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1. 发明授权

US08273880B2 Pyrazole compounds with inhibitory activity against ROS kinase 有权
标题翻译：吡唑类化合物对ROS激酶具有抑制活性
公开(公告)号：US08273880B2
公开(公告)日：2012-09-25
申请号：US12605074
申请日：2009-10-23
申请人： So Ha Lee , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
发明人： So Ha Lee , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
IPC分类号： C07D403/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents.
摘要翻译：本文公开了新颖的吡唑化合物，其药学上可接受的盐，其制备方法及其作为抗癌剂的用途。

2. 发明申请

US20110015395A1 PYRAZOLE COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST ROS KINASE 有权
标题翻译：具有抑制ROS激酶活性的吡咯化合物
公开(公告)号：US20110015395A1
公开(公告)日：2011-01-20
申请号：US12605074
申请日：2009-10-23
申请人： So Ha LEE , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
发明人： So Ha LEE , Kyung Ho Yoo , Chang Hyun Oh , Dong Keun Han , Ibrahim Mustafa El-Deeb , Byung Sun Park , Su Jin Jung
IPC分类号： A61K31/506 , C07D403/04 , C07D401/14 , C07D401/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Disclosed herein are novel pyrazole compounds, pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof as anticancer agents.
摘要翻译：本文公开了新颖的吡唑化合物，其药学上可接受的盐，其制备方法及其作为抗癌剂的用途。

3. 发明申请

US20120130069A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：新颖的吲哚衍生物或其药学上可接受的盐作为蛋白激酶抑制剂用于增殖性疾病治疗，以及含有作为活性成分的药物组合物
公开(公告)号：US20120130069A1
公开(公告)日：2012-05-24
申请号：US13132772
申请日：2009-12-04
申请人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
发明人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
IPC分类号： C07D413/14 , C07D409/12 , C07D403/12 , C07D405/12 , A61P17/06 , C07D401/12 , C07D417/12 , C07D417/14 , A61P35/00 , A61P35/02 , C07D231/56 , C07D413/12
CPC分类号： C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
摘要翻译：公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病增殖。

4. 发明授权

US08754209B2 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient 有权
标题翻译：作为用于增殖性疾病治疗的蛋白激酶抑制剂的吲唑衍生物或其药学上可接受的盐，以及含有该活性成分的药物组合物
公开(公告)号：US08754209B2
公开(公告)日：2014-06-17
申请号：US13132772
申请日：2009-12-04
申请人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
发明人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
IPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D401/12 , C07D405/12 , C07D403/12 , C07D409/12 , C07D231/56
CPC分类号： C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
摘要翻译：公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病增殖。

5. 发明授权

US08765749B2 1,6-disubstituted indole compounds as protein kinase inhibitors 有权
标题翻译： 1,6-二取代的吲哚化合物作为蛋白激酶抑制剂
公开(公告)号：US08765749B2
公开(公告)日：2014-07-01
申请号：US13504355
申请日：2010-10-20
申请人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
发明人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
IPC分类号： C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14
CPC分类号： C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
摘要翻译：公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

6. 发明授权

US08329708B2 1,3,6-substituted indole derivatives having inhibitory activity for protein kinase 有权
标题翻译：具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物
公开(公告)号：US08329708B2
公开(公告)日：2012-12-11
申请号：US12858114
申请日：2010-08-17
申请人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
发明人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
摘要翻译：公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

7. 发明申请

US20120271048A1 NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：新的1,6-二异氰酸酯化合物作为蛋白激酶抑制剂
公开(公告)号：US20120271048A1
公开(公告)日：2012-10-25
申请号：US13504355
申请日：2010-10-20
申请人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
发明人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
IPC分类号： C07D403/04 , C07D487/04 , C07D413/14
CPC分类号： C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
摘要翻译：公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

8. 发明申请

US20110046370A1 1,3,6-SUBSTITUTED INDOLE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 有权
标题翻译：具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物
公开(公告)号：US20110046370A1
公开(公告)日：2011-02-24
申请号：US12858114
申请日：2010-08-17
申请人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
发明人： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
IPC分类号： C07D401/14 , C07D401/04 , C07D413/14
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14
摘要： Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
摘要翻译：公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。

9. 发明申请

US20090071492A1 Extension hair production 审中-公开
标题翻译：延长头发生产
公开(公告)号：US20090071492A1
公开(公告)日：2009-03-19
申请号：US11900662
申请日：2007-09-13
申请人： Chang Hyun Oh
发明人： Chang Hyun Oh
IPC分类号： A41G5/00
CPC分类号： A41G5/006
摘要： The present invention comprises various hair extension methods for implementing without glue. Our system does not require heat or chemicals for attachment or strong solvents for removal. Anyone familiar with the hair industry knows what damage that these harsh chemicals can cause. This invention looks and feels completely natural and are easy to wash and style and also can be colored or permed. Our system is so gentle that it can be used on the most sensitive and difficult areas such as the top area of head. It is as light as feather, you won't even know that you're wearing it.This hair extension method can add more length and volume without the discomfort of weaves and glues. It's gentle, light and ultra thin. User can even add hair to the sensitive top area.
摘要翻译：本发明包括用于无胶水实施的各种发丝方法。我们的系统不需要热或化学物质的附着或强溶剂去除。任何熟悉头发行业的人都知道这些恶劣的化学物质会造成什么损害。本发明看起来和感觉完全自然，易于洗涤和风格，也可以着色或烫发。我们的系统非常温和，可以用于最敏感和困难的领域，如头顶部。它像羽毛一样轻，你甚至不知道你穿着它。这种发丝方法可以增加更多的长度和体积，而不会造成编织和胶水的不适。它温柔，轻盈，超薄。用户甚至可以将头发添加到敏感的顶部区域。

10. 发明授权

US08168797B2 Oxazolidinone derivative with difluorophenyl moiety, pharmaceutically acceptable salt thereof, preparation method thereof and antibiotic composition containing the same as an active ingredient 有权
标题翻译：具有二氟苯基部分的恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和含有其作为活性成分的抗生素组合物
公开(公告)号：US08168797B2
公开(公告)日：2012-05-01
申请号：US12277364
申请日：2008-11-25
申请人： Chang Hyun Oh , Jung Hyuck Cho
发明人： Chang Hyun Oh , Jung Hyuck Cho
IPC分类号： C07D413/00 , C07D263/00 , A61K31/42 , A61K31/421
CPC分类号： C07D413/10
摘要： Novel oxazolidinone derivatives with a difluorophenyl moiety, represented by Chemical Formula 1, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same as an active ingredient are provided. Exhibiting potent inhibitory activity against Gram-positive bacteria including Haemophilus influenza and Coagulase negative staphylococci and resistant bacteria including vancomycin-resistant enterococci (VRE), the pharmaceutical composition is useful as an antibiotic (wherein, R is as defined in the specification).
摘要翻译：提供了具有二氟苯基部分的新型恶唑烷酮衍生物，由化学式1表示，其药学上可接受的盐，其制备方法和含有该活性成分的药物组合物。对抗革兰氏阳性菌（包括嗜血杆菌流感和凝固酶阴性葡萄球菌）和抗万古霉素抗性肠球菌（VRE）的抗性细菌具有强效抑制活性，该药物组合物可用作抗生素（其中R如说明书中所定义）。

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