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1. 发明授权

US08010184B2 Method and apparatus for automatically characterizing a malignancy 有权
标题翻译：用于自动表征恶性肿瘤的方法和装置
公开(公告)号：US08010184B2
公开(公告)日：2011-08-30
申请号：US11291830
申请日：2005-11-30
申请人： Ricardo Avila , Floribertus Heukensfeldt Jansen , Dinko Gonzalez Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
发明人： Ricardo Avila , Floribertus Heukensfeldt Jansen , Dinko Gonzalez Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
IPC分类号： A61B5/055
CPC分类号： G01T1/1611 , A61B6/037 , A61B34/10 , G01R33/4808 , G01R33/481 , G01R33/4812 , G01R33/4814
摘要： A region of interest is automatically evaluated. The automatic evaluation is based on assessments of one or more characteristics. The one or more characteristics of the region of interest are assessed in a plurality of image data sets acquired by a respective plurality of imaging modalities. In some embodiments, the evaluation is based on assessments of one or more characteristics for each region of interest derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.
摘要翻译：自动评估感兴趣的区域。自动评估是基于一个或多个特征的评估。在由相应的多个成像模式获取的多个图像数据集中评估感兴趣区域的一个或多个特征。在一些实施例中，评估基于从结构和功能图像数据的组合导出的每个感兴趣区域的一个或多个特征的评估。在一个实施例中，该组结构图像数据是一组CT图像数据，并且功能图像数据集合是一组PET图像数据。在结构和/或功能图像数据中可以通过自动程序或临床医生或其他审查者的目视检查来检测一个或多个损伤。

2. 发明申请

US20070167697A1 Method and apparatus for automatically characterizing a malignancy 有权
标题翻译：用于自动表征恶性肿瘤的方法和装置
公开(公告)号：US20070167697A1
公开(公告)日：2007-07-19
申请号：US11291830
申请日：2005-11-30
申请人： Ricardo Avila , Floribertus Jansen , Dinko Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
发明人： Ricardo Avila , Floribertus Jansen , Dinko Trotter , James Miller , Ravindra Manjeshwar , Thomas Sebastian
IPC分类号： A61B5/05
CPC分类号： G01T1/1611 , A61B6/037 , A61B34/10 , G01R33/4808 , G01R33/481 , G01R33/4812 , G01R33/4814
摘要： A malignancy probability is automatically calculated for one or more lesions. The malignancy probability is based on assessments of one or more malignancy characteristics for each lesion derived from two or more structural and/or functional image data sets. Likewise, in some embodiments, the malignancy probability is based on assessments of one or more malignancy characteristics for each lesion derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.
摘要翻译：自动计算一个或多个病变的恶性概率。恶性概率基于从两个或多个结构和/或功能图像数据集导出的每个病变的一个或多个恶性特征的评估。类似地，在一些实施例中，恶性概率基于从结构和功能图像数据的组合导出的每个损伤的一个或多个恶性特征的评估。在一个实施例中，该组结构图像数据是一组CT图像数据，并且功能图像数据集合是一组PET图像数据。在结构和/或功能图像数据中可以通过自动程序或临床医生或其他审查者的目视检查来检测一个或多个损伤。

3. 发明申请

US20060097175A1 Method and system for imaging a patient 有权
公开(公告)号：US20060097175A1
公开(公告)日：2006-05-11
申请号：US10985752
申请日：2004-11-10
申请人： Alexander Ganin , Floribertus Philippus Martinus Jansen , Ricardo Avila , Dinko Eduardo Trotter , Ravindra Manjeshwar , James Miller , Thomas Sebastian
发明人： Alexander Ganin , Floribertus Philippus Martinus Jansen , Ricardo Avila , Dinko Eduardo Trotter , Ravindra Manjeshwar , James Miller , Thomas Sebastian
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1611 , G01T1/1615
摘要： Methods and systems for imaging a patient are provided. The method includes determining a location of a volume of interest within the patient and acquiring a plurality of frames of emission data, at least one frame including the volume of interest. The method further includes determining a time-of-flight (TOF) information of at least a portion of the annihilations detected along a line of response between corresponding coincidence detectors and generating an image of the patient from the emission data using the determined TOF information.

4. 发明申请

US20070205368A1 Method and system for calibrating a time of flight positron emission tomography system 失效
标题翻译：校准飞行时间正电子发射断层扫描系统的方法和系统
公开(公告)号：US20070205368A1
公开(公告)日：2007-09-06
申请号：US11786951
申请日：2007-04-13
申请人： Floribertus Heukensfeldt Jansen , Ravindra Manjeshwar
发明人： Floribertus Heukensfeldt Jansen , Ravindra Manjeshwar
IPC分类号： G01T1/161
CPC分类号： G01T1/2985
摘要： A method and system for calibrating a time of flight (TOF) positron emission tomography (PET) scanner are provided. The method stores acquired scan data from detector pairs including data and timing information. The method further calculates an intensity distribution of emission sources based on the scan data and defines a timing pivot point based on a median of an intensity histogram. The method determines a timing correction for each detector based on the location of the timing pivot point. The positron emission tomography (PET) system further provides a plurality of detectors, used in performing imaging scans, and a processor. The processor is configured to determine a timing correction for each detector.
摘要翻译：提供了一种用于校准飞行时间（TOF）正电子发射断层摄影（PET）扫描仪的方法和系统。该方法存储来自检测器对的获取的扫描数据，包括数据和定时信息。该方法还基于扫描数据计算发射源的强度分布，并且基于强度直方图的中值来定义定时枢轴点。该方法基于定时枢轴点的位置确定每个检测器的定时校正。正电子发射断层摄影（PET）系统还提供用于执行成像扫描的多个检测器和处理器。处理器被配置为确定每个检测器的定时校正。

5. 发明申请

US20070040122A1 Technique for reconstructing PET scan images 有权
标题翻译： PET扫描图像重建技术
公开(公告)号：US20070040122A1
公开(公告)日：2007-02-22
申请号：US11205067
申请日：2005-08-17
申请人： Ravindra Manjeshwar , Floribertus Heukensfeldt Jansen , Charles Stearns
发明人： Ravindra Manjeshwar , Floribertus Heukensfeldt Jansen , Charles Stearns
IPC分类号： G01T1/164
CPC分类号： G01T1/2985
摘要： The invention is directed to a technique for reconstructing PET scan images. According to one embodiment, the invention relates to a method for reconstructing PET scan images. The method comprises: detecting a plurality of coincidence events in a PET scanner; storing data associated with the plurality of coincidence events in a chronological list based on a detection time for each of the plurality of coincidence events; generating correction data based on scatter coincidence events and random coincidence events in the plurality of coincidence events; and reconstructing one or more PET scan images based at least in part on the chronological list of data and the correction data.
摘要翻译：本发明涉及一种重建PET扫描图像的技术。根据一个实施例，本发明涉及一种重建PET扫描图像的方法。该方法包括：在PET扫描器中检测多个符合事件; 基于多个重合事件中的每一个的检测时间，将与所述多个重合事件相关联的数据存储在时序列表中; 基于所述多个重合事件中的分散符合事件和随机符合事件生成校正数据; 以及至少部分地基于时间顺序的数据列表和校正数据重建一个或多个PET扫描图像。

6. 发明授权

US08575555B2 Nuclear medicine imaging system and method using multiple types of imaging detectors 有权
标题翻译：核医学成像系统和使用多种成像检测器的方法
公开(公告)号：US08575555B2
公开(公告)日：2013-11-05
申请号：US13077540
申请日：2011-03-31
申请人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
发明人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
IPC分类号： G01T1/166
CPC分类号： G01T1/166 , A61B6/037 , G01T1/1603 , G01T1/1644 , G01T1/249
摘要： A Nuclear Medicine (NM) imaging system and method using multiple types of imaging detectors are provided. One NM imaging system includes a gantry, at least a first imaging detector coupled to the gantry, wherein the first imaging detector is a non-moving detector, and at least a second imaging detector coupled to the gantry, wherein the second imaging detector is a moving detector. The first imaging detector is larger than the second imaging detector and the first and second imaging detectors have different detector configurations. The NM imaging system further includes a controller configured to control the operation of the first and second imaging detectors during an imaging scan of an object to acquire Single Photon Emission Computed Tomography (SPECT) image information such that at least the first imaging detector remains stationary with respect to the gantry during image acquisition.
摘要翻译：提供了使用多种成像检测器的核医学（NM）成像系统和方法。一个NM成像系统包括台架，至少第一成像检测器，其耦合到台架，其中第一成像检测器是非移动检测器，以及耦合到台架的至少第二成像检测器，其中第二成像检测器是移动探测器。第一成像检测器大于第二成像检测器，并且第一和第二成像检测器具有不同的检测器配置。 NM成像系统还包括控制器，其被配置为在对象的成像扫描期间控制第一和第二成像检测器的操作，以获取单光子发射计算机断层扫描（SPECT）图像信息，使得至少第一成像检测器保持静止，在图像采集期间对台架的尊重。

7. 发明申请

US20120248320A1 NUCLEAR MEDICINE IMAGING SYSTEM AND METHOD USING MULTIPLE TYPES OF IMAGING DETECTORS 有权
标题翻译：核医学成像系统和使用多种成像检测器的方法
公开(公告)号：US20120248320A1
公开(公告)日：2012-10-04
申请号：US13077540
申请日：2011-03-31
申请人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
发明人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
IPC分类号： G01T1/166
CPC分类号： G01T1/166 , A61B6/037 , G01T1/1603 , G01T1/1644 , G01T1/249
摘要： A Nuclear Medicine (NM) imaging system and method using multiple types of imaging detectors are provided. One NM imaging system includes a gantry, at least a first imaging detector coupled to the gantry, wherein the first imaging detector is a non-moving detector, and at least a second imaging detector coupled to the gantry, wherein the second imaging detector is a moving detector. The first imaging detector is larger than the second imaging detector and the first and second imaging detectors have different detector configurations. The NM imaging system further includes a controller configured to control the operation of the first and second imaging detectors during an imaging scan of an object to acquire Single Photon Emission Computed Tomography (SPECT) image information such that at least the first imaging detector remains stationary with respect to the gantry during image acquisition.
摘要翻译：提供了使用多种成像检测器的核医学（NM）成像系统和方法。一个NM成像系统包括台架，至少第一成像检测器，其耦合到台架，其中第一成像检测器是非移动检测器，以及耦合到台架的至少第二成像检测器，其中第二成像检测器是移动探测器。第一成像检测器大于第二成像检测器，并且第一和第二成像检测器具有不同的检测器配置。 NM成像系统还包括控制器，其被配置为在对象的成像扫描期间控制第一和第二成像检测器的操作，以获取单光子发射计算机断层扫描（SPECT）图像信息，使得至少第一成像检测器保持静止，在图像采集期间对台架的尊重。

8. 发明授权

US08131044B2 Method and apparatus for determining the effectiveness of an image transformation process 有权
标题翻译：用于确定图像变换过程的有效性的方法和装置
公开(公告)号：US08131044B2
公开(公告)日：2012-03-06
申请号：US12099261
申请日：2008-04-08
申请人： Scott David Wollenweber , Alexander Ganin , Ravindra Manjeshwar , Girishankar Gopalakrishnan , Evren Asma
发明人： Scott David Wollenweber , Alexander Ganin , Ravindra Manjeshwar , Girishankar Gopalakrishnan , Evren Asma
IPC分类号： A61B6/03
CPC分类号： G01T1/1611 , A61B6/032 , A61B6/037 , A61B6/508 , A61B6/5235 , A61B6/541 , G06T7/30 , G06T2207/10076 , G06T2207/10081 , G06T2207/10104 , G06T2207/30004
摘要： A method for determining the effectiveness of an image transformation process includes acquiring a four-dimensional (4D) image data set, sorting the 4D image data set into separate field-of-view bins using a temporal gating system generating a plurality of deformation vectors using the sorted 4D image data set, and using the plurality of deformation vectors to generate a transformation effectiveness value that is representative of the effectiveness of the image transformation process. The method further includes acquiring a respiratory signal, calculating a power spectrum of the respiratory signal, calculating a power spectrum for each of the plurality of deformation vectors, and comparing the power spectrum of the respiratory signal to the power spectrum of the plurality of deformation vectors to generate the transformation effectiveness value.
摘要翻译：一种用于确定图像变换过程的有效性的方法包括获取四维（4D）图像数据集，使用使用多个变形向量生成多个变形向量的时间门控系统将4D图像数据集排列成单独的视野区域分类的4D图像数据集，并且使用多个变形向量来生成代表图像变换处理的有效性的变换有效值。该方法还包括获取呼吸信号，计算呼吸信号的功率谱，计算多个变形矢量中的每一个的功率谱，并将呼吸信号的功率谱与多个变形矢量的功率谱进行比较以产生变换有效值。

9. 发明申请

US20090253980A1 METHOD AND APPARATUS FOR DETERMINING THE EFFECTIVENESS OF AN IMAGE TRANSFORMATION PROCESS 有权
标题翻译：用于确定图像变换过程的有效性的方法和装置
公开(公告)号：US20090253980A1
公开(公告)日：2009-10-08
申请号：US12099261
申请日：2008-04-08
申请人： Scott David Wollenweber , Alexander Ganin , Ravindra Manjeshwar , Girishankar Gopalakrishnan , Evren Asma
发明人： Scott David Wollenweber , Alexander Ganin , Ravindra Manjeshwar , Girishankar Gopalakrishnan , Evren Asma
IPC分类号： A61B5/05
CPC分类号： G01T1/1611 , A61B6/032 , A61B6/037 , A61B6/508 , A61B6/5235 , A61B6/541 , G06T7/30 , G06T2207/10076 , G06T2207/10081 , G06T2207/10104 , G06T2207/30004
摘要： A method for determining the effectiveness of an image transformation process includes acquiring a four-dimensional (4D) image data set, sorting the 4D image data set into separate field-of-view bins using a temporal gating system generating a plurality of deformation vectors using the sorted 4D image data set, and using the plurality of deformation vectors to generate a transformation effectiveness value that is representative of the effectiveness of the image transformation process. The method further includes acquiring a respiratory signal, calculating a power spectrum of the respiratory signal, calculating a power spectrum for each of the plurality of deformation vectors, and comparing the power spectrum of the respiratory signal to the power spectrum of the plurality of deformation vectors to generate the transformation effectiveness value.
摘要翻译：一种用于确定图像变换过程的有效性的方法包括获取四维（4D）图像数据集，使用使用多个变形向量生成多个变形向量的时间门控系统将4D图像数据集排列成单独的视野区域分类的4D图像数据集，并且使用多个变形向量来生成代表图像变换处理的有效性的变换有效值。该方法还包括获取呼吸信号，计算呼吸信号的功率谱，计算多个变形矢量中的每一个的功率谱，并将呼吸信号的功率谱与多个变形矢量的功率谱进行比较以产生变换有效值。

10. 发明申请

US20060102846A1 METHOD AND SYSTEM FOR IMAGING USING A FILTER FOR TIME-OF-FLIGHT PET 失效
标题翻译：使用过滤器进行成像的方法和系统
公开(公告)号：US20060102846A1
公开(公告)日：2006-05-18
申请号：US10988878
申请日：2004-11-15
申请人： Ravindra Manjeshwar , Charles Stearns
发明人： Ravindra Manjeshwar , Charles Stearns
IPC分类号： G01T1/164
CPC分类号： G06T11/005
摘要： Methods and systems for imaging by using a filter for Time-Of-Flight Positron Emission Tomography (TOF PET) are described. The described methods of imaging a patient by using a positron emission tomography (PET) system includes acquiring a plurality of frames of sinogram data, filtering the acquired sinogram data and back-projecting the filtered sinogram data to form an output image of the patient. The acquired sinogram data defines a line of response (LOR) and a time-of-flight (TOF) measurement that localizes positron annihilation within the patient. The filtering of the acquired sinogram data is performed using the TOF measurement.
摘要翻译：描述了使用飞行时间正电子发射断层扫描（TOF PET）的滤波器进行成像的方法和系统。所描述的通过使用正电子发射断层摄影（PET）系统对患者进行成像的方法包括获取正弦图数据的多个帧，对所获取的正弦图数据进行滤波，以及反投影过滤的正弦图数据以形成患者的输出图像。获得的正中图数据定义了定位在患者体内的正电子湮灭的响应线（LOR）和飞行时间（TOF）测量。使用TOF测量来执行所获取的正弦图数据的滤波。

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