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1. 发明授权

US10106402B2 Biomedical implants comprising surface-modified metal particles and biodegradable polymers, its use for suppressing inflammation, and preparation method thereof 有权
公开(公告)号：US10106402B2
公开(公告)日：2018-10-23
申请号：US12985549
申请日：2011-01-06
申请人： Dong Keun Han , Kwi Deok Park , Jong Hee Kang , Bong Soo Lee , Ji Yeon Choi , Chang Hun Kum
发明人： Dong Keun Han , Kwi Deok Park , Jong Hee Kang , Bong Soo Lee , Ji Yeon Choi , Chang Hun Kum
IPC分类号： B32B5/16 , A61L31/10 , B82Y5/00 , A61L17/06 , A61L27/04 , A61L27/34 , A61L27/58 , A61L31/02 , A61L31/14
摘要： Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.

2. 发明授权

US09212259B2 Nitric oxide delivery system using thermosensitive synthetic polymers 有权
标题翻译：使用热敏合成聚合物的一氧化氮输送系统
公开(公告)号：US09212259B2
公开(公告)日：2015-12-15
申请号：US13877384
申请日：2011-10-04
申请人： Won Jong Kim , Yanggy Lee , Kwideok Park , Jihoon Kim , Dong Keun Han
发明人： Won Jong Kim , Yanggy Lee , Kwideok Park , Jihoon Kim , Dong Keun Han
IPC分类号： A61K47/34 , A61L27/34 , C08L71/02 , C08G73/02 , A61L27/54 , C08G63/685
CPC分类号： C08G73/024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/114 , C08G63/6852 , C08G73/0206 , C08L71/02
摘要： A donor capable of controlled release of nitric monoxide and a prosthetic implant whose surface is coated with this donor are disclosed. The donor comprises a main chain of an organic polymer and a side chain that is covalently linked to the main chain and has a diazeniumdiolate functional group. The donor for controlled release of nitric monoxide exists in a fluid state such as liquid at room temperature and undergoes a sol-to-gel phase transition at a physiological pH as the temperature increases above the critical temperature. The critical temperature of the phase transition is in the range of 25 to 35° C., and the gel is a hydrogel without chemical cross-links.
摘要翻译：公开了能够控制释放一氧化氮的供体和其表面涂覆有该供体的假体植入物。供体包括有机聚合物的主链和共价连接到主链并具有二氮烯二硫酸酯官能团的侧链。用于控制释放一氧化氮的供体以室温下的液体状态存在，并且随着温度升高到临界温度以上，在生理pH下经历溶胶 - 凝胶相变。相变的临界温度在25至35℃的范围内，凝胶是没有化学交联的水凝胶。

3. 发明申请

US20110111367A1 NANOCOUPLING FOR IMPROVEMENT OF COATING ADHESION OF POLYMER ON METAL SUBSTRATES 有权
标题翻译：用于改善聚合物在金属基材上的涂料粘合性的纳米结构
公开(公告)号：US20110111367A1
公开(公告)日：2011-05-12
申请号：US12912913
申请日：2010-10-27
申请人： Dong Keun HAN , Kwi Deok PARK , Jae-Jin KIM , Chul Ho PARK , Seong Bae CHO
发明人： Dong Keun HAN , Kwi Deok PARK , Jae-Jin KIM , Chul Ho PARK , Seong Bae CHO
IPC分类号： A61C8/00 , B05D3/10 , B05D3/06 , B32B15/08 , B32B5/00 , A61F2/82
CPC分类号： B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
摘要： Disclosed is nanocoupling of a polymer onto a surface of a metal substrate for improving coating adhesion of the polymer on the metal substrate, and in vivo stability and durability of the polymer. In accordance with the present invention, the polymers can be grafted via a chemical bonding on the surface of the metal substrate by the nanocoupling, by which adhesion, biocompatibility and durability of a polymer-coated layer which is to be formed later on the metal substrate were remarkably improved; therefore, the nanocoupling according to the present invention can be applied to surface modification of a metal implant, such as stents, mechanical valves, and an articular, a spinal, a dental and an orthopedic implants.
摘要翻译：公开了聚合物在金属基材的表面上的纳米偶联，用于改善聚合物在金属基材上的涂层粘附性，以及聚合物的体内稳定性和耐久性。根据本发明，聚合物可以通过纳米偶联在金属基材的表面上通过化学键接合，由此将在金属基材上稍后形成的聚合物涂覆层的粘附性，生物相容性和耐久性显着改善; 因此，根据本发明的纳米偶联可以应用于诸如支架，机械瓣膜以及关节，脊柱，牙科和矫形植入物的金属植入物的表面改性。

4. 发明申请

US20090317478A1 METHOD OF PREPARING COVERED POROUS BIODEGRADABLE POLYMER MICROSPHERES FOR SUSTAINED-RELEASE DRUG DELIVERY AND TISSUE REGENERATION 有权
标题翻译：制备覆盖多孔生物可降解聚合物微球的方法，用于持续释放药物递送和组织再生
公开(公告)号：US20090317478A1
公开(公告)日：2009-12-24
申请号：US12255163
申请日：2008-10-21
申请人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
发明人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
IPC分类号： A61K9/14 , A61K38/21
CPC分类号： A61K9/1647 , A61K9/1694 , A61K38/00
摘要： The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration.
摘要翻译：本发明涉及用于持续释放药物递送和组织再生的覆盖多孔可生物降解聚合物微球，其具有互连的具有宽表面积和高孔隙率的内开孔结构以及微球表面被覆盖的外封闭孔结构具有可生物降解聚合物的薄层，从而形成在表面上并暴露于外部的孔闭合; 及其制备方法。由于这样的特征性的孔结构，本发明的被覆多孔生物降解性聚合物微球体可以防止生物活性物质在给药后立即早期过度释放，之后可以通过使用生物活性物质逐渐释放生物活性物质随着可生物降解的聚合物薄层的退化，延长的互连内孔结构。因此，本发明的微球体可以有效地用于缓释药物递送和组织再生。

5. 发明申请

US20130189340A1 NITRIC OXIDE DELIVERY SYSTEM USING THERMOSENSITIVE SYNTHETIC POLYMERS 有权
标题翻译：使用热敏合成聚合物的氮氧化物输送系统
公开(公告)号：US20130189340A1
公开(公告)日：2013-07-25
申请号：US13877384
申请日：2011-10-04
申请人： Won Jong Kim , Yanggy Lee , Kwideok Park , Jihoon Kim , Dong Keun Han
发明人： Won Jong Kim , Yanggy Lee , Kwideok Park , Jihoon Kim , Dong Keun Han
IPC分类号： C08G73/02 , A61L27/34
CPC分类号： C08G73/024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/114 , C08G63/6852 , C08G73/0206 , C08L71/02
摘要： A donor capable of controlled release of nitric monoxide and a prosthetic implant whose surface is coated with this donor are disclosed. The donor comprises a main chain of an organic polymer and a side chain that is covalently linked to the main chain and has a diazeniumdiolate functional group. The donor for controlled release of nitric monoxide exists in a fluid state such as liquid at room temperature and undergoes a sol-to-gel phase transition at a physiological pH as the temperature increases above the critical temperature. The critical temperature of the phase transition is in the range of 25 to 35° C., and the gel is a hydrogel without chemical cross-links.
摘要翻译：公开了能够控制释放一氧化氮的供体和其表面涂覆有该供体的假体植入物。供体包括有机聚合物的主链和共价连接到主链并具有二氮烯二硫酸酯官能团的侧链。用于控制释放一氧化氮的供体以室温下的液体状态存在，并且随着温度升高到临界温度以上，在生理pH下经历溶胶 - 凝胶相变。相变的临界温度在25至35℃的范围内，凝胶是没有化学交联的水凝胶。

6. 发明申请

US20130101635A1 METHOD OF PREPARING SELF-ASSEMBLED EXTRACELLULAR MATRICES AND USE OF SELF-ASSEMBLED EXTRACELLULAR MATRICES FORMED BY USING THE METHOD 审中-公开
标题翻译：制备自组装细胞外基质的方法和使用方法制备的自组装细胞外基质的方法
公开(公告)号：US20130101635A1
公开(公告)日：2013-04-25
申请号：US13650670
申请日：2012-10-12
申请人： Kwideok PARK , Soon Eon BAE , Dong Keun HAN
发明人： Kwideok PARK , Soon Eon BAE , Dong Keun HAN
IPC分类号： C12N5/00 , A61K35/32 , A61K35/28
CPC分类号： C12N5/0062 , A61K35/28 , A61K35/32 , C12N2533/90
摘要： Methods of preparing a self-assembled matrix from cell-derived extracellular matrice, and of inducing cell proliferation and differentiation by using the self-assembled matrix, and applying the self-assembled matrix into cell therapy. In detail, unique extracellular matrices obtained from particular cells are collected and then subjected to decellularization in order to form a self-assembled matrix including nano fibers only formed of extracellular matrix. In addition, the matrix prepared as described above provides a platform that is effective for the induction of the mass proliferation or differentiation of cells, and thus, may be applied in manufacturing cell therapy products.
摘要翻译：从细胞衍生的细胞外基质制备自组装基质的方法，以及通过使用自组装基质诱导细胞增殖和分化，以及将自组装基质应用于细胞治疗。详细地，从特定细胞获得的独特的细胞外基质被收集，然后进行脱细胞化以形成仅由细胞外基质形成的纳米纤维的自组装基质。此外，如上所述制备的基质提供了对诱导细胞的大量增殖或分化有效的平台，因此可以应用于制造细胞治疗产品。

7. 发明申请

US20110015395A1 PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE 有权
标题翻译：具有抑制ROS激酶活性的吡咯化合物
公开(公告)号：US20110015395A1
公开(公告)日：2011-01-20
申请号：US12605074
申请日：2009-10-23
申请人： So Ha LEE , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
发明人： So Ha LEE , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
IPC分类号： A61K31/506 , C07D403/04 , C07D401/14 , C07D401/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents.
摘要翻译：本文公开了新颖的吡唑化合物，其药学上可接受的盐，其制备方法及其作为抗癌剂的用途。

8. 发明授权

US06339113B1 Photopolymerizable composite resin compositions for dental restoration 失效
标题翻译：用于牙科修复的光聚合复合树脂组合物
公开(公告)号：US06339113B1
公开(公告)日：2002-01-15
申请号：US09698037
申请日：2000-10-30
申请人： Dong-Keun Han , Kwang-Duk Ahn , Jong-Man Kim , Jin-Hee Jeong
发明人： Dong-Keun Han , Kwang-Duk Ahn , Jong-Man Kim , Jin-Hee Jeong
IPC分类号： C08F246
CPC分类号： C08F2/46 , A61K6/083 , C08F222/1006 , C08F2222/1046 , Y10S522/908 , C08F2222/1033 , C08F2222/1013 , C08L33/00
摘要： The invention relates to a photopolymerizable composite resin composition for dental restoration i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (“Bis-GMA”) and multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in this Bis-GMA molecules, and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The photopolymerizable composite resin composition for dental restoration based on multifunctional prepolymer mixture has better physical and mechanical properties and biocompatibility than the conventional composition based on only Bis-GMA itself.
摘要翻译：本发明涉及一种用于牙科修复的光聚合复合树脂组合物，i）基于2,2-双（4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基）丙烷（“Bis-GMA”）和通过在该Bis-GMA分子中用甲基丙烯酸酯基取代羟基中的氢原子形成的多官能预聚物，和ii）包含稀释剂，无机填料，光引发体系和其它添加剂。基于多官能预聚物混合物的用于牙科修复的可光聚合复合树脂组合物比仅基于Bis-GMA本身的常规组合物具有更好的物理机械性能和生物相容性。

9. 发明授权

US5216087A Process for the preparation of sulfonated polyethyleneoxide-substituted polymers with improved blood compatibility 失效
标题翻译：具有改善血液相容性的磺化聚环氧乙烷取代聚合物的制备方法
公开(公告)号：US5216087A
公开(公告)日：1993-06-01
申请号：US701888
申请日：1991-05-17
申请人： Young-Ha Kim , Seo-Young Jeong , Kwang-Duk Ahn , Dong-Keun Han
发明人： Young-Ha Kim , Seo-Young Jeong , Kwang-Duk Ahn , Dong-Keun Han
IPC分类号： A61L33/00 , A61L33/06 , B01D67/00 , C08G18/08 , C08G18/10 , C08G18/83 , C08G65/22 , C08G65/334
CPC分类号： B01D67/0093 , A61L33/0082 , A61L33/068 , C08G18/0828 , C08G18/10 , C08G18/83 , C08G65/22 , C08G65/3344
摘要： Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide [PEO--(SO.sub.3 H).sub.n ].The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.
摘要翻译：提供了具有改善的血液相容性的新型磺化聚环氧乙烷取代聚合物。通过用具有磺化聚环氧乙烷[PEO-（SO 3 H）n]的氨基甲酸酯，聚酰胺和聚丙烯酰胺等具有酰胺或酰胺基团的活性位点的聚合物底物代替聚合物。根据本发明的聚合物作为与血液接触的循环系统的人造器官如人造心脏，人造血管，人造肾等的建筑材料是有价值的。

10. 发明授权

US08273880B2 Pyrazole compounds with inhibitory activity against ROS kinase 有权
标题翻译：吡唑类化合物对ROS激酶具有抑制活性
公开(公告)号：US08273880B2
公开(公告)日：2012-09-25
申请号：US12605074
申请日：2009-10-23
申请人： So Ha Lee , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
发明人： So Ha Lee , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
IPC分类号： C07D403/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents.
摘要翻译：本文公开了新颖的吡唑化合物，其药学上可接受的盐，其制备方法及其作为抗癌剂的用途。

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