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1. 发明申请

WO2005026154A1 QUINOLONE ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹诺酮类抗生素
公开(公告)号：WO2005026154A1
公开(公告)日：2005-03-24
申请号：PCT/IB2004/002845
申请日：2004-08-30
申请人： WARNER-LAMBERT COMPANY LLC , ELLSWORTH, Edmund, Lee , HUTCHINGS, Kim, Marie , KUSS, Timothy, David, Otto , POWELL, Sharon, Anne , SCIOTTI, Richard, John , STARR, Jeremy, Tyson , MURPHY, Sean, Timothy , TRAN, Tuan, Phong
发明人： ELLSWORTH, Edmund, Lee , HUTCHINGS, Kim, Marie , KUSS, Timothy, David, Otto , POWELL, Sharon, Anne , SCIOTTI, Richard, John , STARR, Jeremy, Tyson , MURPHY, Sean, Timothy , TRAN, Tuan, Phong
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式（I）化合物及其制备方法。还公开了制备式（I）的生物活性化合物以及包含式（I）化合物的药学上可接受的组合物的方法。本文公开的式（I）化合物可用于多种应用，包括用作抗菌剂。

2. 发明申请

WO2005026153A1 QUINAZOLINE-2, 4-DIONES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹唑啉-2,4-二氧杂环己酮作为抗菌剂
公开(公告)号：WO2005026153A1
公开(公告)日：2005-03-24
申请号：PCT/IB2004/002839
申请日：2004-08-30
申请人： WARNER-LAMBERT COMPANY LLC , ELLSWORTH, Edmund, Lee , SCIOTTI, Richard, John , STARR, Jeremy, Tyson
发明人： SCIOTTI, Richard, John , STARR, Jeremy, Tyson
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D473/04
摘要： Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式I化合物及其制备方法。还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用，包括用作抗菌剂。

3. 发明申请

WO2005026145A2 QUINOLONE ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹诺酮类抗生素
公开(公告)号：WO2005026145A2
公开(公告)日：2005-03-24
申请号：PCT/IB2004002817
申请日：2004-08-30
申请人： WARNER LAMBERT CO , ELLSWORTH EDMUND LEE , LIMBERAKIS CHRIS , TAYLOR CLARKE BENTLEY
发明人： ELLSWORTH EDMUND LEE , LIMBERAKIS CHRIS , TAYLOR CLARKE BENTLEY
IPC分类号： A61P31/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04 , C07D498/06 , A61K31/4709 , A61K31/519 , A61K31/5383
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D471/04
摘要： Compounds of formula (I, II, III, IV, V, and VI) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.
摘要翻译：公开了式（I，II，III，IV，V和VI）的化合物及其制备方法。还公开了制备式（I）的生物活性化合物以及包含式（I）化合物的药学上可接受的组合物的方法。本文公开的式（I）化合物可用于多种应用，包括用作抗菌剂。

4. 发明申请

WO2002102793A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2002102793A2
公开(公告)日：2002-12-27
申请号：PCT/IB2002/001768
申请日：2002-05-13
申请人： WARNER-LAMBERT COMPANY , ELLSWORTH, Edmund, Lee , SHOWALTER, Howard, Daniel, Hollis , POWELL, Sharon, Anne , SANCHEZ, Joseph, Peter , KERSCHEN, James, Alan , STIER, Michael, Andrew , TRAN, Tuan, Phong
发明人： ELLSWORTH, Edmund, Lee , SHOWALTER, Howard, Daniel, Hollis , POWELL, Sharon, Anne , SANCHEZ, Joseph, Peter , KERSCHEN, James, Alan , STIER, Michael, Andrew , TRAN, Tuan, Phong
IPC分类号： C07D403/04
CPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/06 , C07D491/04 , C07D493/10 , C07D495/04 , C07F9/6561
摘要： The present invention provides compounds of formula (I): wherein R 1 -R 6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.
摘要翻译：本发明提供式（I）化合物：其中R1-R6和J和K具有说明书中定义的任何值及其药学上可接受的盐，其可用作抗菌剂。还公开了包含一种或多种式I化合物的药物组合物，制备式I化合物的方法和可用于制备式I化合物的中间体。

5. 发明申请

WO1998025932A1 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO1998025932A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022356
申请日：1997-12-05
申请人： WARNER-LAMBERT COMPANY , DOMAGALA, John, Michael , ELLSWORTH, Edmund, Lee , STIER, Michael, Andrew , HUANG, Liren , MICETICH, Ronald, George , SINGH, Rajeshwar , WRIGLEY, Stephen, Keith , WANG, Shouming , ROE, Michael , THORNTON, David, Michael
发明人： WARNER-LAMBERT COMPANY
IPC分类号： C07D498/04
CPC分类号： C07D487/04 , C07D513/04
摘要： Described are antibacterial agents of formula (I): X is O, S or N-R8; R1, R2, R3 and R8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR2, NR'COR', CN, CO2R' or CONR2', halogen, CN, CO2R, COR, CON(R)2, CON(R")2, SR, SON, SCO2R or SCON(R)2; R4 is H, straight or branched alkyl of from 1-6 carbon atoms, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR2, NR'COR', CN, CO2R' or CONR2', halogen, CN, NO2, N(R)2, NRCOR, NRCOR", COR, CO2R, CON(R)2, CON(R")2, NRCON(R)2, NRCO2R; R5 is 1-6 straight or branched alkyl, a cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur or phenyl, all of which rings may be optionally substituted up to 3 times by halogen, OR, NR2, NR'COR', CN, CO2R' or CONR2', halogen, OR, N(R)2, NRCOR, NRCOR", COR, CON(R)2, CON(R")2, SR or SO2R; R6, R7 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, COR, COR", SO2NR2, CONR2 and these may be optionally substituted by any of the groups listed for R5; R is H, straight or branched alkyl of 1-6 carbon atoms, cycloalkyl of from 3-6 carbon atoms, heterocyclic ring of from 5-8 atoms with 1-3 heteroatoms as nitrogen, oxygen or sulfur, or pheny, all of which may be optionally substituted by halogen, OR', NR'2, NR'COR', CN, CO2R', CONR'2; R' is H, alkyl of from 1-3 carbon atoms or Ph; R" is part of a naturally occurring amino acid connected via an amide or acyl bond as determined by the formula; halogen is any one of fluoro, chloro, bromo or iodo; or a pharmaceutically acceptable salt.
摘要翻译：描述了式（I）的抗菌剂：X是O，S或N-R8; R1，R2，R3和R8独立地为H，1-6个碳的直链或支链烷基，3-6个碳原子的环烷基，2-6个碳原子的烯基或炔基，5-8个原子的杂环，1-3个杂原子作为氮，氧或硫或苯基，所有这些环可以任选被卤素，OR，NR 2，NR'COR'，CN，CO 2 R'或CONR 2'，卤素，CN，CO 2 R，COR ，CON（R）2，CON（R“）2，SR，SON，SCO 2 R或SCON R 2; R 4是H，1-6个碳原子的直链或支链烷基，2至6的烯基或炔基原子，5-8个原子与1-3个杂原子作为氮原子的杂环，氧或硫或苯基，所有这些环可以任选地被卤素OR，NR 2，NR'COR'，CN， CO 2 R，CONR 2，CON（R“）2，NRCON（R）2，NRCO 2 R; R 5是 1-6个直链或支链烷基，3-6个碳原子的环烷基，2-6个碳原子的烯基或炔基，5-8个原子的杂环和1-3个杂原子作为氮，氧或硫或苯基，所有这些环可以任选被卤素，OR，NR 2，NR'COR'，CN，CO 2 R'或CONR 2'，卤素，OR，N（R） 2，NRCOR，NRCOR“，COR，CON（R）2，CON（R”）2，SR或SO2R; R 6，R 7独立地是H，1-6个碳的直链或支链烷基，3-6个碳的环烷基，COR，COR“，SO2NR2，CONR2，并且它们可以任选被R5所列的任何基团取代; R是H ，1-6个碳原子的直链或支链烷基，3-6个碳原子的环烷基，5-8个原子的杂环，1-3个杂原子作为氮，氧或硫或苯基，所有这些可以是任选的被卤素取代，OR'，NR'2，NR'COR'，CN，CO2R'，CONR'2; R'是H，1-3个碳原子的烷基或Ph; R“是天然存在的氨基通过由式决定的酰胺或酰基键连接酸; 卤素是氟，氯，溴或碘中的任何一种; 或药学上可接受的盐。

6. 发明申请

WO02102793A3 QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹诺酮类作为抗菌剂
公开(公告)号：WO02102793A3
公开(公告)日：2003-04-10
申请号：PCT/IB0201768
申请日：2002-05-13
申请人： WARNER LAMBERT CO , ELLSWORTH EDMUND LEE , SHOWALTER HOWARD DANIEL HOLLIS , POWELL SHARON ANNE , SANCHEZ JOSEPH PETER , KERSCHEN JAMES ALAN , STIER MICHAEL ANDREW , TRAN TUAN PHONG
发明人： ELLSWORTH EDMUND LEE , SHOWALTER HOWARD DANIEL HOLLIS , POWELL SHARON ANNE , SANCHEZ JOSEPH PETER , KERSCHEN JAMES ALAN , STIER MICHAEL ANDREW , TRAN TUAN PHONG
IPC分类号： C07D239/96 , A61K31/517 , A61K31/519 , A61K31/5383 , A61P31/04 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/06 , C07D491/04 , C07D491/048 , C07D493/10 , C07D495/04 , C07D498/06 , C07F9/6561 , C07D413/04 , C07D471/06 , C07D498/08
CPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/06 , C07D491/04 , C07D493/10 , C07D495/04 , C07F9/6561
摘要： The present invention provides compounds of formula (I): wherein R1-R6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.
摘要翻译：本发明提供式（I）化合物：其中R1-R6和J和K具有说明书中定义的任何值及其药学上可接受的盐，其可用作抗菌剂。还公开了包含一种或多种式I化合物的药物组合物，制备式I化合物的方法和可用于制备式I化合物的中间体。

8. 发明申请

WO2012038851A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS 审中-公开
标题翻译： ISOXAZOLINE OXIMES作为抗菌剂
公开(公告)号：WO2012038851A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/053929
申请日：2011-09-08
申请人： PFIZER INC. , CURTIS, Michael, Paul , ELLSWORTH, Edmund, Lee
发明人： CURTIS, Michael, Paul , ELLSWORTH, Edmund, Lee
IPC分类号： C07D261/04 , A01N29/10 , A61K31/42 , A61P33/00
CPC分类号： C07D261/04 , A01N43/80
摘要： This invention recites isoxazoline oxime derivatives of Formula (1) stereoisomers thereof, pharmaceutically or veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in an animal.
摘要翻译：本发明叙述式（1）的立体异构体的异恶唑啉肟衍生物，其药学上或兽医学上可接受的盐，其组合物及其作为动物中杀寄生虫剂的用途。

9. 发明申请

WO2010032147A3 HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：羟基酸衍生物作为抗菌剂有用
公开(公告)号：WO2010032147A3
公开(公告)日：2010-06-03
申请号：PCT/IB2009053809
申请日：2009-09-01
申请人： PFIZER , BROWN MATTHEW FRANK , DONOVAN CHARLES FRANCIS , ELLSWORTH EDMUND LEE , HOYER DENTON WADE , JOHNSON TIMOTHY ALLEN , LALL MANJINDER SINGH , LIMBERAKIS CHRIS , MURPHY SEAN TIMOTHY , SHERRY DEBRA ANN , TAYLOR CLARKE BENTLEY , WARMUS JOSEPH SCOTT
发明人： BROWN MATTHEW FRANK , DONOVAN CHARLES FRANCIS , ELLSWORTH EDMUND LEE , HOYER DENTON WADE , JOHNSON TIMOTHY ALLEN , LALL MANJINDER SINGH , LIMBERAKIS CHRIS , MURPHY SEAN TIMOTHY , SHERRY DEBRA ANN , TAYLOR CLARKE BENTLEY , WARMUS JOSEPH SCOTT
IPC分类号： C07C239/14 , A61K31/16
CPC分类号： C07C259/06 , C07C2601/04 , C07D207/267 , C07D213/30 , C07D213/38 , C07D213/55 , C07D231/12 , C07D233/64 , C07D237/04 , C07D239/26 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/28 , C07D277/30 , C07D285/06 , C07D307/14 , C07D307/42 , C07D307/54 , C07D309/10 , C07D413/04 , C07D413/12 , C07D471/04 , C07F9/653
摘要： The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：G为式（II）基团; 其药学上可接受的盐，前体药物，水合物或溶剂化物，其中A，B，L1-L4A，B，R1-R4和m如本文所定义。本发明还涉及包含式（I）化合物及其在治疗细菌感染中的用途的药物组合物。

10. 发明申请

WO2010032147A2 HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：用作抗菌剂的羟氨酸衍生物
公开(公告)号：WO2010032147A2
公开(公告)日：2010-03-25
申请号：PCT/IB2009/053809
申请日：2009-09-01
申请人： PFIZER INC. , BROWN, Matthew Frank , DONOVAN, Charles Francis , ELLSWORTH, Edmund Lee , HOYER, Denton Wade , JOHNSON, Timothy Allen , LALL, Manjinder Singh , LIMBERAKIS, Chris , MURPHY, Sean Timothy , SHERRY, Debra Ann , TAYLOR, Clarke Bentley , WARMUS, Joseph Scott
发明人： BROWN, Matthew Frank , DONOVAN, Charles Francis , ELLSWORTH, Edmund Lee , HOYER, Denton Wade , JOHNSON, Timothy Allen , LALL, Manjinder Singh , LIMBERAKIS, Chris , MURPHY, Sean Timothy , SHERRY, Debra Ann , TAYLOR, Clarke Bentley , WARMUS, Joseph Scott
IPC分类号： C07C239/14
CPC分类号： C07C259/06 , C07C2601/04 , C07D207/267 , C07D213/30 , C07D213/38 , C07D213/55 , C07D231/12 , C07D233/64 , C07D237/04 , C07D239/26 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/28 , C07D277/30 , C07D285/06 , C07D307/14 , C07D307/42 , C07D307/54 , C07D309/10 , C07D413/04 , C07D413/12 , C07D471/04 , C07F9/653
摘要： The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L 1 -L 4 A, B, R 1 -R 4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：G为式（II）的基团; 及其药学上可接受的盐，前药，水合物或溶剂合物，其中A，B，L，L，L，L，R，R 1， > -R 4和m如本文所定义。本发明还涉及包含式（I）化合物及其在治疗细菌感染中的用途的药物组合物。

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