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1. 发明申请

WO2004069832A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004069832A2
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000237
申请日：2004-01-27
申请人： WARNER-LAMBERT COMPANY LLC , CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , KIM, Ji-Young , CHOY, Allison, Laura , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
发明人： CHUPAK, Louis, Stanley , KANEKO, Takushi , JOSYULA, Vara, Prasad, Venkata, Nagendra , KIM, Ji-Young , CHOY, Allison, Laura , HAGEN, Susan, Elizabeth , BOYER, Frederick, Earl, Jr.
IPC分类号： C07D413/04
CPC分类号： C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式I化合物及其制备方法。还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用，包括用作抗菌剂。

2. 发明申请

WO2005028473A1 ACYLOXYMETHYLCARBAMATE PRODRUGS OF OXAZOLIDINONES 审中-公开
标题翻译：乙氧基甲硅烷氧基甲基丙烯酸酯的制备方法
公开(公告)号：WO2005028473A1
公开(公告)日：2005-03-31
申请号：PCT/IB2004/002983
申请日：2004-09-13
申请人： PHARMACIA & UPJOHN COMPANY , JOSYULA, Vara, Prasad, Venkata, Nagendra , GADWOOD, Robert, C. , THOMASCO, Lisa, Marie , KIM, Ji-Young , CHOY, Allison, Laura , BOYER, Frederick, Earl, Jr.
发明人： JOSYULA, Vara, Prasad, Venkata, Nagendra , GADWOOD, Robert, C. , THOMASCO, Lisa, Marie , KIM, Ji-Young , CHOY, Allison, Laura , BOYER, Frederick, Earl, Jr.
IPC分类号： C07D413/10
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and Gram-negative bacteria.
摘要翻译：本发明涉及酰氧基甲基氨基甲酸恶唑烷酮。本发明的化合物对革兰氏阳性和革兰氏阴性菌具有优异的口服生物利用度的有效活性。

3. 发明申请

WO2007088438A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2007088438A2
公开(公告)日：2007-08-09
申请号：PCT/IB2007/000179
申请日：2007-01-22
申请人： PFIZER PRODUCTS INC. , CHOY, Allison, Laura , JOSYULA, Vara Prasad Venkata Nagendra
发明人： CHOY, Allison, Laura , JOSYULA, Vara Prasad Venkata Nagendra
IPC分类号： C07D413/04 , C07D413/14 , A61K31/415 , A61P31/00
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides a compound of Formula (I) Or a pharmaceutically acceptable salt thereof wherein: W is CH 2 NHC(=Z)R 1 , C(=Z)NHR 2 , or CH 2 het; X is H, C 1-6 alkyl, or C 2-6 alkenyl; Y is H, or F; Z is O, or S; R 1 is C 1-6 alkyl, NHC 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, or OC 1-4 alkyl; R 2 is H, C 1-4 alkyl, or -OC 1-4 alkyl; and het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring, wherein each carbon atom in het is optionally substituted with C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo, OR 3 , CN, NO 2 , NHR 3 R 3 , oxo, CF 3 , OCF 3 , C(=O)C 1-4 alkyl, OC(=O)C 1-4 alkyl, or C(=O)OR 3 ; wherein R 3 is H, or C 1-4 alkyl.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中：W是CH 2 NHC（= Z）R 1，C（= Z） NHR 2或CH 2 H 2; X是H，C 1-6烷基或C 2-6链烯基; Y是H或F; Z是O或S; R 1是C 1-6烷基，NHC 1-6烷基，C 3-7环烷基，C 2-6个或更多个烯基或OC 1-4烷基; R 2是H，C 1-4烷基或-OC 1-4烷基; 并且它是在环中具有1-4个选自氧，硫和氮的1-4个杂原子的五（5）或六（6）元杂环，其中每个碳原子在Ht中任选地被C C 1-4烷基，C 2-4链烯基，C 2-4 2-4炔基，卤素，OR 3， CN，NO 2，NHR 3，SO 3，氧代，CF 3，OCF 3， C（= O）C 1-4烷基，OC（= O）C 1-4烷基或C（= O）OR 3 ; 其中R 3是H或C 1-4烷基。

4. 发明申请

WO2010100475A1 HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS 审中-公开
标题翻译：羟基酸衍生物作为抗菌抗菌剂
公开(公告)号：WO2010100475A1
公开(公告)日：2010-09-10
申请号：PCT/GB2010/050351
申请日：2010-03-01
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BENENATO, Kerry, Ellen , CHOY, Allison, Laura , HALE, Michael, Robin , HILL, Pamela , MARONE, Valerie , MILLER, Matthew
发明人： BENENATO, Kerry, Ellen , CHOY, Allison, Laura , HALE, Michael, Robin , HILL, Pamela , MARONE, Valerie , MILLER, Matthew
IPC分类号： C07D209/08 , C07D213/78 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/56 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D295/155 , C07C259/10 , C07D401/12
CPC分类号： C07D213/78 , C07C259/10 , C07D209/08 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/56 , C07D239/42 , C07D239/48 , C07D295/155 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to chemical compounds of formula (IB): or a salt thereof. In some embodiments, the invention relates to inhibitors of UDP-3-0 — (R-S-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC). In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and/or treatment of Gram- negative bacterial infections.
摘要翻译：本发明涉及式（IB）化合物或其盐。在一些实施方案中，本发明涉及UDP-3-0-（R-S-羟基肉豆蔻酰）-N-乙酰葡糖胺脱乙酰酶（LpxC）的抑制剂。在另外的实施方案中，本发明涉及包含本文公开的化合物的药物组合物及其在预防和/或治疗革兰氏阴性细菌感染中的用途。

5. 发明申请

WO2010136817A1 HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：杂环尿素衍生物及其使用方法
公开(公告)号：WO2010136817A1
公开(公告)日：2010-12-02
申请号：PCT/GB2010/050908
申请日：2010-05-28
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BIFULCO, Neil , CHOY, Allison, Laura , QUIROGA, Olga , SHERER, Brian
发明人： BIFULCO, Neil , CHOY, Allison, Laura , QUIROGA, Olga , SHERER, Brian
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/04
CPC分类号： C07D471/04
摘要： Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译：描述了式（IA）化合物及其药学上可接受的盐。还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

6. 发明申请

WO2009147433A1 HETEROCYCLIC UREA DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：用于治疗细菌感染的杂环尿素衍生物
公开(公告)号：WO2009147433A1
公开(公告)日：2009-12-10
申请号：PCT/GB2009/050611
申请日：2009-06-03
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , HILL, Pamela , MANCHESTER, John, Irvin , SHERER, Brian , CHOY, Allison, Laura
发明人： HILL, Pamela , MANCHESTER, John, Irvin , SHERER, Brian , CHOY, Allison, Laura
IPC分类号： C07D417/14 , C07D498/06 , A61P31/04 , A61K31/4709 , A61K31/4738
CPC分类号： C07D417/14 , C07D498/06
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
摘要翻译：描述式（I）化合物及其药学上可接受的盐。还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

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