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1. 发明公开

EP0707464A4 OCULAR INSERT WITH ANCHORING PROTRUSIONS 失效
标题翻译：眼睛固定凸起USE
公开(公告)号：EP0707464A4
公开(公告)日：1997-03-26
申请号：EP94923238
申请日：1994-06-20
申请人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
发明人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00
CPC分类号： A61F9/0017 , A61K9/0051

2. 发明公开

EP0707464A1 OCULAR INSERT WITH ANCHORING PROTRUSIONS 失效
标题翻译：眼睛固定凸起USE
公开(公告)号：EP0707464A1
公开(公告)日：1996-04-24
申请号：EP94923238.0
申请日：1994-06-20
申请人： Darougar, Sohrab , Weiner, Alan L. , Bhatt, Padmanabh Pravinchandra , Raul, Victor Albert , Gantner, David Clayton
发明人： Darougar, Sohrab , Weiner, Alan L. , Bhatt, Padmanabh Pravinchandra , Raul, Victor Albert , Gantner, David Clayton
IPC分类号： A61F9 , A61K9 , B82B1
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. As shown in Figure 7, the device (70) with ribbed configuration has circular cylindrical walls (72) with domed end portions (74). A series of arcuate shaped ribs (76), of circular, toroidal cross section, are provided at intervals along the length of the device (70).

3. 发明申请

WO2005051442A1 METHOD FOR ADHERING SILICONE GELS TO PLASTICS 审中-公开
标题翻译：将硅胶粘附到塑料上的方法
公开(公告)号：WO2005051442A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/032568
申请日：2004-09-30
申请人： DOW CORNING CORPORATION , GANTNER, David, Clayton , LOUBERT, Gary, Lee , SCHALAU, Gerald, Kenneth, II , THOMAS, Xavier, Jean-Paul
发明人： GANTNER, David, Clayton , LOUBERT, Gary, Lee , SCHALAU, Gerald, Kenneth, II , THOMAS, Xavier, Jean-Paul
IPC分类号： A61L15/58
CPC分类号： A61L15/58 , A61L24/046 , A61L31/06 , C08L83/00 , C09J5/02 , C08L83/04
摘要： A method for increasing the adherence of a silicone gel to a substrate using a primer material. The method is particularly useful for adhering a medical prosthesis to a human or animal body.
摘要翻译：使用底漆材料增加硅凝胶对基材的粘附性的方法。该方法对于将医疗假体粘附到人或动物身体特别有用。

4. 发明申请

WO1995001764A2 OCULAR INSERT WITH ANCHORING PROTRUSIONS 审中-公开
标题翻译：具有锚定推理的OCULAR插入
公开(公告)号：WO1995001764A2
公开(公告)日：1995-01-19
申请号：PCT/US1994007136
申请日：1994-06-20
申请人： DAROUGAR, Sohrab , WEINER, Alan, L. , BHATT, Padmanabh, Pravinchandra , RAUL, Victor, Albert , GANTNER, David, Clayton
IPC分类号： A61F09/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs (76), screw threads (86), dimples or bumps (92), truncated cone-shaped segments (102) or winding braid segments (113). In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.
摘要翻译：一种柔性眼部插入装置，适于将眼药物的受控持续释放到眼睛中。在一个实施方案中，该装置包括呈杆形或管状形式的聚合物材料的细长体，其包含药物活性成分，并具有至少两个从身体径向向外延伸的锚定突起。该装置具有至少8mm的长度，并且其主体部分包括突起的直径不超过1.9mm。持续释放机制可以例如通过扩散或渗透或生物侵蚀。插入装置有利地插入到眼睛的上部或下部穹窿中，以便凭借穹窿解剖结构独立于眼睛的移动。突起可以是各种形状，例如肋（76），螺纹（86），凹坑或凸起（92），截头圆锥形段（102）或卷绕编织段（113）。在另一个实施方案中，用于身体的聚合物材料选择为在液体环境中溶胀的聚合物材料。因此，可以采用较小初始尺寸的装置。本插入装置的尺寸和构造使得在插入上部或下部穹窿中时，该装置保持离开视野，以便在长时间的使用中被良好地保持在适当位置并且被患者察觉不到。该装置可以保留在上，下穹顶7至14天或更长时间。

5. 发明申请

WO2008057155A1 SILICONE SKIN ADHESIVE GELS 审中-公开
标题翻译：硅胶粘合胶
公开(公告)号：WO2008057155A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/019781
申请日：2007-09-12
申请人： DOW CORNING CORPORATION , GANTNER, David, Clayton , SCHALAU, Gerald, K., II , THOMAS, Xavier, Jean-Paul
发明人： GANTNER, David, Clayton , SCHALAU, Gerald, K., II , THOMAS, Xavier, Jean-Paul
IPC分类号： C09J183/04
CPC分类号： C09J183/04 , C08L83/00
摘要： This invention pertains to silicone gel forming compositions that have an average RHAIk of 0.7 to 1.5, typically 0.8 to 0.95 and with an average RH CE of 0.4 to 1, typically 0.8 to 0.95 and the silicone gels produced by curing the gel forming composition. These gels are suitable for temporarily adhering a medical device to a biological substrate such as skin. The silicone gels provide high adhesion to skin and low peel release force from polyethylene substrate.
摘要翻译：本发明涉及具有平均RHAIk为0.7至1.5，通常为0.8至0.95，平均RH CE为0.4至1，通常为0.8至0.95的硅凝胶形成组合物，并且由固化凝胶形成组合物。这些凝胶适用于临时将医疗装置粘附到诸如皮肤的生物基底上。硅氧烷凝胶对皮肤提供高粘合力，并且聚乙烯基材具有低的剥离力。

6. 发明申请

WO2005102403A1 SILICONE SKIN ADHESIVE GELS 审中-公开
标题翻译：硅胶粘合胶
公开(公告)号：WO2005102403A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/009518
申请日：2005-03-18
申请人： DOW CORNING CORPORATION , GANTNER, David, Clayton , THOMAS, Xavier, Jean-Paul
发明人： GANTNER, David, Clayton , THOMAS, Xavier, Jean-Paul
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , A61L15/58 , C08L83/04
摘要： A method for adhering a medical substrate to a human or animal using a silicone gel containing a hydroxy substituted siloxane resin.
摘要翻译：一种使用含有羟基取代的硅氧烷树脂的硅凝胶将医用基材粘合到人或动物的方法。

7. 发明专利

CA2165071A1 Ocular Insert with Anchoring Protrusions 未知
公开(公告)号：CA2165071A1
公开(公告)日：1995-01-19
申请号：CA2165071
申请日：1994-06-20
申请人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
发明人： DAROUGAR SOHRAB , WEINER ALAN L , BHATT PADMANABH PRAVINCHANDRA , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00 , A61M31/00
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments. In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.

8. 发明申请

WO2007139812A3 NOVEL SILICONE FILM FORMER FOR DELIVERY OF ACTIVES 审中-公开
标题翻译：用于交付活动的新型硅胶膜
公开(公告)号：WO2007139812A3
公开(公告)日：2008-03-27
申请号：PCT/US2007012260
申请日：2007-05-23
申请人： DOW CORNING , GENENCOR INT , THOMAS XAVIER , CAPRASSE VIRGINIE , JOFFRE ERIC JUDE , KOLLAR CSILLA , GANTNER DAVID CLAYTON , RAUL VICTOR A
发明人： THOMAS XAVIER , CAPRASSE VIRGINIE , JOFFRE ERIC JUDE , KOLLAR CSILLA , GANTNER DAVID CLAYTON , RAUL VICTOR A
IPC分类号： A61K31/695
CPC分类号： A61K9/7015 , A61K9/7069 , C08G77/14 , C08G77/388 , C08K5/55 , C08L83/06 , C08L83/08 , C08L83/00
摘要： The invention provides: a film-forming composition comprising a) a saccharide- siloxane copolymer; b) a crossl inking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the the saccharide-siloxane copolymer has the following formula: R 2 aR 1 (3-a)SiO-[( SiR 2 R 1 O)m-( SiR 1 2O)n ]y- SiR 1 (3-a) R 2 a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component; films; and methods related thereto. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.
摘要翻译：本发明提供：一种成膜组合物，其包含：a）糖 - 硅氧烷共聚物; b）交联剂; c）一种或多种活性/不活泼成分; 和d）任选的溶剂或溶剂混合物，其中所述糖 - 硅氧烷共聚物具有下式：R 2 a a R 1（3-a）SiO- [ （SiR 2 R 1 O）m - （SiR 1 2 O）n] y -SiR 1（3） -a）R 2进一步公式定义，其中糖 - 硅氧烷共聚物是官能化的有机硅氧烷聚合物和至少一种羟基官能糖的反应产物，使得有机硅氧烷组分共价连接通过与糖组分的连接基团; 薄膜; 和相关的方法。本发明还提供包括局部和透皮剂递送贴片的制品，其包含新的成膜组合物和/或膜。

9. 发明申请

WO2007139812A2 NOVEL SILICONE FILM FORMER FOR DELIVERY OF ACTIVES 审中-公开
标题翻译：用于交付活动的新型硅胶膜
公开(公告)号：WO2007139812A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012260
申请日：2007-05-23
申请人： DOW CORNING CORPORATION , GENENCOR INTERNATIONAL, INC. , KOLLAR, Csilla , THOMAS, Xavier , CAPRASSE, Virginie , JOFFRE, Eric, Jude , GANTNER, David, Clayton , RAUL, Victor, A.
发明人： KOLLAR, Csilla , THOMAS, Xavier , CAPRASSE, Virginie , JOFFRE, Eric, Jude , GANTNER, David, Clayton , RAUL, Victor, A.
IPC分类号： H01L51/00
CPC分类号： A61K9/7015 , A61K9/7069 , C08G77/14 , C08G77/388 , C08K5/55 , C08L83/06 , C08L83/08 , C08L83/00
摘要： The invention provides: a film-forming composition comprising a) a saccharide- siloxane copolymer; b) a crossl inking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the the saccharide-siloxane copolymer has the following formula: R 2 aR 1 (3-a)SiO-[( SiR 2 R 1 O)m-( SiR 1 2O)n ]y- SiR 1 (3-a) R 2 a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component; films; and methods related thereto. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.
摘要翻译：本发明提供：一种成膜组合物，其包含a）糖 - 硅氧烷共聚物; b）交联剂; c）一种或多种活性/非活性成分; 和d）任选的溶剂或溶剂混合物，其中所述糖 - 硅氧烷共聚物具有下式：R 2 a a R 1（3-a）SiO- [ （SiR 2 R 1 O）m - （SiR 1 2 O）n] y -SiR 1（3） -a）R 2进一步定义并且其中所述糖 - 硅氧烷共聚物是官能化的有机硅氧烷聚合物和至少一种羟基官能糖的反应产物，使得所述有机硅氧烷组分共价连接通过与糖组分的连接基团; 薄膜; 和相关的方法。本发明还提供了包括局部和透皮剂递送贴片的制品，其包含新的成膜组合物和/或膜。

10. 发明申请

WO2007084266A3 SILICONE ADHESIVE FOR ADHESION TO WET SURFACES 审中-公开
标题翻译：有机硅粘合剂，用于粘接潮湿表面
公开(公告)号：WO2007084266A3
公开(公告)日：2007-11-29
申请号：PCT/US2007000062
申请日：2007-01-03
申请人： DOW CORNING , SCHALAU GERALD KENNETH II , THOMAS XAVIER JEAN-PAUL , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
发明人： SCHALAU GERALD KENNETH II , THOMAS XAVIER JEAN-PAUL , RAUL VICTOR ALBERT , GANTNER DAVID CLAYTON
IPC分类号： C09J183/04 , A61K9/70
CPC分类号： A61K9/7069 , A61K9/7007 , A61M5/14248 , A61M2205/0205 , A61M2205/0238 , C08G2170/40 , C08L83/00 , C09J183/04
摘要： A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups; (ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm 2 / s at 25 o C; (iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm 2 / s at 25 o C; (iv) a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and optionally, (v) a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds. Other components such as a silicone polyether, a silicone wax, a drug, an excipient, and/or an active ingredient can also be included.
摘要翻译：用于将装置或物质粘附到湿表面上的有机硅粘合剂组合物包含（i）硅氧烷树脂，其是三烷基可水解硅烷和硅酸烷基酯的共水解产物，其中共水解产物含有多个与硅键合的羟基 ; （ii）含有末端硅键合羟基的线性有机聚硅氧烷流体，其在25℃具有200,000mm 2 / s以上的粘度; （iii）在25℃下粘度为100,000-600,000mm 2 / s的三烷基甲硅烷氧基封端的聚有机硅氧烷流体; （iv）选自分子量为100,000至8,000,000的聚（环氧乙烷）聚合物，分子量为500,000至4,500,000,000的丙烯酸聚合物和羟乙基纤维素聚合物的水溶性粘膜粘合剂聚合物，所述羟乙基纤维素聚合物具有分子量为90,000至1,300,000,000; 和（v）选自脂族烃，芳族烃，酯，挥发性直链和环状硅氧烷化合物的溶剂。也可以包括其他组分，例如硅酮聚醚，硅酮蜡，药物，赋形剂和/或活性成分。

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