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1. 发明申请

WO2009112578A1 PROCESS FOR THE PURIFICATION OF POLYOL PFPE DERIVATIVE 审中-公开
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：WO2009112578A1
公开(公告)日：2009-09-17
申请号：PCT/EP2009/052999
申请日：2009-03-13
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
发明人： TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
IPC分类号： C08G65/30
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： The invention pertains to a process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO-CH 2 -CH(OH)-CH 2 -O-CH 2 -CF 2 -O-R f -CF 2 -CH 2 O-CH 2 -CH(OH)-CH 2 OH (I), wherein R f represents a fluoropolyoxyalkene chain (chain R f ), i.e. a fluorocarbon segment comprising ether linkages in main chain, from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)], said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain R f terminated with at least one end group of formula: -CF 2 CH 2 OH) -CF 2 CH 2 O-CH(OH)-CH 2 -O-CH 2 -CH(OH)-CH 2 OH; said process comprising: step 1 : reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture [mixture (P)]; step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture [mixture (P f )]; step 3: fractional distillation of the mixture (P f ) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); step 4. hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：本发明涉及纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH2-CH（OH）-CH2-O-CH2-CF2-O-Rf-CF2-CH2O -CH 2 -CH（OH）-CH 2 OH（I），其中R f表示氟代聚氧亚烷基链（链Rf），即包含主链中的醚键的氟烃链段，由羟基（全）氟聚醚衍生物的混合物[混合物（M） ]，所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE（OH）），其包含用至少一个具有下列结构的末端基团终止的链Rf：-CF 2 CH 2 OH）-CF 2 CH 2 O-CH（OH） CH2-O-CH2-CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物[混合物（P）]; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，使得能够进行实质的挥发性改性，以获得官能化的保护的混合物[混合物（Pf）]; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 步骤4.水解四醇（T）的缩醛/缩酮衍生物，以回收纯四醇（T）。

2. 发明申请

WO2009043928A1 PROCESS FOR THE MANUFACTURE OF POLYOL PERFLUOROPOLYETHER DERIVATIVE 审中-公开
标题翻译：聚氟乙烯衍生物的制备方法
公开(公告)号：WO2009043928A1
公开(公告)日：2009-04-09
申请号：PCT/EP2008/063278
申请日：2008-10-03
申请人： SOLVAY SOLEXIS S.P.A. , TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero , DI MEO, Antonella
发明人： TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero , DI MEO, Antonella
IPC分类号： C08G65/00 , C08G65/48
CPC分类号： C07C41/26 , C07C43/126 , C08G65/007 , C08G65/22 , C08G65/2639 , C08G65/3312 , C10M2211/063
摘要： The invention pertains to a process for the manufacture of a polyol (per)fluoropolyether derivative [polyol PFPE (PFPE-OH)], said process comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group [protected triol (PT)] with an activating agent, to yield an activated protected triol [activated protected triol (APT)]; 2. reacting said activated protected triol with a functional (per)fluoropolyether derivative of formula (Ia) [functional PFPE (E)], wherein: R f represents a fluoropolyoxyalkene chain (chain R f ), i.e. a fluorocarbon segment comprising ether linkages in main chain; T 1 and T 2 , equal to or different from each other, are independently selected from - non-functional groups of formula: -CF 3 , -CF 2 -CF 3 , -CF 2 CI, -CF 2 CF 2 CI, -CF 2 -COF, -COF : and - functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T 1 and T 2 is a functional hydroxyl group as above detailed; to yield a protected polyol (per)fluoropolyether derivative [protected polyol PFPE (p-PFPE-OH)]; 3. deprotecting said protected polyol PFPE (p-PFPE-OH) to yield the polyol PFPE (PFPE-OH).
摘要翻译：本发明涉及制备多元醇（全）氟聚醚衍生物[多元醇PFPE（PFPE-OH）]的方法，所述方法包括：使至少一种具有两个保护的羟基官能团和游离羟基的三醇[保护的三醇（PT）]与活化剂反应，得到活化的保护三醇[活性保护三醇（APT）]; 2.使所述活化的被保护的三醇与式（Ia）的功能性（全）氟聚醚衍生物[功能性PFPE（E）]反应，其中：Rf表示氟聚氧亚烷基链（链Rf），即在主链中包含醚键的氟烃链段 ; T1和T2彼此相同或不同，独立地选自以下的非官能团：-CF 3，-CF 2 -CF 3，-CF 2 Cl，-CF 2 CF 2 Cl，-CF 2 -COF，-COF：和 - 官能羟基包含至少一个羟基的基团，条件是T1和T2中的至少一个是如上详述的官能羟基; 得到受保护的多元醇（全）氟聚醚衍生物[保护的多元醇PFPE（p-PFPE-OH）]; 3.将保护的多元醇PFPE（p-PFPE-OH）脱保护，得到多元醇PFPE（PFPE-OH）。

3. 发明申请

WO2007141317A1 MANUFACTURE OF MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒制造
公开(公告)号：WO2007141317A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055626
申请日：2007-06-07
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio , GAVEZOTTI, Piero , LAMENDOLA, Ritalba
发明人： TONELLI, Claudio , GAVEZOTTI, Piero , LAMENDOLA, Ritalba
IPC分类号： A61L27/14 , A61L28/00 , A61L29/04 , A61L31/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture of a medical implant, said process comprising: - reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; - moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及一种用于制造医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97（混合物（M） ]与合适的反应物制备热塑性弹性体; - 模制如此获得的热塑性弹性体以产生至少一部分医用植入物。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被生物流体减少的化学品提取的医用植入物。

4. 发明申请

WO2009010533A1 AROMATIC HYDROGENATED POLYMERS CONTAINING FLUORINE 审中-公开
标题翻译：含有氟的芳族加氢聚合物
公开(公告)号：WO2009010533A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059306
申请日：2008-07-16
申请人： SOLVAY SOLEXIS S.p.A. , TONELLI, Claudio
发明人： TONELLI, Claudio
IPC分类号： C08F283/00 , C08G63/91 , C08G69/48 , C08G85/00 , C08L101/04
CPC分类号： C08G63/916 , C08G63/672 , C08G63/6826 , C08G65/007 , C08G69/26 , C08G69/28 , C08G69/40 , C08G69/42 , C08G69/48 , C08G2650/48 , C08L67/00 , C08L71/02 , C08L77/00 , C08L81/02 , C08L2666/14 , C08L2666/22
摘要： Aromatic hydrogenated polymers comprising perfluoropolyether (PFPE) chains bonded to the aromatic rings to form sequences randomly distributed in the polymer structure, having the formula (I): (T 1 -CF 2 O-Rf-CF 2 ) n -T 3 in which: n is an integer from 1 to 10, T 1 is an aromatic group of the backbone of the hydrogenated polymer, or alternatively condensed aromatic groups, T 3 may be equal to T 1 , or alternatively a functional group -COOH or -COF, Rf is a (per)fluoropolyoxyalkylene chain, in which the starting hydrogenated aromatic polymers are obtained by polycondensation, stepwise polyaddition or polyaddition of cyclic monomers in which the ring is formed by at least 3 atoms.
摘要翻译：包含与芳环结合的全氟聚醚（PFPE）链的芳族氢化聚合物，以形成随机分布在聚合物结构中的序列，具有式（I）：（T1-CF2O-Rf-CF2）n-T3，其中：n是整数 1至10，T1是氢化聚合物的主链的芳族基团，或者可选的稠合芳族基团，T3可以等于T1，或者可以是官能团-COOH或-COF，Rf是（全）氟聚氧化烯链其中起始氢化芳族聚合物通过环状单体的缩聚，逐步加聚或加聚获得，其中环由至少3个原子形成。

5. 发明申请

WO2005102417A3 AN INFUSION DEVICE FOR MEDICAL FLUIDS. 审中-公开
公开(公告)号：WO2005102417A3
公开(公告)日：2005-11-03
申请号：PCT/IB2005/000893
申请日：2005-04-06
申请人： GAMBRO LUNDIA AB , TONELLI, Claudio , LIGABUE, Andrea , CESTARI, Silvano
发明人： TONELLI, Claudio , LIGABUE, Andrea , CESTARI, Silvano
IPC分类号： A61M5/168
摘要： The infusion device comprises a pusher for a plunger (10) of a syringe (6) containing a liquid to be infused. A load cell (14) measures the push force. An encoder associated to a motor (13) commanding the pusher measures the displacement of the pusher. A controller (15) signals an alarm when the ratio between the variation of the push force and the displacement exceeds a predetermined threshold. The device, which serves for infusing an anticoagulant into an extracorporeal blood circuit in a dialysis apparatus, is able to signal an onset of an anomalous situation of lack of infusion in good time.

6. 发明授权

EP2254931B1 PROCESS FOR THE PURIFICATION OF POLYOL PFPE DERIVATIVE 有权
标题翻译：程序对清洁PFPE多元醇衍生物
公开(公告)号：EP2254931B1
公开(公告)日：2011-08-31
申请号：EP09721134.6
申请日：2009-03-13
申请人： Solvay Solexis S.p.A.
发明人： TONELLI, Claudio , VEZZULLI, Graziano, Giuseppe , PICOZZI, Rosaldo , GAVEZOTTI, Piero
IPC分类号： C08G65/30
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： The invention pertains to a process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO-CH
2 -CH(OH)-CH
2 -O-CH
2 -CF
2 -O-R
f -CF
2 -CH
2 O-CH
2 -CH(OH)-CH
2 OH (I), wherein R
f represents a fluoropolyoxyalkene chain (chain R
f ), i.e. a fluorocarbon segment comprising ether linkages in main chain, from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)], said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain R
f terminated with at least one end group of formula: -CF
2 CH
2 OH) -CF
2 CH
2 O-CH(OH)-CH
2 -O-CH
2 -CH(OH)-CH
2 OH; said process comprising: step 1 : reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture [mixture (P)]; step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture [mixture (P
f )]; step 3: fractional distillation of the mixture (P
f ) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); step 4. hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).

7. 发明公开

EP2029185A1 MANUFACTURE OF MEDICAL IMPLANTS 有权
标题翻译：生产的医用植入物
公开(公告)号：EP2029185A1
公开(公告)日：2009-03-04
申请号：EP07729988.1
申请日：2007-06-07
申请人： Solvay Solexis S.p.A.
发明人： TONELLI, Claudio , GAVEZOTTI, Piero , LAMENDOLA, Ritalba
IPC分类号： A61L27/14 , A61L28/00 , A61L29/04 , A61L31/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture of a medical implant, said process comprising: - reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; - moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.

8. 发明申请

WO2003070314A1 METHOD OF MONITORING THE OPERATIONALITY OF A FLOW CUT-OFF MEMBER AND FLOW ARRESTING SYSTEM, FOR AN EXTRACORPOREAL FLUID CIRCUIT 审中-公开
标题翻译：监测流动切断构件和流动回收系统的操作方法，用于超流体流路
公开(公告)号：WO2003070314A1
公开(公告)日：2003-08-28
申请号：PCT/IB2003/000448
申请日：2003-02-11
申请人： GAMBRO LUNDIA AB , TONELLI, Claudio , PARALUPPI, Marco
发明人： TONELLI, Claudio , PARALUPPI, Marco
IPC分类号： A61M39/28
CPC分类号： A61M39/281 , A61M1/16 , A61M2205/18 , A61M2205/50 , A61M2205/702
摘要： A description is given of a method of monitoring the operationality of a flow cut-off member for an extracorporeal fluid circuit (2); also described is a system for arresting the flow of blood that implements this monitoring method; the system comprises a flowcut-off member (9) active on a radially deformable length of tube (10) forming part of the circuit, and a unit (15) capable of casuing a movement of a movable portion (11) of the cut-off membmer towards a closed condition, detecting when the said movable portion passes through a first predetermined position, determining the value assumed by a dynamic parameter associated with the motion of the said movable portion at the first position, and checking that this value is within a predetermined criterion of acceptability; and lastly, a blood treatment appliance (1) is described that implements the described method and system.
摘要翻译：给出了一种用于监测体外流体回路（2）的流动截止部件的操作性的方法的描述; 还描述了实施该监测方法的用于阻止血流的系统; 该系统包括在形成电路的一部分的管（10）的可径向变形的长度上有效的切断构件（9），以及能够启动切断构件的可动部分（11）的运动的单元（15）检测所述可移动部分何时通过第一预定位置，确定由与所述可移动部分在第一位置处的运动相关联的动态参数所假设的值，并且检查该值是否在预定的可接受标准; 最后，描述了实现所述方法和系统的血液处理设备（1）。

9. 发明公开

EP2170968A1 AROMATIC HYDROGENATED POLYMERS CONTAINING FLUORINE 有权
标题翻译： FLUOR含有芳香氢化聚合物
公开(公告)号：EP2170968A1
公开(公告)日：2010-04-07
申请号：EP08775127.7
申请日：2008-07-16
申请人： Solvay Solexis S.p.A.
发明人： TONELLI, Claudio
IPC分类号： C08F283/00 , C08G63/91 , C08G69/48 , C08G85/00 , C08L101/04
CPC分类号： C08G63/916 , C08G63/672 , C08G63/6826 , C08G65/007 , C08G69/26 , C08G69/28 , C08G69/40 , C08G69/42 , C08G69/48 , C08G2650/48 , C08L67/00 , C08L71/02 , C08L77/00 , C08L81/02 , C08L2666/14 , C08L2666/22
摘要： Aromatic hydrogenated polymers comprising perfluoropolyether (PFPE) chains bonded to the aromatic rings to form sequences randomly distributed in the polymer structure, having the formula (I): (T1-CF2O-Rf-CF2)n-T3 in which: n is an integer from 1 to 10, T1 is an aromatic group of the backbone of the hydrogenated polymer, or alternatively condensed aromatic groups, T3 may be equal to T1, or alternatively a functional group -COOH or -COF, Rf is a (per)fluoropolyoxyalkylene chain, in which the starting hydrogenated aromatic polymers are obtained by polycondensation, stepwise polyaddition or polyaddition of cyclic monomers in which the ring is formed by at least 3 atoms.

10. 发明申请

WO2004069312A1 A SUPPORT DEVICE FOR CONTAINERS IN EXTRACORPOREAL BLOOD TREATMENT MACHINES. 审中-公开
标题翻译：超声波血液治疗机器中的容器支持装置。
公开(公告)号：WO2004069312A1
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000061
申请日：2004-01-14
申请人： GAMBRO LUNDIA AB , MEZIERE, Cyril , BARALDI, Vincenzo , TONELLI, Claudio , ZACCARELLI, Massimo , CHEVALLET, Jacques , FRESSINET, Jean Louis , AUDOUARD, Yves
发明人： MEZIERE, Cyril , BARALDI, Vincenzo , TONELLI, Claudio , ZACCARELLI, Massimo , CHEVALLET, Jacques , FRESSINET, Jean Louis , AUDOUARD, Yves
IPC分类号： A61M1/36
CPC分类号： A61M1/16 , A61M1/36 , A61M2209/082
摘要： The support device for bags, applicable in machines for extracorporeal blood treatment or in machines for renal failure treatment, comprises a base body (2) and a support element (3) associated to the base body (2) in such a way as to be displaceable with respect to the base body between at least one operative loading position and an operative work position. In particular the support element (3) is telescopically engaged to the base body (2) and is slidable along a predetermined movement direction (4). The special configuration of the support device enables an easy loading of the machine and a subsequent optimal control of the machine stability.
摘要翻译：适用于体外血液处理的机器或用于肾衰竭治疗的机器中的袋支撑装置包括基体（2）和与基体（2）相关的支撑元件（3），其方式为在至少一个操作装载位置和操作工作位置之间可相对于基体移动。特别地，支撑元件（3）可伸缩地接合到基体（2）并且可沿着预定的移动方向（4）滑动。支撑装置的特殊配置使得能够容易地装载机器并且随后对机器稳定性进行最佳控制。

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