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    • 3. 发明申请
    • CYCLIC, CYSTEIN-FREE PROTEIN
    • 循环,半胱氨酸游离蛋白
    • WO2009073909A1
    • 2009-06-18
    • PCT/AT2008000448
    • 2008-12-12
    • APEPTICO FORSCHUNG UND ENTWICKFISCHER BERNHARDLUCAS RUDOLF
    • FISCHER BERNHARDLUCAS RUDOLF
    • C07K14/525A61K38/19
    • A61K38/191C07K14/525
    • The invention relates to a protein which is selected from the amino acid sequence of the region valine Val(91) to glycine Gly(121) of the mature, human tumor necrosis factor, or a part thereof, provided that the protein comprises at least the amino acid sequence of the region lysine Lys(98) to glutamic acid Glu(116), the cysteine Cys(101) being replaced by a glycine and an amide bond being formed between the amino group of the side chain of the lysine Lys(98) and the carboxyl group of the side chain of the glutamic acid Glu(116). The protein activates epithelial ion channels and improves the pulmonary function and can be used to produce drugs for the treatment of diseases that are associated with the pulmonary function, such as oedema.
    • 蛋白质,从华菱缬氨酸区域(91)的氨基酸序列选择,以甘氨酸成熟的人肿瘤坏死因子的甘氨酸(121),或其一部分,条件是所述蛋白的至少区域赖氨酸赖氨酸(98)的氨基酸序列,以 是形成谷氨酸谷氨酸(116),其中半胱氨酸的Cys(101)被替换为甘氨酸,并且其中谷氨酸谷氨酸(116)中,上皮的侧链的羧基的氨基的赖氨酸的Lys(98)的侧链之间的酰胺键和 离子通道活化并改善肺功能,和用于制备药物的用于治疗与肺功能相关的疾病,如可以使用水肿的治疗。
    • 6. 发明申请
    • FLUID DOSING DEVICE WITH A THROTTLE POINT
    • 节气门点流体计量
    • WO0236959A3
    • 2003-09-12
    • PCT/DE0104089
    • 2001-10-29
    • SIEMENS AGKAPPEL ANDREASFISCHER BERNHARDMOCK RANDOLFGOTTLIEB BERNHARDULIVIERI ENRICO
    • KAPPEL ANDREASFISCHER BERNHARDMOCK RANDOLFGOTTLIEB BERNHARDULIVIERI ENRICO
    • F02M51/06F02M61/08F02M61/16F16K41/10
    • F02M51/0603F02M61/08F02M61/16F02M2200/16
    • The invention relates to a fluid dosing device for a pressurized liquid, comprising a chamber (35) which is arranged in a housing (3) and which is supplied with pressurized liquid by means of a liquid supply line (17, 19); in addition to a valve needle (9) which is guided through the chamber (35), the first end section of said valve needle being able to be lifted and the second end section thereof forming a valve which is connected to the chamber (35), in conjunction with a valve seat disposed on the housing (3). In order to provide a tight and enduring leadthrough for the valve needle, metal bellows (33) are provided as a leadthrough element for the first end section of the valve needle (9) when seen from the chamber (35) in an outward direction. The metal bellows seal the chamber in said region in a tight manner. A throttle point (37, 39) is provided between the valve needle (9) and the inner wall of the chamber between the metal bellows (33) and the mouth (18) of the liquid supply line (17) leading into the chamber.
    • 在用于加压流体的流体计量装置具有容纳在容纳室(9.1,9.2),其通过流体供应管线(8)中,加压流体被供给,并与通过腔室(9.1,9.2)引导阀针(3 ),所述第一端部可在腔室外部被加载在与行程并且其第二端部形成有具有设置在壳体上的阀座的阀室连通。 为了提供阀针,这也实现了所需要的蠕变强度,一个金属波纹管(1),馈通元件,用于从所述腔室(9.1,9.2)到外部的阀针(3)的第一端部的密封的通道设置在此将金属波纹管室 紧密地封闭区域,在阀针(3)和所述腔室的内壁在所述腔室(9.1,9.2)之间的金属波纹管(33)和所述流体供给管(8)的口部之间的腔室部分沿周向至少一个节流点被提供。