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1. 发明公开

EP1551453A4 SPECIFICITY GRAFTING OF A MURINE ANTIBODY ONTO A HUMAN FRAMEWORK 审中-公开
标题翻译：小鼠抗体与人类框架特异性接枝
公开(公告)号：EP1551453A4
公开(公告)日：2007-04-25
申请号：EP03760462
申请日：2003-06-17
申请人： US GOV HEALTH & HUMAN SERV , UNIV READING
发明人： RYBAK SUSANNA , KRAUSS JURGEN , ARNDT MICHAELA , MARTIN ANDREW C R
IPC分类号： C07K16/28 , C07K16/46 , C12N15/13 , C12P21/08
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00

2. 发明申请

WO2007045893A3 BETA ADRENERGIC RECEPTOR PHARMACOPHORE 审中-公开
标题翻译：抗体药物受体药物（BETA ADRENERGIC RECEPTOR PHARMACOPHORE）
公开(公告)号：WO2007045893A3
公开(公告)日：2007-11-29
申请号：PCT/GB2006003908
申请日：2006-10-20
申请人： UNIV READING , WATSON KIMBERLY ANN , LAMANNA CLAUDIA MARIA PIA
发明人： WATSON KIMBERLY ANN , LAMANNA CLAUDIA MARIA PIA
IPC分类号： C07C217/34 , C07C233/80 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/46 , C07C311/47 , C07D211/58 , C07D215/22 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07F9/30
CPC分类号： C07C311/08 , C07C217/34 , C07C233/43 , C07C233/80 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/46 , C07C311/47 , C07C2601/14 , C07D211/58 , C07D215/22 , C07D215/227 , C07D401/12 , C07D413/14 , C07D417/12 , C07F9/301 , C07F9/304 , C07F9/60 , G01N2333/726
摘要： The invention provides a pharmacophore for identifying or designing an agonist that binds to a beta-3 adrenergic receptor, wherein the pharmacophore requires the following features: (a) a hydrogen accepting group adjacent to an aromatic moiety; (b) an aromatic moiety containing either an hydroxyl group in the para position or a nitrogen atom in the aromatic ring; (c) a chain having a stereogenic centre bearing a hydroxyl group; (d) a hydrophobic chain having a length of 6 carbon atoms or more; and (e) a hydrophobic chain wherein the direction of the hydrophobic chain is conferred by, or is the same as would be conferred by, the presence of an amide moiety at the start of the chain.
摘要翻译：本发明提供了用于鉴定或设计结合β-3肾上腺素能受体的激动剂的药效团，其中所述药效团需要以下特征：（a）与芳族部分相邻的氢接受基团; （b）在对位具有羟基或芳环中的氮原子的芳族部分; （c）具有带有羟基的立体中心的链; （d）长度为6个碳原子或更多的疏水链; 和（e）疏水链，其中所述疏水链的方向由在链起始处的酰胺部分的存在赋予或与之相同。

3. 发明申请

WO03057359A3 MICROPARTICLES AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译：微生物及其生产方法
公开(公告)号：WO03057359A3
公开(公告)日：2003-08-28
申请号：PCT/GB0300029
申请日：2003-01-07
申请人： UNIV READING , TSANG SHIK CHI , CHAN HENRY BO SO
发明人： TSANG SHIK CHI , CHAN HENRY BO SO
IPC分类号： A61K9/50 , A61K9/51 , A61K47/48 , B01J13/02 , C01G49/00 , C01G51/00 , C09C1/24 , C09C3/12 , C01B31/02 , C09C3/06
CPC分类号： C09C3/12 , A61K51/1244 , B01J13/025 , B82Y30/00 , C01G49/00 , C01G49/0018 , C01G49/08 , C01G51/00 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/42 , C09C1/24
摘要： Microparticles having a metal-containing core encapsulated in a graphitic shell containing hetero atoms are made by forming, in a liquid medium, colloidal particles containing a metal-oxo species of Fe, Co, Ni and Pd, colloidally stabilized by a surfactant and containing source material of carbon and the hetero atoms. These particles are pyrolyzed in inert gas to yield the microparticles. In an alternative method, silica gel coated particles are formed by colloidally stabilizing particles containing metal species and forming silica at the boundary of the stabilized particle.
摘要翻译：具有包含含有杂原子的石墨壳的含金属核的微粒通过在液体介质中形成含有由表面活性剂和含有源的胶体稳定的Fe，Co，Ni和Pd的金属氧代物质的胶体颗粒碳和杂原子的材料。这些颗粒在惰性气体中热解产生微粒。在替代方法中，硅胶涂覆的颗粒通过胶体稳定包含金属物质的颗粒并在稳定化颗粒的边界处形成二氧化硅形成。

4. 发明申请

WO2012131296A3 DEPOSITION METHOD AND PRODUCT OBTAINED THEREBY 审中-公开
标题翻译：沉积方法和产品获得
公开(公告)号：WO2012131296A3
公开(公告)日：2013-09-26
申请号：PCT/GB2012000279
申请日：2012-03-27
申请人： UNIV READING , SQUIRES ADAM , ELLIOTT JOANNE MARGARET , AKBAR SAMINA
发明人： SQUIRES ADAM , ELLIOTT JOANNE MARGARET , AKBAR SAMINA
IPC分类号： C25D3/50 , C25D5/10 , C25D5/34 , H01L31/02 , H01L31/18 , H01M4/04 , H01M4/48 , H01M4/86 , H01M4/88 , H01M4/90 , H01M14/00
CPC分类号： C25D3/50 , C25D5/10 , C25D5/34 , H01L31/022425 , H01L31/022466 , H01L31/1884 , H01M4/0438 , H01M4/48 , H01M4/8605 , H01M4/8853 , H01M4/9016 , H01M14/005 , Y02E10/50
摘要： The invention relates to a process for the preparation of porous or nanostructured, materials comprising metals and other materials, in which a thin layer of a structure-directing agent such as a non-ionic amphiphile in a solvent is applied to a substrate and material deposited onto the substrate electrolytically. The structure directing agent is present as an inverse lyotropic liquid crystalline phase. The process has several practical advantages over known techniques employing a bulk liquid crystalline phase. The films have unexpected properties.
摘要翻译：本发明涉及一种制备多孔或纳米结构材料的方法，其包括金属和其它材料，其中在溶剂中的结构导向剂例如非离子两亲物的薄层施加到基底上并沉积材料电解后在基板上。结构导向剂作为反溶致液晶相存在。该方法与使用本体液晶相的已知技术相比具有若干实际优点。这些电影具有意想不到的特性。

5. 发明申请

WO9015145A3 POLIOVIRUS CHIMAERAS 审中-公开
公开(公告)号：WO9015145A3
公开(公告)日：1991-01-24
申请号：PCT/GB9000841
申请日：1990-05-31
申请人： MEDICAL RES COUNCIL , UNIV READING
发明人： ALMOND JEFFREY WILLIAM , EVANS DAVID JOHN , BURKE KAREN LESLEY
IPC分类号： C07K14/005 , C07K14/025 , C07K14/16 , C07K14/295 , C07K14/73 , C12N15/86 , A61K39/12 , A61K39/13 , C12N7/01
CPC分类号： C12N15/86 , C07K14/005 , C07K14/295 , C07K14/70514 , C12N2710/20022 , C12N2740/16122 , C12N2770/32622
摘要： A cassette vector suitable for use in constructing poliovirus chimaeras, which vector comprises, under the control of a promoter, a full length infectious cDNA of an attenuated strain of type 1 poliovirus having Sal 1 and Dra 1 sites flanking atigenic site 1 of the poliovirus (I), where the numbers represent the numbers of amino acids of the VP1 capsid protein and X represents intervening nucleotides of DNA, present in sufficient numbers to allow the vector to be digested with both Sal 1 and Dra 1, the said Sal 1 and Dra 1 sites being the only Sal 1 and Dra 1 sites in the vector.

6. 发明申请

WO2010082067A2 PROCESSORS 审中-公开
公开(公告)号：WO2010082067A2
公开(公告)日：2010-07-22
申请号：PCT/GB2010050064
申请日：2010-01-15
申请人： UNIV READING , LEACH STEPHEN FREDERICK KNIGHT , ANDERSON JAMES ARTHUR DEAN WALLACE
发明人： LEACH STEPHEN FREDERICK KNIGHT , ANDERSON JAMES ARTHUR DEAN WALLACE
IPC分类号： G06F15/173 , H04L12/43
CPC分类号： G06F15/17312 , G06F15/17337 , H04L45/00 , H04L45/74
摘要： A processing system comprises a plurality of processors (12) and communication means (20) arranged to carry messages between the processors, wherein each of the processors (12) has an operating instruction memory field (32, 34, 36) arranged to hold stored operating instructions including a re-routing target address. Each processor is arranged to receive a message (38) including operating instructions including a target address. On receipt of the message, each processor is arranged to: check the target address in the message to determine whether it corresponds to an address associated with the processor; if the target address in the message does correspond to an address associated with the processor, to check the operating instructions in the message to determine whether the message is to be re-routed; and, if the message is to be re- routed, to replace operating instructions within the message with the stored operating instructions, and place the message on the communication means for delivery to the re-routing target address.
摘要翻译：处理系统包括多个处理器（12）和布置成在处理器之间传送消息的通信装置（20），其中每个处理器（12）具有操作指令存储器字段（32,34,36），其被布置为保存存储操作指令包括重新路由目标地址。每个处理器被布置成接收包括包括目标地址的操作指令的消息（38）。在接收到消息时，每个处理器被设置为：检查消息中的目标地址以确定它是否对应于与处理器相关联的地址; 如果消息中的目标地址确实对应于与处理器相关联的地址，则检查消息中的操作指令以确定消息是否被重新路由; 并且如果消息要被重新路由，则用存储的操作指令来替换消息内的操作指令，并将消息放置在通信装置上以传送到重路由目标地址。

7. 发明申请

WO03033681A3 COMPOSITION COMPRISING A LACTOBACILLUS PENTOSUS STRAIN AND USES THEREOF 审中-公开
标题翻译：包含乳酸杆菌木粉菌株的组合物及其用途
公开(公告)号：WO03033681A3
公开(公告)日：2003-09-04
申请号：PCT/EP0211428
申请日：2002-10-11
申请人： UNIV READING , WYNNE ANTHONY G , GIBSON GLENN R , BROSTOFF JONATHAN
发明人： WYNNE ANTHONY G , GIBSON GLENN R , BROSTOFF JONATHAN
IPC分类号： A61K31/65 , A61K35/74 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/02 , A61P31/04 , A61P31/10 , A61P37/04 , C12N1/00 , C12N1/20
CPC分类号： C12N1/20 , A61K31/65 , A61K35/747 , C12R1/225 , A61K2300/00
摘要： A novel probiotic strain termed Lactobacillus pentosus NCIMB 41114 is capable of preventing growth of pathogenic microorganisms in the GI tract. In particular, this bacterium inhibits Candida overgrowth, and can be employed to prevent and treat associated diseases, including IBS and thrush.
摘要翻译：称为乳酸乳杆菌NCIMB 41114的新型益生菌菌株能够预防GI道中病原微生物的生长。特别地，这种细菌抑制念珠菌过度生长，可用于预防和治疗相关疾病，包括IBS和鹅口疮。

8. 发明申请

WO2005007284A2 COMPOSITE NANOPARTICLES 审中-公开
标题翻译：复合纳米粒子
公开(公告)号：WO2005007284A2
公开(公告)日：2005-01-27
申请号：PCT/GB2004003103
申请日：2004-07-16
申请人： UNIV READING , ASTRAZENECA AB , TSANG SHIK CHI , TAM KIN YIP , GAO XIN
发明人： TSANG SHIK CHI , TAM KIN YIP
IPC分类号： A61K9/16 , A61K9/51 , A61K49/18 , G01N13/00 , B01J13/00
CPC分类号： A61K9/5115 , A61K9/1676 , B82Y5/00 , G01N13/00
摘要： The method of measuring the partition coefficient of a test molecule comprises incorporating the molecule in a composition of nanoparticles having a porous surface and a first solvent, wherein a second solvent has been absorbed into the porous surface, and said first solvent is immiscible with said second solvent, and then separating the nanoparticles and the first solvent. The amount of the molecule which remains in the first solvent is determined to enable calculation of the partition coefficient. The nanoparticles may have a magnetic core to allow easy separation.
摘要翻译：测量分子的分配系数的方法包括将分子掺入具有多孔表面和第一溶剂的纳米颗粒的组合物中，其中第二溶剂已被吸收到多孔表面中，并且所述第一溶剂与所述第二溶剂不混溶溶剂，然后分离纳米颗粒和第一溶剂。确定保留在第一溶剂中的分子的量以能够计算分配系数。纳米颗粒可以具有磁芯以允许容易的分离。

9. 发明申请

WO0001947A3 PUMP MECHANISM 审中-公开
标题翻译：泵机构
公开(公告)号：WO0001947A3
公开(公告)日：2002-09-19
申请号：PCT/GB9902200
申请日：1999-07-07
申请人： UNIV READING , BURTON JOHN DAVID
发明人： BURTON JOHN DAVID
IPC分类号： F04B11/00 , F04B49/24
CPC分类号： F04B49/24 , F04B11/00
摘要： A pumping mechanism has a pumping chamber (5) which receives a liquid such as water from a liquid supply (1) and from which the liquid is driven in a driving phase of the pumping cycle by an actuator (4) into a discharge conduit (6, 8) and in the discharge conduit (6, 8) to an outlet. In addition, liquid passes from the liquid supply (1) to a by-pass conduit (7) to the outlet (3) via at least part of the discharge conduit (6, 8) without having passed through the pumping chamber (5). This arrangement absorbs energy during the driving phase, which energy is released to drive liquid via the by-pass conduit (7) to the outlet (3) at another part of the pumping cycle. The discharge conduit (6, 8) and the by-pass conduit (7) act as fluid inductances (L1, L3, L2). A chamber (9) with a resilient wall may be provided to receive liquid during the driving phase and so act as a liquid capacitance.
摘要翻译：泵送机构具有泵送室（5），其从液体供应源（1）接收诸如水的液体，并且通过致动器（4）将液体从泵送循环的驱动阶段驱动到排出管道中 6,8）和排放管道（6,8）中的一个出口。此外，液体从液体供应源（1）通过排出管道（6,8）的至少一部分而不经过泵送室（5）从旁路管道（7）流到出口（3）。这种布置在驱动阶段吸收能量，该能量被释放以在另一部分泵送循环中通过旁通管道（7）驱动液体到出口（3）。排放管道（6,8）和旁通管道（7）用作流体电感（L1，L3，L2）。可以提供具有弹性壁的室（9）以在驱动阶段期间接收液体，并且作为液体电容。

10. 发明申请

WO0136979A3 PLACENTAL HUMAN NEUROKININ B PRECURSOR 审中-公开
标题翻译：普通人神经元B前列腺
公开(公告)号：WO0136979A3
公开(公告)日：2002-05-02
申请号：PCT/GB0004315
申请日：2000-11-10
申请人： UNIV READING , PAGE NIGEL , LOWRY PHILLIP
发明人： PAGE NIGEL , LOWRY PHILLIP
IPC分类号： G01N33/53 , A61K38/00 , A61K38/04 , A61K45/00 , A61P9/00 , A61P9/12 , A61P15/00 , C07K7/08 , C12N15/09 , C12Q1/68 , G01N33/68 , G01N33/74
CPC分类号： G01N33/689 , A61K38/046 , G01N33/74 , G01N2410/00 , G01N2800/368
摘要： Methods of diagnosing pregnancy induced hypertension or pre-eclampsia by the measuremnt of the production of neurokinin B, its precursor and fragments thereof are provided, as are kits for use in the methods. Treatments of the conditions and methods of preparing suitable medicaments are also provided as are antibodies and useful antigenic materials.
摘要翻译：提供了通过测量神经激肽B的产生，其前体和片段来诊断妊娠诱发的高血压或先兆子痫的方法，以及用于该方法的试剂盒。还提供了制备合适药物的条件和方法的处理，抗体和有用的抗原性材料。

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