura , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
发明人： CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , KIM, Ji-Young , CHOY, Allison, Laura , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
IPC分类号： C07D413/04
CPC分类号： C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式I化合物及其制备方法。还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用，包括用作抗菌剂。

9. 发明申请

WO2004069244A1 OXAZOLIDINONE DERIVATIVES N-SUBSTITUTED BY A BICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：由双环环取代的氧杂环丁酮衍生物，用作抗菌剂
公开(公告)号：WO2004069244A1
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000209
申请日：2004-01-27
申请人： WARNER-LAMBERT COMPANY LLC , CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , PETTERSSON, Martin, Youngjin , LALL, Manjinder, Singh , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
发明人： CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , PETTERSSON, Martin, Youngjin , LALL, Manjinder, Singh , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
IPC分类号： A61K31/421
CPC分类号： C07D263/20 , C07D413/04
摘要： Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents. P is a bicyclic ring system as defined in claim 1.
摘要翻译：公开了式（I）化合物及其制备方法。还公开了制备式（I）的生物活性化合物以及包含式（I）化合物的药学上可接受的组合物的方法。本文公开的式（I）化合物可用于多种应用，包括用作抗菌剂。 P是如权利要求1所定义的双环体系。

10. 发明申请

WO0015634A2 HIV PROTEASE INHIBITORS 审中-公开
标题翻译：艾滋病病毒蛋白酶抑制剂
公开(公告)号：WO0015634A2
公开(公告)日：2000-03-23
申请号：PCT/US9918986
申请日：1999-08-18
申请人： WARNER LAMBERT CO , BOYER FREDERICK EARL JR , DOMAGALA JOHN MICHAEL , ELLSWORTH EDMUND LEE , GAJDA CHRISTOPHER ANDREW , HAGEN SUSAN ELIZABETH , LOVDAHL MICHAEL JAMES , LUNNEY ELIZABETH ANN , MARKOSKI LARRY JAMES , JOSYULA VARA PRASAD VENKATA NA , TAIT BRADLEY DEAN
发明人： BOYER FREDERICK EARL JR , DOMAGALA JOHN MICHAEL , ELLSWORTH EDMUND LEE , GAJDA CHRISTOPHER ANDREW , HAGEN SUSAN ELIZABETH , LOVDAHL MICHAEL JAMES , LUNNEY ELIZABETH ANN , MARKOSKI LARRY JAMES , JOSYULA VARA PRASAD VENKATA NA , TAIT BRADLEY DEAN
IPC分类号： C07D233/64 , A61K31/351 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61P31/14 , A61P31/18 , C07D207/333 , C07D209/12 , C07D209/30 , C07D213/30 , C07D213/71 , C07D231/12 , C07D235/06 , C07D235/26 , C07D239/26 , C07D239/42 , C07D241/44 , C07D277/20 , C07D277/24 , C07D277/46 , C07D277/82 , C07D307/12 , C07D307/42 , C07D309/32 , C07D333/16 , C07D333/32 , C07D333/62 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , A61K31/35 , C07D407/00
CPC分类号： C07D405/06 , C07D309/32 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
摘要翻译：本发明涉及具有改善的药理学性质的具有栓系杂环的新型二氢吡喃酮，其有效抑制HIV天冬氨酰蛋白酶阻断HIV感染性。二氢吡喃可用于开发用于治疗病毒感染和疾病（包括AIDS）的治疗。本发明还涉及合成二氢吡喃的方法和可用于制备最终化合物的中间体。

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