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1. 发明专利

AU2020371001A1 Multi-specific antibody, preparation method therefor and application thereof 未知
公开(公告)号：AU2020371001A1
公开(公告)日：2021-06-10
申请号：AU2020371001
申请日：2020-07-08
申请人： GAO XIN
发明人： GAO XIN , QIAN NILIANG , LI HONGJIE , YANG CUIMA , WANG FUYU , PAN XIUJIE , LIU YUNHUI , HU DONGMEI
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N5/10 , C12N15/13 , C12N15/63
摘要： The present application provides a multi-specific antibody, a preparation method therefor and an application thereof. The multi-specific antibody comprises: a) a Fab fragment capable of specifically binding to a first antigen, wherein the Fab fragment is formed of a light chain, and a CH1 and a variable region of a heavy chain; b) a first peptide linker, the N-terminus of the first peptide linker being fused to the heavy chain; and c) a second peptide linker, the N-terminus of the second peptide linker being fused to the light chain, wherein only one disulfide bond can be formed between the first peptide linker and the second peptide linker, and the first peptide linker and the second peptide linker are independently selected from: a peptide linker containing any of the sequences shown in Seq ID NOs. 1 and 2, wherein X represents any amino acid except Cys, or deletion. The antibody can be easily produced by recombinant expression and can simultaneously target and bind to two different antigens, or different epitopes of a same antigen, or multiple epitopes of more different antigens.

2. 发明专利

AU2003255105A1 TENT 未知
公开(公告)号：AU2003255105A1
公开(公告)日：2004-03-11
申请号：AU2003255105
申请日：2003-08-08
申请人： GAO XIN WEI
发明人： GAO XIN WEI
IPC分类号： E04H15/28
摘要： The present invention relates to a tent including a tent frame and a canvas which covers the periphery of the tent frame, characterized in that the tent frame includes an umbrella-type frame for supporting the canvas and includes a spreader frame for spreading and opening the umbrella-type frame, the spreader frame being positioned in an inner side of an upper part of the umbrella-type frame, the umbrella-type frame including an upper central head in the middle and ribs distributed evenly around the upper central head and hinged to the upper central head, the spreader frame including a lower central head in the middle and spreaders distributed evenly around the lower central head and hinged to the lower central head, outside ends of the spreaders being hinged to upper parts of the ribs. During use, the present apparatus can be pitched and closed like a folding umbrella, is handy and easy to assemble and disassemble, can be adjusted in size in accordance with necessity, and is also substantially advantageous in that it saves time and labor.

3. 发明公开

EP1715730A1 A PHASE SWITCH AND A STANDING WAVE LINEAR ACCELERATOR WITH THE PHASE SWITCH 审中-公开
标题翻译： STEELWELLEN-LINEARBESCHLEUNIGER MIT PHASENSCHALTER
公开(公告)号：EP1715730A1
公开(公告)日：2006-10-25
申请号：EP04733523.7
申请日：2004-05-18
申请人： MIAN YANG GAO XIN QU TWIN PEAK TECHNOLOGY DEVELOP.
发明人： YAO, Chongguo, Room 304, Unit A
IPC分类号： H05H9/04
CPC分类号： H05H9/04
摘要： A phase switch (energy switch) comprising a three-cavity system (an end-coupled cavity + a side-passed accelerate cavity + an end-coupled cavity) and a separate single couple cavity is disclosed. The phase shift between the adjacent accelerate cavities is π when the three-cavities system is disordered (state '0'); and a microwave pass through the three-cavities system to the adjacent accelerate cavities, the phase between the adjacent accelerate cavities is change to 2π (or 0) when the single couple cavity is disordered (state '1'). When the state 0 changes to state 1, the field phase in the structure behind the system is changed to π, thereby to switch the phase. In the two states, the entire structure operates in π/2 mode, that is very stable. That is very important for the medical accelerator. The detaining components have been moved outside the cavity when the single couple cavity or the three-cavity system is in the operate state, without warring about high frequency breakdown. By changing couple between the two end-coupled cavities in the three-cavity system and the adjacent accelerate cavities and between the cavities in the system, the relative field-strength in the acceleration section besides the switching is changed while the phase reverses. It can be used for 6Mev accelerator middle-energy or high-energy accelerator.
摘要翻译：公开了一种包括三腔系统（端耦合腔+侧通加速腔+端耦合腔）和单独耦合腔的相位开关（能量开关）。当三腔系统无序（状态'0'）时，相邻加速腔之间的相移为 - 。并且微波通过三腔系统到相邻的加速腔，当单耦合空腔无序（状态'1'）时，相邻加速腔之间的相位变为2（或0）。当状态0变为状态1时，系统后面的结构中的场相位变为À，从而切换相位。在这两个状态下，整个结构以À/ 2模式运行，非常稳定。这对于医疗加速器非常重要。当单耦合空腔或三腔系统处于工作状态时，锁定部件已经移动到腔体外部，而不会导致高频击穿。通过在三腔系统中的两个端部耦合空腔和相邻加速腔之间以及系统中的空腔之间改变耦合，除了开关之外的加速部分中的相对场强在相位反转时改变。可用于6Mev加速器中能或高能加速器。

4. 发明公开

EP3868788A1 MULTI-SPECIFIC ANTIBODY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 审中-实审
公开(公告)号：EP3868788A1
公开(公告)日：2021-08-25
申请号：EP20878020.5
申请日：2020-07-08
申请人： Gao, Xin
发明人： QIAN, Niliang , LI, Hongjie , YANG, Cuima , WANG, Fuyu , PAN, Xiujie , LIU, Yunhui , HU, Dongmei , GAO, Xin
IPC分类号： C07K16/46 , C12N15/13 , C12N15/63 , C12N5/10 , A61K39/395 , A61P35/00
摘要： The present application provides a multispecific antibody and preparation method and use thereof. The multispecific antibody comprises:
a) a Fab fragment specifically binding to a first antigen, wherein the Fab fragment consists of a light chain and CH1 and a variable region of a heavy chain;
b) a first peptide linker with the N-terminal end fused to the heavy chain;
c) a second peptide linker with the N-terminal end fused to the light chain,
wherein only one disulfide bond can be formed between the first and the second peptide linkers, and each of the first and the second peptide linkers is independently selected from the group consisting of a peptide linker comprising any of the sequences as set forth in SEQ ID NO.1-2, wherein X represents any amino acid other than Cys, or is absent.
The antibody can be readily produced by recombinant expression and can simultaneously target two different antigens or different epitopes of the same antigen, or multiple epitopes of more different antigens.

5. 发明申请

WO2012088643A1 VACUUM CHAMBER METHOD TO FORM POLYMER COATINGS ON POROUS SUPPORT 审中-公开
标题翻译：在多孔支撑上形成聚合物涂层的真空室方法
公开(公告)号：WO2012088643A1
公开(公告)日：2012-07-05
申请号：PCT/CN2010/002227
申请日：2010-12-31
申请人： GENERAL ELECTRIC COMPANY , BARBER, John , YANG, Hai , LU, Su , MACDONALD, Russell, James , DENG, Zhigang , GAO, Xin
发明人： BARBER, John , YANG, Hai , LU, Su , MACDONALD, Russell, James , DENG, Zhigang , GAO, Xin
IPC分类号： H01M4/88 , H01M4/96
CPC分类号： H01M4/0402 , B05D1/32 , B05D5/12 , C02F1/4693 , C02F2001/46128 , C23C18/06 , H01M4/8657 , H01M4/8892 , H01M4/96 , H01M2004/8694 , Y02E60/50
摘要： A bi-polar electrode having ion exchange polymers on opposite faces (13A, 13B) of a porous substrate is formed using a method that includes providing an electrode substrate (12) with activated carbon layers on opposite faces (13A, 13B) of the electrode substrate (12), wherein said faces have an outer perimeter band (14) void of the activated carbon layers. Gaskets (16A, 16B) are placed against the outer perimeter band (14) of the electrode substrate (12) void of activated carbon and the electrode substrate (12) is clamped between two rigid plates (18A, 18B) to form a first airtight chamber (20A) on one side (15A) of the electrode substrate (12) and a second airtight chamber (20B) on the opposite side (15B) of the electrode substrate (12). A first polymerizable monomer mixture having an anion exchange group is added into the first chamber (20A) and a second polymerizable monomer mixture having a cation exchange group is added into the second chamber (20B). The first and second polymerizable monomer mixtures are then polymerized in an oven.
摘要翻译：在多孔基材的相对面（13A，13B）上具有离子交换聚合物的双极电极使用包括在电极的相对面（13A，13B）上设置活性碳层的电极基板（12）衬底（12），其中所述表面具有无活性碳层的外周边带（14）。垫圈（16A，16B）抵靠电极基底（12）的外周带（14）放置在活性炭的空隙处，并且电极基片（12）夹在两个刚性板（18A，18B）之间以形成第一气密在电极基板（12）的一侧（15A）上的室（20A）和电极基板（12）的相对侧（15B）上的第二气密室（20B）。将具有阴离子交换基团的第一可聚合单体混合物加入到第一室（20A）中，并且将具有阳离子交换基团的第二可聚合单体混合物加入到第二室（20B）中。然后将第一和第二可聚合单体混合物在烘箱中聚合。

6. 发明申请

WO2016089432A2 POTENTIAL OF ZERO CHARGE-BASED CAPACITIVE DEIONIZATION 审中-公开
标题翻译：零电荷电容性离子化的潜力
公开(公告)号：WO2016089432A2
公开(公告)日：2016-06-09
申请号：PCT/US2015/000142
申请日：2016-01-15
申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION , GAO, Xin , OMOSEBI, Ayokunle , LANDON, James, Richardson , LIU, Kunlei
发明人： GAO, Xin , OMOSEBI, Ayokunle , LANDON, James, Richardson , LIU, Kunlei
IPC分类号： C02F1/469
CPC分类号： C02F1/4691 , C02F2001/46138 , C02F2209/05
摘要： The invention is a capacitive, aka electrostatic, deionization apparatus and method that solves the problem of short lifetime of conventional capacitive deiohization (CDI) and of membrane capacitive deionization (MCDI) devices and methods by shifting the Potential of Zero Charge of electrode surfaces through surface modifications. Such electrode surface modifications provide very long lifetime capacitive deionization devices and methods.
摘要翻译：本发明是一种电容式静电去离子装置和方法，它解决了常规电容去磁（CDI）和膜电容去离子（MCDI）装置和方法的短寿命问题，通过表面修饰使电极表面零电荷。这种电极表面改性提供了非常长寿命的电容去离子装置和方法。

7. 发明申请

WO2011041013A1 ELECTROCHEMICAL DESALINATION SYSTEM AND METHOD 审中-公开
标题翻译：电化学脱盐系统及方法
公开(公告)号：WO2011041013A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/042505
申请日：2010-07-20
申请人： GENERAL ELECTRIC COMPANY , NIU, Ran , YANG, Hai , BARBER, John, H. , HU, Min , XIONG, Rihua , CAI, Wei , GAO, Xin , LIU, Yunfeng
发明人： NIU, Ran , YANG, Hai , BARBER, John, H. , HU, Min , XIONG, Rihua , CAI, Wei , GAO, Xin , LIU, Yunfeng
IPC分类号： C02F1/469
CPC分类号： C02F1/4691 , C02F2103/08 , C02F2201/46135 , C02F2201/4614 , C02F2209/005
摘要： An electrochemical desalination system (10) includes a first and a second electrochemical device (12, 14) and a controller (18). The first and second electrochemical devices (12, 14) each comprises a electrochemical desalination module comprising at least one pair of electrodes (32, 33, 34, 35) and a compartment between each pair of electrodes (32, 33, 34, 35) for receiving an electrolyte solution. Each of the first and second electrochemical desalination devices comprises a plurality of successive operation cycles. Each cycle comprises a charging mode of operation for charging each pair of electrodes (32, 33, 34, 35) and for adsorbing ions in the electrolyte solution on the electrodes, and a discharging mode of operation for discharging the pair of electrodes (32, 33, 34, 35) and for desorbing ions from the pair of electrodes (32, 33, 34, 35). One of the first and second electrochemical desalination devices is in a discharging mode and the at least one pair of electrodes release electrical current, while the other of the first and second electrochemical desalination devices is in a charging mode of operation and receives the electrical current released from said one of the first and second electrochemical desalination device.
摘要翻译：电化学脱盐系统（10）包括第一和第二电化学装置（12,14）和控制器（18）。第一和第二电化学装置（12,14）各自包括电化学脱盐模块，其包括至少一对电极（32,33,34,35）和每对电极（32,33,34,35）之间的隔室，用于接收电解质溶液。第一和第二电化学脱盐装置中的每一个包括多个连续的操作循环。每个循环包括用于对每对电极（32,33,34,35）充电并用于将电解质中的离子吸附在电极上的充电操作模式，以及用于将一对电极（32,33,34） 33,34,35），并且用于从一对电极（32,33,34,35）解吸离子。第一和第二电化学脱盐装置之一处于放电模式，并且至少一对电极释放电流，而第一和第二电化学脱盐装置中的另一个处于充电操作模式并且接收释放的电流从所述第一和第二电化学脱盐装置中的一个。

8. 发明申请

WO2016089432A3 POTENTIAL OF ZERO CHARGE-BASED CAPACITIVE DEIONIZATION 审中-公开
标题翻译：基于零电荷电容的潜在可能性
公开(公告)号：WO2016089432A3
公开(公告)日：2016-06-30
申请号：PCT/US2015000142
申请日：2016-01-15
申请人： UNIV KENTUCKY RES FOUND , GAO XIN , OMOSEBI AYOKUNLE , LANDON JAMES RICHARDSON , LIU KUNLEI
发明人： GAO XIN , OMOSEBI AYOKUNLE , LANDON JAMES RICHARDSON , LIU KUNLEI
IPC分类号： B01D15/36 , C25B9/04 , H01G2/22 , H01G4/04 , H01G5/012 , H01M10/05
CPC分类号： C02F1/4691 , C02F2001/46138 , C02F2209/05
摘要： The invention is a capacitive, aka electrostatic, deionization apparatus and method that solves the problem of short lifetime of conventional capacitive deiohization (CDI) and of membrane capacitive deionization (MCDI) devices and methods by shifting the Potential of Zero Charge of electrode surfaces through surface modifications. Such electrode surface modifications provide very long lifetime capacitive deionization devices and methods.
摘要翻译：本发明是通过将电极表面的零电荷的电位通过表面移动来解决常规电容脱敏（CDI）和膜电容去离子（MCDI）器件和方法的寿命短的问题的电容性静电去离子装置和方法修改。这种电极表面修饰提供了非常长的寿命的电容去离子器件和方法。

9. 发明申请

WO2005007284A2 COMPOSITE NANOPARTICLES 审中-公开
标题翻译：复合纳米粒子
公开(公告)号：WO2005007284A2
公开(公告)日：2005-01-27
申请号：PCT/GB2004003103
申请日：2004-07-16
申请人： UNIV READING , ASTRAZENECA AB , TSANG SHIK CHI , TAM KIN YIP , GAO XIN
发明人： TSANG SHIK CHI , TAM KIN YIP
IPC分类号： A61K9/16 , A61K9/51 , A61K49/18 , G01N13/00 , B01J13/00
CPC分类号： A61K9/5115 , A61K9/1676 , B82Y5/00 , G01N13/00
摘要： The method of measuring the partition coefficient of a test molecule comprises incorporating the molecule in a composition of nanoparticles having a porous surface and a first solvent, wherein a second solvent has been absorbed into the porous surface, and said first solvent is immiscible with said second solvent, and then separating the nanoparticles and the first solvent. The amount of the molecule which remains in the first solvent is determined to enable calculation of the partition coefficient. The nanoparticles may have a magnetic core to allow easy separation.
摘要翻译：测量分子的分配系数的方法包括将分子掺入具有多孔表面和第一溶剂的纳米颗粒的组合物中，其中第二溶剂已被吸收到多孔表面中，并且所述第一溶剂与所述第二溶剂不混溶溶剂，然后分离纳米颗粒和第一溶剂。确定保留在第一溶剂中的分子的量以能够计算分配系数。纳米颗粒可以具有磁芯以允许容易的分离。

10. 发明申请

WO2012003877A1 MILLING DEVICE WITH ADJUSTABLE MILLING OPERATION 审中-公开
标题翻译：具有可调磨削操作的铣削装置
公开(公告)号：WO2012003877A1
公开(公告)日：2012-01-12
申请号：PCT/EP2010/059872
申请日：2010-07-09
申请人： FREWITT FABRIQUE DE MACHINES SA , GAO, Xin , VIRDIS, Antoine
发明人： GAO, Xin
IPC分类号： B02C4/42 , B02C4/26 , B02C18/26 , B02C18/06
CPC分类号： B02C25/00 , B02C4/26 , B02C4/42 , B02C18/062 , B02C18/144 , B02C18/24 , B02C18/26 , B02C2023/165
摘要： A milling device (1) for performing a milling operation comprising a milling unit (2) comprising a housing (3) defining a milling chamber (16) that can be filled with a material to be milled, a rotor assembly (4) rotatably mounted in the housing (3), and a screen assembly (13) for fractionating the material milled by the rotor assembly (4) in movement and extending below the rotor assembly (4); and a drive unit (20) adapted for controlling the movements of the rotor assembly (4) relative to the screen assembly (13) during the milling operation; wherein said drive unit (20) is configured to produce an oscillating movement of the rotor assembly (4), the oscillating movement having an oscillation angle that can be varied during the milling operation when controlling the movements of the rotor assembly (4) relative to the screen assembly (13). The milling device (1) has improved milling efficiency.
摘要翻译：一种用于执行铣削操作的铣削装置（1），其包括铣削单元（2），所述铣削单元（2）包括限定可被待铣削材料填充的铣削室（16）的壳体（3），转子组件（4）在所述壳体（3）中，以及筛网组件（13），用于分级由所述转子组件（4）铣削的材料移动并延伸到所述转子组件（4）的下方; 以及驱动单元（20），其适于在所述铣削操作期间控制所述转子组件（4）相对于所述筛网组件（13）的运动; 其中所述驱动单元（20）构造成产生所述转子组件（4）的摆动运动，所述摆动运动具有摆动角度，所述摆动角度在所述铣削操作期间可以在控制所述转子组件（4）相对于屏幕组件（13）。铣削装置（1）具有提高的铣削效率。

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