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1. 发明申请

WO1992016632A1 RECOMBINANT DNA CODING FOR A NOVEL PROTEIN HAVING BETA-1,3-GLUCANASE ACTIVITY OF SOYA 审中-公开
标题翻译：具有大豆β-谷氨酰胺酶活性的新型蛋白质的重组DNA编码
公开(公告)号：WO1992016632A1
公开(公告)日：1992-10-01
申请号：PCT/FR1992000268
申请日：1992-03-25
申请人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE , SASS, Catherine , LEGUAY, Jean-Jacques , GRISON, René , TOPPAN, Alain
发明人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE
IPC分类号： C12N15/56
CPC分类号： C12Y302/01039 , C12N9/2402 , C12N15/8279 , C12Y302/01058
摘要： A recombinant DNA coding for a protein having β-1,3-glucanase activity, or a precursor thereof, which includes sequence (a1) or a sequence having a high level of homology therewith. Application: recombinant DNA coding for a new protein having β-1,3-glucanase activity.

2. 发明申请

WO1992009629A1 PROTEIN PRESENTING AN ACTIVITY OF THE CYTOKINE TYPE, RECOMBINANT DNA, EXPRESSION VECTOR AND HOSTS USED TO PRODUCE SUCH PROTEIN 审中-公开
标题翻译：蛋白质提供细胞因子类型的活性，重组DNA，表达载体和用于生产这种蛋白质的宿主
公开(公告)号：WO1992009629A1
公开(公告)日：1992-06-11
申请号：PCT/FR1991000949
申请日：1991-11-29
申请人： ELF SANOFI , CAPUT, Daniel , FERRARA, Pascual , MILOUX, Brigitte , MINTY, Adrian , VITA, Natalio
发明人： ELF SANOFI
IPC分类号： C07K13/00
CPC分类号： C07K14/523 , A61K38/00 , Y02A50/409 , Y02A50/414
摘要： The invention relates to a protein presenting an activity of the cytokine type which has the sequence (a1) and immediately upstream of the sequence (a1), a portion of the sequence (a2) or of a sequence differing by one or a plurality of amino acids from the sequence (a2) and conferring to the protein the same activity. Application: medicament useful particularly as anticancer or immunomodulator agent.
摘要翻译：本发明涉及一种具有细胞因子类型的活性的蛋白质，其具有序列（a1）和紧邻上游的序列（a1），一部分序列（a2）或序列不同于一个或多个氨基来自序列（a2）的酸，并赋予蛋白质相同的活性。应用：特别用作抗癌剂或免疫调节剂的药物。

3. 发明申请

WO1993018002A1 QUATERNARY SALTS OF 4-SUBSTITUTED PIPERIDINES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：四取代哌嗪的季铵盐，其制备方法和含有其的药物组合物
公开(公告)号：WO1993018002A1
公开(公告)日：1993-09-16
申请号：PCT/FR1993000215
申请日：1993-03-03
申请人： ELF SANOFI
发明人： ELF SANOFI , EMONDS-ALT, Xavier , PROIETTO, Vincenzo , VAN BROECK, Didier , BRELIERE, Jean-Claude
IPC分类号： C07D211/14
CPC分类号： C07D401/06 , C07D211/14 , C07D211/44 , C07D211/48 , C07D211/52 , C07D211/58 , C07D409/12
摘要： Quaternary ammonium salts of formula (I), wherein J is a Ar-CXX'-CX" group or a Ar-(CH2)xCX1 group wherein Ar is optionally substituted phenyl, cycloalkyl, pyridyl or thienyl; X is hydrogen; X' is hydrogen or combined with X" below to form a carbon-carbon bond, or X and X' together form an oxo group; x is 0 or 1; X1 is hydrogen (x=0), hydroxyl, alkoxy, acyloxy, carboxy, carbalkoxy, cyano, carbamoylalkyl, mercapto or alkylthio; Q is an alkyl or benzyl group; A is an anion; m is 2 or 3; Ar' is optionally substituted phenyl, thienyl, benzothienyl, naphthyl or optionally N-substituted indolyl; R is hydrogen or C1-6 alkyl; T is -CO- or -CW-NH-, wherein W is an oxygen or sulphur atom; and Z is either hydrogen or M or OM when T is the -CO- group, or M when T is the -CW-NH- group; M in particular is alkyl, alpha -hydroxybenzyl, alpha -hydroxybenzylalkyl, phenylalkyl, pyridylalkyl, naphthylalkyl, pyridylthioalkyl or styryl. The salts may be used particularly in drugs for treating pathological phenomena involving the neurokinin system.
摘要翻译：式（I）的季铵盐，其中J为Ar-CXX'-CX“基或Ar-（CH2）xCX1基，其中Ar为任选取代的苯基，环烷基，吡啶基或噻吩基; X为氢; X'为氢或与X“结合形成碳 - 碳键，或X和X'一起形成氧代基; x为0或1; X 1为氢（x = 0），羟基，烷氧基，酰氧基，羧基，烷氧羰基，氰基，氨基甲酰基烷基，巯基或烷硫基; Q是烷基或苄基; A < - >是阴离子; m为2或3; Ar'是任选取代的苯基，噻吩基，苯并噻吩基，萘基或任选的N-取代的吲哚基; R是氢或C 1-6烷基; T是-CO-或-CW-NH-，其中W是氧或硫原子; 当T为-CO-基团时，Z为氢或M或OM;当T为-CW-NH-基时，Z为M; M特别是烷基，α-羟基苄基，α-羟基苄基烷基，苯基烷基，吡啶基烷基，萘基烷基，吡啶基硫代烷基或苯乙烯基。盐可以特别用于治疗涉及神经激肽系统的病理现象的药物中。

4. 发明申请

WO1993015051A1 N-SULPHONYL-2-OXOINDOLE DERIVATIVES HAVING AFFINITY FOR VASOPRESSIN AND/OR OCYTOCIN RECEPTORS 审中-公开
标题翻译：具有血管收缩素和/或OCYTOCIN受体的亲和力的N-磺酰基-2-氧代衍生物
公开(公告)号：WO1993015051A1
公开(公告)日：1993-08-05
申请号：PCT/FR1993000093
申请日：1993-01-28
申请人： ELF SANOFI , FOULON, Loïc , GARCIA, Georges , NISATO, Dino , ROUX, Richard , SERRADEIL-LEGAL, Claudine , VALETTE, Gérard , WAGNON, Jean
发明人： ELF SANOFI
IPC分类号： C07D209/96
CPC分类号： C07D209/92 , C07D209/34 , C07D209/96 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D471/10 , C07D491/10 , C07D495/10
摘要： N-sulphonyl-2-oxoindole derivatives of formula (I), and any salts thereof, preparation thereof and pharmaceutical compositions containing said derivatives. These compounds have an affinity for vasopressin and/or ocytocin receptors.

5. 发明申请

WO1994013790A1 USE OF A DNA SEQUENCE CODING FOR AN OXALIC ACID DEGRADING PROTEIN AS A SELECTION GENE 审中-公开
标题翻译：使用作为选择基因的酸性降解蛋白的DNA序列编码
公开(公告)号：WO1994013790A1
公开(公告)日：1994-06-23
申请号：PCT/FR1993001203
申请日：1993-12-07
申请人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE , PIGNARD, Annie , GREZES-BESSET, Bruno , GRISON, René , SCHNEIDER, Michel
发明人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE
IPC分类号： C12N09/02
CPC分类号： C12N9/0008 , C07K2319/02 , C12N9/2442 , C12N15/8209 , C12Y102/03004 , C12Y302/01014
摘要： A novel use of a sequence coding for an oxalic acid degrading protein in order to select plant cells incorporating a gene of interest, and a novel method for selecting, on oxalic acid, cells, calli or plants transformed by the recombinant DNA.
摘要翻译：编码草酸降解蛋白的序列的新颖用途，以选择掺入目标基因的植物细胞，以及在由重组DNA转化的草酸，细胞，愈伤组织或植物上选择的新方法。

6. 发明申请

WO1993023059A1 USE OF EXOGENEOUS GLYCOSAMINOGLYCANES OR DERIVATIVES IN THE TREATMENT OF THROMBOPENIAS 审中-公开
标题翻译：异丙肾上腺素或衍生物在治疗感冒中的应用
公开(公告)号：WO1993023059A1
公开(公告)日：1993-11-25
申请号：PCT/FR1993000458
申请日：1993-05-11
申请人： ELF SANOFI , INSTITUT DES VAISSEAUX ET DU SANG , HAN, Zhong, Chao , CAEN, Jacques , LORMEAU, Jean-Claude , PETITOU, Maurice
发明人： ELF SANOFI , INSTITUT DES VAISSEAUX ET DU SANG
IPC分类号： A61K31/725
CPC分类号： A61K31/715 , A61K31/70 , A61K31/795
摘要： Use of exogeneous glycosaminoglycanes, their analogues and their fractions, fragments and derivatives in the preparation of drugs for the treatment of thrombopenias.

7. 发明申请

WO1993003013A1 INDOLINE DERIVATIVES HAVING AN AMIDE FUNCTION, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：具有酰胺官能团的吲哚衍生物，其制备物和含有它们的药物组合物
公开(公告)号：WO1993003013A1
公开(公告)日：1993-02-18
申请号：PCT/FR1992000758
申请日：1992-07-31
申请人： ELF SANOFI
发明人： ELF SANOFI , WAGNON, Jean , PLOUZANE, Claude , SERRADEIL-LEGAL, Claudine , NISATO, Dino , TONNERRE, Bernard
IPC分类号： C07D209/42
CPC分类号： C07D401/06 , C07D209/42 , C07D401/12 , C07D403/06 , C07D417/06
摘要： The invention relates to compounds of formula (I), wherein R1 is a halogen atom, C1-C4 alkyl, hydroxyl, C1-C4 alkoxy, a group benzyloxy, cyano, trifluoromethyl, nitro or amino; R2 is C1-C6 alkyl, C3-C7 cycloalkyl, C5-C7 cycloalcen, a phenyl unsubstituted or substituted one or a plurality of times, C1-C4 alkoxy, halogen, a group trifluoromethyl, a group amino, or R2 is a nitrophenyl unsubstituted or substituted one or a plurality of times; R3 is a hydrogen atom; R4 is a carbamyl group having the formula CONR6R7; R5 is C1-C4 alkyl; naphtyl-1; naphtyl-2; dimethylamino-5 naphtyl-1; a phenyl unsubstituted or substituted one or a plurality of times, or R5 is nitrophenyl unsubstituted or substituted one or a plurality of times; R6 is C1-C6 alkyl, or R6 is similar to R7; R7 is a group piperidin-4-yl; a group azetidin-3-yl, said groups being substituted or unsubstituted on the nitrogen by C1-C4 alkyl, by a benzyloxycarbonyl or by an alkoxycarbonyl in C1-C4; a group (CH2)r itself substituted by a group pyridyl-2, -3 or -4, by a group hydroxyl, by an amino group free or substituted by one or two substituants; or R6 and R7 form together with the nitrogen atom to which they are linked a heterocycle selected amongst: morpholin, thiomorpholin, thiazolidin or 2,2-dimethylthiazolidin unsubstituted or substituted by R8, piperazin unsubstituted or substituted in 4 by a group R''8, an unsaturated mononitrogenated cycle with 5 links substituted by R8 or a saturated mononitrogenated cycle with 3, 4, 5, 6 or 7 links substituted by R8 and R9; R8 is R'8 or a group (CH2)r itself substituted by hydroxyl or by a free amino or substituted by one or two C1-C4 alkyls; R'8 is a group (CH2)q itself substituted by a carboxyl group, a group C1-C4 alkoxycarbonyl, a benzyloxycarbonyl group, a group carbamoyl free or substituted by a hydroxyl or by one or two C1-C4 alkyls, or a group aminocarbothioyl free or substituted by one or two C1-C4 alkyls; R''8 is R'8 or a group (CH2)2NH2 free or substituted by one or two C1-C4; R9 is hydrogen, halogen, a group (CH2)rOR10, a group (CH2)rNR11R12, a group (CH2)sCONR11R'11, a group azido; R10 is hydrogen, C1-C4 alkyl, mesyl or tosyl; R11, R'11 and R12 are each hydrogen or C1-C4 alkyl or R11 is hydrogen and R12 is C1-C4 alkoxycarbonyl or benzyloxycarbonyl; n is 0, 1 or 2; m is 0, 1, or 2; q is 0, 1, 2 or 3; r is 0, 1, 2 or 3 with the provision that r is different from 0 when R8 or R9 is in the alpha position of the intracyclic amidic nitrogen; s is 0 or 1; as well as its optional salts. These compounds are useful in the treatment of affections of the central nervous system, the cardiovascular system and the gastric system in human beings and animals.

8. 发明申请

WO1994021793A1 PLANT PROMOTER, MICROORGANISMS AND PLANT CELLS CONTAINING A UNIT FOR THE EXPRESSION OF A PROTEIN OF INTEREST COMPRISING SAID PROMOTER 审中-公开
标题翻译：植物促进剂，微生物和植物细胞含有表达含有促进剂的蛋白质的单位
公开(公告)号：WO1994021793A1
公开(公告)日：1994-09-29
申请号：PCT/FR1994000316
申请日：1994-03-23
申请人： ELF SANOFI , ELF AQUITAINE , MARCO, Yves , ROBY, Dominique , SCHNEIDER, Michel , TOPPAN, Alain
发明人： ELF SANOFI , ELF AQUITAINE
IPC分类号： C12N15/29
CPC分类号： C12N15/8239 , C07K14/415 , C12N15/8222 , C12N15/8227 , C12N15/8229 , C12N15/8238
摘要： The present invention relates to a plant promoter which comprises the sequence (B) [SEQ ID NO: 4] or a sequence presenting a high homology degree with the sequence (B). Application: protection of plants by genetic engineering and particularly defence of plants in stress conditions.
摘要翻译：本发明涉及包含序列（B）[SEQ ID NO：4]或与序列（B）具有高同源度的序列）的植物启动子。应用：通过遗传工程保护植物，特别是在胁迫条件下保护植物。

9. 发明申请

WO1992017586A1 PROTEIN HAVING A CYTOKININ-TYPE ACTIVITY, RECOMBINANT DNA CODING FOR THIS PROTEIN, TRANSFORMED CELLS AND MICRO-ORGANISMS 审中-公开
标题翻译：具有细胞因子型活性的蛋白质，本蛋白的重组DNA编码，转化细胞和微生物
公开(公告)号：WO1992017586A1
公开(公告)日：1992-10-15
申请号：PCT/FR1992000280
申请日：1992-03-27
申请人： ELF SANOFI , CAPUT, Daniel , FERRARA, Pascual , GUILLEMOT, Jean-Claude , KAGHAD, Mourad , LABIT-LE BOUTEILLER, Christine , LEPLATOIS, Pascal , MAGAZIN, Marilyn , MINTY, Adrian
发明人： ELF SANOFI
IPC分类号： C12N15/19
CPC分类号： C07K14/5446 , A61K38/00 , C07K14/5437 , C07K16/244 , F02B2075/027
摘要： A protein having a cytokinin-type activity, or a precursor of this protein, comprises the sequence of amino acids (a1), in which Xaa denotes Asp or Gly.

10. 发明授权

EP0529715B1 Sulfated glycosaminoglycanoid derivatives 失效
标题翻译：硫酸化糖胺聚糖类衍生物
公开(公告)号：EP0529715B1
公开(公告)日：1997-03-05
申请号：EP92202507.7
申请日：1992-08-17
申请人： Akzo Nobel N.V. , ELF SANOFI
发明人： Petitou, Maurice , van Boeckel, Constant Adriaan Anton
IPC分类号： C07H11/00 , C07H15/04 , C07H15/26 , C07H15/08 , A61K31/70
CPC分类号： C07H11/00 , C07H15/04 , C07H15/08 , C07H15/26

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