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1. 发明申请

WO2007141317A1 MANUFACTURE OF MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒制造
公开(公告)号：WO2007141317A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055626
申请日：2007-06-07
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio , GAVEZOTTI, Piero , LAMENDOLA, Ritalba
发明人： TONELLI, Claudio , GAVEZOTTI, Piero , LAMENDOLA, Ritalba
IPC分类号： A61L27/14 , A61L28/00 , A61L29/04 , A61L31/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture of a medical implant, said process comprising: - reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; - moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及一种用于制造医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97（混合物（M） ]与合适的反应物制备热塑性弹性体; - 模制如此获得的热塑性弹性体以产生至少一部分医用植入物。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被生物流体减少的化学品提取的医用植入物。

2. 发明申请

WO2010130628A1 PROCESS FOR THE PURIFICATION OF POLYOL PFPE DERIVATIVES 审中-公开
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：WO2010130628A1
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056185
申请日：2010-05-06
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio Adolfo Pietro , VEZZULLI, Graziano Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
发明人： TONELLI, Claudio Adolfo Pietro , VEZZULLI, Graziano Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
IPC分类号： C08G65/30
CPC分类号： C08G65/007 , C08G65/30
摘要： The invention pertains to a process for the purification of a polyol (per)fluoropolyether derivative [polyol (P)], said polyol (P) comprising one or more hydroxyl (per)fluoropolyether derivatives [PFPEs (OH)] comprising at least one (per)fluoropolyoxyalkylene chain (chain R f ) and at least one end-group having formula -CF 2 CH 2 OCH 2 CH(OH)CH 2 OCH 2 CH(OH)CH 2 OH (t 3 ), from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)], said mixture (M) comprising said polyol (P) and at least one hydroxyl (per)fluoropolyether derivative [PFPE (OH)] different from polyol (P) and comprising at least one (per)fluoropolyoxyalkylene chain (chain R f ) and at least one end-group selected from those having formulae -CF 2 CH 2 OH (t 1 ) and -CF 2 CH 2 OCH 2 CH(OH)CH 2 OH (t 2 ), said process comprising the following steps: step 1 : reacting the mixture (M) with a ketone and/or an aldehyde so as to yield corresponding mixture of cyclic ketal/acetal (per)fluoropolyether derivatives [PFPEs (OH) p ] [protected mixture (P)]; step 2: submitting the protected mixture (P) to adsorption on silica gel so as to yield an adsorbed protected product [adsorbed product (P p )] and then recovering a desorbed protected product [desorbed product (P p )] by subsequent desorption from silica gel of said adsorbed product (P p ); step 3: distilling the desorbed product (P p ) under reduced pressure so as to isolate a protected product residue [product (P r )]; step 4: hydrolyzing the product (P r ) so as to obtain polyol (P).
摘要翻译：本发明涉及纯化多元醇（全）氟聚醚衍生物[多元醇（P）]的方法，所述多元醇（P）包含一种或多种羟基（全）含氟聚醚衍生物[PFPE（OH）]，其包含至少一种（（OH）CH 2 OH（t3）的至少一个末端基团，由羟基（全）氟代聚醚衍生物[混合物（M）]的混合物，所述混合物（P）和至少一种不同于多元醇（P）的羟基（全）氟聚醚衍生物[PFPE（OH）]并且包含至少一个（全）氟聚氧化烯链（链Rf）和至少一个末端 - 基团选自具有式-CF 2 CH 2 OH（t 1）和-CF 2 CH 2 OCH 2 CH（OH）CH 2 OH（t 2）的那些，所述方法包括以下步骤：步骤1：使混合物（M）与酮和/或醛反应，产生相应的环缩酮/缩醛（全）氟代聚醚衍生物[PFPE（OH）p] [保护的混合物（P） ]。步骤2：将保护的混合物（P）提交到硅胶上吸附，得到吸附的保护产物[吸附产物（Pp）]，然后通过随后的硅胶解吸回收解吸的保护产物[解吸产物（Pp）] 的所述吸附产物（Pp）; 步骤3：在减压下蒸馏除油产物（Pp），以分离受保护的产物残渣[产物（Pr）]; 步骤4：水解产物（Pr）以获得多元醇（P）。

3. 发明申请

WO2009043928A1 PROCESS FOR THE MANUFACTURE OF POLYOL PERFLUOROPOLYETHER DERIVATIVE 审中-公开
标题翻译：聚氟乙烯衍生物的制备方法
公开(公告)号：WO2009043928A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063278
申请日：2008-10-03
申请人： SOLVAY SOLEXIS S.P.A. , TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero , DI MEO, Antonella
发明人： TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero , DI MEO, Antonella
IPC分类号： C08G65/00 , C08G65/48
CPC分类号： C07C41/26 , C07C43/126 , C08G65/007 , C08G65/22 , C08G65/2639 , C08G65/3312 , C10M2211/063
摘要： The invention pertains to a process for the manufacture of a polyol (per)fluoropolyether derivative [polyol PFPE (PFPE-OH)], said process comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group [protected triol (PT)] with an activating agent, to yield an activated protected triol [activated protected triol (APT)]; 2. reacting said activated protected triol with a functional (per)fluoropolyether derivative of formula (Ia) [functional PFPE (E)], wherein: R f represents a fluoropolyoxyalkene chain (chain R f ), i.e. a fluorocarbon segment comprising ether linkages in main chain; T 1 and T 2 , equal to or different from each other, are independently selected from - non-functional groups of formula: -CF 3 , -CF 2 -CF 3 , -CF 2 CI, -CF 2 CF 2 CI, -CF 2 -COF, -COF : and - functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T 1 and T 2 is a functional hydroxyl group as above detailed; to yield a protected polyol (per)fluoropolyether derivative [protected polyol PFPE (p-PFPE-OH)]; 3. deprotecting said protected polyol PFPE (p-PFPE-OH) to yield the polyol PFPE (PFPE-OH).
摘要翻译：本发明涉及制备多元醇（全）氟聚醚衍生物[多元醇PFPE（PFPE-OH）]的方法，所述方法包括：使至少一种具有两个保护的羟基官能团和游离羟基的三醇[保护的三醇（PT）]与活化剂反应，得到活化的保护三醇[活性保护三醇（APT）]; 2.使所述活化的被保护的三醇与式（Ia）的功能性（全）氟聚醚衍生物[功能性PFPE（E）]反应，其中：Rf表示氟聚氧亚烷基链（链Rf），即在主链中包含醚键的氟烃链段 ; T1和T2彼此相同或不同，独立地选自以下的非官能团：-CF 3，-CF 2 -CF 3，-CF 2 Cl，-CF 2 CF 2 Cl，-CF 2 -COF，-COF：和 - 官能羟基包含至少一个羟基的基团，条件是T1和T2中的至少一个是如上详述的官能羟基; 得到受保护的多元醇（全）氟聚醚衍生物[保护的多元醇PFPE（p-PFPE-OH）]; 3.将保护的多元醇PFPE（p-PFPE-OH）脱保护，得到多元醇PFPE（PFPE-OH）。

4. 发明申请

WO2012084745A1 PROCESS FOR PRODUCING FLUORINATED ORGANIC COMPOUNDS 审中-公开
标题翻译：生产氟化有机化合物的方法
公开(公告)号：WO2012084745A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073138
申请日：2011-12-16
申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A. , TORTELLI, Vito , GALIMBERTI, Marco , MONZANI, Cristiano , GAVEZOTTI, Piero
发明人： TORTELLI, Vito , GALIMBERTI, Marco , MONZANI, Cristiano , GAVEZOTTI, Piero
IPC分类号： C07C41/22 , C07C43/12 , C08G65/00 , C08G65/323
CPC分类号： C07C41/22 , C07C41/48 , C08G65/007 , C08G65/3236 , C09K5/00 , C07C43/126 , C07C43/315
摘要： A process for fluorinating hydrocarbon compounds, which comprises: A. providing a compound selected from the group consisting of straight-chain, branched-chain and cyclic alkanes, straight-chain, branched-chain and cyclic ethers, said compound comprising at least one carbon-hydrogen bond and being free from -C(O)- functional groups; B. reacting said compound with fluorine in the presence of at least one (per)haloolefin comprising at least one carbon-carbon double bond and having at least one fluorine or chlorine atom on either one of the carbon atoms of said double bond, to obtain a compound wherein at least one carbon-hydrogen bond has been replaced by a carbon-fluorine bond. Compositions of partially fluorinated compounds obtained with the process are also disclosed.
摘要翻译：一种氟化烃化合物的方法，其包括：A.提供选自直链，支链和环烷烃，直链，支链和环醚的化合物，所述化合物包含至少一个碳 - 氢键并且不含-C（O） - 官能团; 在至少一种包含至少一个碳 - 碳双键并且在所述双键的碳原子上具有至少一个氟或氯原子的（全）卤代烯烃存在下，使所述化合物与氟反应，得到其中至少一个碳 - 氢键已被碳 - 氟键取代的化合物。还公开了通过该方法获得的部分氟化化合物的组合物。

5. 发明申请

WO2008138927A1 FLUORINATED POLYURETHANE COMPOSITION 审中-公开
标题翻译：氟化聚氨酯组合物
公开(公告)号：WO2008138927A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055838
申请日：2008-05-13
申请人： SOLVAY SOLEXIS S.p.A. , RUSSO, Antonio , GAVEZOTTI, Piero , QUALLO, Michael
发明人： RUSSO, Antonio , GAVEZOTTI, Piero , QUALLO, Michael
IPC分类号： C08G18/08 , C08G18/12 , C08G18/32 , C08G18/50 , C08L75/04
CPC分类号： C08G18/0814 , C08G18/0823 , C08G18/3206 , C08G18/3819 , C08G18/3893 , C08G18/5015 , C08G18/755 , C08G18/80 , C08L33/16 , D06M15/277 , D06M15/576 , D06M2200/01 , D06M2200/10 , D06M2200/11 , D06M2200/12 , C08L75/04 , C08L2666/06
摘要： The invention pertains to a composition useful for imparting durable stain repellence and soil release properties to textile substrates, said composition comprising: (A) at least one fluorinated ionisable polyurethane polymer [polymer (PUR)] comprising at least one fluorinated block comprising a fluoropolyoxyalkene chain [chain (R of )], and at least one functional block comprising an hydrocarbon chain [chain (R HC )] having from 2 to 14 carbon atoms, optionally comprising one or more aromatic or cycloaliphatic group, said chain (R HC ) comprising at least one ionisable group, said blocks being linked by urethane moieties of formula (I): wherein E is a divalent hydrocarbon carbon group, linear or branched, optionally comprising aromatic rings, said polymer (PUR) being free from perfluoroalkyl chains [chain (R f )]; (B) at least one fluorocarbon polymer [polymer (F)] comprising at least one perfluoroalkyl chain [chain (R f )] linked by one or more ester moiety of formula (II) and/or urethane moiety of formula (III) and/or urea moiety of formula (IV): (C) at least one crosslinking agent. Still object of the invention are the use of said composition for treating textile substrates and the textile substrates obtained therefrom.
摘要翻译：本发明涉及可用于赋予织物基质持久的防污性和去污性的组合物，所述组合物包含：（A）至少一种含氟可电离聚氨酯聚合物[聚合物（PUR）]，其包含至少一个含氟聚氧亚烷基链的氟化嵌段 [链（R））和至少一个包含具有2至14个碳原子的烃链[链（R）C H]）的官能团，任选地包含一个或更多的芳香族或脂环族基团，所述链（R CH）包含至少一个可离子化基团，所述嵌段通过式（I）的氨基甲酸酯部分连接：其中E是二价烃碳基，线性或支链的，任选地包含芳香环，所述聚合物（PUR）不含全氟烷基链[链（R））。（B）包含至少一个由一个或多个式（II）的酯部分和/或氨基甲酸酯连接的全氟烷基链[链（R））的氟碳聚合物[聚合物（F）]] 式（III）的部分和/或式（IV）的脲部分）：（C）至少一种交联剂。本发明的另一目的是使用所述组合物来处理织物基材和由其获得的织物基材。

6. 发明申请

WO2012175534A1 (PER)FLUOROPOLYETHER BLOCK COPOLYMERS 审中-公开
标题翻译：（PER）氟聚醚嵌段共聚物
公开(公告)号：WO2012175534A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061782
申请日：2012-06-20
申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A. , TONELLI, Claudio Adolfo Pietro , FONTANA, Simonetta, Antonella , GALIMBERTI, Marco , GAVEZOTTI, Piero
发明人： TONELLI, Claudio Adolfo Pietro , FONTANA, Simonetta, Antonella , GALIMBERTI, Marco , GAVEZOTTI, Piero
IPC分类号： C08G65/08 , C08G65/18
CPC分类号： C07C271/24 , C07C41/22 , C07C43/126 , C07C55/32 , C07C67/00 , C07C69/708 , C07C269/02 , C08G65/007
摘要： The invention relates to (per)fluoropolyether block copolymers comprising: A) a fluoropolyoxyalkylene segment (chain R a ) comprising one or more units of formula (CHXCF 2 CF 2 O)- in which X is hydrogen or fluorine; B) a (per)fluoropolyoxyalkylene segment (chain Rf), that is to say a segment comprising recurring units having at least one catenary ether bond and at least one fluorocarbon moiety, said (per)fluoropolyoxyalkylene segment being different from chain R a and having a molecular weight higher than 400 g/mol. These copolymers are endowed with improves lubricant properties or with improved water and oil-repellence properties.
摘要翻译：本发明涉及（全）含氟聚醚嵌段共聚物，其包含：A）包含一种或多种式（CHXCF 2 CF 2 O）单元的氟聚氧亚烷基链（链Ra），其中X是氢或氟; B）（全）氟聚氧亚烷基链段（链Rf），也就是说包含具有至少一个链状醚键的重复单元和至少一个碳氟化合物部分的链段，所述（全）氟聚氧亚烷基链段不同于链Ra，并具有分子量高于400g / mol。这些共聚物具有改善的润滑剂性能或具有改善的防水和防油性能。

7. 发明申请

WO2012168156A1 HYDROXY COMPOUNDS OBTAINED FROM 2,2,3,3-TETRAFLUOROOXETHANE AND DERIVATIVES THEREOF 审中-公开
标题翻译：由2,2,3,3-四氢呋喃和其衍生物获得的羟基化合物
公开(公告)号：WO2012168156A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/060379
申请日：2012-06-01
申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A. , FONTANA, Simonetta, Antonella , TONELLI, Claudio Adolfo Pietro , GAVEZOTTI, Piero
发明人： FONTANA, Simonetta, Antonella , TONELLI, Claudio Adolfo Pietro , GAVEZOTTI, Piero
IPC分类号： C07F9/06
CPC分类号： C07C43/137 , C07C41/02 , C07C41/26 , C07C51/58 , C07F9/091 , C07F9/65814 , C09D7/63 , D06P5/00 , C07C59/135
摘要： The invention relates to a hydroxy compound of formula (I) wherein n is an integer equal to or higher than 1 as an intermediate for the preparation of compounds of formulae (lla) and (IIb) as defined in the specification that can be used as water and oil resistance agents. The invention further relates to water and oil resistance compositions containing compounds (lla) and (IIb).
摘要翻译：本发明涉及式（I）的羟基化合物，其中n是等于或高于1的整数，作为制备如说明书中定义的式（Ⅰa）和（Ⅱb）化合物的中间体，其可以用作耐水和耐油剂。本发明还涉及含有化合物（Ia）和（IIb）的耐水和耐油组合物。

8. 发明申请

WO2010130625A1 PROCESS FOR THE PURIFICATION OF POLYOL PFPE DERIVATIVES 审中-公开
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：WO2010130625A1
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056177
申请日：2010-05-06
申请人： SOLVAY SOLEXIS S.P.A. , VEZZULLI, Graziano Giuseppe , GAVEZOTTI, Piero , MUTTA, Fabrizio , TONELLI, Claudio Adolfo Pietro
发明人： VEZZULLI, Graziano Giuseppe , GAVEZOTTI, Piero , MUTTA, Fabrizio , TONELLI, Claudio Adolfo Pietro
IPC分类号： C08G65/30
CPC分类号： C08G65/007 , C08G65/30
摘要： The invention pertains to a process for the purification of a polyol (per)fluoropolyether derivative [polyol (P)], said polyol (P) comprising one or more hydroxyl (per)fluoropolyether derivatives [PFPE (OH)] comprising at least one (per)fluoropolyoxyalkylene chain (chain R f ) and at least one end-group having formula -CF 2 CH 2 OCH 2 CH(OH)CH 2 OCH 2 CH(OH)CH 2 OH (t3), from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)], said mixture (M) comprising said polyol (P) and at least one hydroxyl (per)fluoropolyether derivative [PFPE (OH)] different from polyol (P) and comprising at least one (per)fluoropolyoxyalkylene chain (chain Rf) and at least one end-group selected from those having formulae -CF 2 CH 2 OH (t 1 ) and -CF 2 CH 2 OCH 2 CH(OH)CH 2 OH (t 2 ), said process comprising the following steps: step 1 : reacting the mixture (M) with a ketone and/or an aldehyde so as to yield corresponding mixture of cyclic ketal/acetal (per)fluoropolyether derivatives [PFPEs (OH) p ] [protected mixture (P)]; step 2: molecular distillation of the protected mixture (P) so as to isolate a protected product heavy residue [product (P r )]; step 3: hydrolyzing the product (P r ) so as to yield a deprotected product [product (P d )]; step 4: distillation under reduced pressure of the product (P d ) so as to obtain polyol (P).
摘要翻译：本发明涉及纯化多元醇（全）氟聚醚衍生物[多元醇（P）]的方法，所述多元醇（P）包含一种或多种羟基（全）含氟聚醚衍生物[PFPE（OH）]，其包含至少一种（（OH）CH 2 OH（t3）的至少一个末端基团，由羟基（全）氟代聚醚衍生物[混合物（M）]的混合物，所述混合物（P）和至少一种不同于多元醇（P）的羟基（全）氟聚醚衍生物[PFPE（OH）]并且包含至少一个（全）氟聚氧化烯链（链Rf）和至少一个末端 - 基团选自具有式-CF 2 CH 2 OH（t 1）和-CF 2 CH 2 OCH 2 CH（OH）CH 2 OH（t 2）的那些，所述方法包括以下步骤：步骤1：使混合物（M）与酮和/或醛反应，产生相应的环缩酮/缩醛（全）氟聚醚衍生物[PFPE（OH）p] [保护的混合物（P） ]。步骤2：保护的混合物（P）的分子蒸馏，以分离受保护的产物重残渣[产物（Pr）]; 步骤3：水解产物（Pr）以产生脱保护的产物[产物（Pd）]; 步骤4：在减压下蒸馏产物（Pd），得到多元醇（P）。

9. 发明申请

WO2009112578A1 PROCESS FOR THE PURIFICATION OF POLYOL PFPE DERIVATIVE 审中-公开
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：WO2009112578A1
公开(公告)日：2009-09-17
申请号：PCT/EP2009/052999
申请日：2009-03-13
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
发明人： TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
IPC分类号： C08G65/30
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： The invention pertains to a process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO-CH 2 -CH(OH)-CH 2 -O-CH 2 -CF 2 -O-R f -CF 2 -CH 2 O-CH 2 -CH(OH)-CH 2 OH (I), wherein R f represents a fluoropolyoxyalkene chain (chain R f ), i.e. a fluorocarbon segment comprising ether linkages in main chain, from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)], said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain R f terminated with at least one end group of formula: -CF 2 CH 2 OH) -CF 2 CH 2 O-CH(OH)-CH 2 -O-CH 2 -CH(OH)-CH 2 OH; said process comprising: step 1 : reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture [mixture (P)]; step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture [mixture (P f )]; step 3: fractional distillation of the mixture (P f ) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); step 4. hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：本发明涉及纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH2-CH（OH）-CH2-O-CH2-CF2-O-Rf-CF2-CH2O -CH 2 -CH（OH）-CH 2 OH（I），其中R f表示氟代聚氧亚烷基链（链Rf），即包含主链中的醚键的氟烃链段，由羟基（全）氟聚醚衍生物的混合物[混合物（M） ]，所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE（OH）），其包含用至少一个具有下列结构的末端基团终止的链Rf：-CF 2 CH 2 OH）-CF 2 CH 2 O-CH（OH） CH2-O-CH2-CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物[混合物（P）]; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，使得能够进行实质的挥发性改性，以获得官能化的保护的混合物[混合物（Pf）]; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 步骤4.水解四醇（T）的缩醛/缩酮衍生物，以回收纯四醇（T）。

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