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1. 发明申请

US20090317478A1 METHOD OF PREPARING COVERED POROUS BIODEGRADABLE POLYMER MICROSPHERES FOR SUSTAINED-RELEASE DRUG DELIVERY AND TISSUE REGENERATION 有权
标题翻译：制备覆盖多孔生物可降解聚合物微球的方法，用于持续释放药物递送和组织再生
公开(公告)号：US20090317478A1
公开(公告)日：2009-12-24
申请号：US12255163
申请日：2008-10-21
申请人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
发明人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
IPC分类号： A61K9/14 , A61K38/21
CPC分类号： A61K9/1647 , A61K9/1694 , A61K38/00
摘要： The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration.
摘要翻译：本发明涉及用于持续释放药物递送和组织再生的覆盖多孔可生物降解聚合物微球，其具有互连的具有宽表面积和高孔隙率的内开孔结构以及微球表面被覆盖的外封闭孔结构具有可生物降解聚合物的薄层，从而形成在表面上并暴露于外部的孔闭合; 及其制备方法。由于这样的特征性的孔结构，本发明的被覆多孔生物降解性聚合物微球体可以防止生物活性物质在给药后立即早期过度释放，之后可以通过使用生物活性物质逐渐释放生物活性物质随着可生物降解的聚合物薄层的退化，延长的互连内孔结构。因此，本发明的微球体可以有效地用于缓释药物递送和组织再生。

2. 发明授权

US08192655B2 Method of preparing covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration 有权
标题翻译：制备覆盖多孔可生物降解聚合物微球用于持续释放药物递送和组织再生的方法
公开(公告)号：US08192655B2
公开(公告)日：2012-06-05
申请号：US12255163
申请日：2008-10-21
申请人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
发明人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Jun Sik Son , Soon Eon Bae
IPC分类号： B29B9/00
CPC分类号： A61K9/1647 , A61K9/1694 , A61K38/00
摘要： The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration.
摘要翻译：本发明涉及用于持续释放药物递送和组织再生的覆盖多孔可生物降解聚合物微球，其具有互连的具有宽表面积和高孔隙率的内开孔结构以及微球表面被覆盖的外封闭孔结构具有可生物降解聚合物的薄层，从而形成在表面上并暴露于外部的孔闭合; 及其制备方法。由于这样的特征性的孔结构，本发明的被覆多孔生物降解性聚合物微球体可以防止生物活性物质在给药后立即早期过度释放，之后可以通过使用生物活性物质逐渐释放生物活性物质随着可生物降解的聚合物薄层的退化，延长的互连内孔结构。因此，本发明的微球体可以有效地用于缓释药物递送和组织再生。

3. 发明申请

US20100129422A1 POROUS BIODEGRADABLE POLYMER SCAFFOLDS FOR IN SITU TISSUE REGENERATION AND METHOD FOR THE PREPARATION THEREOF 有权
标题翻译：用于现场组织再生的多孔生物可降解聚合物组合物及其制备方法
公开(公告)号：US20100129422A1
公开(公告)日：2010-05-27
申请号：US12473850
申请日：2009-05-28
申请人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
发明人： Dong Keun HAN , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
IPC分类号： A61F2/00
CPC分类号： A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/414 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2300/604 , A61L2400/18 , C08L67/04
摘要： The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.
摘要翻译：本发明涉及一种用于原位组织再生的智能多孔可生物降解聚合物支架，其中将具有高分化潜能和生物相容性的两种生理活性物质分别引入聚合物支架并与其表面共轭，的制备。由于智能多孔生物可降解聚合物支架由于引入能够有效诱导细胞增殖和分化至其表面和内部的生理活性物质而显示出改善的生物相容性和分化潜能，因此可直接诱导肌肉骨骼系统的原位组织再生从移植聚合物支架和干细胞到人体中的生物体组织中的干细胞，而不需要额外的体外培养。因此，根据本发明的智能多孔生物可降解聚合物支架可以有效地用于包括肌肉骨骼系统在内的各种组织和器官的再生。

4. 发明授权

US08956643B2 Porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof 有权
标题翻译：用于原位组织再生的多孔可生物降解聚合物支架及其制备方法
公开(公告)号：US08956643B2
公开(公告)日：2015-02-17
申请号：US12473850
申请日：2009-05-28
申请人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
发明人： Dong Keun Han , Kwideok Park , Jae-Jin Kim , Soon Eon Bae
IPC分类号： A61F2/00 , A61F13/00 , A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56
CPC分类号： A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/414 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2300/604 , A61L2400/18 , C08L67/04
摘要： The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.
摘要翻译：本发明涉及一种用于原位组织再生的智能多孔可生物降解聚合物支架，其中将具有高分化潜能和生物相容性的两种生理活性物质分别引入聚合物支架并与其表面共轭，的制备。由于智能多孔生物可降解聚合物支架由于引入能够有效诱导细胞增殖和分化至其表面和内部的生理活性物质而显示出改善的生物相容性和分化潜能，因此可直接诱导肌肉骨骼系统的原位组织再生从移植聚合物支架和干细胞到人体中的生物体组织中的干细胞，而不需要额外的体外培养。因此，根据本发明的智能多孔生物可降解聚合物支架可以有效地用于包括肌肉骨骼系统在内的各种组织和器官的再生。

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