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1. 发明申请

US20070166758A1 Diagnostic method for stroke 有权
标题翻译：中风诊断方法
公开(公告)号：US20070166758A1
公开(公告)日：2007-07-19
申请号：US10568093
申请日：2004-08-16
申请人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
发明人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/6893 , G01N2333/4709 , G01N2333/775 , G01N2333/8128 , G01N2800/2871
摘要： Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.
摘要翻译：通过从取自受试者的体液样品中测定至少一种选自Apo C-III，血清淀粉样蛋白A，Apo C-I，抗凝血酶III片段和Apo A-I的多肽的浓度，在受试者中诊断中风。

2. 发明授权

US07767401B2 Diagnostic method for stroke 有权
标题翻译：中风诊断方法
公开(公告)号：US07767401B2
公开(公告)日：2010-08-03
申请号：US10568093
申请日：2004-08-16
申请人： Pierre Lescuyer , Denis Francois Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
发明人： Pierre Lescuyer , Denis Francois Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
IPC分类号： G01N33/00 , G01N33/543
CPC分类号： G01N33/6893 , G01N2333/4709 , G01N2333/775 , G01N2333/8128 , G01N2800/2871
摘要： Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.
摘要翻译：通过从取自受试者的体液样品中测定至少一种选自Apo C-III，血清淀粉样蛋白A，Apo C-I，抗凝血酶III片段和Apo A-I的多肽的浓度，在受试者中诊断中风。

3. 发明授权

US07368247B2 Diagnostic assay for transmissible spongiform encephalopathies 有权
标题翻译：传染性海绵状脑病的诊断测定
公开(公告)号：US07368247B2
公开(公告)日：2008-05-06
申请号：US10238557
申请日：2002-09-10
申请人： Denis Francois Hochstrasser , Jean-Charles Sanchez , Catherine Gabrielle Zimmermann , Elisabeth Guillaume
发明人： Denis Francois Hochstrasser , Jean-Charles Sanchez , Catherine Gabrielle Zimmermann , Elisabeth Guillaume
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S436/811 , Y10S436/819 , Y10T436/106664
摘要： Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish CJD from AMI requires an assay specific to AMI, e.g. using troponin-1 or CK-MB as a marker, also to be carried out.
摘要翻译：心脏和脑脂肪酸结合蛋白（H-FABP，B-FABP）是TSEs的标志物，特别是CJD。本发明提供了对这些标记之一的诊断测定，优选通过使用其特异性抗体的酶免疫测定。由于H-FABP也是急性心肌梗死（AMI）的标志物，因此区分CJD与AMI需要AMI特异性检测，例如使用肌钙蛋白-1或CK-MB作为标记，也要进行。

4. 发明申请

US20050153360A1 Diagnostic method for stroke 审中-公开
标题翻译：中风诊断方法
公开(公告)号：US20050153360A1
公开(公告)日：2005-07-14
申请号：US10909761
申请日：2004-08-02
申请人： Denis Hochstrasser , Jean-Charles Sanchez , Elisabeth Guillaume , Laure Allard
发明人： Denis Hochstrasser , Jean-Charles Sanchez , Elisabeth Guillaume , Laure Allard
IPC分类号： G01N33/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/6848 , G01N2800/2871
摘要： The present invention provides a method of diagnosis of stroke or the possibility thereof in a subject suspected of suffering from stroke, comprising subjecting a sample of body fluid taken from the subject to mass spectrometry to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da; and determining whether the test amount is consistent with a diagnosis of stroke. The test amount can also be used to determine the type of stroke that is diagnosed, in particular whether it is of the ischemic or hemorrhagic type. The invention also provides use of the polypeptides for diagnostic, prognostic and therapeutic applications. The invention further provides a kit for use in diagnosis of stroke, comprising a probe for receiving a sample of body fluid, and for placement in a mass spectrometer, thereby to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da.
摘要翻译：本发明提供了一种诊断中风的方法或其在怀疑患有中风的受试者中的可能性，包括使得自受试者取得的体液样品进行质谱以确定样品中多肽的检测量，其中该多肽差异包含在中风受影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内; 并确定测试量是否与中风的诊断一致。测试量也可用于确定被诊断的中风的类型，特别是是否是缺血性或出血型。本发明还提供了多肽用于诊断，预后和治疗应用的用途。本发明还提供了一种用于卒中诊断的试剂盒，其包括用于接收体液样品的探针，并用于放置在质谱仪中，由此确定样品中多肽的检测量，其中多肽是差异的包含在中风影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内。

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