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1. 发明申请

WO2012085072A1 GAS-FILLED MICROVESICLES FOR USE AS VACCINE 审中-公开
标题翻译：用作疫苗的气体填充微量元素
公开(公告)号：WO2012085072A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073572
申请日：2011-12-21
申请人： BRACCO SUISSE SA , BIOLEY, Gilles , CORTHESY, Blaise , BUSSAT, Philippe , LASSUS, Anne , SCHNEIDER, Michel
发明人： BIOLEY, Gilles , CORTHESY, Blaise , BUSSAT, Philippe , LASSUS, Anne , SCHNEIDER, Michel
IPC分类号： A61K39/385 , A61K47/48
CPC分类号： A61K9/0087 , A61K39/385 , A61K47/6925 , A61K2039/60
摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
摘要翻译：包含与其结合的抗原的气体填充的微泡和含有所述微泡的含水悬浮液，用于免疫调节制剂，特别是作为疫苗。抗原共价结合到微囊包膜的组分。本发明的微泡在抗原呈递细胞，特别是树突状细胞的摄取中特别有效。

2. 发明申请

WO2009083557A1 QUANTIFICATION ANALISYS OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS 审中-公开
标题翻译：医学成像应用中定量对比剂的定量分析
公开(公告)号：WO2009083557A1
公开(公告)日：2009-07-09
申请号：PCT/EP2008/068247
申请日：2008-12-23
申请人： BRACCO RESEARCH S.A. , ARDITI, Marcel , MESSAGER, Tristan , SCHNEIDER, Michel , FRINKING, Peter
发明人： ARDITI, Marcel , MESSAGER, Tristan , SCHNEIDER, Michel , FRINKING, Peter
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/14 , A61B8/5223 , G06F19/12
摘要： A solution is proposed for analyzing a body part (155) of a patient (160), which is perfused with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target. A corresponding system (105) includes means (405-440) for providing an echo signal indicative of a response over time to an interrogation signal of the body part, means (442,450) for associating the echo signal with a model function of time modeling an evolution over time of the contrast agent in the body part, the model function including a combination of a circulation function modeling the circulation of the contrast agent and a decay function modeling a decay of the echo signal from the immobilized contrast agent, and means (455-475) for estimating at least one kinetics indicator of the contrast agent from the model function.
摘要翻译：提出了一种解决方案，用于分析患者（160）的身体部分（155），其被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。相应的系统（105）包括用于将指示随时间的响应的回波信号提供给身体部位的询问信号的装置（405-440），用于将回波信号与时间建模的模型函数相关联的装置（442,450）模型功能包括建模造影剂循环的循环功能和建模来自固定化造影剂的回波信号衰减的衰减函数的组合，以及装置（455） -475），用于从模型函数估计造影剂的至少一个动力学指示符。

3. 发明申请

WO2005117832A1 LIPOSOMAL ASSEMBLY FOR THERAPEUTIC AND/OR DIAGNOSTIC USE 审中-公开
标题翻译：用于治疗和/或诊断用途的药物组装
公开(公告)号：WO2005117832A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052482
申请日：2005-05-31
申请人： BRACCO RESEARCH SA , TOURNIER, Hervé , HYACINTHE, Roland , SCHNEIDER, Michel
发明人： TOURNIER, Hervé , HYACINTHE, Roland , SCHNEIDER, Michel
IPC分类号： A61K9/127
CPC分类号： A61K9/1075 , A61K9/1271 , A61K48/0091 , A61K49/1812 , C12N15/88 , Y10S977/907 , Y10T428/2982
摘要： Composition for diagnostic or therapeutic use whichcomprises an assembly comprising an active agent. The assembly comprises a Iiposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.
摘要翻译：用于诊断或治疗用途的组合物，其包括包含活性剂的组合物。组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的包膜的外表面相关联。当将活性化合物并入胶束中时，大量的所述活性化合物可以连接到单个脂质体。此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

4. 发明申请

WO2005063305A1 GAS-FILLED MICROVESICLE ASSEMBLY FOR CONTRAST IMAGING 审中-公开
标题翻译：气体填充微波组件对比成像
公开(公告)号：WO2005063305A1
公开(公告)日：2005-07-14
申请号：PCT/IB2004/004230
申请日：2004-12-21
申请人： BRACCO RESEARCH SA , SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , SENENTE, Anne
发明人： SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , SENENTE, Anne
IPC分类号： A61K49/22
CPC分类号： A61K47/6925 , A61K41/0028 , A61K49/225
摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component - MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.
摘要翻译：组件包括充气微泡和能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合的结构实体，从而改变其物理化学性质。所述MAC可以任选地包含靶向配体，生物活性剂，诊断剂或其任何组合。本发明的组件可以由气体填充的微泡或微球和直径小于100μm的MAC，特别是胶束形成，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强在超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术，例如分子共振成像（MRI）或核成像。

5. 发明申请

WO1994021793A1 PLANT PROMOTER, MICROORGANISMS AND PLANT CELLS CONTAINING A UNIT FOR THE EXPRESSION OF A PROTEIN OF INTEREST COMPRISING SAID PROMOTER 审中-公开
标题翻译：植物促进剂，微生物和植物细胞含有表达含有促进剂的蛋白质的单位
公开(公告)号：WO1994021793A1
公开(公告)日：1994-09-29
申请号：PCT/FR1994000316
申请日：1994-03-23
申请人： ELF SANOFI , ELF AQUITAINE , MARCO, Yves , ROBY, Dominique , SCHNEIDER, Michel , TOPPAN, Alain
发明人： ELF SANOFI , ELF AQUITAINE
IPC分类号： C12N15/29
CPC分类号： C12N15/8239 , C07K14/415 , C12N15/8222 , C12N15/8227 , C12N15/8229 , C12N15/8238
摘要： The present invention relates to a plant promoter which comprises the sequence (B) [SEQ ID NO: 4] or a sequence presenting a high homology degree with the sequence (B). Application: protection of plants by genetic engineering and particularly defence of plants in stress conditions.
摘要翻译：本发明涉及包含序列（B）[SEQ ID NO：4]或与序列（B）具有高同源度的序列）的植物启动子。应用：通过遗传工程保护植物，特别是在胁迫条件下保护植物。

6. 发明申请

WO2006018433A1 GAS-FILLED MICROVESICLES COMPOSITION FOR CONTRAST IMAGING 审中-公开
标题翻译：用于对比成像的气体填充微晶组合物
公开(公告)号：WO2006018433A1
公开(公告)日：2006-02-23
申请号：PCT/EP2005/054041
申请日：2005-08-17
申请人： BRACCO RESEARCH SA , BUSSAT, Philippe , FRINKING, Peter , GUILLOT, Christian , SCHNEIDER, Michel
发明人： BUSSAT, Philippe , FRINKING, Peter , GUILLOT, Christian , SCHNEIDER, Michel
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective D V50 values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less.
摘要翻译：本发明涉及一种新的组合物，其包括用于造影成像的充气微泡，其特别适合于向具有不同频率的至少两个选定的超声波提供有效的回波响应。所述组合物优选包含气体填充微泡的至少两种不同制剂，其具有彼此相差至少2MHz的非线性回波影响响应的各个峰，并且优选具有不同中值大小的相应尺寸分布。特别地，所述制剂优选具有各自的D

7. 发明申请

WO1994013790A1 USE OF A DNA SEQUENCE CODING FOR AN OXALIC ACID DEGRADING PROTEIN AS A SELECTION GENE 审中-公开
标题翻译：使用作为选择基因的酸性降解蛋白的DNA序列编码
公开(公告)号：WO1994013790A1
公开(公告)日：1994-06-23
申请号：PCT/FR1993001203
申请日：1993-12-07
申请人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE , PIGNARD, Annie , GREZES-BESSET, Bruno , GRISON, René , SCHNEIDER, Michel
发明人： ELF SANOFI , SOCIETE NATIONALE ELF AQUITAINE
IPC分类号： C12N09/02
CPC分类号： C12N9/0008 , C07K2319/02 , C12N9/2442 , C12N15/8209 , C12Y102/03004 , C12Y302/01014
摘要： A novel use of a sequence coding for an oxalic acid degrading protein in order to select plant cells incorporating a gene of interest, and a novel method for selecting, on oxalic acid, cells, calli or plants transformed by the recombinant DNA.
摘要翻译：编码草酸降解蛋白的序列的新颖用途，以选择掺入目标基因的植物细胞，以及在由重组DNA转化的草酸，细胞，愈伤组织或植物上选择的新方法。

8. 发明申请

WO1986007281A1 METHOD FOR THE PURIFICATION OF BIOACTIVE SUBSTANCES BY BIOSPECIFIC ADSORPTION 审中-公开
标题翻译：通过生物吸附来净化生物物质的方法
公开(公告)号：WO1986007281A1
公开(公告)日：1986-12-18
申请号：PCT/CH1986000081
申请日：1986-06-04
申请人： BATTELLE MEMORIAL INSTITUTE , SCHNEIDER, Michel , GUILLOT, Christian , LAMY, Bernard
发明人： BATTELLE MEMORIAL INSTITUTE
IPC分类号： B01D15/08
CPC分类号： B01D15/3804 , B01J20/08 , B01J20/103 , B01J20/28004 , B01J20/28057 , B01J20/286 , B01J20/3204 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3274 , B01J2220/54 , Y10S977/773 , Y10S977/775 , Y10S977/888
摘要： A ligand specific of a bioactive substance to be purified is fixed through a linkage silane on a mineral particulate support selected amongst SiO2, Al2O3, ZrO2 and TiO2, the particles thereof being submicronic, non porous and of large specific surface. Said support is contacted with an aqueous extract containing amongst other things said bioactive substance, during a time sufficient to specifically fix the bioactive substances to the support; the latter is then separated and, by desorption, the desired bioactive substance is isolated.
摘要翻译：要纯化的生物活性物质的配体特异性通过连接硅烷在选自SiO 2，Al 2 O 3，ZrO 2和TiO 2中的矿物颗粒载体上固定，其颗粒是亚微米级，非多孔性和大比表面积。所述载体与包含所述生物活性物质的水提取物接触，足以将生物活性物质特异性地固定在载体上; 然后分离后者，并通过解吸分离所需的生物活性物质。

9. 发明申请

WO2005063306A1 ASSEMBLY OF GAS-FILLED MICROVESICLE WITH ACTIVE COMPONENT FOR CONTRAST IMAGING 审中-公开
标题翻译：装配有活性成分的气体填充微胶囊用于对比成像
公开(公告)号：WO2005063306A1
公开(公告)日：2005-07-14
申请号：PCT/IB2004/004233
申请日：2004-12-21
申请人： BRACCO RESEARCH SA , SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , SENENTE, Anne
发明人： SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , SENENTE, Anne
IPC分类号： A61K49/22
CPC分类号： A61K41/0028 , A61K47/6925 , A61K49/225
摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component - MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.
摘要翻译：组件包括充气微泡和能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合的结构实体，从而改变其物理化学性质。所述MAC包含靶向配体，诊断剂或其任何组合。可选地，生物活性剂可以进一步与MAC相关联。本发明的组件可以由气体填充的微泡或微球形成，并且MAC具有优选的纳米尺度，例如，胶束，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其它成像技术，例如分子共振成像（MRI）或核成像。

10. 发明申请

WO2004069284A3 ULTRASOUND CONTRAST AGENTS AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
公开(公告)号：WO2004069284A3
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000243
申请日：2004-02-03
申请人： BRACCO RESEARCH SA , SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , GUILLOT, Christian
发明人： SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , GUILLOT, Christian
IPC分类号： A61K49/22
摘要： Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.

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