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    • 1. 发明申请
    • Diagnostic method for stroke
    • 中风诊断方法
    • US20050153360A1
    • 2005-07-14
    • US10909761
    • 2004-08-02
    • Denis HochstrasserJean-Charles SanchezElisabeth GuillaumeLaure Allard
    • Denis HochstrasserJean-Charles SanchezElisabeth GuillaumeLaure Allard
    • G01N33/00G01N33/53G01N33/68
    • G01N33/6893G01N33/6848G01N2800/2871
    • The present invention provides a method of diagnosis of stroke or the possibility thereof in a subject suspected of suffering from stroke, comprising subjecting a sample of body fluid taken from the subject to mass spectrometry to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da; and determining whether the test amount is consistent with a diagnosis of stroke. The test amount can also be used to determine the type of stroke that is diagnosed, in particular whether it is of the ischemic or hemorrhagic type. The invention also provides use of the polypeptides for diagnostic, prognostic and therapeutic applications. The invention further provides a kit for use in diagnosis of stroke, comprising a probe for receiving a sample of body fluid, and for placement in a mass spectrometer, thereby to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da.
    • 本发明提供了一种诊断中风的方法或其在怀疑患有中风的受试者中的可能性,包括使得自受试者取得的体液样品进行质谱以确定样品中多肽的检测量,其中 该多肽差异包含在中风受影响的受试者和非中风受试者的体液中,分子量在3000至30000Da的范围内; 并确定测试量是否与中风的诊断一致。 测试量也可用于确定被诊断的中风的类型,特别是是否是缺血性或出血型。 本发明还提供了多肽用于诊断,预后和治疗应用的用途。 本发明还提供了一种用于卒中诊断的试剂盒,其包括用于接收体液样品的探针,并用于放置在质谱仪中,由此确定样品中多肽的检测量,其中多肽是差异的 包含在中风影响的受试者和非中风受试者的体液中,分子量在3000至30000Da的范围内。